Anxa5 (annexin A5) - Rat Genome Database

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Gene: Anxa5 (annexin A5) Rattus norvegicus
Analyze
Symbol: Anxa5
Name: annexin A5
RGD ID: 2120
Description: Exhibits several functions, including calcium transmembrane transporter activity, phosphorylative mechanism; calcium-dependent phospholipid binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including cellular response to gonadotropin-releasing hormone; cellular response to lead ion; and negative regulation of prolactin secretion. Localizes to several cellular components, including Z disc; intercalated disc; and perikaryon. Biomarker of several diseases, including Wilson disease; cryptorchidism; glomerulonephritis; hyperthyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; myocardial infarction; and systemic scleroderma. Orthologous to human ANXA5 (annexin A5); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: anchorin CII; annexin 5; Annexin V; annexin-5; Anx5; calphobindin I; CBP-I; endonexin II; LC5; lipocortin V; MGC93655; PAP-I; placental anticoagulant protein 4; placental anticoagulant protein I; PP4; thromboplastin inhibitor; VAC-alpha; vascular anticoagulant-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22119,314,007 - 119,344,703 (-)NCBI
Rnor_6.0 Ensembl2123,162,461 - 123,193,130 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02123,162,477 - 123,194,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02142,777,624 - 142,808,420 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42122,949,210 - 122,979,757 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12122,894,171 - 122,924,719 (-)NCBI
Celera2114,271,560 - 114,302,133 (-)NCBICelera
RH 3.4 Map2623.7RGD
Cytogenetic Map2q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(Z)-3-butylidenephthalide  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
atrazine  (ISO)
bacitracin  (EXP)
benzo[a]pyrene  (EXP,ISO)
beryllium sulfate  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buspirone  (EXP)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fentin chloride  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
griseofulvin  (ISO)
hyaluronic acid  (EXP)
hydrazine  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoflavones  (EXP)
ketamine  (EXP)
kojic acid  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
lovastatin  (ISO)
mercury dichloride  (ISO)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitric oxide  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Ptaquiloside  (ISO)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
ruthenium atom  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulindac sulfide  (ISO)
T-2 toxin  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
triphenylstannane  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
warfarin  (ISO)
zearalenone  (ISO)
zinc pyrithione  (ISO)

References

References - curated
1. Bouton CM, etal., Toxicol Appl Pharmacol. 2001 Oct 1;176(1):34-53.
2. Concha NO, etal., Science. 1993 Sep 3;261(5126):1321-4.
3. Cui Y, etal., Cancer Invest. 2009 Aug;27(7):747-55.
4. el Btaouri H, etal., Eur J Biochem. 1996 Dec 15;242(3):506-11.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Giambanco I, etal., J Histochem Cytochem. 1991 Sep;39(9):1189-98.
7. GOA data from the GO Consortium
8. Goldberg M, etal., J Biol Buccale. 1990 Dec;18(4):289-98.
9. Gonzalez-Conejero R, etal., Blood. 2002 Sep 15;100(6):2081-6.
10. Gotow T, etal., Neuroscience. 1996 Nov;75(2):507-21.
11. Habeeb RA, etal., Clin Med Insights Arthritis Musculoskelet Disord. 2010 Apr 28;3:15-23.
12. Imai Y and Kohsaka S, Eur J Biochem 1995 Sep 1;232(2):327-34.
13. Kaikkonen KS, etal., Scand J Clin Lab Invest. 2005;65(2):133-40.
14. Kaneko N, etal., Clin Chim Acta. 1996 Jul 15;251(1):65-80.
15. Kaneko N, etal., Heart Vessels. 1994;9(3):148-54.
16. Kawaminami M, etal., Biochem Biophys Res Commun. 1992 Jul 31;186(2):894-8.
17. Kawaminami M, etal., Endocr J. 2004 Jun;51(3):349-54.
18. Kawaminami M, etal., Mol Cell Endocrinol. 1998 Jun 25;141(1-2):73-8.
19. Kirsch T, etal., Osteoarthritis Cartilage. 2000 Jul;8(4):294-302.
20. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. Lederman M, etal., Invest Ophthalmol Vis Sci. 2010 Jan;51(1):53-8. Epub 2009 Aug 13.
22. Lee BH, etal., Proteomics. 2011 Sep;11(18):3698-705. doi: 10.1002/pmic.201100122. Epub 2011 Aug 9.
23. Li Q, etal., Neuroreport. 2004 Sep 15;15(13):2083-7.
24. Liu N, etal., J Neurosci Res. 2004 Aug 1;77(3):391-401.
25. Matsuda R, etal., Biochem Biophys Res Commun. 1997 Aug 28;237(3):499-503.
26. Matsuda R, etal., Res Exp Med (Berl). 2001 Jan;200(2):77-92.
27. Mo Y, etal., J Biol Chem 2003 Jan 24;278(4):2437-43.
28. Monceau V, etal., Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H965-71. Epub 2006 Feb 24.
29. Monceau V, etal., Cardiovasc Res. 2004 Dec 1;64(3):496-506.
30. Moraru II, etal., Ann N Y Acad Sci. 1998 Sep 16;853:329-32.
31. Naciff JM, etal., J Comp Neurol. 1996 May 6;368(3):356-70.
32. NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Ohsawa K, etal., J Neurochem 1996 Jul;67(1):89-97.
34. Pepinsky RB, etal., J Biol Chem 1988 Aug 5;263(22):10799-811.
35. RGD automated data pipeline
36. RGD automated import pipeline for gene-chemical interactions
37. Seaton BA, etal., J Biol Chem. 1990 Mar 15;265(8):4567-9.
38. Simsek B, etal., Pediatr Nephrol. 2008 Jan;23(1):79-82. Epub 2007 Nov 13.
39. Sohma H, etal., Front Aging Neurosci. 2013 Apr 5;5:15. doi: 10.3389/fnagi.2013.00015. eCollection 2013.
40. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
41. Tao XQ, etal., Zhonghua Nan Ke Xue. 2010 May;16(5):400-4.
42. Vermes I, etal., Mov Disord. 1999 Nov;14(6):1008-10.
43. Wang L, etal., Cardiovasc Res. 1995 Sep;30(3):363-71.
44. Wen Y, etal., Biochem Biophys Res Commun. 1999 May 19;258(3):713-21.
45. Wever KE, etal., PLoS One. 2011;6(8):e24276. doi: 10.1371/journal.pone.0024276. Epub 2011 Aug 30.
46. Yamaguchi M, etal., J Neurosci Res. 2010 Sep;88(12):2682-92. doi: 10.1002/jnr.22427.
47. Yao B and Kawaminami M, J Reprod Dev. 2008 Aug;54(4):259-64. Epub 2008 May 27.
48. Yao B, etal., Urology. 2009 Jun;73(6):1412-6. doi: 10.1016/j.urology.2008.11.021. Epub 2009 Apr 18.
Additional References at PubMed
PMID:2138016   PMID:7583670   PMID:9609693   PMID:12865345   PMID:16085777   PMID:16455971   PMID:17082577   PMID:19056867   PMID:19623612   PMID:19893283   PMID:19934022   PMID:19946888  
PMID:20458337   PMID:20978343   PMID:21362503   PMID:21423176   PMID:21508411   PMID:22871113   PMID:23376485   PMID:23533145   PMID:25002582   PMID:26316108   PMID:28543594   PMID:31515275  


Genomics

Comparative Map Data
Anxa5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22119,314,007 - 119,344,703 (-)NCBI
Rnor_6.0 Ensembl2123,162,461 - 123,193,130 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02123,162,477 - 123,194,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02142,777,624 - 142,808,420 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42122,949,210 - 122,979,757 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12122,894,171 - 122,924,719 (-)NCBI
Celera2114,271,560 - 114,302,133 (-)NCBICelera
RH 3.4 Map2623.7RGD
Cytogenetic Map2q25NCBI
ANXA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4121,667,946 - 121,696,995 (-)EnsemblGRCh38hg38GRCh38
GRCh384121,667,946 - 121,696,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374122,589,101 - 122,618,135 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364122,808,598 - 122,837,626 (-)NCBINCBI36hg18NCBI36
Build 344122,946,752 - 122,975,781NCBI
Celera4119,974,664 - 120,003,661 (-)NCBI
Cytogenetic Map4q27ENTREZGENE
HuRef4118,316,005 - 118,345,109 (-)NCBIHuRef
CHM1_14122,565,582 - 122,594,573 (-)NCBICHM1_1
Anxa5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39336,503,072 - 36,530,036 (-)NCBIGRCm39mm39
GRCm39 Ensembl336,503,072 - 36,530,043 (-)Ensembl
GRCm38336,448,923 - 36,475,887 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl336,448,923 - 36,475,894 (-)EnsemblGRCm38mm10GRCm38
MGSCv37336,347,845 - 36,374,809 (-)NCBIGRCm37mm9NCBIm37
MGSCv36336,640,474 - 36,667,247 (-)NCBImm8
Celera336,332,154 - 36,359,060 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map317.46NCBI
Anxa5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,873,782 - 18,907,955 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542818,873,782 - 18,907,955 (+)NCBIChiLan1.0ChiLan1.0
ANXA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14125,006,038 - 125,034,972 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,006,038 - 125,034,972 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04113,868,218 - 113,897,243 (-)NCBIMhudiblu_PPA_v0panPan3
ANXA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11918,419,936 - 18,450,088 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1918,407,587 - 18,570,378 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1918,636,905 - 18,666,325 (+)NCBI
ROS_Cfam_1.01918,538,322 - 18,568,429 (+)NCBI
UMICH_Zoey_3.11918,489,737 - 18,519,390 (+)NCBI
UNSW_CanFamBas_1.01918,771,009 - 18,800,422 (+)NCBI
UU_Cfam_GSD_1.01919,247,832 - 19,277,209 (+)NCBI
Anxa5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530166,159,815 - 66,193,477 (+)NCBI
SpeTri2.0NW_004936662926,302 - 959,964 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANXA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8102,388,103 - 102,425,750 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18102,387,833 - 102,420,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28109,609,049 - 109,641,864 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANXA5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1768,940,365 - 68,970,324 (-)NCBI
ChlSab1.1 Ensembl768,940,304 - 68,970,811 (-)Ensembl
Anxa5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247771,921,354 - 1,969,772 (-)NCBI

