Anxa5 (annexin A5) - Rat Genome Database

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Gene: Anxa5 (annexin A5) Rattus norvegicus
Symbol: Anxa5
Name: annexin A5
RGD ID: 2120
Description: Enables several functions, including P-type calcium transporter activity; calcium-dependent phospholipid binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including cellular response to gonadotropin-releasing hormone; cellular response to lead ion; and negative regulation of prolactin secretion. Located in several cellular components, including Z disc; intercalated disc; and perikaryon. Is active in synaptic vesicle membrane. Biomarker of several diseases, including Wilson disease; cryptorchidism; glomerulonephritis; hyperthyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; myocardial infarction; and systemic scleroderma. Orthologous to human ANXA5 (annexin A5); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
Previously known as: anchorin CII; annexin 5; Annexin V; annexin-5; Anx5; calphobindin I; CBP-I; CPB-I; endonexin II; LC5; lipocortin V; MGC93655; PAP-I; placental anticoagulant protein 4; placental anticoagulant protein I; PP4; thromboplastin inhibitor; VAC-alpha; vascular anticoagulant-alpha
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22119,314,007 - 119,344,703 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2119,314,007 - 119,353,369 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2125,868,632 - 125,899,139 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02123,981,142 - 124,011,637 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02118,610,122 - 118,640,625 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,162,477 - 123,194,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,162,461 - 123,193,130 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02142,777,624 - 142,808,420 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42122,949,210 - 122,979,757 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12122,894,171 - 122,924,719 (-)NCBI
Celera2114,271,560 - 114,302,133 (-)NCBICelera
RH 3.4 Map2623.7RGD
Cytogenetic Map2q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
atrazine  (EXP,ISO)
bacitracin  (EXP)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beryllium sulfate  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buspirone  (EXP)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
Destruxin B  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fenthion  (ISO)
fentin chloride  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycidyl methacrylate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
griseofulvin  (ISO)
hyaluronic acid  (EXP)
hydrazine  (ISO)
hydrogen peroxide  (EXP,ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
kojic acid  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
lovastatin  (ISO)
mercury dichloride  (ISO)
methidathion  (ISO)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
Myrtucommulone A  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitric oxide  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Ptaquiloside  (ISO)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
ruthenium atom  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulindac sulfide  (ISO)
T-2 toxin  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
triphenylstannane  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
warfarin  (ISO)
zearalenone  (ISO)
zinc pyrithione  (ISO)


References - curated
# Reference Title Reference Citation
1. Microarray analysis of differential gene expression in lead-exposed astrocytes. Bouton CM, etal., Toxicol Appl Pharmacol. 2001 Oct 1;176(1):34-53.
2. Rat annexin V crystal structure: Ca(2+)-induced conformational changes. Concha NO, etal., Science. 1993 Sep 3;261(5126):1321-4.
3. Proteomic and tissue array profiling identifies elevated hypoxia-regulated proteins in pancreatic ductal adenocarcinoma. Cui Y, etal., Cancer Invest. 2009 Aug;27(7):747-55.
4. In vivo modulation of annexins I, II and V expression by thyroxine and methylthiouracil. el Btaouri H, etal., Eur J Biochem. 1996 Dec 15;242(3):506-11.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Immunohistochemical localization of annexin V (CaBP33) in rat organs. Giambanco I, etal., J Histochem Cytochem. 1991 Sep;39(9):1189-98.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Annexins I-VI in secretory ameloblasts and odontoblasts of rat incisor. Goldberg M, etal., J Biol Buccale. 1990 Dec;18(4):289-98.
9. A common polymorphism in the annexin V Kozak sequence (-1C>T) increases translation efficiency and plasma levels of annexin V, and decreases the risk of myocardial infarction in young patients. Gonzalez-Conejero R, etal., Blood. 2002 Sep 15;100(6):2081-6.
