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Gene: Pla2g4a (phospholipase A2 group IVA) Rattus norvegicus
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Symbol: Pla2g4a
Name: phospholipase A2 group IVA
Description: Exhibits calcium-dependent phospholipase A2 activity and histone acetyltransferase binding activity. Involved in several processes, including positive regulation of prostaglandin biosynthetic process; reproductive structure development; and surfactant homeostasis. Localizes to several cellular components, including the cytosol; perinuclear region of cytoplasm; and zymogen granule. Used to study hyperglycemia. Biomarker of asthma; brain ischemia; papilloma; polycystic kidney disease; and transitional cell carcinoma. Orthologous to human PLA2G4A (phospholipase A2 group IVA); PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; endothelin signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cPLA2; cytosolic phospholipase A2; phospholipase A2 cytosolic; Phospholipase A2, cytosolic; phospholipase A2, group IVA (cytosolic, calcium-dependent); Pla2c; Pla2g4
Orthologs:
Homo sapiens (human) : PLA2G4A (phospholipase A2 group IVA)  HGNC  Alliance
Mus musculus (house mouse) : Pla2g4a (phospholipase A2, group IVA (cytosolic, calcium-dependent))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pla2g4a (phospholipase A2 group IVA)
Pan paniscus (bonobo/pygmy chimpanzee) : PLA2G4A (phospholipase A2 group IVA)
Canis lupus familiaris (dog) : PLA2G4A (phospholipase A2 group IVA)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pla2g4a (phospholipase A2 group IVA)
Sus scrofa (pig) : PLA2G4A (phospholipase A2 group IVA)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01367,062,252 - 67,206,688 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1366,988,937 - 67,206,693 (-)Ensembl
Rnor_5.01372,027,801 - 72,172,613 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,135,729 - 64,280,815 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11364,149,803 - 64,294,883 (-)NCBI
Celera1361,840,531 - 61,984,375 (-)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pla2g4a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 67366
Created: 2001-06-01
Species: Rattus norvegicus
Last Modified: 2019-09-03
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.