Position Markers
RH129836  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22119,314,032 - 119,314,235 (+)MAPPER
Rnor_6.02123,162,503 - 123,162,705NCBIRnor6.0
Rnor_5.02142,777,650 - 142,777,852UniSTSRnor5.0
RGSC_v3.42122,949,218 - 122,949,420UniSTSRGSC3.4
Celera2114,271,568 - 114,271,770UniSTS
RH 3.4 Map2664.1UniSTS
Cytogenetic Map2q25UniSTS
RH94545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22119,314,025 - 119,314,207 (+)MAPPER
Rnor_6.02123,162,496 - 123,162,677NCBIRnor6.0
Rnor_5.02142,777,643 - 142,777,824UniSTSRnor5.0
RGSC_v3.42122,949,211 - 122,949,392UniSTSRGSC3.4
Celera2114,271,561 - 114,271,742UniSTS
RH 3.4 Map2623.7UniSTS
Cytogenetic Map2q25UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)216679272245624402Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)223837491149614623Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491169852800Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491169852800Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)223837719169852670Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)223837719169852670Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226186097135654963Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226186097142053534Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)227161361148295267Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)227161361148295267Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)227161361148295267Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227161361148295267Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242776916169852800Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242776916195645082Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243133606217498545Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243133606217498545Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243141290154583160Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243149788198704485Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246537589217498710Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256244671217498710Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260131410135646395Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)260325352147522851Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266828049217498710Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266828236243550655Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)268865414169852800Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)268866454149614466Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)275687495221880419Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278321410158159410Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278321410217498710Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)280631950149614623Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282574487127574487Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)283656855128656855Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283754907237610852Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283819608239166203Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283819608243901375Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284424139132130578Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)291664872136664872Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)291664872136664872Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)291664872136664872Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)291664872136664872Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)293995316169852800Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)295946719140946719Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)295946719140946719Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)296844330141844330Rat
9589093Slep10Serum leptin concentration QTL 103.840.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)2102356980147356980Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2108880910153880910Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2110965721155965721Rat
1581552Pur12Proteinuria QTL 125.190.0009total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2115721880154182196Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2116075644228737869Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2116075644228737869Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2118446646149614623Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2118446646149614623Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2118446646200453484Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2118446646200453484Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2118446646227707979Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2118446793228582621Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2119789823164789823Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2121750419155965721Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2121750419169852800Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23436819

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:50
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000019554
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 3 43 57 41 19 41 8 11 74 35 39 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019554   ⟹   ENSRNOP00000019552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2123,162,461 - 123,193,130 (-)Ensembl
RefSeq Acc Id: NM_013132   ⟹   NP_037264
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22119,314,025 - 119,344,571 (-)NCBI
Rnor_6.02123,162,495 - 123,193,040 (-)NCBI
Rnor_5.02142,777,624 - 142,808,420 (-)NCBI
RGSC_v3.42122,949,210 - 122,979,757 (-)RGD
Celera2114,271,560 - 114,302,133 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232268   ⟹   XP_006232330
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22119,314,007 - 119,344,703 (-)NCBI
Rnor_6.02123,162,477 - 123,193,175 (-)NCBI
Rnor_5.02142,777,624 - 142,808,420 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590652   ⟹   XP_017446141
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02123,162,477 - 123,194,730 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590653   ⟹   XP_017446142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02123,162,477 - 123,194,730 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037264   ⟸   NM_013132
- Sequence:
RefSeq Acc Id: XP_006232330   ⟸   XM_006232268
- Peptide Label: isoform X1
- UniProtKB: Q66HH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446142   ⟸   XM_017590653
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017446141   ⟸   XM_017590652
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000019552   ⟸   ENSRNOT00000019554

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691289
Promoter ID:EPDNEW_R1814
Type:initiation region
Name:Anxa5_1
Description:annexin A5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02123,193,087 - 123,193,147EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2120 AgrOrtholog
Ensembl Genes ENSRNOG00000014453 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019552 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019554 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192977 IMAGE-MGC_LOAD
InterPro Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANX5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25673 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93655 IMAGE-MGC_LOAD
NCBI Gene 25673 ENTREZGENE
PANTHER PTHR10502:SF26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Anxa5 PhenoGen
PRINTS ANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANNEXINV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANNEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6F8X2H2_RAT UniProtKB/TrEMBL
  ANXA5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HH8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Anxa5  annexin A5    annexin 5  Name updated 1299863 APPROVED
2002-11-06 Anxa5  annexin 5  Anx5  Annexin V  Symbol and Name updated 625702 APPROVED
2002-06-10 Anx5  Annexin V      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all tissues examined 634647
gene_function binds phospholipid membranes, binding is calcium dependent 634648
gene_product member of a family of calcium and phospholipid binding proteins 634647
gene_product member of a family of calcium and phospholipid binding proteins 634648
gene_transcript at least four distinct transcripts are detected that may arise via alternative splicing 634647