Kat5 (lysine acetyltransferase 5)

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Gene: Kat5 (lysine acetyltransferase 5) Rattus norvegicus

Analyze

Symbol:

Kat5

Name:

lysine acetyltransferase 5

RGD ID:

621061

Description:

Exhibits chromatin binding activity; phospholipase binding activity; and transcription factor binding activity. Involved in several processes, including cellular response to X-ray; cellular response to hydrogen peroxide; and histone acetylation. Localizes to several cellular components, including chromatin; cytosol; and nucleus. Biomarker of iron deficiency anemia. Orthologous to human KAT5 (lysine acetyltransferase 5); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; INO80 family mediated chromatin remodeling pathway; INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; (-)-epigallocatechin 3-gallate (ortholog).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

60 kDa Tat-interactive protein; histone acetyltransferase HTATIP; histone acetyltransferase KAT5; HIV-1 Tat interactive protein 60 kD; HIV-1 Tat interactive protein, 60 kD; HIV-1 tat interactive protein, homolog; HIV-1 tat interactive protein, homolog (human); Htatip; Htatip1; K(lysine) acetyltransferase 5; MGC95167; Tip60

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KAT5 (lysine acetyltransferase 5)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Kat5 (K(lysine) acetyltransferase 5)	HGNC	NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Kat5 (lysine acetyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KAT5 (lysine acetyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KAT5 (lysine acetyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kat5 (lysine acetyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KAT5 (lysine acetyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	KAT5 (lysine acetyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kat5 (lysine acetyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KAT5 (lysine acetyltransferase 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Kat5 (K(lysine) acetyltransferase 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	kat5b (K(lysine) acetyltransferase 5b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	kat5a (K(lysine) acetyltransferase 5a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	ESA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Tip60	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	mys-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	202,895,751 - 202,903,178 (-)	NCBI
Rnor_6.0 Ensembl	1	220,967,796 - 220,974,597 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	220,967,795 - 220,974,596 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	227,898,843 - 227,906,221 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	208,233,434 - 208,240,738 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	208,387,311 - 208,393,493 (-)	NCBI
Celera	1	200,431,510 - 200,438,814 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres syndrome (ISO)

Aicardi-Goutieres Syndrome 3 (ISO)

B-cell lymphoma (ISO)

breast cancer (ISO)

iron deficiency anemia (IEP)

NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES, SLEEP DISTURBANCE, AND BRAIN ABNORMALITIES (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acrolein (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butyric acid (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

daidzein (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

elemental selenium (ISO)

equol (ISO)

ethanol (ISO)

folic acid (ISO)

genistein (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

ozone (ISO)

paracetamol (ISO)

pentamidine (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

quercitrin (ISO)

resveratrol (ISO)

sarin (ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamibarotene (ISO)

trichostatin A (ISO)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEP)

cellular response to estradiol stimulus (IEA,ISO)

cellular response to hydrogen peroxide (IEP)

cellular response to X-ray (IEP)

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (IEA,ISO,ISS)

double-strand break repair (IEA,ISO)

histone acetylation (IEA,IMP,ISO)

histone H4 acetylation (NAS)

negative regulation of interleukin-2 production (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

negative regulation of transcription, DNA-templated (IBA,ISO)

peptidyl-lysine acetylation (ISO,ISS)

positive regulation of autophagy (IEA,ISO,ISS)

positive regulation of protein acetylation (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IBA,IDA,IEA,ISO)

positive regulation of transcription, DNA-templated (ISO,ISS)

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA,ISO)

protein phosphopantetheinylation (IEA)

regulation of transcription by RNA polymerase II (ISO)

response to heat (IEP)

response to ionizing radiation (IEA,ISO)

Cellular Component

chromatin (IBA,IDA)

cytosol (IDA)

NuA4 histone acetyltransferase complex (ISO,ISS)

nucleolus (IEA,ISO,ISS)

nucleoplasm (ISO,TAS)

nucleus (IDA,ISO)

perinuclear region of cytoplasm (IEA)

Piccolo NuA4 histone acetyltransferase complex (IEA,ISO,ISS)

protein-containing complex (IDA)

Swr1 complex (IEA,ISO,ISS)

transcription regulator complex (IEA,ISO)

