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Gene: P2ry12 (purinergic receptor P2Y12) Rattus norvegicus
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Symbol: P2ry12
Name: purinergic receptor P2Y12
Description: Exhibits ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; inorganic cation transmembrane transport; and intracellular signal transduction. Localizes to the basal plasma membrane; caveola; and external side of plasma membrane. Colocalizes with the mitochondrion. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; ticlopidine pharmacodynamics pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: P2Y purinoceptor 12; P2y12; P2Y12 platelet ADP receptor; purinergic receptor P2Y, G-protein coupled 12; purinergic receptor P2Y, G-protein coupled, 12
Orthologs:
Homo sapiens (human) : P2RY12 (purinergic receptor P2Y12)  HGNC  Alliance
Mus musculus (house mouse) : P2ry12 (purinergic receptor P2Y, G-protein coupled 12)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2ry12 (purinergic receptor P2Y12)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RY12 (purinergic receptor P2Y12)
Canis lupus familiaris (dog) : P2RY12 (purinergic receptor P2Y12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2ry12 (purinergic receptor P2Y12)
Sus scrofa (pig) : P2RY12 (purinergic receptor P2Y12)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02149,440,807 - 149,482,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02168,873,062 - 168,914,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,611,035 - 148,613,985 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12148,560,997 - 148,563,948 (-)NCBI
Celera2137,906,910 - 137,909,860 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on P2ry12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621681
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.