Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pla2g4a
Name: phospholipase A2 group IVA
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:111166480464CTDFluoxetine results in increased expression of PLA2G4A mRNA, Fluoxetine results in increased expression of PLA2G4A protein

PMID:19662385
multiple interactionsISORGD:111166480464CTD[[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein] which results in increased expression of PLA2G4A protein, [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein] which results in increased expression of PLA2G4A protein, N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA], N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein], N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA], N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein], RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA], RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein], U 0126 inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA], U 0126 inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein]

PMID:19662385
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.