GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Siah2 | increases expression | ISO | SIAH2 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of SIAH2 mRNA; Estradiol results in increased expression of SIAH2 protein | PMID:18629630 PMID:19619570 PMID:23019147 PMID:26865669 PMID:28711546 PMID:32387340 | Siah2 | increases expression | ISO | Siah2 (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of SIAH2 mRNA | PMID:22467019 | Siah2 | multiple interactions | ISO | SIAH2 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA; [Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 protein; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SIAH2 mRNA; EGF protein inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA]; EGF protein inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 protein]; ICI 164384 inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA] | PMID:18629630 PMID:19619570 | | ||||||||||||||||||||||
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