10. Preferential localization of annexin V to the axon terminal. Gotow T, etal., Neuroscience. 1996 Nov;75(2):507-21.
11. Anti-annexin v antibodies: association with vascular involvement and disease outcome in patients with systemic sclerosis. Habeeb RA, etal., Clin Med Insights Arthritis Musculoskelet Disord. 2010 Apr 28;3:15-23.
12. Structure of rat annexin V gene and molecular diversity of its transcripts. Imai Y and Kohsaka S, Eur J Biochem 1995 Sep 1;232(2):327-34.
13. The -1C to T polymorphism in the annexin A5 gene is not associated with the risk of acute myocardial infarction or sudden cardiac death in middle-aged Finnish males. Kaikkonen KS, etal., Scand J Clin Lab Invest. 2005;65(2):133-40.
14. Measurement of plasma annexin V by ELISA in the early detection of acute myocardial infarction. Kaneko N, etal., Clin Chim Acta. 1996 Jul 15;251(1):65-80.
15. Purification of cardiac annexin V from the beagle dog heart and changes in its localization in the ischemic rat heart. Kaneko N, etal., Heart Vessels. 1994;9(3):148-54.
16. Association of annexin V with prolactin in the rat anterior pituitary gland. Kawaminami M, etal., Biochem Biophys Res Commun. 1992 Jul 31;186(2):894-8.
17. Annexin 5 inhibits thyrotropin releasing hormone (TRH) stimulated prolactin release in the primary culture of rat anterior pituitary cells. Kawaminami M, etal., Endocr J. 2004 Jun;51(3):349-54.
18. Ovariectomy enhances the expression and nuclear translocation of annexin 5 in rat anterior pituitary gonadotrophs. Kawaminami M, etal., Mol Cell Endocrinol. 1998 Jun 25;141(1-2):73-8.
19. Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage. Kirsch T, etal., Osteoarthritis Cartilage. 2000 Jul;8(4):294-302.
20. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. Association of neovascular age-related macular degeneration with specific gene expression patterns in peripheral white blood cells. Lederman M, etal., Invest Ophthalmol Vis Sci. 2010 Jan;51(1):53-8. Epub 2009 Aug 13.
22. Proteomic analysis of the hepatic tissue of Long-Evans Cinnamon (LEC) rats according to the natural course of Wilson disease. Lee BH, etal., Proteomics. 2011 Sep;11(18):3698-705. doi: 10.1002/pmic.201100122. Epub 2011 Aug 9.
23. Identification of a 35 kDa protein in rat spinal ganglia and sensory fibers. Li Q, etal., Neuroreport. 2004 Sep 15;15(13):2083-7.
24. Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats. Liu N, etal., J Neurosci Res. 2004 Aug 1;77(3):391-401.
25. Presence and comparison of Ca2+ transport activity of annexins I, II, V, and VI in large unilamellar vesicles. Matsuda R, etal., Biochem Biophys Res Commun. 1997 Aug 28;237(3):499-503.
26. Localization of annexin V in rat normal kidney and experimental glomerulonephritis. Matsuda R, etal., Res Exp Med (Berl). 2001 Jan;200(2):77-92.
27. Interfacial basic cluster in annexin V couples phospholipid binding and trimer formation on membrane surfaces. Mo Y, etal., J Biol Chem 2003 Jan 24;278(4):2437-43.
28. Myocyte apoptosis during acute myocardial infarction in rats is related to early sarcolemmal translocation of annexin A5 in border zone. Monceau V, etal., Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H965-71. Epub 2006 Feb 24.
29. Externalization of endogenous annexin A5 participates in apoptosis of rat cardiomyocytes. Monceau V, etal., Cardiovasc Res. 2004 Dec 1;64(3):496-506.
30. Pressure overload induces overexpression of annexins II and V in aortic-banded rats. Moraru II, etal., Ann N Y Acad Sci. 1998 Sep 16;853:329-32.
31. Differential expression of annexins I-VI in the rat dorsal root ganglia and spinal cord. Naciff JM, etal., J Comp Neurol. 1996 May 6;368(3):356-70.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Molecular cloning and characterization of annexin V-binding proteins with highly hydrophilic peptide structure. Ohsawa K, etal., J Neurochem 1996 Jul;67(1):89-97.
