P2ry12 (purinergic receptor P2Y12) - Rat Genome Database

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Gene: P2ry12 (purinergic receptor P2Y12) Rattus norvegicus
Analyze
Symbol: P2ry12
Name: purinergic receptor P2Y12
RGD ID: 621681
Description: Enables G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; monoatomic cation transmembrane transport; and positive regulation of cellular component biogenesis. Located in basal plasma membrane; caveola; and external side of plasma membrane. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; ticlopidine pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: P2Y purinoceptor 12; P2y12; P2Y12 platelet ADP receptor; purinergic receptor P2Y, G-protein coupled 12; purinergic receptor P2Y, G-protein coupled, 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82145,631,487 - 145,673,194 (-)NCBIGRCr8
mRatBN7.22143,481,468 - 143,523,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2143,481,430 - 143,523,361 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2150,121,752 - 150,124,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02148,234,328 - 148,237,278 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02142,866,741 - 142,869,691 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02149,440,807 - 149,482,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2149,441,598 - 149,444,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02168,873,062 - 168,914,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,611,035 - 148,613,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12148,560,997 - 148,563,948 (-)NCBI
Celera2137,906,910 - 137,909,860 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO,ISS)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
calcium ion transmembrane transport  (IDA)
calcium-mediated signaling  (IMP)
cell projection organization  (IMP)
cellular response to ATP  (IMP,ISO,ISS)
cellular response to organic cyclic compound  (ISO)
cerebral cortex radial glia-guided migration  (IMP)
establishment of localization in cell  (ISO)
G protein-coupled adenosine receptor signaling pathway  (IMP)
G protein-coupled purinergic nucleotide receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway  (IBA,IMP,ISO)
glial cell migration  (IMP)
lamellipodium assembly  (IMP)
monoatomic ion transport  (ISO)
negative regulation of cell differentiation  (IMP)
negative regulation of norepinephrine secretion  (IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP)
platelet activation  (ISO)
platelet aggregation  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (IGI)
positive regulation of chemotaxis  (IMP)
positive regulation of integrin activation by cell surface receptor linked signal transduction  (IDA)
positive regulation of microglial cell migration  (IMP)
positive regulation of monoatomic ion transport  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
positive regulation of ruffle assembly  (IMP)
potassium ion transmembrane transport  (IDA)
regulation of calcium ion transport  (IMP)
regulation of chemotaxis  (IMP)
regulation of microglial cell migration  (ISO,ISS)
response to axon injury  (IDA)
substrate-dependent cell migration, cell extension  (ISO,ISS)
visual system development  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain. Ando RD, etal., Br J Pharmacol. 2010 Mar;159(5):1106-17. Epub 2010 Feb 5.
2. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. Andre P, etal., J Clin Invest. 2003 Aug;112(3):398-406.
3. Long-term outcome of tumor necrosis factor alpha antagonist's treatment in pediatric Crohn's disease. Assa A, etal., J Crohns Colitis. 2012 Apr 4.
4. Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts. Barrabes JA, etal., Thromb Haemost. 2010 Jul;104(1):128-35. Epub 2010 Apr 29.
5. Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma. Bunyavanich S, etal., Clin Exp Allergy. 2012 Feb;42(2):229-37.
6. Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model. Dai J, etal., J Vasc Surg. 2009 Mar;49(3):719-27. Epub 2008 Nov 22.
7. TGF-beta and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. De Simone R, etal., J Neurochem. 2010 Oct;115(2):450-9. doi: 10.1111/j.1471-4159.2010.06937.x. Epub 2010 Aug 30.
8. P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study. Fontana P, etal., Circulation. 2003 Dec 16;108(24):2971-3. Epub 2003 Dec 8.
9. Clopidogrel, a P2Y12 receptor antagonist, potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis. Garcia AE, etal., PLoS One. 2011;6(10):e26035. Epub 2011 Oct 18.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Activated platelets in heparinized shed blood: the "second hit" of acute lung injury in trauma/hemorrhagic shock models. Harr JN, etal., Shock. 2011 Dec;36(6):595-603.
12. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Hollopeter G, etal., Nature 2001 Jan 11;409(6817):202-7.
13. Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia. Irino Y, etal., J Neurosci Res. 2008 May 15;86(7):1511-9. doi: 10.1002/jnr.21610.
14. Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells. Krzeminski P, etal., Brain Res Bull. 2007 Mar 30;71(6):587-92. Epub 2006 Dec 22.
15. Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels. Lechner SG, etal., Eur J Neurosci. 2004 Dec;20(11):2917-28.
16. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Maeda M, etal., Glia. 2010 Nov 15;58(15):1838-46.
17. Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior. Malin SA and Molliver DC, Mol Pain. 2010 Apr 15;6:21.
18. P2Y12 receptors play a significant role in the development of platelet microaggregation in patients with diabetes. Matsuno H, etal., J Clin Endocrinol Metab. 2005 Feb;90(2):920-7. Epub 2004 Oct 13.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. Ohsawa K, etal., Glia. 2007 Apr 15;55(6):604-16. doi: 10.1002/glia.20489.
22. P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP. Ohsawa K, etal., Glia. 2010 May;58(7):790-801.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. Paruchuri S, etal., J Exp Med. 2009 Oct 26;206(11):2543-55. Epub 2009 Oct 12.
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. Quintas C, etal., Neurochem Int. 2009 Dec;55(7):505-13. Epub 2009 May 15.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain. Sasaki Y, etal., Glia. 2003 Dec;44(3):242-50. doi: 10.1002/glia.10293.
31. Impaired platelet function in a patient with P2Y12 deficiency caused by a mutation in the translation initiation codon. Shiraga M, etal., J Thromb Haemost. 2005 Oct;3(10):2315-23.
32. Characterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cells. Simon J, etal., J Biol Chem 2002 Aug 30;277(35):31390-400.
33. CalDAG-GEFI deficiency protects mice in a novel model of Fcgamma RIIA-mediated thrombosis and thrombocytopenia. Stolla M, etal., Blood. 2011 Jul 28;118(4):1113-20. Epub 2011 Jun 7.
34. P2Y1, P2Y6, and P2Y12 receptors in rat splenic sinus endothelial cells: an immunohistochemical and ultrastructural study. Uehara K and Uehara A, Histochem Cell Biol. 2011 Nov;136(5):557-67. Epub 2011 Aug 31.
35. Both ADP and thrombin regulate arteriolar thrombus stabilization and embolization, but are not involved in initial hemostasis as induced by micropuncture. van Gestel MA, etal., Microcirculation. 2007 Apr-May;14(3):193-205.
36. Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis. van Giezen JJ, etal., Thromb Res. 2009 Nov;124(5):565-71. Epub 2009 Aug 18.
37. P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B. Van Kolen K and Slegers H, J Neurochem. 2004 Apr;89(2):442-53.
38. 2-Alkylthio-substituted platelet P2Y12 receptor antagonists reveal pharmacological identity between the rat brain Gi-linked ADP receptors and P2Y12. Vasiljev KS, etal., Neuropharmacology. 2003 Jul;45(1):145-54.
39. Transcriptional down-regulation of the platelet ADP receptor P2Y(12) and clusterin in patients with systemic lupus erythematosus. Wang L, etal., J Thromb Haemost. 2004 Aug;2(8):1436-42.
40. Involvement of platelet activation by P2Y12 receptor in the development of transplant arteriosclerosis in mice. Yashiro K, etal., Transplantation. 2009 Mar 15;87(5):660-7.
41. Association of a functional polymorphism in the clopidogrel target receptor gene, P2Y12, and the risk for ischemic cerebrovascular events in patients with peripheral artery disease. Ziegler S, etal., Stroke. 2005 Jul;36(7):1394-9. Epub 2005 Jun 2.
