Gene: Pthlh (parathyroid hormone-like peptide) Mus musculus
Analyze
Symbol:
Pthlh
Name:
parathyroid hormone-like peptide
Description:
Predicted to have hormone activity and peptide hormone receptor binding activity. Involved in several processes, including animal organ development; osteoblast development; and surfactant homeostasis. Predicted to localize to the Golgi apparatus; cytosol; and nucleoplasm. Used to study Albright's hereditary osteodystrophy and achondroplasia. Human ortholog(s) of this gene implicated in brachydactyly type E2. Is expressed in several structures, including brain; integumental system; limb; sensory organ; and skeletal system. Orthologous to human PTHLH (parathyroid hormone like hormone).
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
parathyroid hormone-like hormone; parathyroid hormone-like protein; parathyroid hormone-related peptide; parathyroid hormone-related protein; PLP; PTH-like; PTH-related peptide; PTH-rP; Pthrp
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PTHLH (parathyroid hormone like hormone) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Rattus norvegicus (Norway rat):
Pthlh (parathyroid hormone-like hormone) HGNC
NCBI, HomoloGene, Panther
Chinchilla lanigera (long-tailed chinchilla):
Pthlh (parathyroid hormone like hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PTHLH (parathyroid hormone like hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PTHLH (parathyroid hormone like hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Pthlh (parathyroid hormone like hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PTHLH (parathyroid hormone like hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
PTHLH (parathyroid hormone like hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Pthlh (parathyroid hormone like hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Pthlh (parathyroid hormone-like hormone)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
PTHLH (parathyroid hormone like hormone)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
pthlhb (parathyroid hormone-like hormone b)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam, ZFIN)
Danio rerio (zebrafish):
pthlha (parathyroid hormone-like hormone a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 6 147,252,101 - 147,264,183 (-) Ensembl GRCm38 6 147,252,109 - 147,264,013 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 6 147,200,632 - 147,212,607 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 6 147,209,270 - 147,221,371 (-) NCBI mm8 Celera 6 150,289,180 - 150,301,102 (-) NCBI Celera Cytogenetic Map 6 G3 NCBI cM Map 6 78.19 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
Acute Necrotizing Pancreatitis ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25035110 alcoholic pancreatitis ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22280800 bone resorption disease ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16769263 Breast Neoplasms ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22267197 Cachexia ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17878525 Chronic Pancreatitis ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25035110 Congenital Foot Deformities ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20170896 Congenital Hand Deformities ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20170896 Edema ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25035110 Growth Disorders ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20170896 Hyperalgesia ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16769263 hypercalcemia ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:3616618 more ... lung disease ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20857298 lung non-small cell carcinoma ISO RGD:736996 11554173 CTD Direct Evidence: therapeutic CTD PMID:17676588 multiple myeloma ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11054717 neuroendocrine tumor ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17625444 Osteolysis ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11054717 pancreatic cancer ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17625444 Prostatic Neoplasms ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16243370 Spontaneous Abortions ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18539642 Superior Vena Cava Syndrome ISO RGD:736996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12358896
Imported Annotations - MGI
achondroplasia IEA 13592920 OMIM:100800 MouseDO Albright's hereditary osteodystrophy IEA 13592920 OMIM:103580 MouseDO Imported Annotations - OMIM
brachydactyly type E2 ISO RGD:736996 7240710 OMIM
1-nitropyrene increases expression ISO RGD:736996 6480464 1-nitropyrene results in increased expression of PTHLH mRNA CTD PMID:19041380 17beta-estradiol increases expression ISO RGD:736996 6480464 Estradiol results in increased expression of PTHLH mRNA CTD PMID:9790998 17beta-estradiol increases secretion ISO RGD:736996 6480464 Estradiol results in increased secretion of PTHLH protein CTD PMID:9790998 17beta-estradiol multiple interactions ISO RGD:736996 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of PTHLH mRNA, [Progesterone co-treated with Estradiol] results in decreased expression of PTHLH mRNA CTD PMID:17404688 , PMID:30165855 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases expression ISO RGD:736996 6480464 Metribolone results in decreased expression of PTHLH protein CTD PMID:17676588 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO RGD:736996 6480464 Dihydrotestosterone results in decreased expression of PTHLH protein CTD PMID:17676588 2,6-di-tert-butyl-4-methylphenol increases expression EXP 6480464 Butylated Hydroxytoluene results in increased expression of PTHLH mRNA CTD PMID:19925653 2-hydroxypropanoic acid decreases expression ISO RGD:736996 6480464 Lactic Acid results in decreased expression of PTHLH mRNA CTD PMID:30851411 3',5'-cyclic AMP increases abundance ISO RGD:736996 6480464 PTHLH protein results in increased abundance