RGD Reference Report - A locus for eosinophilia in the MES rat is on Chromosome 19. - Rat Genome Database

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A locus for eosinophilia in the MES rat is on Chromosome 19.

Authors: Li, G  Guo, Z  Higuchi, K  Kawakubo, M  Matsumoto, K  Mori, M 
Citation: Li G, etal., Mamm Genome. 2005 Jul;16(7):516-23.
RGD ID: 5135221
Pubmed: (View Article at PubMed) PMID:16151696
DOI: Full-text: DOI:10.1007/s00335-004-2454-5

Matsumoto Eosinophilia Shinshu (MES) is a rat strain that spontaneously develops eosinophilia and eosinophil-related inflammatory lesions in many organs. We performed chromosomal mapping of the gene for eosinophilia by breeding backcross progeny. The onset of eosinophilia appeared to be delayed in the progeny compared with that in MES, with the prevalence of eosinophilia in the backcross progeny at 12 weeks of age being 22.5%. Genetic linkage analysis with marker loci indicated the major locus for eosinophilia was located at the end of the q arm region of Chromosome 19 (between D19Rat8 and telomere). The locus was denoted eosinophilia 1 (eos1). These data will form the basis for identification of the eos1 gene using a reverse genetic approach, which will hopefully lead to elucidation of the mechanisms involved in eosinophilia and eosinophilopoiesis.

Annotation

Disease Annotations    
Eosinophilia  (IAGP)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Leukc1  (Leukocyte quantity QTL 1)
Leukc2  (Leukocyte quantity QTL 2)

Objects referenced in this article
QTL Leukc3 Leukocyte quantity QTL 3 Rattus norvegicus
Strain MES/Slc Matsumoto Eosinophilia Shinshu Rattus norvegicus

Additional Information