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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pthlh
Name: parathyroid hormone-like hormone
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pthlhaffects response to substanceEXP 6480464CTDPTHLH protein affects the susceptibility to EthanolPMID:22280800
Pthlhdecreases expressionEXP 6480464CTDEthanol results in decreased expression of PTHLH mRNA; Ethanol results in decreased expression of PTHLH proteinPMID:36174738
Pthlhincreases expressionEXP 6480464CTDEthanol results in increased expression of PTHLH mRNA; Ethanol results in increased expression of PTHLH proteinPMID:22280800
Pthlhmultiple interactionsEXP 6480464CTDEthanol results in increased susceptibility to [Ceruletide results in increased expression of PTHLH mRNA]; PTHLH protein inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA]; PTHLH protein inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]PMID:22280800
Pthlhincreases expressionISOPthlh (Mus musculus)6480464CTDEthanol results in increased expression of PTHLH mRNA; Ethanol results in increased expression of PTHLH proteinPMID:22280800
Pthlhmultiple interactionsISOPTHLH (Homo sapiens)6480464CTD[[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of PTHLH mRNAPMID:29432896
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