Additional References at PubMed
PMID:11104774   PMID:11413167   PMID:12578987   PMID:15914557   PMID:16236484   PMID:16831517   PMID:17115040   PMID:17989111   PMID:18337420   PMID:18463248   PMID:19811450   PMID:22139091  
PMID:22458630   PMID:22871113   PMID:23382103   PMID:23479225   PMID:24117220   PMID:24747445   PMID:24971933   PMID:25064036   PMID:26743169   PMID:26948129   PMID:29159762   PMID:29574630  
PMID:30084083   PMID:30598122   PMID:33908199   PMID:35581507   PMID:35644421  


Genomics

Comparative Map Data
P2ry12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82145,631,487 - 145,673,194 (-)NCBIGRCr8
mRatBN7.22143,481,468 - 143,523,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2143,481,430 - 143,523,361 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2150,121,752 - 150,124,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02148,234,328 - 148,237,278 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02142,866,741 - 142,869,691 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02149,440,807 - 149,482,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2149,441,598 - 149,444,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02168,873,062 - 168,914,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,611,035 - 148,613,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12148,560,997 - 148,563,948 (-)NCBI
Celera2137,906,910 - 137,909,860 (-)NCBICelera
Cytogenetic Map2q26NCBI
P2RY12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383151,336,843 - 151,384,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3151,336,843 - 151,384,753 (-)EnsemblGRCh38hg38GRCh38
GRCh373151,054,631 - 151,102,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363152,538,066 - 152,585,234 (-)NCBINCBI36Build 36hg18NCBI36
Build 343152,538,073 - 152,541,283NCBI
Celera3149,468,086 - 149,515,254 (-)NCBICelera
Cytogenetic Map3q25.1NCBI
HuRef3148,427,988 - 148,475,876 (-)NCBIHuRef
CHM1_13151,017,744 - 151,065,720 (-)NCBICHM1_1
T2T-CHM13v2.03154,087,845 - 154,135,691 (-)NCBIT2T-CHM13v2.0
P2ry12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39359,123,692 - 59,170,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl359,123,693 - 59,170,292 (-)EnsemblGRCm39 Ensembl
GRCm38359,216,271 - 59,262,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl359,216,272 - 59,262,871 (-)EnsemblGRCm38mm10GRCm38
MGSCv37359,020,193 - 59,066,753 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36359,304,201 - 59,350,751 (-)NCBIMGSCv36mm8
Celera358,903,452 - 58,949,752 (-)NCBICelera
Cytogenetic Map3DNCBI
cM Map329.01NCBI
P2ry12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554482,442,368 - 2,488,567 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554482,442,368 - 2,488,567 (-)NCBIChiLan1.0ChiLan1.0
P2RY12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22149,235,279 - 149,282,898 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13149,240,013 - 149,287,633 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03148,364,151 - 148,412,231 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13155,934,333 - 155,981,818 (-)NCBIpanpan1.1PanPan1.1panPan2
P2RY12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12345,908,574 - 45,954,675 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2345,909,485 - 45,910,526 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2345,774,299 - 45,775,340 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02346,535,240 - 46,581,332 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2346,535,243 - 46,581,291 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12346,125,167 - 46,126,208 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02346,177,435 - 46,178,476 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02346,454,355 - 46,455,396 (-)NCBIUU_Cfam_GSD_1.0
P2ry12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560290,143,659 - 90,185,986 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367581,581,897 - 1,592,222 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367581,581,828 - 1,624,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1391,521,817 - 91,572,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11391,522,754 - 91,572,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21399,604,550 - 99,654,172 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11539,315,140 - 39,361,614 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1539,359,612 - 39,360,637 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604112,130,267 - 12,177,497 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2ry12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473028,772,525 - 28,782,431 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473028,771,020 - 28,819,179 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2ry12
192 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:42
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000018600
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2142323368146786035Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2142323368146786035Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2142323368146786035Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2142323368146786035Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368147803808Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
