SIAH2 (siah E3 ubiquitin protein ligase 2)

Gene: SIAH2 (siah E3 ubiquitin protein ligase 2) Pan paniscus

Analyze

Symbol:

SIAH2

Name:

siah E3 ubiquitin protein ligase 2

RGD ID:

11899012

Description:

ENCODES a protein that exhibits ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN negative regulation of canonical Wnt signaling pathway (ortholog); regulation of protein ubiquitination (ortholog); PARTICIPATES IN estrogen signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease XV (ortholog); lens disease (ortholog); FOUND IN early endosome (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

E3 ubiquitin-protein ligase SIAH2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	148,630,486 - 148,652,743 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	148,635,203 - 148,657,271 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	147,759,375 - 147,781,639 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	155,332,751 - 155,354,135 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	155,332,751 - 155,354,139 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

glycogen storage disease XV (ISO)

lens disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (IEA)

negative regulation of apoptotic process (IEA)

negative regulation of canonical Wnt signaling pathway (IEA,ISO)

negative regulation of extrinsic apoptotic signaling pathway (IEA)

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA)

protein ubiquitination (IEA)

regulation of circadian rhythm (IEA)

regulation of protein ubiquitination (ISO)

rhythmic process (IEA)

ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

early endosome (ISO)

intracellular membrane-bounded organelle (IEA)

neuronal cell body (ISO)

nucleoplasm (IEA)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

transferase activity (IEA)

ubiquitin conjugating enzyme binding (IEA,ISO)

ubiquitin protein ligase activity (IEA)

ubiquitin-protein transferase activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

estrogen signaling pathway (ISO)

nuclear factor, erythroid 2 like 2 signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SIAH2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	148,630,486 - 148,652,743 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	148,635,203 - 148,657,271 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	147,759,375 - 147,781,639 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	155,332,751 - 155,354,135 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	155,332,751 - 155,354,139 (-)	Ensembl	panpan1.1		panPan2

SIAH2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	150,741,125 - 150,763,169 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	150,741,125 - 150,763,477 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	150,458,912 - 150,480,956 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	151,941,600 - 151,963,953 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	151,941,608 - 151,963,961	NCBI
Celera	3	148,871,981 - 148,894,332 (-)	NCBI		Celera
Cytogenetic Map	3	q25.1	NCBI
HuRef	3	147,832,386 - 147,876,859 (-)	NCBI		HuRef
CHM1_1	3	150,421,938 - 150,444,291 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	153,492,334 - 153,514,363 (-)	NCBI		T2T-CHM13v2.0

Siah2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	58,582,370 - 58,599,857 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	58,582,359 - 58,599,821 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	58,674,949 - 58,692,439 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	58,674,938 - 58,692,400 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	58,478,871 - 58,496,310 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	58,762,878 - 58,780,317 (-)	NCBI		MGSCv36	mm8
Celera	3	58,369,358 - 58,387,000 (-)	NCBI		Celera
Cytogenetic Map	3	D	NCBI
cM Map	3	28.68	NCBI

Siah2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	145,063,847 - 145,081,675 (-)	NCBI		GRCr8
mRatBN7.2	2	142,913,924 - 142,931,752 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	142,914,003 - 142,931,950 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	149,552,206 - 149,570,039 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	147,658,831 - 147,676,654 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	142,291,261 - 142,309,088 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	148,874,151 - 148,891,900 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	148,874,151 - 148,891,900 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	168,292,053 - 168,309,802 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	148,022,641 - 148,040,390 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	147,972,605 - 147,990,353 (-)	NCBI
Celera	2	137,342,181 - 137,359,932 (-)	NCBI		Celera
Cytogenetic Map	2	q26	NCBI

Siah2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955448	1,907,401 - 1,926,445 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955448	1,907,478 - 1,926,445 (-)	NCBI	ChiLan1.0	ChiLan1.0

SIAH2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	45,366,343 - 45,418,960 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	45,341,199 - 45,385,546 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	45,233,446 - 45,252,449 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	45,995,112 - 46,014,122 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	45,996,108 - 46,014,111 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	45,585,094 - 45,604,128 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	45,637,159 - 45,656,202 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	45,913,240 - 45,932,290 (-)	NCBI		UU_Cfam_GSD_1.0

Siah2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	90,635,588 - 90,651,834 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936758	1,116,056 - 1,213,442 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936758	1,115,980 - 1,132,225 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIAH2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	90,949,021 - 90,971,411 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	90,951,798 - 90,971,538 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	99,076,306 - 99,096,119 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SIAH2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	39,939,209 - 39,960,750 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	39,939,832 - 39,959,734 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	12,757,953 - 12,779,570 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Siah2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	28,158,750 - 28,178,810 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	28,159,096 - 28,178,832 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003826639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000032405 ⟹ ENSPPAP00000009762

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	155,332,751 - 155,354,139 (-)	Ensembl

RefSeq Acc Id:

XM_003826639 ⟹ XP_003826687

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	148,630,486 - 148,652,743 (-)	NCBI
NHGRI_mPanPan1	3	148,635,203 - 148,657,271 (-)	NCBI
Mhudiblu_PPA_v0	3	147,759,375 - 147,781,639 (-)	NCBI
PanPan1.1	3	155,332,751 - 155,354,135 (-)	NCBI

Sequence:

show sequence

TCTCGGGCCCCGGCGGCGGCGGCGGGGCCGGCCCGGTGTCCCCGCAGCACCACGAGCTGACCTC
GCTCTTCGAGTGTCCGGTCTGCTTTGACTATGTCCTGCCTCCTATTCTGCAGTGCCAGGCCGGG
CACCTGGTGTGTAACCAATGCCGCCAGAAGTTGAGCTGCTGCCCGACGTGCAGGGGCGCCCTGA
CGCCCAGCATCAGGAACCTGGCTATGGAGAAGGTGGCCTCGGCAGTCCTGTTTCCCTGTAAGTA
TGCCACCACGGGCTGTTCCCTGACCCTGCACCATACGGAGAAACCAGAACATGAAGACATATGT
GAATACCGTCCCTACTCCTGCCCATGTCCTGGTGCTTCCTGCAAGTGGCAGGGGTCCCTGGAAG
CTGTGATGTCCCATCTCATGCACGCCCACAAGAGCATTACCACCCTTCAAGGAGAAGACATCGT
CTTTCTAGCTACAGACATTAACTTGCCAGGGGCTGTCGACTGGGTGATGATGCAGTCATGTTTT
GGCCATCACTTCATGCTGGTGCTGGAGAAACAAGAGAAGTACGAAGGCCACCAGCAGTTTTTTG
CCATCGTCCTGCTCATTGGCACCCGCAAGCAAGCCGAGAACTTTGCCTACAGACTGGAGTTGAA
TGGGAACCGGCGGAGATTGACCTGGGAGGCCACGCCCCGTTCGATTCATGACGGTGTGGCTGCG
GCCATCATGAACAGCGACTGCCTTGTTTTCGACACAGCCATAGCACATCTTTTTGCAGATAATG
GGAACCTTGGAATCAATGTTACTATTTCTACATGTTGTCCATGATGTGACTTTCGTAAACCTTC
AAAATTATTTGGGCATAGTGCTCTATGTTTAATAAAGGTTTTTATAGATGTTTTATTCCATATG
TCTTCACAAGTCAGGACCCACAATTACCCGTGTTTTGTTTGAACAGCAGTTTCCCATCTGGCTT
CGACCCAACAAAGTTCATTAACCTGGGATGAATGGGGTTGGCCTGTTGGTAATTTGGATGCTGT
TCTGTGATCTAAAACAACTCTTATTGAATTGTATTTACTCCCTAAACAACACTTGACAGGCTGT
TGCACAGGGCTTCTATAGATCAGTGTGTTAGGAATGGGAGGCCCCTTCCTGCCTGCCTTCCCAT
ATTGGTCCCTTGACATTGACAAAAGCACAGTGACTGTCAGCAGATTCCTTTACTTTTGTTTGTG
GGAGGTAGGAATTGTTTTAATGCATTTTAAACAGTGTTTCTGAAATTGGATGGCTGGCTAATAG
ACACTGAATCACCCGGAGTGCTTATCTTAAAATTGCAGATTTAGGGAGCCTGCCAATTTAACAG
TCTCATCAGGTGATTCTTTTCAACAGTAATGTTTGCGAATTACTGGGTTAAATTGTGGGAAAGG
GTCCAGATTTTAAAGGTGCTTTAAGGTTGCCCTCTGCCGATACTGTTTGTCTTTCTACTGTTTC
ATCCCCTAACTTCCCCCAACCCTCAAATTAAAACTAGAACTATAGATCCACATGAACGCACGCC
TGAGATTTGGTCACTCACCTATGTTTTGGGTGGATTGCCTAGGAAAGCAAGTCATATGGCCATT
GATAGTTCTCATGTAATTAGTTTTGCTCACCACTAGTACAGATGACCCGTTTACACGTGGCTTC
CCTCGGAAGCCCTCCTCAACAGTAGCTGGTGTGAAAGACTAAATCAGTAGAGCTGGAAAAGCTT
TATAACCGGTGTGTCATATGCTTGCTATTTAAAGCTGTGTGTTGGTTTTGTTTTTCTGCCACAT
TCACTAGTTTTTTAATAAATATTTTCCAAAAATGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003826687	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000009762.1

RefSeq Acc Id:

XP_003826687 ⟸ XM_003826639

- UniProtKB:

A0A2R8ZYV9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMH
AHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGT
RKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVT
ISTCCP

hide sequence

RefSeq Acc Id:

ENSPPAP00000009762 ⟸ ENSPPAT00000032405

Protein Domains

RING-type SIAH-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000028118	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000032405.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
InterPro	7-in-absentia-prot_TRAF-dom	UniProtKB/TrEMBL
	SINA-like_animal	UniProtKB/TrEMBL
	Sina-like_RING	UniProtKB/TrEMBL
	TRAF-like	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_SIAH	UniProtKB/TrEMBL
NCBI Gene	SIAH2	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE SIAH2	UniProtKB/TrEMBL
	PTHR45877	UniProtKB/TrEMBL
Pfam	Sina	UniProtKB/TrEMBL
	Sina_RING	UniProtKB/TrEMBL
	Sina_ZnF	UniProtKB/TrEMBL
PROSITE	ZF_RING_2	UniProtKB/TrEMBL
	ZF_SIAH	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	TRAF domain-like	UniProtKB/TrEMBL
UniProt	A0A2R8ZYV9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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