Aadacl2l (arylacetamide deacetylase-like 2 like) - Rat Genome Database

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Gene: Aadacl2l (arylacetamide deacetylase-like 2 like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Aadacl2l
Name: arylacetamide deacetylase-like 2 like
RGD ID: 1559622
Description: Predicted to enable hydrolase activity; INTERACTS WITH Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arylacetamide deacetylase-like 2; LOC295071; RGD1559622; similar to hypothetical protein C130079G13
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82145,910,400 - 145,950,303 (-)NCBIGRCr8
mRatBN7.22143,761,288 - 143,800,486 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2143,761,608 - 143,800,682 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02149,714,565 - 149,754,734 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2149,715,198 - 149,754,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02169,147,767 - 169,186,140 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,896,756 - 148,935,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2138,185,091 - 138,225,578 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aadacl2lRatCuprizon decreases expressionEXP 6480464Cuprizone results in decreased expression of AADACL2L mRNACTDPMID:26577399


Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aadacl2lRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Aadacl2lRathydrolase activity enablesIEAInterPro:IPR0130941600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Aadacl2l
140 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
2 149716391 149716392 C G snv F344/NRrrc (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:113
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000035057, ENSRNOT00000057821
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 66 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat

1 to 10 of 66 rows



appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
1 1 19 18 18 10 8 10 6 26 15 7 9 8



Ensembl Acc Id: ENSRNOT00000035057   ⟹   ENSRNOP00000032213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2143,761,608 - 143,800,682 (-)Ensembl
Rnor_6.0 Ensembl2149,715,198 - 149,754,776 (-)Ensembl
RefSeq Acc Id: XM_017591266   ⟹   XP_017446755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82145,910,400 - 145,950,297 (-)NCBI
mRatBN7.22143,761,288 - 143,800,486 (-)NCBI
Rnor_6.02149,714,565 - 149,754,734 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282898   ⟹   XP_063138968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82145,910,406 - 145,950,303 (-)NCBI
Protein RefSeqs NP_001419330 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419337 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446755 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138968 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14844 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032213
  ENSRNOP00000032213.6
RefSeq Acc Id: XP_017446755   ⟸   XM_017591266
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000032213   ⟸   ENSRNOT00000035057
RefSeq Acc Id: XP_063138968   ⟸   XM_063282898
- Peptide Label: isoform X2
Alpha/beta hydrolase fold-3

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXW5-F1-model_v2 AlphaFold D3ZXW5 1-401 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691354
Promoter ID:EPDNEW_R1875
Type:single initiation site
Name:RGD1559622_1
Description:similar to hypothetical protein C130079G13
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02149,754,725 - 149,754,785EPDNEW


1 to 19 of 19 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-52983 BioCyc
Ensembl Genes ENSRNOG00000025219 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035057 ENTREZGENE
  ENSRNOT00000035057.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  AB_hydrolase_3 UniProtKB/TrEMBL
  Arylacetamide_deacetylase UniProtKB/TrEMBL
  GDXG_lipolytic_enzyme UniProtKB/TrEMBL
NCBI Gene 295071 ENTREZGENE
PANTHER AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C UniProtKB/TrEMBL
  ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Abhydrolase_3 UniProtKB/TrEMBL
PhenoGen Aadacl2l PhenoGen
PIRSF Arylacetamide_deacetylase UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025219 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A6JVK8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXW5 ENTREZGENE, UniProtKB/TrEMBL
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Aadacl2l  arylacetamide deacetylase-like 2 like  RGD1559622  similar to hypothetical protein C130079G13  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1559622  similar to hypothetical protein C130079G13   RGD1559622_predicted  similar to hypothetical protein C130079G13 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559622_predicted  similar to hypothetical protein C130079G13 (predicted)  LOC295071  similar to hypothetical protein C130079G13  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC295071  similar to hypothetical protein C130079G13      Symbol and Name status set to provisional 70820 PROVISIONAL