Molecular Function

chromatin binding (IDA)

histone acetyltransferase activity (IBA,IEA,ISO,ISS,NAS)

histone binding (IBA)

metal ion binding (IEA)

peptide-lysine-N-acetyltransferase activity (ISO,ISS)

phospholipase binding (IPI)

protein binding (IPI,ISO)

protein-containing complex binding (IPI)

repressing transcription factor binding (IEA,ISO)

transcription coactivator activity (IEA,ISO,ISS)

transcription coregulator activity (IBA)

transcription factor binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

ataxia telangiectasia-mutated (ATM) signaling pathway (ISO)

histone modification pathway (ISO)

INO80 family mediated chromatin remodeling pathway (ISO)

p53 signaling pathway (ISO)

References

References - curated


1.	Aksenov MY, etal., Brain Res 2003 Oct 10;987(1):1-9.
2.	Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
3.	Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
4.	Cao X and Sudhof TC, Science. 2001 Jul 6;293(5527):115-20.
5.	Carlson ES, etal., Brain Res. 2008 Aug 7.
6.	Coffey K, etal., PLoS One. 2012;7(10):e45539. doi: 10.1371/journal.pone.0045539. Epub 2012 Oct 8.
7.	Frank SR, etal., EMBO Rep 2003 Jun;4(6):575-80.
8.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9.	GOA data from the GO Consortium
10.	Gorrini C, etal., Nature. 2007 Aug 30;448(7157):1063-7.
11.	Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
12.	MGD data from the GO Consortium
13.	Muckova K, etal., Am J Physiol Renal Physiol. 2006 Jan;290(1):F70-9. Epub 2005 Jun 28.
14.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	Patani N, etal., Anticancer Res. 2011 Dec;31(12):4115-25.
16.	Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
17.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18.	Prendergast MA, etal., Brain Res 2002 Nov 8;954(2):300-7.
19.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20.	RGD automated import pipeline for gene-chemical interactions
21.	Sheridan AM, etal., Mol Cell Biol. 2001 Jul;21(14):4470-81.
22.	Stante M, etal., Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5093-8. doi: 10.1073/pnas.0810869106. Epub 2009 Mar 12.
23.	Stracker TH, etal., Front Genet. 2013 Mar 25;4:37. doi: 10.3389/fgene.2013.00037. eCollection 2013.
24.	Tetievsky A and Horowitz M, J Appl Physiol (1985). 2010 Nov;109(5):1552-61. doi: 10.1152/japplphysiol.00469.2010. Epub 2010 Sep 2.
25.	Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.

Additional References at PubMed

PMID:10966108	PMID:12464179	PMID:12477932	PMID:14966270	PMID:15489334	PMID:15944124	PMID:16387653	PMID:17360565	PMID:17996965	PMID:18397884	PMID:22539723	PMID:23637611
PMID:24012345	PMID:24075908	PMID:24463511	PMID:27454757	PMID:30704899

Genomics

Comparative Map Data

Kat5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	202,895,751 - 202,903,178 (-)	NCBI
Rnor_6.0 Ensembl	1	220,967,796 - 220,974,597 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	220,967,795 - 220,974,596 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	227,898,843 - 227,906,221 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	208,233,434 - 208,240,738 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	208,387,311 - 208,393,493 (-)	NCBI
Celera	1	200,431,510 - 200,438,814 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

KAT5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	11	65,711,996 - 65,719,604 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	11	65,712,018 - 65,719,604 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	11	65,479,723 - 65,487,075 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	65,236,065 - 65,243,651 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	11	65,236,064 - 65,243,650	NCBI
Celera	11	62,806,503 - 62,814,088 (+)	NCBI
Cytogenetic Map	11	q13.1	NCBI
HuRef	11	61,806,327 - 61,813,930 (+)	NCBI		HuRef
CHM1_1	11	65,363,389 - 65,370,993 (+)	NCBI		CHM1_1

Kat5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	5,653,042 - 5,661,584 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	19	5,653,042 - 5,660,265 (-)	Ensembl
GRCm38	19	5,603,014 - 5,611,556 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	5,603,014 - 5,610,237 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	5,603,418 - 5,610,029 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	19	5,603,418 - 5,610,029 (-)	NCBI			mm8
Celera	19	5,473,388 - 5,479,999 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI

Kat5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	19,557,498 - 19,565,036 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	19,557,498 - 19,565,044 (-)	NCBI	ChiLan1.0	ChiLan1.0

KAT5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	64,405,088 - 64,412,667 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	64,404,572 - 64,412,667 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	61,071,118 - 61,078,667 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

KAT5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	18	51,499,938 - 51,576,699 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	18	51,499,615 - 51,507,434 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Kat5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936599	3,767,526 - 3,775,416 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KAT5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	6,560,513 - 6,572,466 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	6,560,544 - 6,572,461 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	5,668,370 - 5,676,947 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KAT5
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	8,528,097 - 8,544,512 (-)	NCBI
ChlSab1.1 Ensembl	1	8,526,788 - 8,544,972 (-)	Ensembl

Kat5
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624767	20,668,759 - 20,675,367 (-)	NCBI

Position Markers

RH132564

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	220,967,990 - 220,968,193	NCBI	Rnor6.0
Rnor_5.0	1	227,899,040 - 227,899,243	UniSTS	Rnor5.0
RGSC_v3.4	1	208,233,629 - 208,233,832	UniSTS	RGSC3.4
Celera	1	200,431,705 - 200,431,908	UniSTS
RH 3.4 Map	1	1548.9	UniSTS
Cytogenetic Map	1	q43	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	217372257	244992610	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	193220385	238220385	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	215711860	260711860	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	156446196	274977688	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	189514504	234514504	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	161321152	273792054	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	198585664	236763415	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	137787261	236763528	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	156446196	243311614	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	215828102	260828102	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	216324817	261324817	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	197963658	242963658	Rat
1331790	Bp201	Blood pressure QTL 201	3.127		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	216213318	245529710	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	167394665	278228889	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	205603081	244401301	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	100131562	236763528	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	191825895	279986079	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	197187728	230420772	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	215711860	258765521	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	153834077	232297227	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	189170900	234170900	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	189170900	234170900	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	189170900	234170900	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	189170900	234170900	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	189170900	234170900	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	189170900	234170900	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	189170900	234170900	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	189170900	234170900	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	205195290	250195290	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	198446729	240017341	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	217054291	281795785	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	193968438	261264776	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	210960636	236763528	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	215828102	260828102	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	195598053	265002735	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	215684498	260684498	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	194554354	239554354	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	213476630	278978026	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	213476630	278978026	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	213476630	278978026	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	161321256	273791893	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	196395041	282763074	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	161321256	273791893	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	82788437	239853971	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	201146802	241482368	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	108986301	238830534	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	161784169	278228889	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	192639698	278228889	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	161784169	278228889	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	192639698	278228889	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	185390068	230390068	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	161784169	278228889	Rat
1359018	Hrtrt20	Heart rate QTL 20	3.08		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	201358068	221983732	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	196738546	241738546	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	163796316	282763074	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	210360774	264802828	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	174905700	264802994	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	174905700	233490237	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	198655722	244992610	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	167394665	238830534	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	201358068	252480016	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	161784422	246226103	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	208517798	266948272	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	190282646	235282646	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	0.00000081	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	216324817	261324817	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	188850303	233850303	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	137787261	236763528	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	215828102	260828102	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	197187728	238220385	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	202571665	264802994	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	122614824	262664716	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	144634295	241482368	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	125875758	262433692	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	210652654	255652654	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	202571665	264802994	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	210990171	255990171	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	194872362	239872362	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	140
Count of miRNA genes:	54
Interacting mature miRNAs:	62
Transcripts:	ENSRNOT00000028107, ENSRNOT00000041916
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	36	49	33	19	33	2	5	74	35	41	11	2
Low		7	8	8		8	6	6					6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF333984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227931	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233931	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000088799 ⟹ ENSRNOP00000075290

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	220,967,796 - 220,974,597 (-)	Ensembl

RefSeq Acc Id:

NM_001005872 ⟹ NP_001005872

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	202,895,753 - 202,903,057 (-)	NCBI
Rnor_6.0	1	220,967,795 - 220,974,596 (-)	NCBI
Rnor_5.0	1	227,898,843 - 227,906,221 (-)	NCBI
RGSC_v3.4	1	208,233,434 - 208,240,738 (-)	RGD
Celera	1	200,431,510 - 200,438,814 (-)	RGD

Sequence:

show sequence

GGAAGATGGCGGAGGTGGGGGAGATAATCGAGGGCTGCCGCCTGCCCGTGCTGCGGCGCAACCA
GGACAACGAAGATGAGTGGCCCCTGGCTGAGATCCTGAGCGTGAAGGACATCAGTGGCCGGAAG
CTTTTCTATGTCCATTACATTGATTTCAACAAACGTCTGGATGAATGGGTGACTCACGAGCGGC
TGGACTTAAAGAAGATCCAATTTCCCAAGAAAGAAGCCAAGACACCTACCAAGAACGGACTTCC
TGGGTCCCGCCCCGGCTCTCCCGAAAGAGAGGTGCCGGCCTCCGCCCAGGCCAGCGGGAAGACC
TTGCCAATCCCGGTCCAGATCACACTCCGCTTCAACCTGCCCAAGGAGCGGGAGGCCATTCCAG
GTGGCGAGCCTGACCAGCCGCTCTCCTCCAGCTCCTGCCTGCAACCCAACCACCGCTCAACGAA
ACGGAAGGTGGAGGTGGTTTCACCAGCAACTCCAGTGCCCAGCGAGACAGCCCCAGCTTCAGTT
TTCCCCCAGAATGGATCAGCCCGTAGGGCAGTGGCAGCACAGCCAGGACGGAAGCGGAAATCTA
ATTGCCTGGGCACTGATGAGGATTCTCAGGACAGCTCAGATGGAATACCGTCAGCACCACGCAT
GACTGGCAGTTTGGTGTCTGACCGGAGCCACGACGACATTGTCACCCGGATGAAGAACATTGAG
TGTATTGAGCTTGGCCGGCACCGCCTCAAGCCGTGGTACTTCTCCCCGTACCCTCAAGAGCTTA
CCACGCTACCTGTCCTCTACCTGTGCGAATTTTGCCTCAAATATGGCCGTAGCCTCAAGTGTCT
GCAGCGCCACTTGACCAAATGTGATCTTCGACACCCTCCAGGCAATGAAATTTACCGCAAGGGC
ACCATCTCCTTTTTTGAGATTGATGGGCGGAAAAACAAGAGTTACTCACAAAACCTGTGTCTTC
TGGCCAAGTGTTTCCTCGACCACAAGACATTGTACTATGACACAGACCCCTTCCTTTTCTATGT
AATGACGGAGTATGACTGCAAGGGCTTCCACATCGTGGGCTACTTCTCCAAGGAAAAGGAGTCC
ACAGAAGATTACAATGTGGCCTGCATCTTGACTCTGCCACCTTATCAGCGCCGGGGCTATGGAA
AGCTGCTTATTGAGTTCAGCTATGAACTCTCGAAAGTAGAAGGGAAGACAGGAACTCCTGAGAA
ACCCCTGTCAGATCTTGGCCTTCTATCCTACCGAAGTTACTGGTCCCAAACCATCTTGGAGATC
CTGATGGGGCTGAAGTCGGAGAGTGGGGAGAGACCACAGATCACCATCAATGAGATCAGTGAAA
TCACTAGTATCAAGAAAGAAGATGTCATTTCCACACTGCAGTATCTCAATCTCATCAATTACTA
CAAGGGCCAGTATATCCTCACTCTGTCAGAAGACATCGTGGATGGGCATGAGCGGGCTATGCTC
AAGCGGCTCCTTCGAATTGACTCCAAGTGTCTGCACTTCACTCCCAAAGACTGGAGCAAGAGAG
GAAAGTGGTGACACACACACTCTCACTGCAACACCGCGAAAGCCAGCTGAACACGGCTGTCATC
CTGTCGTATCCCATTCGAGCTTCGAAGAGTCATGCAAAGGGAGACAGGCCAAAGGACAGACCCA
AAAGAAGAAGAGGCCTAGGAGGGGCCAACTAGTGGCCAGTACCAAAGCGAGCTCAGGTCTAGGC
CGACTCCAAGGATAGCTGGCTTGTTGGCTCAGGTCCGCTCTGAACACAGGGACCAGGGGGACCC
AGGCAGCTGTGTACACTAAGGCGGGTGGGGAGCATCTGTACAGGACTGGTGACTGTAAAAATTT
CTTTTGTAAAGGAGGAGCTGGAGGGTGGGGTGGGCGCTGGTTGCAAAGTTCTGGCCCTCCCTGC
CCCCAGAAATAAATTGTTTTTATAGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039092592 ⟹ XP_038948520

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	202,895,753 - 202,903,077 (-)	NCBI

RefSeq Acc Id:

XM_039092631 ⟹ XP_038948559

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	202,895,753 - 202,903,076 (-)	NCBI

RefSeq Acc Id:

XM_039092652 ⟹ XP_038948580

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	202,895,753 - 202,903,178 (-)	NCBI

RefSeq Acc Id:

XM_039092686 ⟹ XP_038948614

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	202,895,753 - 202,903,075 (-)	NCBI

RefSeq Acc Id:

XM_039092727 ⟹ XP_038948655

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	202,895,751 - 202,903,174 (-)	NCBI

RefSeq Acc Id:

XM_039092756 ⟹ XP_038948684

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	202,895,751 - 202,902,758 (-)	NCBI

RefSeq Acc Id:

XM_039092812 ⟹ XP_038948740

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	202,895,751 - 202,902,802 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001005872	(Get FASTA)	NCBI Sequence Viewer
	XP_038948520	(Get FASTA)	NCBI Sequence Viewer
	XP_038948559	(Get FASTA)	NCBI Sequence Viewer
	XP_038948580	(Get FASTA)	NCBI Sequence Viewer
	XP_038948614	(Get FASTA)	NCBI Sequence Viewer
	XP_038948655	(Get FASTA)	NCBI Sequence Viewer
	XP_038948684	(Get FASTA)	NCBI Sequence Viewer
	XP_038948740	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83879	(Get FASTA)	NCBI Sequence Viewer
	AAK20836	(Get FASTA)	NCBI Sequence Viewer
	EDM12509	(Get FASTA)	NCBI Sequence Viewer
	EDM12510	(Get FASTA)	NCBI Sequence Viewer
	EDM12511	(Get FASTA)	NCBI Sequence Viewer
	EDM12512	(Get FASTA)	NCBI Sequence Viewer
	Q99MK2	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001005872 ⟸ NM_001005872

- UniProtKB:

Q99MK2 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLD
LKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGG
EPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGSARRAVAAQPGRKRKSNC
LGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTT
LPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLA
KCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKL
LIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEIT
SIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGK
W

hide sequence

RefSeq Acc Id:

ENSRNOP00000075290 ⟸ ENSRNOT00000088799

RefSeq Acc Id:	XP_038948655 ⟸ XM_039092727
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038948740 ⟸ XM_039092812
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038948684 ⟸ XM_039092756
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038948580 ⟸ XM_039092652
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038948520 ⟸ XM_039092592
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038948559 ⟸ XM_039092631
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038948614 ⟸ XM_039092686
- Peptide Label:	isoform X4

Protein Domains

MYST-type HAT

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621061	AgrOrtholog
Ensembl Genes	ENSRNOG00000061012	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000075290	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000088799	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7130366	IMAGE-MGC_LOAD
InterPro	Acyl_CoA_acyltransferase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Chromo-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Chromo/chromo_shadow_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Esa1/KAT5/Tip60	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HAT_MYST-type	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tudor-knot	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Zf-MYST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:192218	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:95167	IMAGE-MGC_LOAD
NCBI Gene	192218	ENTREZGENE
PANTHER	PTHR10615:SF183	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	MOZ_SAS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tudor-knot	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-MYST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Kat5	PhenoGen
PROSITE	MYST_HAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	CHROMO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF54160	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55729	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2KA75_RAT	UniProtKB/TrEMBL
	KAT5_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q5XI16	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Kat5	lysine acetyltransferase 5	Kat5	K(lysine) acetyltransferase 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-17	Kat5	K(lysine) acetyltransferase 5	Htatip	HIV-1 tat interactive protein, homolog (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Htatip	HIV-1 tat interactive protein, homolog (human)		HIV-1 Tat interactive protein, 60 kD	Name updated	1299863	APPROVED
2002-08-07	Htatip	HIV-1 Tat interactive protein, 60 kD			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)