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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pla2g4a
Name: phospholipase A2 group IVA
Acc ID: CHEBI:18295
Term: histamine
Definition: A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Chemical ID: MESH:D006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7358726480464CTDHistamine results in increased expression of PLA2G4A mRNA

PMID:9609743
multiple interactionsISORGD:7358726480464CTDDexamethasone inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA], Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA], MK-886 inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]

PMID:9609743
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.