Plk4 (polo-like kinase 4) - Rat Genome Database

Name: Plk4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Plk4 (polo-like kinase 4) Rattus norvegicus

Analyze

Symbol:

Plk4

Name:

polo-like kinase 4

RGD ID:

1305390

Description:

Predicted to enable identical protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in organelle assembly; positive regulation of centriole replication; and trophoblast giant cell differentiation. Predicted to be located in several cellular components, including XY body; deuterosome; and microtubule organizing center. Predicted to be part of procentriole replication complex. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC310344; PLK-4; polo-like kinase 4 (Drosophila); serine/threonine-protein kinase PLK4; serine/threonine-protein kinase Sak

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PLK4 (polo like kinase 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Plk4 (polo like kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Plk4 (polo like kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PLK4 (polo like kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PLK4 (polo like kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Plk4 (polo like kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PLK4 (polo like kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PLK4 (polo like kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Plk4 (polo like kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PLK4 (polo like kinase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Plk4 (polo like kinase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	plk4 (polo-like kinase 4 (Drosophila))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	SAK	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	plk4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	123,802,527 - 123,820,942 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	123,802,512 - 123,820,942 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	130,373,009 - 130,391,421 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	128,485,441 - 128,503,853 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	123,114,577 - 123,132,993 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	127,686,911 - 127,705,518 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	127,686,925 - 127,705,518 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	147,289,950 - 147,308,585 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	127,760,508 - 127,779,640 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	127,710,374 - 127,729,098 (+)	NCBI
Celera	2	118,710,474 - 118,728,860 (+)	NCBI		Celera
Cytogenetic Map	2	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast ductal carcinoma (ISO)

colon cancer (ISO)

diabetic retinopathy (IEP)

Dwarfism (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Hereditary Eye Diseases (ISO)

microcephaly (ISO)

microcephaly and chorioretinopathy 1 (ISO)

microcephaly and chorioretinopathy 2 (ISO)

neuronal ceroid lipofuscinosis 7 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-butoxyethanol (ISO)

2-methylcholine (ISO)

3-methylcholanthrene (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cis-caffeic acid (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

corticosterone (EXP)

coumestrol (ISO)

Cuprizon (EXP)

curcumin (ISO)

cyclosporin A (ISO)

dexamethasone (EXP)

diarsenic trioxide (ISO)

diazinon (EXP)

dicrotophos (ISO)

dieldrin (EXP)

dioxygen (ISO)

doxorubicin (ISO)

Echimidine (ISO)

Enterolactone (ISO)

furan (EXP)

genistein (ISO)

glycidol (EXP)

Lasiocarpine (ISO)

lead diacetate (EXP,ISO)

lucanthone (ISO)

methotrexate (ISO)

monocrotaline (ISO)

N-nitrosodiethylamine (ISO)

nickel dichloride (EXP)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctanoic acid (ISO)

phenethyl isothiocyanate (ISO)

phenobarbital (ISO)

pirinixic acid (EXP)

piroxicam (ISO)

progesterone (ISO)

propanal (ISO)

resveratrol (ISO)

riddelliine (ISO)

rotenone (EXP)

senecionine (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

succimer (ISO)

sunitinib (ISO)

tamibarotene (ISO)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

Tiron (ISO)

topotecan (EXP)

trans-caffeic acid (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

centriole replication (IEA,ISO,ISS)

cilium assembly (IEA,ISO,ISS)

de novo centriole assembly involved in multi-ciliated epithelial cell differentiation (IEA,ISO,ISS)

phosphorylation (IEA)

positive regulation of centriole replication (IEA,ISO,ISS)

trophoblast giant cell differentiation (IEA,ISO,ISS)

Cellular Component

centriole (IEA,ISO,ISS)

centrosome (IEA,ISO,ISS)

cleavage furrow (IEA)

cytoplasm (IEA)

cytosol (IEA,ISO)

deuterosome (IEA,ISO,ISS)

nucleolus (IEA,ISO,ISS)

procentriole (IEA,ISO)

procentriole replication complex (IEA,ISO)

XY body (IEA,ISO)

Molecular Function

ATP binding (IEA)

identical protein binding (IEA,ISO)

protein binding (ISO)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Loss of KLF14 triggers centrosome amplification and tumorigenesis.	Fan G, etal., Nat Commun. 2015 Oct 6;6:8450. doi: 10.1038/ncomms9450.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice.	Ward A, etal., BMC Cancer. 2011 Feb 15;11:71. doi: 10.1186/1471-2407-11-71.
8.	MicroRNA‑126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting polo‑like kinase 4.	Zheng Y, etal., Int J Mol Med. 2021 Jan;47(1):151-160. doi: 10.3892/ijmm.2020.4775. Epub 2020 Oct 30.

Additional References at PubMed

PMID:12477932	PMID:16189514	PMID:16244668	PMID:17174311	PMID:17681131	PMID:17891141	PMID:21399614	PMID:21725316	PMID:22020124	PMID:22349705	PMID:22854038	PMID:24240477
PMID:24997597	PMID:25416956	PMID:27107012	PMID:27796307

Genomics

Comparative Map Data

Plk4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	123,802,527 - 123,820,942 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	123,802,512 - 123,820,942 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	130,373,009 - 130,391,421 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	128,485,441 - 128,503,853 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	123,114,577 - 123,132,993 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	127,686,911 - 127,705,518 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	127,686,925 - 127,705,518 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	147,289,950 - 147,308,585 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	127,760,508 - 127,779,640 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	127,710,374 - 127,729,098 (+)	NCBI
Celera	2	118,710,474 - 118,728,860 (+)	NCBI		Celera
Cytogenetic Map	2	q26	NCBI

PLK4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	127,880,893 - 127,899,224 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	127,880,893 - 127,899,224 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	128,802,048 - 128,820,379 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	129,021,495 - 129,039,803 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	129,159,705 - 129,177,532	NCBI
Celera	4	126,180,969 - 126,199,332 (+)	NCBI		Celera
Cytogenetic Map	4	q28.1	NCBI
HuRef	4	124,529,792 - 124,548,157 (+)	NCBI		HuRef
CHM1_1	4	128,778,476 - 128,796,837 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	131,183,905 - 131,202,250 (+)	NCBI		T2T-CHM13v2.0

Plk4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	40,754,463 - 40,771,318 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	40,754,454 - 40,771,318 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	40,799,951 - 40,816,883 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	40,800,019 - 40,816,883 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	40,603,873 - 40,620,805 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	40,896,599 - 40,913,432 (+)	NCBI		MGSCv36	mm8
Celera	3	40,529,562 - 40,546,495 (+)	NCBI		Celera
Cytogenetic Map	3	B	NCBI
cM Map	3	19.54	NCBI

Plk4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955428	13,549,000 - 13,566,516 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955428	13,548,485 - 13,566,786 (-)	NCBI	ChiLan1.0	ChiLan1.0

PLK4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	4	125,907,865 - 125,928,520 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	120,044,423 - 120,062,544 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	131,349,562 - 131,367,832 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	131,349,562 - 131,371,054 (+)	Ensembl	panpan1.1		panPan2

PLK4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	13,041,739 - 13,060,300 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	13,041,742 - 13,060,072 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	13,230,516 - 13,249,086 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	13,131,767 - 13,150,342 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	13,131,770 - 13,150,336 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	13,104,502 - 13,123,557 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	13,390,106 - 13,408,959 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	13,852,450 - 13,871,021 (-)	NCBI		UU_Cfam_GSD_1.0

Plk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	61,544,655 - 61,562,496 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936642	2,837,022 - 2,855,103 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936642	2,837,041 - 2,855,369 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLK4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	96,991,847 - 97,013,461 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	96,989,011 - 97,013,324 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	103,855,622 - 103,876,526 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PLK4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	75,005,468 - 75,023,768 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	75,006,431 - 75,023,730 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	54,141,868 - 54,160,207 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Plk4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624777	8,804,593 - 8,825,257 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624777	8,804,372 - 8,825,669 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Plk4
43 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	50
Count of miRNA genes:	41
Interacting mature miRNAs:	49
Transcripts:	ENSRNOT00000016946
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	72532993	157142209	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	76539322	150540526	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	78665616	143657569	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	80270434	125270434	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	81018907	126018907	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	82345893	130923501	Rat
7207808	Bmd89	Bone mineral density QTL 89	4.1		femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	2	88862519	133862519	Rat
2300165	Bmd49	Bone mineral density QTL 49	4.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	2	88862519	133862519	Rat
2300170	Bmd45	Bone mineral density QTL 45	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
2300185	Bmd46	Bone mineral density QTL 46	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
1598862	Glom9	Glomerulus QTL 9	3.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	2	92337601	137337601	Rat
1598863	Cm65	Cardiac mass QTL 65	2.3		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	92337601	137337601	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	102803808	147803808	Rat
8662836	Vetf8	Vascular elastic tissue fragility QTL 8	0.66		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	104559726	149559726	Rat
1581552	Pur12	Proteinuria QTL 12	5.19	0.0009	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	2	112103657	148076632	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1354594	Despr10	Despair related QTL 10		0.00000249	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	2	114654253	159654253	Rat
1359035	Bp276	Blood pressure QTL 276			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	143657569	Rat
1359035	Bp276	Blood pressure QTL 276			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	143657569	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	185876470	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
5135226	Leukc2	Leukocyte quantity QTL 2			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	2	118111229	149559726	Rat
1582257	Gluco21	Glucose level QTL 21	3.1	0.0035	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	118111229	157142209	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	118189491	163189491	Rat

Markers in Region

Stk18

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	123,808,409 - 123,808,600 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	127,692,823 - 127,693,013	NCBI	Rnor6.0
Rnor_5.0	2	147,295,890 - 147,296,080	UniSTS	Rnor5.0
RGSC_v3.4	2	127,766,406 - 127,766,596	UniSTS	RGSC3.4
Celera	2	118,716,330 - 118,716,520	UniSTS
Cytogenetic Map	2	q26	UniSTS

RH130777

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	123,820,517 - 123,820,700 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	127,705,094 - 127,705,276	NCBI	Rnor6.0
Rnor_5.0	2	147,308,161 - 147,308,343	UniSTS	Rnor5.0
RGSC_v3.4	2	127,779,218 - 127,779,400	UniSTS	RGSC3.4
Celera	2	118,728,438 - 118,728,620	UniSTS
RH 3.4 Map	2	661.4	UniSTS
Cytogenetic Map	2	q26	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	28	22	14	22			37	20	35
Low	1	13	23	13	5	13	5	5	37	15	6	11	5
Below cutoff		4	6	6		6	3	5					3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001395103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000016946 ⟹ ENSRNOP00000016946

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	123,802,527 - 123,820,942 (+)	Ensembl
Rnor_6.0 Ensembl	2	127,686,972 - 127,705,518 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000086653 ⟹ ENSRNOP00000070950

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	123,802,512 - 123,820,940 (+)	Ensembl
Rnor_6.0 Ensembl	2	127,686,925 - 127,705,516 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093651

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	123,802,512 - 123,807,759 (+)	Ensembl
Rnor_6.0 Ensembl	2	127,687,155 - 127,692,172 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095320 ⟹ ENSRNOP00000086620

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	123,803,062 - 123,820,942 (+)	Ensembl

RefSeq Acc Id:

NM_001395103 ⟹ NP_001382032

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	123,802,527 - 123,820,942 (+)	NCBI

RefSeq Acc Id:

XM_006232300 ⟹ XP_006232362

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	123,802,754 - 123,820,533 (+)	NCBI
Rnor_6.0	2	127,687,907 - 127,705,518 (+)	NCBI
Rnor_5.0	2	147,289,950 - 147,308,585 (+)	NCBI

Sequence:

