Hsd17b2 (hydroxysteroid (17-beta) dehydrogenase 2) - Rat Genome Database

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Gene: Hsd17b2 (hydroxysteroid (17-beta) dehydrogenase 2) Rattus norvegicus
Analyze
Symbol: Hsd17b2
Name: hydroxysteroid (17-beta) dehydrogenase 2
RGD ID: 621803
Description: Enables estradiol 17-beta-dehydrogenase [NAD(P)] activity and testosterone dehydrogenase (NAD+) activity. Involved in bone development; cellular response to metal ion; and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 17-beta hydroxysteroid dehydrogenase type 2; 17-beta-HSD 2; 17-beta-hydroxysteroid dehydrogenase 2; 17-beta-hydroxysteroid dehydrogenase type 2; estradiol 17-beta-dehydrogenase 2; testosterone 17-beta-dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21945,753,576 - 45,825,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,753,574 - 45,825,202 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1952,565,001 - 52,636,759 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01953,216,191 - 53,287,955 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01955,460,429 - 55,532,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01950,246,404 - 50,317,892 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1950,246,402 - 50,317,891 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01961,033,236 - 61,101,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,729,519 - 47,802,933 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11947,734,400 - 47,807,814 (-)NCBI
Celera1945,023,173 - 45,093,239 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methoxyestrone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-dichloroaniline  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
acetoacetyl-CoA  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (ISO)
antimony(0)  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (EXP)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dienogest  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
diuron  (EXP,ISO)
dydrogesterone  (ISO)
endosulfan  (EXP)
epoxiconazole  (EXP)
estrone  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
glyphosate  (EXP)
graphite  (EXP)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imidacloprid  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (EXP)
leflunomide  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
methoxychlor  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nevirapine  (EXP)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
PD 0325901  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
progesterone  (ISO)
promegestone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
triadimefon  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
valproic acid  (EXP)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes. Akinola LA, etal., Endocrinology 1996 May;137(5):1572-9.
2. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. Banu SK, etal., Toxicol Appl Pharmacol. 2008 Oct 15;232(2):180-9. Epub 2008 Jun 17.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats. Jazbutyte V, etal., Hypertension. 2006 Oct;48(4):579-86. Epub 2006 Aug 28.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation. van der Eerden BC, etal., J Endocrinol. 2004 Mar;180(3):457-67.
Additional References at PubMed
PMID:8099587   PMID:12477932   PMID:17538076   PMID:18048640   PMID:22837477  


Genomics

Comparative Map Data
Hsd17b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21945,753,576 - 45,825,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,753,574 - 45,825,202 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1952,565,001 - 52,636,759 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01953,216,191 - 53,287,955 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01955,460,429 - 55,532,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01950,246,404 - 50,317,892 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1950,246,402 - 50,317,891 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01961,033,236 - 61,101,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,729,519 - 47,802,933 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11947,734,400 - 47,807,814 (-)NCBI
Celera1945,023,173 - 45,093,239 (+)NCBICelera
Cytogenetic Map19q12NCBI
HSD17B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381682,035,253 - 82,098,534 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1682,035,004 - 82,098,534 (+)EnsemblGRCh38hg38GRCh38
GRCh371682,068,858 - 82,132,139 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361680,626,364 - 80,689,638 (+)NCBINCBI36Build 36hg18NCBI36
Build 341680,626,363 - 80,689,638NCBI
Celera1666,367,527 - 66,430,804 (+)NCBICelera
Cytogenetic Map16q23.3NCBI
HuRef1667,822,411 - 67,885,688 (+)NCBIHuRef
CHM1_11683,480,225 - 83,543,515 (+)NCBICHM1_1
T2T-CHM13v2.01688,098,974 - 88,162,234 (+)NCBIT2T-CHM13v2.0
Hsd17b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398118,427,721 - 118,485,769 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8118,428,643 - 118,485,766 (+)EnsemblGRCm39 Ensembl
GRCm388117,700,982 - 117,759,030 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8117,701,904 - 117,759,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv378120,225,846 - 120,282,929 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368120,587,962 - 120,644,851 (+)NCBIMGSCv36mm8
Celera8121,922,376 - 121,979,885 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map864.82NCBI
Hsd17b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555641,922,703 - 1,983,966 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555641,884,235 - 1,984,182 (-)NCBIChiLan1.0ChiLan1.0
HSD17B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11697,705,141 - 97,768,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01662,642,316 - 62,705,261 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11682,062,047 - 82,125,039 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1682,062,042 - 82,125,139 (+)Ensemblpanpan1.1panPan2
HSD17B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1569,927,888 - 70,009,306 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl569,927,984 - 70,009,179 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha569,936,380 - 70,023,461 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0570,226,818 - 70,314,083 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl570,232,641 - 70,314,177 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1570,169,271 - 70,257,042 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0570,005,963 - 70,093,190 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0570,423,292 - 70,510,487 (-)NCBIUU_Cfam_GSD_1.0
Hsd17b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,094,893 - 30,162,355 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647529,426,883 - 29,494,225 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647529,426,922 - 29,494,215 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl66,292,707 - 6,360,633 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.166,296,429 - 6,360,434 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.266,885,015 - 6,885,284 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1567,464,986 - 67,529,079 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl567,464,334 - 67,529,182 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660478,304,938 - 8,368,998 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247465,368,142 - 5,446,429 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247465,372,176 - 5,445,726 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsd17b2
305 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:63
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000018795
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat

