SIAH2 (siah E3 ubiquitin protein ligase 2) - Rat Genome Database

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Gene: SIAH2 (siah E3 ubiquitin protein ligase 2) Sus scrofa
Analyze
Symbol: SIAH2
Name: siah E3 ubiquitin protein ligase 2
RGD ID: 14059190
Description: ENCODES a protein that exhibits ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN negative regulation of canonical Wnt signaling pathway (ortholog); regulation of protein ubiquitination (ortholog); PARTICIPATES IN estrogen signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease XV (ortholog); lens disease (ortholog); FOUND IN early endosome (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase SIAH2; seven in absentia homolog 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1390,949,021 - 90,971,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11390,951,798 - 90,971,538 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21399,076,306 - 99,096,119 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SIAH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1390,949,021 - 90,971,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11390,951,798 - 90,971,538 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21399,076,306 - 99,096,119 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIAH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383150,741,125 - 150,763,169 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3150,741,125 - 150,763,477 (-)EnsemblGRCh38hg38GRCh38
GRCh373150,458,912 - 150,480,956 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363151,941,600 - 151,963,953 (-)NCBINCBI36Build 36hg18NCBI36
Build 343151,941,608 - 151,963,961NCBI
Celera3148,871,981 - 148,894,332 (-)NCBICelera
Cytogenetic Map3q25.1NCBI
HuRef3147,832,386 - 147,876,859 (-)NCBIHuRef
CHM1_13150,421,938 - 150,444,291 (-)NCBICHM1_1
T2T-CHM13v2.03153,492,334 - 153,514,363 (-)NCBIT2T-CHM13v2.0
Siah2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39358,582,370 - 58,599,857 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl358,582,359 - 58,599,821 (-)EnsemblGRCm39 Ensembl
GRCm38358,674,949 - 58,692,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl358,674,938 - 58,692,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv37358,478,871 - 58,496,310 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36358,762,878 - 58,780,317 (-)NCBIMGSCv36mm8
Celera358,369,358 - 58,387,000 (-)NCBICelera
Cytogenetic Map3DNCBI
cM Map328.68NCBI
Siah2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82145,063,847 - 145,081,675 (-)NCBIGRCr8
mRatBN7.22142,913,924 - 142,931,752 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2142,914,003 - 142,931,950 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2149,552,206 - 149,570,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02147,658,831 - 147,676,654 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02142,291,261 - 142,309,088 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02148,874,151 - 148,891,900 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2148,874,151 - 148,891,900 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02168,292,053 - 168,309,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,022,641 - 148,040,390 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12147,972,605 - 147,990,353 (-)NCBI
Celera2137,342,181 - 137,359,932 (-)NCBICelera
Cytogenetic Map2q26NCBI
Siah2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554481,907,401 - 1,926,445 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554481,907,478 - 1,926,445 (-)NCBIChiLan1.0ChiLan1.0
SIAH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22148,630,486 - 148,652,743 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13148,635,203 - 148,657,271 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03147,759,375 - 147,781,639 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13155,332,751 - 155,354,135 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3155,332,751 - 155,354,139 (-)Ensemblpanpan1.1panPan2
SIAH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12345,366,343 - 45,418,960 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2345,341,199 - 45,385,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2345,233,446 - 45,252,449 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02345,995,112 - 46,014,122 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2345,996,108 - 46,014,111 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12345,585,094 - 45,604,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02345,637,159 - 45,656,202 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02345,913,240 - 45,932,290 (-)NCBIUU_Cfam_GSD_1.0
Siah2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560290,635,588 - 90,651,834 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367581,116,056 - 1,213,442 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367581,115,980 - 1,132,225 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIAH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11539,939,209 - 39,960,750 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1539,939,832 - 39,959,734 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604112,757,953 - 12,779,570 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Siah2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473028,158,750 - 28,178,810 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473028,159,096 - 28,178,832 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SIAH2
361 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 1 2
Low 10 3 2 5 2 22 2 1 3
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000036924   ⟹   ENSSSCP00000046937
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1390,949,021 - 90,971,411 (-)Ensembl
RefSeq Acc Id: XM_003358611   ⟹   XP_003358659
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11390,951,798 - 90,971,538 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003358659   ⟸   XM_003358611
- UniProtKB: A0A287ASV6 (UniProtKB/TrEMBL),   A0A4X1SW38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000046937   ⟸   ENSSSCT00000036924
Protein Domains
RING-type   SIAH-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031388 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015076615 UniProtKB/TrEMBL
  ENSSSCG00025017397 UniProtKB/TrEMBL
  ENSSSCG00030032904 UniProtKB/TrEMBL
  ENSSSCG00035015245 UniProtKB/TrEMBL
  ENSSSCG00040073215 UniProtKB/TrEMBL
  ENSSSCG00045026320 UniProtKB/TrEMBL
  ENSSSCG00050032889 UniProtKB/TrEMBL
  ENSSSCG00055016942 UniProtKB/TrEMBL
  ENSSSCG00060064094 UniProtKB/TrEMBL
  ENSSSCG00065069488 UniProtKB/TrEMBL
  ENSSSCG00070004583 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000036924 ENTREZGENE
  ENSSSCT00000036924.2 UniProtKB/TrEMBL
  ENSSSCT00015103373.1 UniProtKB/TrEMBL
  ENSSSCT00025023494.1 UniProtKB/TrEMBL
  ENSSSCT00030045497.1 UniProtKB/TrEMBL
  ENSSSCT00035019400.1 UniProtKB/TrEMBL
  ENSSSCT00040100937.1 UniProtKB/TrEMBL
  ENSSSCT00045044777.1 UniProtKB/TrEMBL
  ENSSSCT00050044134.1 UniProtKB/TrEMBL
  ENSSSCT00055033410.1 UniProtKB/TrEMBL
  ENSSSCT00060087464.1 UniProtKB/TrEMBL
  ENSSSCT00065095407.1 UniProtKB/TrEMBL
  ENSSSCT00070008643.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro 7-in-absentia-prot_TRAF-dom UniProtKB/TrEMBL
  SINA-like UniProtKB/TrEMBL
  Sina-like_RING UniProtKB/TrEMBL
  TRAF-like UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_SIAH UniProtKB/TrEMBL
KEGG Report ssc:100622531 UniProtKB/TrEMBL
NCBI Gene SIAH2 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE SIAH2 UniProtKB/TrEMBL
  PTHR45877 UniProtKB/TrEMBL
Pfam Sina UniProtKB/TrEMBL
  Sina_RING UniProtKB/TrEMBL
  Sina_ZnF UniProtKB/TrEMBL
PROSITE ZF_RING_2 UniProtKB/TrEMBL
  ZF_SIAH UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/TrEMBL
UniProt A0A287ASV6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SW38 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:92866 ENTREZGENE