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Gene: SIAH1 (siah E3 ubiquitin protein ligase 1) Homo sapiens
Symbol: SIAH1
Name: siah E3 ubiquitin protein ligase 1
Description: This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin-protein ligase SIAH1; FLJ08065; hSIAH1; HUMSIAH; RING-type E3 ubiquitin transferase SIAH1; seven in absentia homolog 1; Siah-1; Siah-1a; SIAH1A
Mus musculus (house mouse) : Siah1a (siah E3 ubiquitin protein ligase 1A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Siah1 (siah E3 ubiquitin protein ligase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Siah1 (siah E3 ubiquitin protein ligase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIAH1 (siah E3 ubiquitin protein ligase 1)
Canis lupus familiaris (dog) : SIAH1 (siah E3 ubiquitin protein ligase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Siah1 (siah E3 ubiquitin protein ligase 1)
Sus scrofa (pig) : SIAH1 (siah E3 ubiquitin protein ligase 1)
more info ...
Related Pseudogenes: SIAH1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381648,354,581 - 48,448,435 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371648,394,442 - 48,419,229 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361646,951,943 - 46,976,730 (-)NCBINCBI36hg18NCBI36
Build 341646,951,946 - 46,954,901NCBI
Celera1632,903,789 - 32,928,589 (-)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1634,285,181 - 34,290,523 (-)NCBIHuRef
CHM1_11649,802,241 - 49,826,886 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SIAH1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351073
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.