Markers in Region
RH129256  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21945,824,987 - 45,825,180 (+)MAPPERmRatBN7.2
Rnor_6.01950,317,677 - 50,317,869NCBIRnor6.0
Rnor_5.01961,101,246 - 61,101,438UniSTSRnor5.0
RGSC_v3.41947,729,542 - 47,729,734UniSTSRGSC3.4
Celera1945,093,024 - 45,093,216UniSTS
RH 3.4 Map19610.4UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 1 1
Medium 3 38 38 38 13 2
Low 2 5 2 6 2 18 25 7
Below cutoff 13 12 13 6 7 35 4 9 4 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018795   ⟹   ENSRNOP00000018795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1945,753,574 - 45,825,202 (+)Ensembl
Rnor_6.0 Ensembl1950,246,402 - 50,317,891 (+)Ensembl
RefSeq Acc Id: NM_024391   ⟹   NP_077367
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21945,753,576 - 45,825,203 (+)NCBI
Rnor_6.01950,246,404 - 50,317,892 (+)NCBI
Rnor_5.01961,033,236 - 61,101,461 (+)NCBI
RGSC_v3.41947,729,519 - 47,802,933 (-)RGD
Celera1945,023,173 - 45,093,239 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077367 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88134 (Get FASTA)   NCBI Sequence Viewer  
  CAA62617 (Get FASTA)   NCBI Sequence Viewer  
  EDL92656 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018795
  ENSRNOP00000018795.2
GenBank Protein Q62730 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_077367   ⟸   NM_024391
- UniProtKB: Q62730 (UniProtKB/Swiss-Prot),   Q5I0N4 (UniProtKB/TrEMBL),   F7EZ71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018795   ⟸   ENSRNOT00000018795

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62730-F1-model_v2 AlphaFold Q62730 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701173
Promoter ID:EPDNEW_R11696
Type:single initiation site
Name:Hsd17b2_1
Description:hydroxysteroid (17-beta) dehydrogenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01950,246,395 - 50,246,455EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621803 AgrOrtholog
BioCyc Gene G2FUF-5537 BioCyc
Ensembl Genes ENSRNOG00000013982 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018795 ENTREZGENE
  ENSRNOT00000018795.4 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7326035 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108672 IMAGE-MGC_LOAD
NCBI Gene 79243 ENTREZGENE
PANTHER 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd17b2 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013982 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DHB2_RAT UniProtKB/Swiss-Prot
  F7EZ71 ENTREZGENE, UniProtKB/TrEMBL
  Q5I0N4 ENTREZGENE, UniProtKB/TrEMBL
  Q62730 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hsd17b2  hydroxysteroid (17-beta) dehydrogenase 2    17-beta hydroxysteroid dehydrogenase type 2  Name updated 1299863 APPROVED
2002-08-07 Hsd17b2  17-beta hydroxysteroid dehydrogenase type 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function converts estradiol to estrone and testosterone into androstenedione 728619
gene_function appears to oxidize 17-betahydroxysteroids into their relatively inactive keto derivatives 728619
gene_homology protein shares 77% similarity and 62% identity with human homolog 728619
gene_protein protein has predicted mass of 42 kDa 728619