show sequence

CTACTTGGTAAAGGATCATTTGCTGGTGTCTACAGAGCTGAGTCCATACACACTGGTTTGGAAG
TTGCAATCAAAATGATAAGAAAGCCATGTACAAAGCTGGAATGGTACAGAGAGTCCAAAATGAG
GTGAAAATACATTGCCAGTTGAAACACCCCTCTGTCTTGGAGCTCTATAATTACTTTGAAGATA
ACAATTACGTATACCTGGTATTAGAAATGTGCCACAACGGAGAAATGAACAGGTACCTAAAGAA
CAGAATGAAGCCTTTCTCCGAAAGCGAAGCCAGGCACTTCATGCACCAGATCATCACAGGAATG
CTGTATCTTCATTCTCACGGCATACTACACCGCGACCTCACACTCTCTAACATCTTACTTACAC
GGAATATGAACATAAAAATTGCTGACTTTGGACTAGCAACACAATTGAAAATGCCACATGAGAA
GCATTACACCCTGTGTGGAACCCCTAATTATATTTCACCAGAAATTGCAACTCGAAGTGCACAT
GGACTTGAATCTGATATTTGGTCATTGGGCTGTATGTTTTATACATTACTTATTGGAAGACCAC
CTTTTGACACTGATACAGTCAAAAACACATTGAACAAAGTAGTATTGGCAGATTATGAAATGCC
AGCCTTTTTGTCACGAGAGGCCCAGGACCTTATCCACCAATTACTTCGTAGAAACCCTGCAGAT
CGGTTAAGTCTGTCTTCTGTGTTGGACCATCCTTTTATGTCACGAAATCCTTCAACAAAGAGTA
AAGACTTAGGGACTGTAGAGGACTCAATGGATAGTGGGCATGCCACACTTTCCACAACAATTAC
AGCTTCTTCCGGAACCAGTTTGAGTGGTAGCCTACTTGACAGAAGAAGACTTTTGGTTGGTCAA
CCACTTCCAAATAAAATTACTGTATTTCAAAAAAATAAAAATTCAAGTGACTTTTCTTCAGGAG
ATGGAAGTAATTTTTGTACTCAATGGGGAAATCCAGAACAAGAAGCTAATAATAGGGGGCGGGG
AAGAGTAATTGAAGATGCAGAAGAAAGGCCACATTCTCGATACCTTCGCAGAGCTCATTCCTCT
GATAGATCCAACCCTTCTAATCAGTCTCGAGCAAAAACATACTCAATAGAGCGGTGTCACTCAG
TAGAAATGCTTTCAAAGCCCAGAAGATCATCACTGGATGAAACTAAACACAGTTCCAATCATCA
TTGTCTAGGGAAAACTCCTTTTCCATTTGCAGACCAGACACCTCAGATGGAGATAGTACAACAG
TGGTTTGGGAATCTGCAAATGAATGGAGAAACTAGTGAGCACAACACCATTAGCCCAAACAGAG
ATTTCCAGGACTATCCTGATGTGCAGGACACATTAAGAAATACTTGGACTGACACAAGAGCCAG
CAAGAATTCCGATAATTCTGCTAACGTTCATCCTGCAAAGCAGCTGAGTACCATGAAATACATG
ACTGCACATCACCATAAACCTGAGATCATGCAGCAAGAGCTGGCCATACATCCTCATTCTGAAC
AAAACAAGAGTAGAAGTATGGAGTCAACATTGGGTTACAGGAAACCTACCTTAAGAAGCATTAC
CTCTCCTTTGGTTGCTCACAGACTAAAACCAATCAGACAGAAAACCAAAAAGGCTGTGGTGAGC
ATCCTTGATTCAGAGGAGGTGTGTGTGGAGCTTCTAAAAGAGTGTACATCTGAAGGACATGTGA
AAGAAGTTCTTCAGATATCTAGTGATGGGACTACGATCACCGTTTATTACCCAAATGATGGAAG
AGGCTTTCCTCTTGCTGATAGACCACCCTTGCCTACTGACAACATCAGCAGGTACAGCTTTGAC
AGTTTACCAGAAAAATACTGGCGGAAATATCAGTATGCTTCCAGATTCATTCAGCTTGTAAGGT
CCAAAACTCCCAAAATCACTTACTTTACAAGATATGCTAAATGTATTTTGATGGAAAATTCTCC
TGGTGCTGATTTTGAAGTTTGGTTTTATGATGGAGCCAAAATACATAAAACAGAAGATGTAATT
CACATAATTGAAAAAACTGGGTTATCTTACACTTTAAAAAATGAGAATGACTTTACCAGCTTGA
AAGAGGAAGTAAAAATCTATATGGACCATGCCAATGAGGGTCACCGTACTTGCTTGGCACTGGA
ATCTGTAATCTCTGAAGAGGAAAAAAGAAGCAGGGGCTCTTCATTCTTCCCAATAATTGTAGGA
AGAAAACCTGGTACTACTAGTTCACCTAAAGCCTTATCACCACCTCCTGTGGACCCAGGCTACT
CAAAGGGAGAGCAAGCATCATCAAGCAGATTGAGCGCGAATAGTGCGGCTTTCCCAACACAGAC
ACCAGTACTCAGTCCTTCTGCTGTGACAGTGGAAGGACCTGGCCAAACAGCAGCTACTACAGGA
ACAAGCATCTCTTCAAGTCTTCCTAAATCAGCACAGCTTTTGAAATCTGTTTTTGTGAAAAATG
TTGGTTGGGCTACACAGCTAACTAGTGGAGCTGTGTGGGTTCAGTTTAATGATGGGTCACAGTT
GGTTGTCCAGGCAGGAGTATCTTCCATCAGTTATACATCACCAGACGGTCAGACAACTAGGTAT
GGAGAAAATGAAAAATTGCCTGAATACATCAAACAGAAATTGCAATGTCTTTCTTCCATCCTTC
TGATGTTTTCTAATCCAACTCCTAGTTTTCAGTAATTTAAGTCTTGGATGTCTATATTTAATAA
ATGATTTTTTGCTTGGCTTTCAAGTAAGTGATTTTTTTTAAATTTACTTTAACTTCAGAAAGCC
TTTCTATTAAACAGAATTTTAATCTACACCATTAAAAAATATACTAAGAAAACAATAAAATTAT
AGTTACCAAATACAGTGGTCATAAAGCTAATTTTGCTCCAAGCATGTAATCCTTCAGACTTTTG
TGCTCCTATACTTGTATTGAACTAAGTTGTGTGTGGCGTGTTTTTTTATTTTCTTTTTTAATAA
GACATTGAGAATCATGGACAAAACATGCTAGTTTTACCATTTTGAATATGTAAATATTGTATGT
ATAAGCAATATGTAAACGTGTATATTTTATATTTATTTTTATAGCACTTGTGTCTGATAAGATT
TCTGTAAACACATTTTATAAAATAAACACAGTTGTAAGTTTTCCTTAA