34. Five distinct calcium and phospholipid binding proteins share homology with lipocortin I. Pepinsky RB, etal., J Biol Chem 1988 Aug 5;263(22):10799-811.
35. GOA pipeline RGD automated data pipeline
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Purification, crystallization, and preliminary X-ray diffraction analysis of rat kidney annexin V, a calcium-dependent phospholipid-binding protein. Seaton BA, etal., J Biol Chem. 1990 Mar 15;265(8):4567-9.
38. Urinary annexin V in children with nephrotic syndrome: a new prognostic marker? Simsek B, etal., Pediatr Nephrol. 2008 Jan;23(1):79-82. Epub 2007 Nov 13.
39. Evaluation of annexin A5 as a biomarker for Alzheimer's disease and dementia with lewy bodies. Sohma H, etal., Front Aging Neurosci. 2013 Apr 5;5:15. doi: 10.3389/fnagi.2013.00015. eCollection 2013.
40. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
41. [Expression of rat annexin 5 and its effect on human sperm motility in vitro]. Tao XQ, etal., Zhonghua Nan Ke Xue. 2010 May;16(5):400-4.
42. Decreased concentration of annexin V in parkinsonian cerebrospinal fluid: speculation on the underlying cause. Vermes I, etal., Mov Disord. 1999 Nov;14(6):1008-10.
43. Annexin V is localized in association with Z-line of rat cardiac myocytes. Wang L, etal., Cardiovasc Res. 1995 Sep;30(3):363-71.
44. Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1. Wen Y, etal., Biochem Biophys Res Commun. 1999 May 19;258(3):713-21.
45. Diannexin protects against renal ischemia reperfusion injury and targets phosphatidylserines in ischemic tissue. Wever KE, etal., PLoS One. 2011;6(8):e24276. doi: 10.1371/journal.pone.0024276. Epub 2011 Aug 30.
46. Investigation of annexin A5 as a biomarker for Alzheimer's disease using neuronal cell culture and mouse model. Yamaguchi M, etal., J Neurosci Res. 2010 Sep;88(12):2682-92. doi: 10.1002/jnr.22427.
47. Stimulation of annexin A5 expression by gonadotropin releasing hormone (GnRH) in the Leydig cells of rats. Yao B and Kawaminami M, J Reprod Dev. 2008 Aug;54(4):259-64. Epub 2008 May 27.
48. Testicular annexin A5 expression augmented by experimental cryptorchidism and could affect germ cell apoptosis in rats. Yao B, etal., Urology. 2009 Jun;73(6):1412-6. doi: 10.1016/j.urology.2008.11.021. Epub 2009 Apr 18.
Additional References at PubMed
PMID:2138016   PMID:7583670   PMID:9609693   PMID:12865345   PMID:16085777   PMID:16455971   PMID:17082577   PMID:19056867   PMID:19623612   PMID:19893283   PMID:19934022   PMID:19946888  
PMID:20458337   PMID:20978343   PMID:21362503   PMID:21423176   PMID:21508411   PMID:22871113   PMID:23376485   PMID:23533145   PMID:25002582   PMID:26316108   PMID:28543594   PMID:31515275  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22119,314,007 - 119,344,703 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2119,314,007 - 119,353,369 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2125,868,632 - 125,899,139 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02123,981,142 - 124,011,637 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02118,610,122 - 118,640,625 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,162,477 - 123,194,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,162,461 - 123,193,130 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02142,777,624 - 142,808,420 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42122,949,210 - 122,979,757 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12122,894,171 - 122,924,719 (-)NCBI
Celera2114,271,560 - 114,302,133 (-)NCBICelera
RH 3.4 Map2623.7RGD
Cytogenetic Map2q25NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384121,667,946 - 121,696,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4121,667,946 - 121,696,995 (-)EnsemblGRCh38hg38GRCh38
GRCh374122,589,101 - 122,618,135 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364122,808,598 - 122,837,626 (-)NCBINCBI36Build 36hg18NCBI36
Build 344122,946,752 - 122,975,781NCBI
Celera4119,974,664 - 120,003,661 (-)NCBICelera
Cytogenetic Map4q27ENTREZGENE
HuRef4118,316,005 - 118,345,109 (-)NCBIHuRef
CHM1_14122,565,582 - 122,594,573 (-)NCBICHM1_1
