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85 kDa cytosolic phospholipase A2 is a target for chronic lithium in rat brain.

Authors: Rintala, J  Seemann, R  Chandrasekaran, K  Rosenberger, TA  Chang, L  Contreras, MA  Contreras, MA  Rapoport, SI  Chang, MC 
Citation: Rintala J, etal., Neuroreport. 1999 Dec 16;10(18):3887-90.
Pubmed: (View Article at PubMed) PMID:10716228

The mechanism by which chronic lithium exerts its therapeutic effect in brains of bipolar patients is not known. One possibility, suggested by our demonstration in the rat brain, is that chronic lithium inhibits turnover of arachidonic acid (AA) by reducing the activity of an AA-specific phospholipase A2 (PLA2). To test this further, mRNA levels of two AA-specific PLA2s, cytosolic PLA2 (cPLA2) type IV and intracellular PLA2 (iPLA2) type VIII, and protein level of cPLA2 were quantified in the brain of rats given lithium for 6 weeks. Chronic lithium markedly reduced brain mRNA and protein level of cPLA2, but had no effect on mRNA level of iPLA2. These results suggest that the final common path effect of chronic lithium administration is to reduce turnover of AA in brain by down-regulating cPLA2.


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RGD Object Information
RGD ID: 8694084
Created: 2014-07-23
Species: All species
Last Modified: 2014-07-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.