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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pthlh
Name: parathyroid hormone-like hormone
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pthlhincreases expressionISOPTHLH (Homo sapiens)6480464CTDEstradiol results in increased expression of PTHLH mRNAPMID:9790998
Pthlhincreases secretionISOPTHLH (Homo sapiens)6480464CTDEstradiol results in increased secretion of PTHLH proteinPMID:9790998
Pthlhmultiple interactionsISOPTHLH (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in increased expression of PTHLH mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of PTHLH mRNAPMID:17404688 PMID:30165855
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