Il21 (interleukin 21) - Rat Genome Database

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Gene: Il21 (interleukin 21) Rattus norvegicus
Analyze
Symbol: Il21
Name: interleukin 21
RGD ID: 1307384
Description: Predicted to enable interleukin-2 receptor binding activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune effector process; and tyrosine phosphorylation of STAT protein. Predicted to act upstream of or within positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency 11; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH bisphenol A; D-penicillamine; 1-chloro-2,4-dinitrobenzene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-21; interleukin-21; LOC365769
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Iddm32
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22120,119,598 - 120,126,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,119,444 - 120,126,996 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,682,458 - 126,689,816 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02124,794,962 - 124,802,318 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02119,423,940 - 119,431,294 (-)NCBIRnor_WKY
Rnor_6.02123,965,021 - 123,972,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,965,021 - 123,972,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,573,215 - 143,580,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,774,331 - 123,781,697 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,697,822 - 123,750,231 (-)NCBI
Celera2115,067,969 - 115,075,326 (-)NCBICelera
Cytogenetic Map2q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis. Abe K, etal., Springerplus. 2016 Jun 18;5(1):777. doi: 10.1186/s40064-016-2512-y. eCollection 2016.
2. Possible role of interleukin 21 and interleukin 33 in patients with genital warts. Abu El-Hamd M, etal., Dermatol Ther. 2019 Sep;32(5):e13063. doi: 10.1111/dth.13063. Epub 2019 Aug 29.
3. Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis. Andersson A, etal., PLoS One. 2008;3(11):e3682. Epub 2008 Nov 10.
4. Interleukin-21-dependent modulation of T cell antigen receptor reactivity towards low affinity peptide ligands in autoreactive CD8(+) T lymphocytes. Bobbala D, etal., Cytokine. 2016 Sep;85:83-91. doi: 10.1016/j.cyto.2016.06.011. Epub 2016 Jun 11.
5. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. Caruso R, etal., J Immunol. 2007 May 1;178(9):5957-65. doi: 10.4049/jimmunol.178.9.5957.
6. A common exonic variant of interleukin21 confers susceptibility to atopic asthma. Chatterjee R, etal., Int Arch Allergy Immunol. 2009;148(2):137-46. Epub 2008 Sep 19.
7. Genome-wide analysis of extended pedigrees confirms IL2-IL21 linkage and shows additional regions of interest potentially influencing coeliac disease risk. Einarsdottir E, etal., Tissue Antigens. 2011 Dec;78(6):428-37. doi: 10.1111/j.1399-0039.2011.01791.x.
8. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. Eto D, etal., PLoS One. 2011 Mar 14;6(3):e17739. doi: 10.1371/journal.pone.0017739.
9. HCV-specific interleukin-21+CD4+ T cells responses associated with viral control through the modulation of HCV-specific CD8+ T cells function in chronic hepatitis C patients. Feng G, etal., Mol Cells. 2013 Oct;36(4):362-7. doi: 10.1007/s10059-013-0181-z. Epub 2013 Oct 22.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Promotion of a functional B cell germinal center response after Leishmania species co-infection is associated with lesion resolution. Gibson-Corley KN, etal., Am J Pathol. 2012 May;180(5):2009-17. doi: 10.1016/j.ajpath.2012.01.012. Epub 2012 Mar 17.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Combinatory gene therapy with electrotransfer of midkine promoter-HSV-TK and interleukin-21. Hanari N, etal., Anticancer Res. 2007 Jul-Aug;27(4B):2305-10.
14. Antitumor efficacy of viable tumor vaccine modified by heterogenetic ESAT-6 antigen and cytokine IL-21 in melanomatous mouse. He X, etal., Immunol Res. 2012 Jun;52(3):240-9. doi: 10.1007/s12026-012-8332-4.
15. Association of IL-17, IL-21, and IL-23R gene polymorphisms with HBV infection in kidney transplant patients. Hejr S, etal., Viral Immunol. 2013 Jun;26(3):201-6. doi: 10.1089/vim.2013.0007. Epub 2013 May 8.
16. IL-21 administration into the nostril alleviates murine allergic rhinitis. Hiromura Y, etal., J Immunol. 2007 Nov 15;179(10):7157-65.
17. Interleukin-21 mRNA expression during virus infections. Holm C, etal., Cytokine. 2006 Jan 7;33(1):41-5. doi: 10.1016/j.cyto.2005.11.014. Epub 2006 Jan 5.
