Plk4 (polo-like kinase 4) - Rat Genome Database

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Gene: Plk4 (polo-like kinase 4) Rattus norvegicus
Analyze
Symbol: Plk4
Name: polo-like kinase 4
RGD ID: 1305390
Description: Predicted to enable identical protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including organelle assembly; regulation of cell cycle process; and trophoblast giant cell differentiation. Predicted to be located in several cellular components, including XY body; centriole; and deuterosome. Predicted to be part of procentriole replication complex. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC310344; PLK-4; polo-like kinase 4 (Drosophila); serine/threonine-protein kinase PLK4; serine/threonine-protein kinase Sak
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22123,802,512 - 123,820,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2123,802,512 - 123,820,942 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2130,373,009 - 130,391,421 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02128,485,441 - 128,503,853 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02123,114,577 - 123,132,993 (+)NCBIRnor_WKY
Rnor_6.02127,686,911 - 127,705,518 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2127,686,925 - 127,705,518 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02147,289,950 - 147,308,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42127,760,508 - 127,779,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12127,710,374 - 127,729,098 (+)NCBI
Celera2118,710,474 - 118,728,860 (+)NCBICelera
Cytogenetic Map2q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
Enterolactone  (ISO)
furan  (EXP)
genistein  (ISO)
glycidol  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
lucanthone  (ISO)
methotrexate  (ISO)
monocrotaline  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (EXP)
senecionine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
Tiron  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centriole  (IEA,ISO,ISS)
centrosome  (IBA,ISO,ISS)
cleavage furrow  (IEA)
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
deuterosome  (ISO,ISS)
nucleolus  (ISO,ISS)
nucleus  (IBA)
procentriole  (ISO)
procentriole replication complex  (ISO)
spindle pole  (IBA)
XY body  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Loss of KLF14 triggers centrosome amplification and tumorigenesis. Fan G, etal., Nat Commun. 2015 Oct 6;6:8450. doi: 10.1038/ncomms9450.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice. Ward A, etal., BMC Cancer. 2011 Feb 15;11:71. doi: 10.1186/1471-2407-11-71.
Additional References at PubMed
PMID:12477932   PMID:16189514   PMID:16244668   PMID:17174311   PMID:17681131   PMID:17891141   PMID:21399614   PMID:21725316   PMID:22020124   PMID:22349705   PMID:22854038   PMID:24240477  
PMID:24997597   PMID:25416956   PMID:27107012   PMID:27796307   PMID:33416109  


Genomics

Comparative Map Data
Plk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22123,802,512 - 123,820,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2123,802,512 - 123,820,942 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2130,373,009 - 130,391,421 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02128,485,441 - 128,503,853 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02123,114,577 - 123,132,993 (+)NCBIRnor_WKY
Rnor_6.02127,686,911 - 127,705,518 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2127,686,925 - 127,705,518 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02147,289,950 - 147,308,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42127,760,508 - 127,779,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12127,710,374 - 127,729,098 (+)NCBI
Celera2118,710,474 - 118,728,860 (+)NCBICelera
Cytogenetic Map2q25NCBI
PLK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384127,880,893 - 127,899,224 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4127,880,893 - 127,899,224 (+)EnsemblGRCh38hg38GRCh38
GRCh374128,802,048 - 128,820,379 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364129,021,495 - 129,039,803 (+)NCBINCBI36Build 36hg18NCBI36
Build 344129,159,705 - 129,177,532NCBI
Celera4126,180,969 - 126,199,332 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4124,529,792 - 124,548,157 (+)NCBIHuRef
CHM1_14128,778,476 - 128,796,837 (+)NCBICHM1_1
T2T-CHM13v2.04131,183,905 - 131,202,250 (+)NCBIT2T-CHM13v2.0
Plk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39340,754,386 - 40,771,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl340,754,454 - 40,771,318 (+)EnsemblGRCm39 Ensembl
GRCm38340,799,951 - 40,816,883 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl340,800,019 - 40,816,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv37340,603,873 - 40,620,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36340,896,599 - 40,913,432 (+)NCBIMGSCv36mm8
Celera340,529,562 - 40,546,495 (+)NCBICelera
Cytogenetic Map3BNCBI
Plk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542813,549,000 - 13,566,516 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542813,548,485 - 13,566,786 (-)NCBIChiLan1.0ChiLan1.0
PLK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14131,349,562 - 131,367,832 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4131,349,562 - 131,371,054 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04120,044,423 - 120,062,544 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11913,041,739 - 13,060,300 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1913,041,742 - 13,060,072 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1913,230,516 - 13,249,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01913,131,767 - 13,150,342 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1913,131,770 - 13,150,336 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11913,104,502 - 13,123,557 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01913,390,106 - 13,408,959 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01913,852,450 - 13,871,021 (-)NCBIUU_Cfam_GSD_1.0
Plk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530161,544,655 - 61,562,496 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366422,837,022 - 2,855,103 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366422,837,041 - 2,855,369 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl896,991,847 - 97,013,461 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1896,989,011 - 97,013,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28103,855,622 - 103,876,526 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1775,005,468 - 75,023,768 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl775,006,431 - 75,023,730 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603754,141,868 - 54,160,207 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247778,804,593 - 8,825,257 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247778,804,372 - 8,825,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plk4
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:41
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000016946
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat

Markers in Region
Stk18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22123,808,409 - 123,808,600 (+)MAPPERmRatBN7.2
Rnor_6.02127,692,823 - 127,693,013NCBIRnor6.0
Rnor_5.02147,295,890 - 147,296,080UniSTSRnor5.0
RGSC_v3.42127,766,406 - 127,766,596UniSTSRGSC3.4
Celera2118,716,330 - 118,716,520UniSTS
Cytogenetic Map2q26UniSTS
RH130777  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22123,820,517 - 123,820,700 (+)MAPPERmRatBN7.2
Rnor_6.02127,705,094 - 127,705,276NCBIRnor6.0
Rnor_5.02147,308,161 - 147,308,343UniSTSRnor5.0
RGSC_v3.42127,779,218 - 127,779,400UniSTSRGSC3.4
Celera2118,728,438 - 118,728,620UniSTS
RH 3.4 Map2661.4UniSTS
Cytogenetic Map2q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 28 22 14 22 37 20 35
Low 1 13 23 13 5 13 5 5 37 15 6 11 5
Below cutoff 4 6 6 6 3 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016946   ⟹   ENSRNOP00000016946
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2123,802,527 - 123,820,942 (+)Ensembl
Rnor_6.0 Ensembl2127,686,972 - 127,705,518 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086653   ⟹   ENSRNOP00000070950
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2123,802,512 - 123,820,940 (+)Ensembl
Rnor_6.0 Ensembl2127,686,925 - 127,705,516 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093651
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2123,802,512 - 123,807,759 (+)Ensembl
Rnor_6.0 Ensembl2127,687,155 - 127,692,172 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095320   ⟹   ENSRNOP00000086620
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2123,803,062 - 123,820,942 (+)Ensembl
RefSeq Acc Id: NM_001107669   ⟹   NP_001101139
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22123,802,512 - 123,820,940 (+)NCBI
Rnor_6.02127,686,925 - 127,705,516 (+)NCBI
Rnor_5.02147,289,950 - 147,308,585 (+)NCBI
RGSC_v3.42127,760,508 - 127,779,640 (+)RGD
Celera2118,710,474 - 118,728,860 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232299   ⟹   XP_006232361
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22123,802,527 - 123,820,942 (+)NCBI
Rnor_6.02127,686,911 - 127,705,518 (+)NCBI
Rnor_5.02147,289,950 - 147,308,585 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232300   ⟹   XP_006232362
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22123,802,754 - 123,820,533 (+)NCBI
Rnor_6.02127,687,907 - 127,705,518 (+)NCBI
Rnor_5.02147,289,950 - 147,308,585 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590857   ⟹   XP_017446346
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22123,802,844 - 123,820,942 (+)NCBI
Rnor_6.02127,687,220 - 127,705,518 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001101139   ⟸   NM_001107669
- Sequence:
RefSeq Acc Id: XP_006232361   ⟸   XM_006232299
- Peptide Label: isoform X2
- UniProtKB: B2GUY1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232362   ⟸   XM_006232300
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017446346   ⟸   XM_017590857
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A6C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016946   ⟸   ENSRNOT00000016946
RefSeq Acc Id: ENSRNOP00000070950   ⟸   ENSRNOT00000086653
RefSeq Acc Id: ENSRNOP00000086620   ⟸   ENSRNOT00000095320
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUY1-F1-model_v2 AlphaFold B2GUY1 1-924 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691304
Promoter ID:EPDNEW_R1829
Type:single initiation site
Name:Plk4_1
Description:polo-like kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02127,686,940 - 127,687,000EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305390 AgrOrtholog
BioCyc Gene G2FUF-53256 BioCyc
Ensembl Genes ENSRNOG00000011654 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016946 ENTREZGENE
  ENSRNOP00000016946.6 UniProtKB/TrEMBL
  ENSRNOP00000070950.1 UniProtKB/TrEMBL
  ENSRNOP00000086620 ENTREZGENE
  ENSRNOP00000086620.1 UniProtKB/TrEMBL
  ENSRNOP00000094693.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016946 ENTREZGENE
  ENSRNOT00000016946.8 UniProtKB/TrEMBL
  ENSRNOT00000086653.2 UniProtKB/TrEMBL
  ENSRNOT00000093651.2 UniProtKB/TrEMBL
  ENSRNOT00000095320 ENTREZGENE
  ENSRNOT00000095320.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1120.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8371068 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plk4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_Plk4_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_Plk4_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_Plk4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser_Thr-PK_POLO_box_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310344 UniProtKB/TrEMBL
MGC_CLONE MGC:187673 IMAGE-MGC_LOAD
NCBI Gene 310344 ENTREZGENE
PANTHER PTHR24345:SF89 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plk4_PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plk4_PB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plk4 PhenoGen
PROSITE CPB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_BOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZ86_RAT UniProtKB/TrEMBL
  A0A8I6A6C6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B1D8_RAT UniProtKB/TrEMBL
  A0A8L2Q8F8_RAT UniProtKB/TrEMBL
  B2GUY1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Plk4  polo-like kinase 4  Plk4  polo-like kinase 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Plk4  polo-like kinase 4 (Drosophila)   Plk4_predicted  polo-like kinase 4 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Plk4_predicted  polo-like kinase 4 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED