Pla2g4a (phospholipase A2 group IVA) - Rat Genome Database

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Gene: Pla2g4a (phospholipase A2 group IVA) Chinchilla lanigera
Analyze
Symbol: Pla2g4a
Name: phospholipase A2 group IVA
RGD ID: 8877296
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent phospholipase A2 activity (ortholog); calcium-dependent phospholipid binding (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); arachidonate secretion (ortholog); cellular response to antibiotic (ortholog); PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; endothelin signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); amyotrophic lateral sclerosis (ortholog); asthma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytosolic phospholipase A2; phospholipase A2, group IVA (cytosolic, calcium-dependent)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540625,257,355 - 25,394,206 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540625,257,361 - 25,392,079 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pla2g4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540625,257,355 - 25,394,206 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540625,257,361 - 25,392,079 (+)NCBIChiLan1.0ChiLan1.0
PLA2G4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,828,949 - 186,988,981 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,828,949 - 186,988,981 (+)EnsemblGRCh38hg38GRCh38
GRCh371186,798,081 - 186,958,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,064,655 - 185,224,736 (+)NCBINCBI36Build 36hg18NCBI36
Build 341183,529,761 - 183,689,770NCBI
Celera1159,908,366 - 160,068,522 (+)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1158,032,476 - 158,192,352 (+)NCBIHuRef
CHM1_11188,219,298 - 188,379,410 (+)NCBICHM1_1
T2T-CHM13v2.01186,183,301 - 186,343,553 (+)NCBIT2T-CHM13v2.0
Pla2g4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,705,369 - 149,837,041 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,705,369 - 149,837,041 (-)EnsemblGRCm39 Ensembl
GRCm381149,829,618 - 149,961,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,829,618 - 149,961,290 (-)EnsemblGRCm38mm10GRCm38
MGSCv371151,676,752 - 151,808,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,591,840 - 151,723,502 (-)NCBIMGSCv36mm8
Celera1152,270,492 - 152,407,425 (-)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.51NCBI
Pla2g4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,427,921 - 64,572,352 (-)NCBIGRCr8
mRatBN7.21361,877,818 - 62,022,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1361,877,813 - 62,022,266 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1364,503,114 - 64,647,490 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01365,794,043 - 65,938,034 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,055,598 - 63,199,601 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,062,252 - 67,206,688 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1366,988,937 - 67,206,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,027,801 - 72,172,613 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,135,729 - 64,280,815 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,149,803 - 64,294,883 (-)NCBI
Celera1361,840,531 - 61,984,375 (-)NCBICelera
Cytogenetic Map13q21NCBI
PLA2G4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2162,725,111 - 62,884,722 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1162,405,808 - 62,566,032 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,362,600 - 162,521,974 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,512,870 - 166,672,114 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,512,870 - 166,672,101 (+)Ensemblpanpan1.1panPan2
PLA2G4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,804,412 - 19,955,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,832,664 - 19,966,936 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha719,327,033 - 19,477,842 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0719,541,768 - 19,692,656 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,570,229 - 19,692,274 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,447,440 - 19,598,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,556,751 - 19,707,439 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,688,892 - 19,840,168 (+)NCBIUU_Cfam_GSD_1.0
Pla2g4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934485,712,619 - 85,843,081 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364813,559,358 - 3,689,833 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364813,559,377 - 3,689,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,859,051 - 128,162,638 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19127,853,581 - 128,164,825 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29140,386,385 - 140,623,416 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12542,443,480 - 42,590,895 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2542,443,385 - 42,590,431 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605543,569,644 - 43,761,073 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248146,597,005 - 6,744,286 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248146,597,248 - 6,744,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000019293   ⟹   ENSCLAP00000019108
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540625,257,355 - 25,394,206 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000019294   ⟹   ENSCLAP00000019109
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540625,281,649 - 25,337,712 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000019295   ⟹   ENSCLAP00000019110
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540625,301,026 - 25,389,256 (+)Ensembl
RefSeq Acc Id: XM_005375092   ⟹   XP_005375149
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540625,257,361 - 25,392,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013521775   ⟹   XP_013377229
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540625,257,361 - 25,392,079 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005375149 (Get FASTA)   NCBI Sequence Viewer  
  XP_013377229 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000019108
  ENSCLAP00000019108.1
  ENSCLAP00000019109.1
  ENSCLAP00000019110.1
RefSeq Acc Id: XP_005375149   ⟸   XM_005375092
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VQQ4 (UniProtKB/TrEMBL),   A0A8C2YS19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013377229   ⟸   XM_013521775
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YS19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000019110   ⟸   ENSCLAT00000019295
Ensembl Acc Id: ENSCLAP00000019108   ⟸   ENSCLAT00000019293
Ensembl Acc Id: ENSCLAP00000019109   ⟸   ENSCLAT00000019294
Protein Domains
C2   PLA2c


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013091 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019293 ENTREZGENE
  ENSCLAT00000019293.1 UniProtKB/TrEMBL
  ENSCLAT00000019294.1 UniProtKB/TrEMBL
  ENSCLAT00000019295.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
  Cytosolic phospholipase A2 catalytic domain UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/TrEMBL
  C2_cPLA2 UniProtKB/TrEMBL
  C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  LysoPLipase_cat_dom UniProtKB/TrEMBL
  Synaptotagmin_plant UniProtKB/TrEMBL
NCBI Gene Pla2g4a ENTREZGENE
PANTHER C2 CALCIUM/LIPID-BINDING ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE-RELATED UniProtKB/TrEMBL
  CYTOSOLIC PHOSPHOLIPASE A2 UniProtKB/TrEMBL
  CYTOSOLIC PHOSPHOLIPASE A2 UniProtKB/TrEMBL
  EXTENDED SYNAPTOTAGMIN-RELATED UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/TrEMBL
  PLA2_B UniProtKB/TrEMBL
PROSITE PLA2C UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART PLAc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF52151 UniProtKB/TrEMBL
UniProt A0A8C2VQQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YS19 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YS22_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Pla2g4a  phospholipase A2 group IVA    phospholipase A2, group IVA (cytosolic, calcium-dependent)  Symbol and/or name change 5135510 APPROVED