18. Immunization with DNA vaccine expressing herpes simplex virus type 1 gD and IL-21 protects against mouse herpes keratitis. Hu K, etal., Immunol Invest. 2011;40(3):265-78. doi: 10.3109/08820139.2010.534219. Epub 2011 Jan 4.
19. Interleukin-21 is upregulated in hepatitis B-related acute-on-chronic liver failure and associated with severity of liver disease. Hu X, etal., J Viral Hepat. 2011 Jul;18(7):458-67. doi: 10.1111/j.1365-2893.2011.01475.x. Epub 2011 Jun 1.
20. Interleukin-21 receptor signalling is important for innate immune protection against HSV-2 infections. Kratholm SK, etal., PLoS One. 2013 Dec 16;8(12):e81790. doi: 10.1371/journal.pone.0081790. eCollection 2013.
21. Gene-gene and gene-sex epistatic interactions of MiR146a, IRF5, IKZF1, ETS1 and IL21 in systemic lupus erythematosus. Leng RX, etal., PLoS One. 2012;7(12):e51090. doi: 10.1371/journal.pone.0051090. Epub 2012 Dec 7.
22. Interleukin-21 responses in patients with chronic hepatitis B. Li J, etal., J Interferon Cytokine Res. 2015 Feb;35(2):134-42. doi: 10.1089/jir.2013.0119. Epub 2014 Sep 22.
23. IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection. Li N, etal., Hum Immunol. 2013 May;74(5):567-73. doi: 10.1016/j.humimm.2013.01.005. Epub 2013 Jan 24.
24. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
25. Interleukin-21 Is Associated with Early Antiviral Response in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B and Nonalcoholic Fatty Liver Disease. Liu X, etal., J Interferon Cytokine Res. 2016 Jun;36(6):367-73. doi: 10.1089/jir.2015.0129. Epub 2016 Feb 3.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection. Moretto MM and Khan IA, J Immunol. 2016 Jan 1;196(1):375-84. doi: 10.4049/jimmunol.1501258. Epub 2015 Nov 23.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Increased levels of IL-21 responses are associated with the severity of liver injury in patients with chronic active hepatitis B. Pan Q, etal., J Viral Hepat. 2014;21(9):e78-88. doi: 10.1111/jvh.12242. Epub 2014 Mar 10.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria. Pérez-Mazliah D, etal., PLoS Pathog. 2015 Mar 12;11(3):e1004715. doi: 10.1371/journal.ppat.1004715. eCollection 2015 Mar.
32. Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Rajaei T, etal., Med Microbiol Immunol. 2017 Jun;206(3):195-201. doi: 10.1007/s00430-017-0492-3. Epub 2017 Apr 4.
33. Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1. Ren G, etal., AIDS. 2012 Nov 13;26(17):2145-53. doi: 10.1097/QAD.0b013e328359b7ae.
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Comprehensive gene review and curation RGD comprehensive gene curation
37. IL-21 and IL-15 cytokine DNA augments HSV specific effector and memory CD8+ T cell response. Rodrigues L, etal., Mol Immunol. 2009 Apr;46(7):1494-504. doi: 10.1016/j.molimm.2008.12.033. Epub 2009 Feb 23.
38. Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes. Rydén AK, etal., J Autoimmun. 2017 Nov;84:65-74. doi: 10.1016/j.jaut.2017.07.006. Epub 2017 Jul 12.
39. IL-21-based therapies induce clearance of hepatitis B virus persistence in mouse models. Shen Z, etal., Theranostics. 2019 May 31;9(13):3798-3811. doi: 10.7150/thno.35331. eCollection 2019.
40. Characterization of IL-21-expressing recombinant hepatitis B virus (HBV) as a therapeutic agent targeting persisting HBV infection. Shen Z, etal., Theranostics. 2020 Apr 25;10(12):5600-5612. doi: 10.7150/thno.44715. eCollection 2020.
41. IL-21 promotes the pathologic immune response to pneumovirus infection. Spolski R, etal., J Immunol. 2012 Feb 15;188(4):1924-32. Epub 2012 Jan 11.
42. IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection. Stumhofer JS, etal., PLoS One. 2013 May 7;8(5):e62889. doi: 10.1371/journal.pone.0062889. Print 2013.
43. Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal dysbiosis in rats through T helper 17/T regulatory cell signaling pathway. Sun Z, etal., J Tradit Chin Med. 2020 Feb;40(1):38-48.
44. Interleukin 21 Reinvigorates the Antiviral Activity of Hepatitis B Virus (HBV)-Specific CD8+ T Cells in Chronic HBV Infection. Tang L, etal., J Infect Dis. 2019 Feb 15;219(5):750-759. doi: 10.1093/infdis/jiy576.
45. Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis. Tang R, etal., Immunotherapy. 2018 Mar;10(3):189-200. doi: 10.2217/imt-2017-0060.
46. Dynamics of interleukin-21 production during the clinical course of primary and secondary dengue virus infections. Vivanco-Cid H, etal., Immunol Lett. 2014 Sep;161(1):89-95. doi: 10.1016/j.imlet.2014.05.006. Epub 2014 May 22.
47. Immune correlates of hepatitis B surface antigen spontaneous seroconversion in hepatitis B e antigen negative chronic hepatitis B patients. Vyas AK, etal., Liver Int. 2018 Jan;38(1):38-49. doi: 10.1111/liv.13475. Epub 2017 Jun 1.
48. Dysregulated Response of Follicular Helper T Cells to Hepatitis B Surface Antigen Promotes HBV Persistence in Mice and Associates With Outcomes of Patients. Wang X, etal., Gastroenterology. 2018 Jun;154(8):2222-2236. doi: 10.1053/j.gastro.2018.03.021. Epub 2018 Mar 12.
49. Role of interleukin-21 and interleukin-21 receptor polymorphisms in the treatment of HBeAg-positive chronic hepatitis B patients with peginterferon. Wang X, etal., Medicine (Baltimore). 2018 Jun;97(23):e10891. doi: 10.1097/MD.0000000000010891.
50. Cerebrospinal fluid IL-21 levels in Neuromyelitis Optica and multiple sclerosis. Wu A, etal., Can J Neurol Sci. 2012 Nov;39(6):813-20. doi: 10.1017/s0317167100015663.
51. Increased frequency of follicular helper T cells in mice viral myocarditis is relevant with anti-ANT antoantibody. Yang F, etal., Virol J. 2015 Feb 11;12:20. doi: 10.1186/s12985-015-0257-9.
52. Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population. Yao JY, etal., World J Gastroenterol. 2015 Apr 14;21(14):4232-9. doi: 10.3748/wjg.v21.i14.4232.
53. Interleukin-21 (IL-21) Downregulates Dendritic Cell Cytokine Responses to Helicobacter pylori and Modulates T Lymphocyte IL-17A Expression in Peyer's Patches during Infection. Yasmin S, etal., Infect Immun. 2019 Oct 18;87(11). pii: IAI.00237-19. doi: 10.1128/IAI.00237-19. Print 2019 Nov.
54. Fusobacterium Nucleatum Subspecies Animalis Influences Proinflammatory Cytokine Expression and Monocyte Activation in Human Colorectal Tumors. Ye X, etal., Cancer Prev Res (Phila). 2017 Jul;10(7):398-409. doi: 10.1158/1940-6207.CAPR-16-0178. Epub 2017 May 8.
55. IL-21 promotes late activator APC-mediated T follicular helper cell differentiation in experimental pulmonary virus infection. Yoo JK and Braciale TJ, PLoS One. 2014 Sep 24;9(9):e105872. doi: 10.1371/journal.pone.0105872. eCollection 2014.
Additional References at PubMed
PMID:11081504   PMID:12244150   PMID:12504082   PMID:14635054   PMID:14764669   PMID:15207081   PMID:16482511   PMID:17673207   PMID:18005035   PMID:19322899  


Genomics

Comparative Map Data
Il21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22120,119,598 - 120,126,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,119,444 - 120,126,996 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,682,458 - 126,689,816 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02124,794,962 - 124,802,318 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02119,423,940 - 119,431,294 (-)NCBIRnor_WKY
Rnor_6.02123,965,021 - 123,972,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,965,021 - 123,972,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,573,215 - 143,580,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,774,331 - 123,781,697 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,697,822 - 123,750,231 (-)NCBI
Celera2115,067,969 - 115,075,326 (-)NCBICelera
Cytogenetic Map2q25NCBI
IL21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,610,108 - 122,621,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4122,610,108 - 122,621,066 (-)EnsemblGRCh38hg38GRCh38
GRCh374123,531,263 - 123,542,221 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,739,272 - 123,761,662 (-)NCBINCBI36Build 36hg18NCBI36
Build 344123,891,388 - 123,899,817NCBI
Celera4120,916,832 - 120,925,261 (-)NCBICelera
Cytogenetic Map4q27NCBI
HuRef4119,260,228 - 119,268,550 (-)NCBIHuRef
CHM1_14123,510,250 - 123,518,679 (-)NCBICHM1_1
T2T-CHM13v2.04125,914,209 - 125,925,168 (-)NCBIT2T-CHM13v2.0
Il21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,276,908 - 37,286,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,276,908 - 37,286,785 (-)EnsemblGRCm39 Ensembl
GRCm38337,222,759 - 37,232,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,222,759 - 37,232,636 (-)EnsemblGRCm38mm10GRCm38
MGSCv37337,121,681 - 37,131,540 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,107,141 - 37,117,000 (-)NCBIMGSCv36mm8
MGSCv36337,414,308 - 37,424,167 (-)NCBIMGSCv36mm8
Celera337,106,874 - 37,116,609 (-)NCBICelera
Cytogenetic Map3BNCBI
Il21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,057,096 - 18,065,492 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542818,057,096 - 18,065,492 (+)NCBIChiLan1.0ChiLan1.0
IL21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14125,940,979 - 125,951,915 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,943,495 - 125,951,915 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04114,795,979 - 114,806,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IL21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,641,833 - 17,651,275 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1917,641,833 - 17,651,266 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,860,011 - 17,869,452 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,760,158 - 17,769,609 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1917,760,158 - 17,769,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11917,712,780 - 17,722,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,993,018 - 18,002,469 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,463,313 - 18,472,753 (+)NCBIUU_Cfam_GSD_1.0
Il21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530165,422,896 - 65,429,900 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366621,689,879 - 1,696,883 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366621,689,879 - 1,696,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,532,531 - 101,541,713 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,532,742 - 101,540,712 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,688,772 - 108,696,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1769,859,793 - 69,872,237 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl769,863,535 - 69,872,025 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603748,822,863 - 48,834,392 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,054,368 - 3,061,304 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247773,054,368 - 3,061,304 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il21
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:62
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000023348
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 8 9 3 8 3 28 10 1
Below cutoff 23 19 15 10 15 4 5 31 20 24 7 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023348   ⟹   ENSRNOP00000023348
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2120,119,638 - 120,126,996 (-)Ensembl
Rnor_6.0 Ensembl2123,965,021 - 123,972,356 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110753   ⟹   ENSRNOP00000097142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2120,119,444 - 120,126,996 (-)Ensembl
RefSeq Acc Id: NM_001108943   ⟹   NP_001102413
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22120,119,598 - 120,126,941 (-)NCBI
Rnor_6.02123,965,021 - 123,972,356 (-)NCBI
Rnor_5.02143,573,215 - 143,580,530 (-)NCBI
RGSC_v3.42123,774,331 - 123,781,697 (-)RGD
Celera2115,067,969 - 115,075,326 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102413 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A3QPB9 (Get FASTA)   NCBI Sequence Viewer  
  ABD52001 (Get FASTA)   NCBI Sequence Viewer  
  CBE74756 (Get FASTA)   NCBI Sequence Viewer  
  EDM01297 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102413   ⟸   NM_001108943
- Peptide Label: precursor
- UniProtKB: A3QPB9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023348   ⟸   ENSRNOT00000023348
RefSeq Acc Id: ENSRNOP00000097142   ⟸   ENSRNOT00000110753

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A3QPB9-F1-model_v2 AlphaFold A3QPB9 1-146 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307384 AgrOrtholog
BioCyc Gene G2FUF-53308 BioCyc
Ensembl Genes ENSRNOG00000017376 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023348.5 UniProtKB/TrEMBL
  ENSRNOP00000097142 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023348.5 UniProtKB/TrEMBL
  ENSRNOT00000110753 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-15/IL-21_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:365769 UniProtKB/Swiss-Prot
NCBI Gene 365769 ENTREZGENE
PANTHER PTHR14356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL15 UniProtKB/Swiss-Prot
PhenoGen Il21 PhenoGen
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QC17_RAT UniProtKB/TrEMBL
  A3QPB9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Il21  interleukin 21   Il21_predicted  interleukin 21 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Il21_predicted  interleukin 21 (predicted)      Symbol and Name status set to approved 70820 APPROVED