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Gene: Litaf (lipopolysaccharide-induced TNF factor) Rattus norvegicus
Symbol: Litaf
Name: lipopolysaccharide-induced TNF factor
RGD ID: 69294
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; WW domain binding activity; and zinc ion binding activity. Involved in aging. Predicted to localize to several cellular components, including cytoplasmic side of endosome membrane; cytoplasmic side of lysosomal membrane; and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1C. Orthologous to human LITAF (lipopolysaccharide induced TNF factor); INTERACTS WITH (+)-schisandrin B; 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: EET-1; estrogen-enhanced transcript protein 1; estrogen-responsive uterine transcript; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; LPS-induced TN factor; LPS-induced TNF-alpha factor; LPS-induced TNF-alpha factor homolog; Pig7
Homo sapiens (human) : LITAF (lipopolysaccharide induced TNF factor)  HGNC  Alliance
Mus musculus (house mouse) : Litaf (LPS-induced TN factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Litaf (lipopolysaccharide induced TNF factor)
Pan paniscus (bonobo/pygmy chimpanzee) : LITAF (lipopolysaccharide induced TNF factor)
Canis lupus familiaris (dog) : LITAF (lipopolysaccharide induced TNF factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Litaf (lipopolysaccharide induced TNF factor)
Sus scrofa (pig) : LITAF (lipopolysaccharide induced TNF factor)
Chlorocebus sabaeus (African green monkey) : LITAF (lipopolysaccharide induced TNF factor)
Heterocephalus glaber (naked mole-rat) : Litaf (lipopolysaccharide induced TNF factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0104,753,546 - 4,763,272 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,719,713 - 4,763,510 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,580,243 - 3,589,969 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,614,177 - 4,623,903 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1104,587,486 - 4,623,903 (+)NCBI
Celera103,704,946 - 3,714,672 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Litaf
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69294
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.