BF392058  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22143,482,492 - 143,482,610 (+)MAPPERmRatBN7.2
Rnor_6.02149,441,629 - 149,441,746NCBIRnor6.0
Rnor_5.02168,873,884 - 168,874,001UniSTSRnor5.0
RGSC_v3.42148,611,066 - 148,611,183UniSTSRGSC3.4
Celera2137,906,941 - 137,907,058UniSTS
RH 3.4 Map2964.9UniSTS
Cytogenetic Map2q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000018600   ⟹   ENSRNOP00000018600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2143,481,430 - 143,523,361 (-)Ensembl
Rnor_6.0 Ensembl2149,441,598 - 149,444,548 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097839   ⟹   ENSRNOP00000089320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2143,482,397 - 143,491,709 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116463   ⟹   ENSRNOP00000086953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2143,481,468 - 143,523,361 (-)Ensembl
RefSeq Acc Id: NM_022800   ⟹   NP_073637
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82145,632,276 - 145,635,226 (-)NCBI
mRatBN7.22143,482,462 - 143,485,412 (-)NCBI
Rnor_6.02149,441,598 - 149,444,548 (-)NCBI
Rnor_5.02168,873,062 - 168,914,912 (-)NCBI
RGSC_v3.42148,611,035 - 148,613,985 (-)RGD
Celera2137,906,910 - 137,909,860 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232407   ⟹   XP_006232469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82145,631,487 - 145,673,194 (-)NCBI
mRatBN7.22143,481,468 - 143,523,340 (-)NCBI
Rnor_6.02149,440,807 - 149,482,592 (-)NCBI
Rnor_5.02168,873,062 - 168,914,912 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232408   ⟹   XP_006232470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82145,631,487 - 145,635,687 (-)NCBI
mRatBN7.22143,481,468 - 143,485,943 (-)NCBI
Rnor_6.02149,440,807 - 149,446,188 (-)NCBI
Rnor_5.02168,873,062 - 168,914,912 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282498   ⟹   XP_063138568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82145,631,487 - 145,673,153 (-)NCBI
RefSeq Acc Id: XM_063282499   ⟹   XP_063138569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82145,631,487 - 145,673,146 (-)NCBI
RefSeq Acc Id: NP_073637   ⟸   NM_022800
- UniProtKB: Q9EPX4 (UniProtKB/Swiss-Prot),   A6JVK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232469   ⟸   XM_006232407
- Peptide Label: isoform X1
- UniProtKB: Q9EPX4 (UniProtKB/Swiss-Prot),   A6JVK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232470   ⟸   XM_006232408
- Peptide Label: isoform X1
- UniProtKB: Q9EPX4 (UniProtKB/Swiss-Prot),   A6JVK4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018600   ⟸   ENSRNOT00000018600
Ensembl Acc Id: ENSRNOP00000089320   ⟸   ENSRNOT00000097839
Ensembl Acc Id: ENSRNOP00000086953   ⟸   ENSRNOT00000116463
RefSeq Acc Id: XP_063138568   ⟸   XM_063282498
- Peptide Label: isoform X1
- UniProtKB: Q9EPX4 (UniProtKB/Swiss-Prot),   A6JVK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138569   ⟸   XM_063282499
- Peptide Label: isoform X1
- UniProtKB: Q9EPX4 (UniProtKB/Swiss-Prot),   A6JVK4 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPX4-F1-model_v2 AlphaFold Q9EPX4 1-343 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621681 AgrOrtholog
BioCyc Gene G2FUF-52985 BioCyc
Ensembl Genes ENSRNOG00000013902 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018749 UniProtKB/Swiss-Prot
  ENSRNOG00060005045 UniProtKB/Swiss-Prot
  ENSRNOG00065024609 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018600.5 UniProtKB/Swiss-Prot
  ENSRNOT00000097839.1 UniProtKB/TrEMBL
  ENSRNOT00000116463.1 UniProtKB/Swiss-Prot
  ENSRNOT00055031962 UniProtKB/Swiss-Prot
  ENSRNOT00055031968 UniProtKB/Swiss-Prot
  ENSRNOT00060008399 UniProtKB/Swiss-Prot
  ENSRNOT00060008402 UniProtKB/Swiss-Prot
  ENSRNOT00065042232 UniProtKB/Swiss-Prot
  ENSRNOT00065042243 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y12_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64803 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64803 ENTREZGENE
PANTHER P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24233:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB P2RY12 RGD
PhenoGen P2ry12 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y12PRNCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2YPURNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013902 RatGTEx
  ENSRNOG00055018749 RatGTEx
  ENSRNOG00060005045 RatGTEx
  ENSRNOG00065024609 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GHZ9_RAT UniProtKB/TrEMBL
  A6JVK4 ENTREZGENE, UniProtKB/TrEMBL
  P2Y12_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2ry12  purinergic receptor P2Y12  P2ry12  purinergic receptor P2Y, G-protein coupled, 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-01-14 P2ry12  purinergic receptor P2Y, G-protein coupled, 12  P2ry12  purinergic receptor P2Y, G-protein coupled 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 P2ry12  purinergic receptor P2Y, G-protein coupled 12  P2y12    Symbol updated 1299863 APPROVED
2005-01-20 P2y12  purinergic receptor P2Y, G-protein coupled 12    P2Y12 platelet ADP receptor  Name updated 1299863 APPROVED
2002-08-07 P2y12  P2Y12 platelet ADP receptor      Symbol and Name status set to provisional 70820 PROVISIONAL