Spry1 (sprouty RTK signaling antagonist 1) - Rat Genome Database

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Gene: Spry1 (sprouty RTK signaling antagonist 1) Rattus norvegicus
Analyze
Symbol: Spry1
Name: sprouty RTK signaling antagonist 1
RGD ID: 1309293
Description: Involved in epithelial to mesenchymal transition involved in cardiac fibroblast development. Located in cytosol. Orthologous to human SPRY1 (sprouty RTK signaling antagonist 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC294981; protein sprouty homolog 1; sprouty homolog 1 (Drosophila); sprouty homolog 1, antagonist of FGF signaling; sprouty homolog 1, antagonist of FGF signaling (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,484,995 - 122,490,008 (+)NCBIGRCr8
mRatBN7.22120,557,256 - 120,561,917 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,556,706 - 120,566,189 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2127,120,252 - 127,124,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02125,232,775 - 125,237,438 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,861,729 - 119,866,392 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02124,400,689 - 124,405,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,400,679 - 124,405,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02144,010,441 - 144,015,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42124,213,692 - 124,218,334 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12124,164,062 - 124,168,594 (+)NCBI
Celera2115,501,106 - 115,505,962 (+)NCBICelera
Cytogenetic Map2q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
baicalein  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
kenpaullone  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methylparaben  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nutlin-3  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
temozolomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,IEA,ISO)
Golgi apparatus  (IEA,ISO)
membrane  (IEA)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1. Bronnum H, etal., PLoS One. 2013;8(2):e56280. doi: 10.1371/journal.pone.0056280. Epub 2013 Feb 18.
2. MicroRNA-21 contributes to high glucose-induced fibrosis in peritoneal mesothelial cells in rat models by activation of the Ras-MAPK signaling pathway via Sprouty-1. Gao Q, etal., J Cell Physiol. 2019 May;234(5):5915-5925. doi: 10.1002/jcp.26941. Epub 2018 Dec 4.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11585837   PMID:12477932   PMID:15691764   PMID:16339969   PMID:16481357   PMID:17141539   PMID:17537792   PMID:19043405   PMID:21764747   PMID:22236546   PMID:22880013   PMID:30635790  


Genomics

Comparative Map Data
Spry1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,484,995 - 122,490,008 (+)NCBIGRCr8
mRatBN7.22120,557,256 - 120,561,917 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,556,706 - 120,566,189 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2127,120,252 - 127,124,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02125,232,775 - 125,237,438 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,861,729 - 119,866,392 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02124,400,689 - 124,405,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,400,679 - 124,405,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02144,010,441 - 144,015,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42124,213,692 - 124,218,334 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12124,164,062 - 124,168,594 (+)NCBI
Celera2115,501,106 - 115,505,962 (+)NCBICelera
Cytogenetic Map2q25NCBI
SPRY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384123,396,795 - 123,403,760 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4123,396,795 - 123,403,760 (+)EnsemblGRCh38hg38GRCh38
GRCh374124,317,950 - 124,324,915 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364124,537,406 - 124,544,360 (+)NCBINCBI36Build 36hg18NCBI36
Build 344124,675,560 - 124,682,512NCBI
Celera4121,700,490 - 121,707,443 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4120,044,807 - 120,051,767 (+)NCBIHuRef
CHM1_14124,294,629 - 124,301,588 (+)NCBICHM1_1
T2T-CHM13v2.04126,700,894 - 126,707,854 (+)NCBIT2T-CHM13v2.0
Spry1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,694,096 - 37,698,748 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,694,096 - 37,698,747 (+)EnsemblGRCm39 Ensembl
GRCm38337,639,947 - 37,644,599 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,639,947 - 37,644,598 (+)EnsemblGRCm38mm10GRCm38
MGSCv37337,538,872 - 37,543,521 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,831,525 - 37,836,146 (+)NCBIMGSCv36mm8
Celera337,514,171 - 37,518,800 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.46NCBI
Spry1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542817,451,703 - 17,455,695 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542817,451,703 - 17,455,695 (-)NCBIChiLan1.0ChiLan1.0
SPRY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23121,170,151 - 121,177,157 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14121,437,960 - 121,456,736 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04115,570,788 - 115,578,824 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14126,715,650 - 126,720,973 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4126,718,811 - 126,719,770 (+)Ensemblpanpan1.1panPan2
SPRY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11916,969,869 - 16,976,573 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1916,970,904 - 16,972,089 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,183,429 - 17,189,923 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,082,115 - 17,088,610 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1917,079,998 - 17,088,580 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11917,039,814 - 17,046,311 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,317,762 - 17,324,256 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01917,789,162 - 17,795,661 (-)NCBIUU_Cfam_GSD_1.0
Spry1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530164,874,359 - 64,879,870 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366622,243,326 - 2,244,291 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366622,241,928 - 2,245,616 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8100,450,266 - 100,863,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18100,449,476 - 100,863,780 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,191,807 - 108,199,235 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPRY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1770,626,524 - 70,634,084 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl770,631,925 - 70,632,884 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603749,599,467 - 49,606,489 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spry1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,731,299 - 3,735,373 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247773,728,984 - 3,735,373 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spry1
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:842
Count of miRNA genes:244
Interacting mature miRNAs:302
Transcripts:ENSRNOT00000058495, ENSRNOT00000067034
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000058495   ⟹   ENSRNOP00000055291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2120,557,186 - 120,563,061 (+)Ensembl
Rnor_6.0 Ensembl2124,400,679 - 124,405,329 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000067034   ⟹   ENSRNOP00000058906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2124,400,689 - 124,405,331 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102538   ⟹   ENSRNOP00000080595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2120,556,706 - 120,566,189 (+)Ensembl
RefSeq Acc Id: NM_001395072   ⟹   NP_001382001
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82122,485,347 - 122,490,008 (+)NCBI
mRatBN7.22120,557,256 - 120,561,917 (+)NCBI
RefSeq Acc Id: NM_001395073   ⟹   NP_001382002
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82122,485,347 - 122,490,008 (+)NCBI
mRatBN7.22120,557,256 - 120,561,917 (+)NCBI
RefSeq Acc Id: XM_063281571   ⟹   XP_063137641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82122,484,995 - 122,490,008 (+)NCBI
Ensembl Acc Id: ENSRNOP00000058906   ⟸   ENSRNOT00000067034
Ensembl Acc Id: ENSRNOP00000055291   ⟸   ENSRNOT00000058495
Ensembl Acc Id: ENSRNOP00000080595   ⟸   ENSRNOT00000102538
RefSeq Acc Id: NP_001382001   ⟸   NM_001395072
- UniProtKB: B5DFH3 (UniProtKB/TrEMBL),   A0A8I5ZQE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382002   ⟸   NM_001395073
- UniProtKB: B5DFH3 (UniProtKB/TrEMBL),   A0A8I5ZQE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137641   ⟸   XM_063281571
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFH3-F1-model_v2 AlphaFold B5DFH3 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691302
Promoter ID:EPDNEW_R1824
Type:multiple initiation site
Name:Spry1_1
Description:sprouty RTK signaling antagonist 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02124,400,670 - 124,400,730EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309293 AgrOrtholog
BioCyc Gene G2FUF-53298 BioCyc
Ensembl Genes ENSRNOG00000025371 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058495.3 UniProtKB/TrEMBL
  ENSRNOT00000102538 ENTREZGENE
  ENSRNOT00000102538.1 UniProtKB/TrEMBL
  ENSRNOT00000159365 ENTREZGENE
InterPro Sprouty UniProtKB/TrEMBL
  Sprouty_domain UniProtKB/TrEMBL
NCBI Gene 294981 ENTREZGENE
PANTHER PTHR12365:SF10 UniProtKB/TrEMBL
  SPROUTY UniProtKB/TrEMBL
Pfam Sprouty UniProtKB/TrEMBL
PhenoGen Spry1 PhenoGen
PROSITE SPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025371 RatGTEx
UniProt A0A8I5ZQE3 ENTREZGENE, UniProtKB/TrEMBL
  B5DFH3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Spry1  sprouty RTK signaling antagonist 1  Spry1  sprouty homolog 1, antagonist of FGF signaling (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Spry1  sprouty homolog 1, antagonist of FGF signaling (Drosophila)  Spry1  sprouty homolog 1 (Drosophila)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Spry1  sprouty homolog 1 (Drosophila)   Spry1_predicted  sprouty homolog 1 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Spry1_predicted  sprouty homolog 1 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED