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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pthlh
Name: parathyroid hormone-like hormone
Acc ID: CHEBI:3087
Term: betulinic acid
Definition: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.
Chemical ID: MESH:C002070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pthlhdecreases expressionISOPTHLH (Homo sapiens)6480464CTDBetulinic Acid results in decreased expression of PTHLH mRNAPMID:24463094
Pthlhdecreases response to substanceISOPTHLH (Homo sapiens)6480464CTDBetulinic Acid results in decreased susceptibility to PTHLH proteinPMID:24463094
Pthlhdecreases secretionISOPTHLH (Homo sapiens)6480464CTDBetulinic Acid results in decreased secretion of PTHLH proteinPMID:24463094
Pthlhmultiple interactionsISOPTHLH (Homo sapiens)6480464CTDBetulinic Acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]PMID:24463094
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