hide sequence

RefSeq Acc Id:

XM_017590857 ⟹ XP_017446346

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	123,802,844 - 123,820,942 (+)	NCBI
Rnor_6.0	2	127,687,220 - 127,705,518 (+)	NCBI

Sequence:

show sequence

GTCCGAGTGAGGCGGACTCTGATATTCGGGGACCGACTAAGCTGAGGTGCACCGAGCACTGTGC
TGAGGGAAGGTCGGAATACCGCTTGGTACAAACACCGGAGCGGGCGGGCGCAGGCTGAGTTAGT
CTGGATGAGGCGCTCGCTCACTCACTGGTGCTCAGTGACACAGGTAATGCGGTGTTCCGCGGGC
AGGCGCAGTGACTGGGCAGATTGTGGAGGGACCAGCGAAGCGGCCCGCCCCTGGGAGCCCCGCC
CGGAGGGGAGCGCCTGGTACCCAGCAAGTGTGTCGCCAGCTGTGGGCCCCGCCCGGTCCCGGCT
CCCCTAGGCGTCGGATTGCCACTCCCGCCTCCAAAGCCGCGCTCCGCCTGCCCCCTCCCCGGGG
ACGGCGGTTACCGTGGCGGGAGCTGCGGCGGGAGCCTGATGGACCAGAGTTGGGACCCGAGTTA
ACCAGCTCATTAGAGTCCTTAGCTTCCAACAGGGCTGGAGCTTAGAAAGTCTCTCAGCATCAAG
ATGCCTTCCACCCCAGACACCTGCATCATCGAGGACTTTAAGGTTGGAAATCTACTTGGTAAAG
GATCATTTGCTGGTGTCTACAGAGCTGAGTCCATACACACTGGTTTGGAAGTTGCAATCAAAAT
GATAGATAAGAAAGCCATGTACAAAGCTGGAATGGTACAGAGAGTCCAAAATGAGGTGAAAATA
CATTGCCAGTTGAAACACCCCTCTGTCTTGGAGCTCTATAATTACTTTGAAGATAACAATTACG
TATACCTGGTATTAGAAATGTGCCACAACGGAGAAATGAACAGGTACCTAAAGAACAGAATGAA
GCCTTTCTCCGAAAGCGAAGCCAGGCACTTCATGCACCAGATCATCACAGGAATGCTGTATCTT
CATTCTCACGGCATACTACACCGCGACCTCACACTCTCTAACATCTTACTTACACGGAATATGA
ACATAAAAATTGCTGACTTTGGACTAGCAACACAATTGAAAATGCCACATGAGAAGCATTACAC
CCTGTGTGGAACCCCTAATTATATTTCACCAGAAATTGCAACTCGAAGTGCACATGGACTTGAA
TCTGATATTTGGTCATTGGGCTGTATGTTTTATACATTACTTATTGGAAGACCACCTTTTGACA
CTGATACAGTCAAAAACACATTGAACAAAGTAGTATTGGCAGATTATGAAATGCCAGCCTTTTT
GTCACGAGAGGCCCAGGACCTTATCCACCAATTACTTCGTAGAAACCCTGCAGATCGGTTAAGT
CTGTCTTCTGTGTTGGACCATCCTTTTATGTCACGAAATCCTTCAACAAAGAGTAAAGACTTAG
GGACTGTAGAGGACTCAATGGATAGTGGGCATGCCACACTTTCCACAACAATTACAGCTTCTTC
CGGAACCAGTTTGAGTGGTAGCCTACTTGACAGAAGAAGACTTTTGGTTGGTCAACCACTTCCA
AATAAAATTACTGTATTTCAAAAAAATAAAAATTCAAGTGACTTTTCTTCAGGAGATGGAAGTA
ATTTTTGTACTCAATGGGGAAATCCAGAACAAGAAGCTAATAATAGGGGGCGGGGAAGAGTAAT
TGAAGATGCAGAAGAAAGGCCACATTCTCGATACCTTCGCAGAGCTCATTCCTCTGATAGATCC
AACCCTTCTAATCAGTCTCGAGCAAAAACATACTCAATAGAGCGGTGTCACTCAGTAGAAATGC
TTTCAAAGCCCAGAAGATCATCACTGGATGAAACTAAACACAGTTCCAATCATCATTGTCTAGG
GAAAACTCCTTTTCCATTTGCAGACCAGACACCTCAGATGGAGATAGTACAACAGTGGTTTGGG
AATCTGCAAATGAATGGAGAAACTAGTGAGCACAACACCATTAGCCCAAACAGAGATTTCCAGG
ACTATCCTGATGTGCAGGACACATTAAGAAATACTTGGACTGACACAAGAGCCAGCAAGAATTC
CGATAATTCTGCTAACGTTCATCCTGCAAAGCAGCTGAGTACCATGAAATACATGACTGCACAT
CACCATAAACCTGAGATCATGCAGCAAGAGCTGGCCATACATCCTCATTCTGAACAAAACAAGA
GTAGAAGTATGGAGTCAACATTGGGTTACAGGAAACCTACCTTAAGAAGCATTACCTCTCCTTT
GGTTGCTCACAGACTAAAACCAATCAGACAGAAAACCAAAAAGGCTGTGGTGAGCATCCTTGAT
TCAGAGGAGGTGTGTGTGGAGCTTCTAAAAGAGTGTACATCTGAAGGACATGTGAAAGAAGTTC
TTCAGATATCTAGTGATGGGACTACGATCACCGTTTATTACCCAAATGATGGAAGAGGCTTTCC
TCTTGCTGATAGACCACCCTTGCCTACTGACAACATCAGCAGGTACAGCTTTGACAGTTTACCA
GAAAAATACTGGCGGAAATATCAGTATGCTTCCAGATTCATTCAGCTTGTAAGGTCCAAAACTC
CCAAAATCACTTACTTTACAAGATATGCTAAATGTATTTTGATGGAAAATTCTCCTGGTGCTGA
TTTTGAAGTTTGGTTTTATGATGGAGCCAAAATACATAAAACAGAAGATGTAATTCACATAATT
GAAAAAACTGGGTTATCTTACACTTTAAAAAATGAGAATGACTTTACCAGCTTGAAAGAGGAAG
TAAAAATCTATATGGACCATGCCAATGAGGGTCACCGTACTTGCTTGGCACTGGAATCTGTAAT
CTCTGAAGAGGAAAAAAGAAGCAGGGGCTCTTCATTCTTCCCAATAATTGTAGGAAGAAAACCT
GGTACTACTAGTTCACCTAAAGCCTTATCACCACCTCCTGTGGACCCAGGCTACTCAAAGGGAG
AGCAAGCATCATCAAGCAGATTGAGCGCGAATAGTGCGGCTTTCCCAACACAGACACCAGTACT
CAGTCCTTCTGCTGTGACAGTGGAAGGACCTGGCCAAACAGCAGCTACTACAGGAACAAGCATC
TCTTCAAGTCTTCCTAAATCAGCACAGCTTTTGAAATCTGTTTTTGTGAAAAATGTTGGTTGGG
CTACACAGCTAACTAGTGGAGCTGTGTGGGTTCAGTTTAATGATGGGTCACAGTTGGTTGTCCA
GGCAGGAGTATCTTCCATCAGTTATACATCACCAGACGGTCAGACAACTAGGTATGGAGAAAAT
GAAAAATTGCCTGAATACATCAAACAGAAATTGCAATGTCTTTCTTCCATCCTTCTGATGTTTT
CTAATCCAACTCCTAGTTTTCAGTAATTTAAGTCTTGGATGTCTATATTTAATAAATGATTTTT
TGCTTGGCTTTCAAGTAAGTGATTTTTTTTAAATTTACTTTAACTTCAGAAAGCCTTTCTATTA
AACAGAATTTTAATCTACACCATTAAAAAATATACTAAGAAAACAATAAAATTATAGTTACCAA
ATACAGTGGTCATAAAGCTAATTTTGCTCCAAGCATGTAATCCTTCAGACTTTTGTGCTCCTAT
ACTTGTATTGAACTAAGTTGTGTGTGGCGTGTTTTTTTATTTTCTTTTTTAATAAGACATTGAG
AATCATGGACAAAACATGCTAGTTTTACCATTTTGAATATGTAAATATTGTATGTATAAGCAAT
ATGTAAACGTGTATATTTTATATTTATTTTTATAGCACTTGTGTCTGATAAGATTTCTGTAAAC
ACATTTTATAAAATAAACACAGTTGTAAGTTTTCCTTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001382032	(Get FASTA)	NCBI Sequence Viewer
	XP_006232362	(Get FASTA)	NCBI Sequence Viewer
	XP_017446346	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66450	(Get FASTA)	NCBI Sequence Viewer
	B2GUY1	(Get FASTA)	NCBI Sequence Viewer
	EDM01330	(Get FASTA)	NCBI Sequence Viewer
	EDM01331	(Get FASTA)	NCBI Sequence Viewer
	EDM01332	(Get FASTA)	NCBI Sequence Viewer
	EDM01333	(Get FASTA)	NCBI Sequence Viewer
	EDM01334	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016946
	ENSRNOP00000016946.6
	ENSRNOP00000070950.1
	ENSRNOP00000086620
	ENSRNOP00000086620.1
	ENSRNOP00000094693.1