T2T-CHM13v2.04124,971,975 - 125,001,007 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39336,503,072 - 36,530,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl336,503,072 - 36,530,043 (-)EnsemblGRCm39 Ensembl
GRCm38336,448,923 - 36,475,887 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl336,448,923 - 36,475,894 (-)EnsemblGRCm38mm10GRCm38
MGSCv37336,347,845 - 36,374,809 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36336,640,474 - 36,667,247 (-)NCBIMGSCv36mm8
Celera336,332,154 - 36,359,060 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map317.46NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542818,873,782 - 18,907,955 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542818,873,782 - 18,907,955 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan14119,732,681 - 119,761,758 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04113,868,218 - 113,897,243 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14125,006,038 - 125,034,972 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,006,038 - 125,034,972 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11918,419,936 - 18,450,088 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1918,407,587 - 18,570,378 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1918,636,905 - 18,666,325 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01918,538,322 - 18,568,429 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1918,538,347 - 18,569,685 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11918,489,737 - 18,519,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01918,771,009 - 18,800,422 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01919,247,832 - 19,277,209 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530166,159,815 - 66,193,477 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936662925,940 - 939,451 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936662926,302 - 959,964 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl8102,388,103 - 102,425,750 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18102,387,833 - 102,420,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28109,609,049 - 109,641,864 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1768,940,365 - 68,970,324 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl768,940,304 - 68,970,811 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603747,900,616 - 47,930,596 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247771,919,602 - 1,970,059 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247771,921,354 - 1,969,772 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Anxa5
179 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23436819

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:50
Interacting mature miRNAs:53
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22119,314,032 - 119,314,235 (+)MAPPERmRatBN7.2
Rnor_6.02123,162,503 - 123,162,705NCBIRnor6.0
Rnor_5.02142,777,650 - 142,777,852UniSTSRnor5.0
RGSC_v3.42122,949,218 - 122,949,420UniSTSRGSC3.4
Celera2114,271,568 - 114,271,770UniSTS
RH 3.4 Map2664.1UniSTS
Cytogenetic Map2q25UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22119,314,025 - 119,314,207 (+)MAPPERmRatBN7.2
Rnor_6.02123,162,496 - 123,162,677NCBIRnor6.0
Rnor_5.02142,777,643 - 142,777,824UniSTSRnor5.0
RGSC_v3.42122,949,211 - 122,949,392UniSTSRGSC3.4
Celera2114,271,561 - 114,271,742UniSTS
RH 3.4 Map2623.7UniSTS
Cytogenetic Map2q25UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 3 43 57 41 19 41 8 11 74 35 39 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000019554   ⟹   ENSRNOP00000019552
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2119,314,010 - 119,344,795 (-)Ensembl
Rnor_6.0 Ensembl2123,162,461 - 123,193,130 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104744   ⟹   ENSRNOP00000087773
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2119,314,007 - 119,344,610 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108710   ⟹   ENSRNOP00000090883
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2119,314,010 - 119,344,795 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109811   ⟹   ENSRNOP00000086538
