Pthlh (parathyroid hormone-like hormone) - Rat Genome Database

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Gene: Pthlh (parathyroid hormone-like hormone) Rattus norvegicus
Analyze
Symbol: Pthlh
Name: parathyroid hormone-like hormone
RGD ID: 3441
Description: Enables hormone activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in brachydactyly type E2. Orthologous to human PTHLH (parathyroid hormone like hormone); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH 1-Oleoyl-2-acetyl-sn-glycerol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: parathyroid hormone-like peptide; parathyroid hormone-like protein; parathyroid hormone-related protein; parathyroid-like peptide; PLP; PTH-rP; PTHrP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84181,919,400 - 181,930,454 (-)NCBIGRCr8
mRatBN7.24180,188,792 - 180,199,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4180,188,792 - 180,199,847 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4186,472,387 - 186,483,481 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04182,256,935 - 182,268,028 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04180,877,368 - 180,888,461 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04181,663,425 - 181,674,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04245,811,895 - 245,822,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44184,887,702 - 184,898,841 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14185,132,825 - 185,143,965 (-)NCBI
Celera4168,675,915 - 168,686,473 (-)NCBICelera
RH 3.4 Map41091.1RGD
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
1-Oleoyl-2-acetyl-sn-glycerol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium carbonate  (ISO)
candesartan  (EXP)
ceruletide  (EXP,ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
enalapril  (EXP)
ethanol  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (ISO)
losartan  (EXP)
manganese(II) chloride  (EXP)
mercury dichloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-Nitrosopyrrolidine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentane-2,3-dione  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
quinapril hydrochloride  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
styrene  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
thiamethoxam  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichostatin A  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
extracellular region  (IEA)
Golgi apparatus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Alvarez J, etal., Development. 2002 Apr;129(8):1913-24.
2. Parathyroid hormone-related protein induction in focal stroke: a neuroprotective vascular peptide. Funk JL, etal., Am J Physiol Regul Integr Comp Physiol 2003 Apr;284(4):R1021-30.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homologue. Karaplis AC, etal., Mol Endocrinol 1990 Mar;4(3):441-6.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Expression of parathyroid hormone-related peptide and insulin-like growth factor I during rat fracture healing. Okazaki K, etal., J Orthop Res. 2003 May;21(3):511-20.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
17. Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells. Tfelt-Hansen J, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E329-37. Epub 2003 Apr 15.
18. Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. Thiede MA and Rodan GA, Science 1988 Oct 14;242(4876):278-80.
19. Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue. Yasuda T, etal., Mol Endocrinol 1989 Mar;3(3):518-25.
Additional References at PubMed
PMID:90087   PMID:8314082   PMID:8895385   PMID:9008714   PMID:9477327   PMID:9832460   PMID:9921650   PMID:11606467   PMID:12647298   PMID:15162506   PMID:15579504   PMID:16007342  
PMID:16672315   PMID:16940239   PMID:17200368   PMID:17328886   PMID:17435078   PMID:18048500   PMID:18401831   PMID:19574446   PMID:19674967   PMID:19910689   PMID:21073445   PMID:22093939  
PMID:22508055   PMID:23038778   PMID:23546599   PMID:24253735   PMID:25159845   PMID:25278090   PMID:25645361   PMID:26538570   PMID:26859332   PMID:30504697   PMID:31311343   PMID:31471966  


Genomics

Comparative Map Data
Pthlh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84181,919,400 - 181,930,454 (-)NCBIGRCr8
mRatBN7.24180,188,792 - 180,199,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4180,188,792 - 180,199,847 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4186,472,387 - 186,483,481 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04182,256,935 - 182,268,028 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04180,877,368 - 180,888,461 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04181,663,425 - 181,674,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04245,811,895 - 245,822,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44184,887,702 - 184,898,841 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14185,132,825 - 185,143,965 (-)NCBI
Celera4168,675,915 - 168,686,473 (-)NCBICelera
RH 3.4 Map41091.1RGD
Cytogenetic Map4q44NCBI
PTHLH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381227,958,084 - 27,972,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1227,958,084 - 27,972,733 (-)EnsemblGRCh38hg38GRCh38
GRCh371228,111,017 - 28,125,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,002,284 - 28,016,183 (-)NCBINCBI36Build 36hg18NCBI36
Build 341228,002,283 - 28,014,161NCBI
Celera1233,256,594 - 33,270,557 (-)NCBICelera
Cytogenetic Map12p11.22NCBI
HuRef1227,880,337 - 27,894,279 (-)NCBIHuRef
CHM1_11228,076,045 - 28,089,944 (-)NCBICHM1_1
T2T-CHM13v2.01227,829,831 - 27,844,463 (-)NCBIT2T-CHM13v2.0
Pthlh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396147,153,607 - 147,165,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6147,153,599 - 147,165,681 (-)EnsemblGRCm39 Ensembl
GRCm386147,252,109 - 147,264,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6147,252,101 - 147,264,183 (-)EnsemblGRCm38mm10GRCm38
MGSCv376147,200,632 - 147,212,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366147,209,270 - 147,221,371 (-)NCBIMGSCv36mm8
Celera6150,289,180 - 150,301,102 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map678.19NCBI
Pthlh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555056,834,533 - 6,847,335 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555056,834,533 - 6,846,909 (+)NCBIChiLan1.0ChiLan1.0
PTHLH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21068,846,032 - 68,858,167 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11268,842,410 - 68,854,564 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01258,341,361 - 58,355,804 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11260,959,327 - 60,973,749 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1260,960,071 - 60,973,750 (+)Ensemblpanpan1.1panPan2
PTHLH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12719,781,557 - 19,795,078 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2719,781,557 - 19,795,078 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2726,604,753 - 26,729,826 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02719,869,742 - 19,989,315 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2719,975,781 - 19,989,312 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12719,676,917 - 19,795,837 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02719,703,486 - 19,822,427 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02726,761,823 - 26,881,419 (-)NCBIUU_Cfam_GSD_1.0
Pthlh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494581,724,063 - 81,735,818 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936760197,525 - 209,518 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936760197,525 - 209,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTHLH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl545,751,292 - 45,763,415 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1545,750,968 - 45,763,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2549,159,951 - 49,172,393 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTHLH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11127,682,300 - 27,694,808 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1127,682,338 - 27,694,898 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660697,351,760 - 7,364,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pthlh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247788,008,056 - 8,019,612 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247788,007,358 - 8,019,538 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pthlh
45 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat

Markers in Region
D4Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24180,200,975 - 180,201,064 (+)MAPPERmRatBN7.2
Rnor_6.04181,675,452 - 181,675,540NCBIRnor6.0
Rnor_5.04245,823,922 - 245,824,010UniSTSRnor5.0
RGSC_v3.44184,899,968 - 184,900,058RGDRGSC3.4
RGSC_v3.44184,899,969 - 184,900,057UniSTSRGSC3.4
RGSC_v3.14185,145,092 - 185,145,182RGD
RH 3.4 Map41091.9UniSTS
RH 3.4 Map41091.9RGD
RH 2.0 Map41106.7RGD
Cytogenetic Map4q44UniSTS
RH94501  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24180,188,895 - 180,189,095 (+)MAPPERmRatBN7.2
Rnor_6.04181,663,529 - 181,663,728NCBIRnor6.0
Rnor_5.04245,811,999 - 245,812,198UniSTSRnor5.0
RGSC_v3.44184,887,806 - 184,888,005UniSTSRGSC3.4
Celera4168,676,019 - 168,676,218UniSTS
RH 3.4 Map41091.1UniSTS
Cytogenetic Map4q44UniSTS
RH130039  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24180,188,864 - 180,189,084 (+)MAPPERmRatBN7.2
Rnor_6.04181,663,498 - 181,663,717NCBIRnor6.0
Rnor_5.04245,811,968 - 245,812,187UniSTSRnor5.0
RGSC_v3.44184,887,775 - 184,887,994UniSTSRGSC3.4
Celera4168,675,988 - 168,676,207UniSTS
Cytogenetic Map4q44UniSTS


Expression


Sequence


Ensembl Acc Id: ENSRNOT00000112037   ⟹   ENSRNOP00000078983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4180,188,792 - 180,199,847 (-)Ensembl
RefSeq Acc Id: NM_012636   ⟹   NP_036768
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84181,919,400 - 181,930,454 (-)NCBI
mRatBN7.24180,188,792 - 180,199,847 (-)NCBI
Rnor_6.04181,663,425 - 181,674,181 (-)NCBI
Rnor_5.04245,811,895 - 245,822,651 (-)NCBI
RGSC_v3.44184,887,702 - 184,898,841 (-)RGD
Celera4168,675,915 - 168,686,473 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036768 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41889 (Get FASTA)   NCBI Sequence Viewer  
  AAA41980 (Get FASTA)   NCBI Sequence Viewer  
  AAA41981 (Get FASTA)   NCBI Sequence Viewer  
  EDM01395 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078983.1
  ENSRNOP00055013261
  ENSRNOP00060000480
  ENSRNOP00065006503
GenBank Protein P13085 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036768   ⟸   NM_012636
- Peptide Label: preproprotein
- UniProtKB: P13085 (UniProtKB/Swiss-Prot),   A0A8I5ZLU3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000078983   ⟸   ENSRNOT00000112037

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13085-F1-model_v2 AlphaFold P13085 1-177 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3441 AgrOrtholog
BioCyc Gene G2FUF-42415 BioCyc
Ensembl Genes ENSRNOG00000069267 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055009727 UniProtKB/Swiss-Prot
  ENSRNOG00060000917 UniProtKB/Swiss-Prot
  ENSRNOG00065006029 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000112037.1 UniProtKB/TrEMBL
  ENSRNOT00055016465 UniProtKB/Swiss-Prot
  ENSRNOT00060001193 UniProtKB/Swiss-Prot
  ENSRNOT00065009114 UniProtKB/Swiss-Prot
InterPro PTH-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTH/PTH-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24695 UniProtKB/Swiss-Prot
NCBI Gene 24695 ENTREZGENE
PANTHER PARATHYROID HORMONE-RELATED PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR17223 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Parathyroid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pthlh PhenoGen
PROSITE PARATHYROID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000069267 RatGTEx
  ENSRNOG00055009727 RatGTEx
  ENSRNOG00060000917 RatGTEx
  ENSRNOG00065006029 RatGTEx
SMART PTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZLU3 ENTREZGENE, UniProtKB/TrEMBL
  A6IN44_RAT UniProtKB/TrEMBL
  P13085 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-20 Pthlh  parathyroid hormone-like hormone  Pthlh  parathyroid hormone-like peptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Pthlh  parathyroid hormone-like peptide    parathyroid-like peptide  Name updated 629478 APPROVED
2002-06-10 Pthlh  parathyroid-like peptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function may be a hormone for the mobilization and/or transfer of calcium to milk  
gene_process plays a role in lactation  
gene_process regulates epidermal development.  
gene_process may have intracrine effects in the nucleus of cells that produce it in addition to having juxtacrine, paracrine, and possibly endocrine effects after secretion 61489