RefSeq Acc Id:	XP_006232362 ⟸ XM_006232300
- Peptide Label:	isoform X3
- UniProtKB:	A0A0G2JZ86 (UniProtKB/TrEMBL), A6II34 (UniProtKB/TrEMBL)
- Sequence:	show sequence MYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSES EARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLKMPHEKHYTLCGTP NYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQ DLIHQLLRRNPADRLSLSSVLDHPFMSRNPSTKSKDLGTVEDSMDSGHATLSTTITASSGTSLS GSLLDRRRLLVGQPLPNKITVFQKNKNSSDFSSGDGSNFCTQWGNPEQEANNRGRGRVIEDAEE RPHSRYLRRAHSSDRSNPSNQSRAKTYSIERCHSVEMLSKPRRSSLDETKHSSNHHCLGKTPFP FADQTPQMEIVQQWFGNLQMNGETSEHNTISPNRDFQDYPDVQDTLRNTWTDTRASKNSDNSAN VHPAKQLSTMKYMTAHHHKPEIMQQELAIHPHSEQNKSRSMESTLGYRKPTLRSITSPLVAHRL KPIRQKTKKAVVSILDSEEVCVELLKECTSEGHVKEVLQISSDGTTITVYYPNDGRGFPLADRP PLPTDNISRYSFDSLPEKYWRKYQYASRFIQLVRSKTPKITYFTRYAKCILMENSPGADFEVWF YDGAKIHKTEDVIHIIEKTGLSYTLKNENDFTSLKEEVKIYMDHANEGHRTCLALESVISEEEK RSRGSSFFPIIVGRKPGTTSSPKALSPPPVDPGYSKGEQASSSRLSANSAAFPTQTPVLSPSAV TVEGPGQTAATTGTSISSSLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSS ISYTSPDGQTTRYGENEKLPEYIKQKLQCLSSILLMFSNPTPSFQ hide sequence

RefSeq Acc Id:	XP_017446346 ⟸ XM_017590857
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A6C6 (UniProtKB/TrEMBL), A6II36 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPSTPDTCIIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKI HCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSESEARHFMHQIITGMLYL HSHGILHRDLTLSNILLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE SDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLS LSSVLDHPFMSRNPSTKSKDLGTVEDSMDSGHATLSTTITASSGTSLSGSLLDRRRLLVGQPLP NKITVFQKNKNSSDFSSGDGSNFCTQWGNPEQEANNRGRGRVIEDAEERPHSRYLRRAHSSDRS NPSNQSRAKTYSIERCHSVEMLSKPRRSSLDETKHSSNHHCLGKTPFPFADQTPQMEIVQQWFG NLQMNGETSEHNTISPNRDFQDYPDVQDTLRNTWTDTRASKNSDNSANVHPAKQLSTMKYMTAH HHKPEIMQQELAIHPHSEQNKSRSMESTLGYRKPTLRSITSPLVAHRLKPIRQKTKKAVVSILD SEEVCVELLKECTSEGHVKEVLQISSDGTTITVYYPNDGRGFPLADRPPLPTDNISRYSFDSLP EKYWRKYQYASRFIQLVRSKTPKITYFTRYAKCILMENSPGADFEVWFYDGAKIHKTEDVIHII EKTGLSYTLKNENDFTSLKEEVKIYMDHANEGHRTCLALESVISEEEKRSRGSSFFPIIVGRKP GTTSSPKALSPPPVDPGYSKGEQASSSRLSANSAAFPTQTPVLSPSAVTVEGPGQTAATTGTSI SSSLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPDGQTTRYGEN EKLPEYIKQKLQCLSSILLMFSNPTPSFQ hide sequence

RefSeq Acc Id:

ENSRNOP00000016946 ⟸ ENSRNOT00000016946

RefSeq Acc Id:

ENSRNOP00000070950 ⟸ ENSRNOT00000086653

RefSeq Acc Id:

ENSRNOP00000086620 ⟸ ENSRNOT00000095320

RefSeq Acc Id:	NP_001382032 ⟸ NM_001395103
- UniProtKB:	B2GUY1 (UniProtKB/Swiss-Prot), A0A8L2Q8F8 (UniProtKB/TrEMBL)

Protein Domains

Cryptic POLO box 1 (CPB1) Cryptic POLO box 2 (CPB2) POLO box Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2GUY1-F1-model_v2	AlphaFold	B2GUY1	1-924	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691304

Promoter ID:

EPDNEW_R1829

Type:

single initiation site

Name:

Plk4_1

Description:

polo-like kinase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	127,686,940 - 127,687,000	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305390	AgrOrtholog
BioCyc Gene	G2FUF-53256	BioCyc
Ensembl Genes	ENSRNOG00000011654	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016946	ENTREZGENE
	ENSRNOT00000016946.8	UniProtKB/TrEMBL
	ENSRNOT00000086653.2	UniProtKB/TrEMBL
	ENSRNOT00000093651.2	UniProtKB/TrEMBL
	ENSRNOT00000095320	ENTREZGENE
	ENSRNOT00000095320.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.930	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.1120.120	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.1120.130	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8371068	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Plk4-like_POLO_box_2_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POLO_box_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POLO_box_Plk4_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POLO_box_Plk4_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POLO_box_Plk4_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser_Thr-PK_POLO_box_1_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:310344	UniProtKB/TrEMBL
MGC_CLONE	MGC:187673	IMAGE-MGC_LOAD
NCBI Gene	310344	ENTREZGENE
PANTHER	PTHR24345:SF89	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE PLK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Plk4_PB1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Plk4_PB2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Plk4	PhenoGen
PROSITE	CPB1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CPB2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POLO_BOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011654	RatGTEx
Superfamily-SCOP	Polo-box domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JZ86	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A6C6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6B1D8_RAT	UniProtKB/TrEMBL
	A0A8L2Q8F8	ENTREZGENE, UniProtKB/TrEMBL
	A6II34	ENTREZGENE, UniProtKB/TrEMBL
	A6II36	ENTREZGENE, UniProtKB/TrEMBL
	B2GUY1	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-02	Plk4	polo-like kinase 4	Plk4	polo-like kinase 4 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Plk4	polo-like kinase 4 (Drosophila)	Plk4_predicted	polo-like kinase 4 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Plk4_predicted	polo-like kinase 4 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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