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2119,314,007 - 119,344,600 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111490   ⟹   ENSRNOP00000097911
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2119,314,014 - 119,353,369 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113833   ⟹   ENSRNOP00000082480
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2119,314,014 - 119,332,426 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116052   ⟹   ENSRNOP00000088704
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2119,314,014 - 119,353,369 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116908   ⟹   ENSRNOP00000094623
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2119,314,014 - 119,353,369 (-)Ensembl
RefSeq Acc Id: NM_013132   ⟹   NP_037264
Rat AssemblyChrPosition (strand)Source
mRatBN7.22119,314,025 - 119,344,571 (-)NCBI
Rnor_6.02123,162,495 - 123,193,040 (-)NCBI
Rnor_5.02142,777,624 - 142,808,420 (-)NCBI
RGSC_v3.42122,949,210 - 122,979,757 (-)RGD
Celera2114,271,560 - 114,302,133 (-)RGD
RefSeq Acc Id: XM_006232268   ⟹   XP_006232330
Rat AssemblyChrPosition (strand)Source
mRatBN7.22119,314,007 - 119,344,703 (-)NCBI
Rnor_6.02123,162,477 - 123,193,175 (-)NCBI
Rnor_5.02142,777,624 - 142,808,420 (-)NCBI
RefSeq Acc Id: NP_037264   ⟸   NM_013132
- UniProtKB: P14668 (UniProtKB/Swiss-Prot),   Q66HH8 (UniProtKB/TrEMBL),   A6IHX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232330   ⟸   XM_006232268
- Peptide Label: isoform X1
- UniProtKB: P14668 (UniProtKB/Swiss-Prot),   Q66HH8 (UniProtKB/TrEMBL),   A6IHX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019552   ⟸   ENSRNOT00000019554
RefSeq Acc Id: ENSRNOP00000086538   ⟸   ENSRNOT00000109811
RefSeq Acc Id: ENSRNOP00000097911   ⟸   ENSRNOT00000111490
RefSeq Acc Id: ENSRNOP00000094623   ⟸   ENSRNOT00000116908
RefSeq Acc Id: ENSRNOP00000090883   ⟸   ENSRNOT00000108710
RefSeq Acc Id: ENSRNOP00000082480   ⟸   ENSRNOT00000113833
RefSeq Acc Id: ENSRNOP00000088704   ⟸   ENSRNOT00000116052
RefSeq Acc Id: ENSRNOP00000087773   ⟸   ENSRNOT00000104744

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14668-F1-model_v2 AlphaFold P14668 1-319 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2120 AgrOrtholog
BioCyc Gene G2FUF-53319 BioCyc
Ensembl Genes ENSRNOG00000014453 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019552 ENTREZGENE
  ENSRNOP00000019552.5 UniProtKB/TrEMBL
  ENSRNOP00000082480.1 UniProtKB/TrEMBL
  ENSRNOP00000086538.1 UniProtKB/TrEMBL
  ENSRNOP00000087773.1 UniProtKB/TrEMBL
  ENSRNOP00000088704.1 UniProtKB/TrEMBL
  ENSRNOP00000090883.1 UniProtKB/TrEMBL
  ENSRNOP00000094623.1 UniProtKB/TrEMBL
  ENSRNOP00000097911.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019554 ENTREZGENE
  ENSRNOT00000019554.7 UniProtKB/TrEMBL
  ENSRNOT00000104744.1 UniProtKB/TrEMBL
  ENSRNOT00000108710.1 UniProtKB/TrEMBL
  ENSRNOT00000109811.1 UniProtKB/TrEMBL
  ENSRNOT00000111490.1 UniProtKB/TrEMBL
  ENSRNOT00000113833.1 UniProtKB/TrEMBL
  ENSRNOT00000116052.1 UniProtKB/TrEMBL
  ENSRNOT00000116908.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANX5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25673 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10502:SF26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Anxa5 PhenoGen
  ANNEXINV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANNEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6F8X2H2_RAT UniProtKB/TrEMBL
UniProt Secondary A6IHX7 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Anxa5  annexin A5    annexin 5  Name updated 1299863 APPROVED
2002-11-06 Anxa5  annexin 5  Anx5  Annexin V  Symbol and Name updated 625702 APPROVED
2002-06-10 Anx5  Annexin V      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all tissues examined 634647
gene_function binds phospholipid membranes, binding is calcium dependent 634648
gene_product member of a family of calcium and phospholipid binding proteins 634647
gene_product member of a family of calcium and phospholipid binding proteins 634648
gene_transcript at least four distinct transcripts are detected that may arise via alternative splicing 634647