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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pla2g4a
Name: phospholipase A2 group IVA
Acc ID: CHEBI:17489
Term: 3',5'-cyclic AMP
Definition: A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase.
Chemical ID: MESH:D000242
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCyclic AMP results in increased expression of PLA2G4A mRNA, Cyclic AMP results in increased expression of PLA2G4A protein

PMID:22187434
multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cyclic AMP results in increased expression of PLA2G4A mRNA], 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cyclic AMP results in increased expression of PLA2G4A protein]

PMID:22187434
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.