Siah2 (siah E3 ubiquitin protein ligase 2) - Rat Genome Database

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Gene: Siah2 (siah E3 ubiquitin protein ligase 2) Rattus norvegicus
Analyze
Symbol: Siah2
Name: siah E3 ubiquitin protein ligase 2
RGD ID: 620778
Description: Enables ubiquitin conjugating enzyme binding activity. Involved in regulation of protein ubiquitination. Located in early endosome and neuronal cell body. Orthologous to human SIAH2 (siah E3 ubiquitin protein ligase 2); PARTICIPATES IN estrogen signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase SIAH2; RING-type E3 ubiquitin transferase SIAH2; seven in absentia 2; seven in absentia homolog 2; siah-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82145,063,847 - 145,081,675 (-)NCBIGRCr8
mRatBN7.22142,913,924 - 142,931,752 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2142,914,003 - 142,931,950 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2149,552,206 - 149,570,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02147,658,831 - 147,676,654 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02142,291,261 - 142,309,088 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02148,874,151 - 148,891,900 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2148,874,151 - 148,891,900 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02168,292,053 - 168,309,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,022,641 - 148,040,390 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12147,972,605 - 147,990,353 (-)NCBI
Celera2137,342,181 - 137,359,932 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clomiphene  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hexestrol  (ISO)
ICI-164384  (ISO)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
manganese(II) chloride  (EXP)
mestranol  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
naphthalenes  (EXP)
paracetamol  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phytoestrogen  (ISO)
picene  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
4. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. Wheeler TC, etal., J Biol Chem 2002 Mar 22;277(12):10273-82.
Additional References at PubMed
PMID:12952940   PMID:19028597   PMID:19224863   PMID:21586138   PMID:26070566   PMID:26392558  


Genomics

Comparative Map Data
Siah2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82145,063,847 - 145,081,675 (-)NCBIGRCr8
mRatBN7.22142,913,924 - 142,931,752 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2142,914,003 - 142,931,950 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2149,552,206 - 149,570,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02147,658,831 - 147,676,654 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02142,291,261 - 142,309,088 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02148,874,151 - 148,891,900 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2148,874,151 - 148,891,900 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02168,292,053 - 168,309,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,022,641 - 148,040,390 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12147,972,605 - 147,990,353 (-)NCBI
Celera2137,342,181 - 137,359,932 (-)NCBICelera
Cytogenetic Map2q26NCBI
SIAH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383150,741,125 - 150,763,169 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3150,741,125 - 150,763,477 (-)EnsemblGRCh38hg38GRCh38
GRCh373150,458,912 - 150,480,956 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363151,941,600 - 151,963,953 (-)NCBINCBI36Build 36hg18NCBI36
Build 343151,941,608 - 151,963,961NCBI
Celera3148,871,981 - 148,894,332 (-)NCBICelera
Cytogenetic Map3q25.1NCBI
HuRef3147,832,386 - 147,876,859 (-)NCBIHuRef
CHM1_13150,421,938 - 150,444,291 (-)NCBICHM1_1
T2T-CHM13v2.03153,492,334 - 153,514,363 (-)NCBIT2T-CHM13v2.0
Siah2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39358,582,370 - 58,599,857 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl358,582,359 - 58,599,821 (-)EnsemblGRCm39 Ensembl
GRCm38358,674,949 - 58,692,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl358,674,938 - 58,692,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv37358,478,871 - 58,496,310 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36358,762,878 - 58,780,317 (-)NCBIMGSCv36mm8
Celera358,369,358 - 58,387,000 (-)NCBICelera
Cytogenetic Map3DNCBI
cM Map328.68NCBI
Siah2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554481,907,401 - 1,926,445 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554481,907,478 - 1,926,445 (-)NCBIChiLan1.0ChiLan1.0
SIAH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22148,630,486 - 148,652,743 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13148,635,203 - 148,657,271 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03147,759,375 - 147,781,639 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13155,332,751 - 155,354,135 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3155,332,751 - 155,354,139 (-)Ensemblpanpan1.1panPan2
SIAH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12345,366,343 - 45,418,960 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2345,341,199 - 45,385,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2345,233,446 - 45,252,449 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02345,995,112 - 46,014,122 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2345,996,108 - 46,014,111 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12345,585,094 - 45,604,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02345,637,159 - 45,656,202 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02345,913,240 - 45,932,290 (-)NCBIUU_Cfam_GSD_1.0
Siah2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560290,635,588 - 90,651,834 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367581,116,056 - 1,213,442 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367581,115,980 - 1,132,225 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIAH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1390,949,021 - 90,971,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11390,951,798 - 90,971,538 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21399,076,306 - 99,096,119 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIAH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11539,939,209 - 39,960,750 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1539,939,832 - 39,959,734 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604112,757,953 - 12,779,570 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Siah2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473028,158,750 - 28,178,810 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473028,159,096 - 28,178,832 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Siah2
85 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:101
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000018488
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2142323368146786035Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2142323368146786035Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2142323368146786035Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2142323368146786035Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368147803808Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 10 7 7 4 7 41 13 2
Low 33 50 34 15 34 8 11 33 35 28 9 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000018488   ⟹   ENSRNOP00000018488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2142,914,003 - 142,931,752 (-)Ensembl
Rnor_6.0 Ensembl2148,874,151 - 148,891,900 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096984   ⟹   ENSRNOP00000095454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2142,914,003 - 142,931,950 (-)Ensembl
RefSeq Acc Id: NM_134457   ⟹   NP_604452
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82145,063,847 - 145,081,675 (-)NCBI
mRatBN7.22142,913,924 - 142,931,752 (-)NCBI
Rnor_6.02148,874,151 - 148,891,900 (-)NCBI
Rnor_5.02168,292,053 - 168,309,802 (-)NCBI
RGSC_v3.42148,022,641 - 148,040,390 (-)RGD
Celera2137,342,181 - 137,359,932 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_604452 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL91363 (Get FASTA)   NCBI Sequence Viewer  
  BAB70754 (Get FASTA)   NCBI Sequence Viewer  
  EDM14859 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018488.1
  ENSRNOP00000095454.1
  ENSRNOP00055025433
  ENSRNOP00060006081
  ENSRNOP00065033756
GenBank Protein Q8R4T2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_604452   ⟸   NM_134457
- UniProtKB: Q920M8 (UniProtKB/Swiss-Prot),   Q8R4T2 (UniProtKB/Swiss-Prot),   A6JVJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018488   ⟸   ENSRNOT00000018488
RefSeq Acc Id: ENSRNOP00000095454   ⟸   ENSRNOT00000096984
Protein Domains
RING-type   SIAH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R4T2-F1-model_v2 AlphaFold Q8R4T2 1-325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691345
Promoter ID:EPDNEW_R1870
Type:initiation region
Name:Siah2_1
Description:siah E3 ubiquitin protein ligase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02148,891,911 - 148,891,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620778 AgrOrtholog
BioCyc Gene G2FUF-52996 BioCyc
Ensembl Genes ENSRNOG00000013703 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018534 UniProtKB/Swiss-Prot
  ENSRNOG00060004879 UniProtKB/Swiss-Prot
  ENSRNOG00065024096 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018488.3 UniProtKB/Swiss-Prot
  ENSRNOT00000096984.1 UniProtKB/TrEMBL
  ENSRNOT00055031497 UniProtKB/Swiss-Prot
  ENSRNOT00060008113 UniProtKB/Swiss-Prot
  ENSRNOT00065041326 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 7-in-absentia-prot_TRAF-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SINA-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sina-like_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_SIAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140593 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 140593 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE SIAH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45877 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sina UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sina_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sina_ZnF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Siah2 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_SIAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013703 RatGTEx
  ENSRNOG00055018534 RatGTEx
  ENSRNOG00060004879 RatGTEx
  ENSRNOG00065024096 RatGTEx
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AQV5_RAT UniProtKB/TrEMBL
  A6JVJ3 ENTREZGENE, UniProtKB/TrEMBL
  Q8R4T2 ENTREZGENE
  Q920M8 ENTREZGENE
  SIAH2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q920M8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-07 Siah2  siah E3 ubiquitin protein ligase 2  Siah2  seven in absentia 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Siah2  seven in absentia 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Siah2  seven in absentia 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to cytosolic and membrane-associated pools 633984