of Cyclic AMP CTD PMID:10600786 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of PTHLH mRNA CTD PMID:25172293 4,4'-diaminodiphenylmethane affects expression EXP 6480464 4, 4'-diaminodiphenylmethane affects the expression of PTHLH mRNA CTD PMID:18648102 4-nitroquinoline N-oxide increases expression EXP 6480464 4-Nitroquinoline-1-oxide results in increased expression of PTHLH mRNA CTD PMID:27148699 5-azacytidine decreases expression ISO RGD:736996 6480464 Azacitidine results in decreased expression of PTHLH mRNA CTD PMID:20823114 6-propyl-2-thiouracil decreases expression ISO RGD:3441 6480464 Propylthiouracil results in decreased expression of PTHLH mRNA CTD PMID:24780913 8-Br-cAMP increases expression ISO RGD:736996 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PTHLH mRNA CTD PMID:20147733 9-cis-retinoic acid decreases expression ISO RGD:736996 6480464 Alitretinoin results in decreased expression of PTHLH mRNA CTD PMID:16243370 9-cis-retinoic acid multiple interactions ISO RGD:736996 6480464 Alitretinoin promotes the reaction [Calcitriol results in decreased expression of PTHLH mRNA] CTD PMID:16243370 acrylamide decreases expression ISO RGD:3441 6480464 Acrylamide results in decreased expression of PTHLH mRNA CTD PMID:28959563 afimoxifene increases secretion ISO RGD:736996 6480464 afimoxifene results in increased secretion of PTHLH protein CTD PMID:9790998 aflatoxin B1 increases expression ISO RGD:736996 6480464 Aflatoxin B1 results in increased expression of PTHLH mRNA CTD PMID:22100608 aflatoxin B1 decreases methylation ISO RGD:736996 6480464 Aflatoxin B1 results in decreased methylation of PTHLH gene CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:736996 6480464 Tretinoin results in increased expression of PTHLH protein CTD PMID:8018908 all-trans-retinoic acid increases expression ISO RGD:3441 6480464 Tretinoin results in increased expression of PTHLH mRNA, Tretinoin results in increased expression of PTHLH protein CTD PMID:20857298 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of PTHLH mRNA CTD PMID:16350840 antirheumatic drug increases expression ISO RGD:736996 6480464 Antirheumatic Agents results in increased expression of PTHLH mRNA CTD PMID:24449571 arsane multiple interactions ISO RGD:3441 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of PTHLH protein CTD PMID:23604592 arsenic atom multiple interactions ISO RGD:3441 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of PTHLH protein CTD PMID:23604592 arsenite(3-) increases methylation ISO RGD:736996 6480464 arsenite results in increased methylation of PTHLH promoter CTD PMID:23974009 arsenite(3-) decreases expression ISO RGD:736996 6480464 arsenite results in decreased expression of PTHLH mRNA CTD PMID:23974009 benzene increases response to substance EXP 6480464 PTHLH gene polymorphism results in increased susceptibility to Benzene CTD PMID:12807761 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PTHLH mRNA CTD PMID:21569818 betulinic acid multiple interactions ISO RGD:736996 6480464 betulinic acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein] CTD PMID:24463094 betulinic acid decreases response to substance ISO RGD:736996 6480464 betulinic acid results in decreased susceptibility to PTHLH protein CTD PMID:24463094 betulinic acid decreases expression ISO RGD:736996 6480464 betulinic acid results in decreased expression of PTHLH mRNA CTD PMID:24463094 betulinic acid decreases secretion ISO RGD:736996 6480464 betulinic acid results in decreased secretion of PTHLH protein CTD PMID:24463094 bis(2-ethylhexyl) phthalate increases expression ISO RGD:736996 6480464 Diethylhexyl Phthalate results in increased expression of PTHLH mRNA CTD PMID:31163220 bisphenol A decreases expression ISO RGD:3441 6480464 bisphenol A results in decreased expression of PTHLH mRNA CTD PMID:25181051 , PMID:30816183 bortezomib decreases expression ISO RGD:736996 6480464 Bortezomib results in decreased expression of PTHLH mRNA CTD PMID:18089816 butan-1-ol multiple interactions ISO RGD:736996 6480464 [[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of PTHLH mRNA CTD PMID:29432896 butane-2,3-dione decreases expression ISO RGD:736996 6480464 Diacetyl results in decreased expression of PTHLH mRNA CTD PMID:30710127 cadmium atom multiple interactions ISO RGD:3441 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of PTHLH protein CTD PMID:23604592 cadmium dichloride multiple interactions ISO RGD:3441 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of PTHLH protein, Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of PTHLH protein] CTD PMID:23604592 , PMID:23750309 cadmium dichloride increases expression ISO RGD:3441 6480464 Cadmium Chloride results in increased expression of PTHLH mRNA CTD PMID:23750309 calcitriol multiple interactions ISO RGD:736996 6480464 alitretinoin promotes the reaction [Calcitriol results in decreased expression of PTHLH mRNA] more ... CTD PMID:16243370 , PMID:21664243 calcitriol increases degradation ISO RGD:736996 6480464 Calcitriol results in increased degradation of PTHLH protein CTD PMID:21664243 calcitriol decreases expression ISO RGD:736996 6480464 Calcitriol results in decreased expression of PTHLH mRNA, Calcitriol results in decreased expression of PTHLH protein CTD PMID:16002434 , PMID:16243370 calcium carbonate decreases expression ISO RGD:736996 6480464 Calcium Carbonate results in decreased expression of PTHLH protein CTD PMID:16006300 candesartan multiple interactions ISO RGD:3441 6480464 candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA], candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein] CTD PMID:15728788 ceruletide increases expression ISO RGD:736996 6480464 Ceruletide results in increased expression of PTHLH mRNA, Ceruletide results in increased expression of PTHLH protein CTD PMID:25035110 ceruletide multiple interactions ISO RGD:736996 6480464 PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA] more ... CTD PMID:25035110 ceruletide multiple interactions ISO RGD:3441 6480464 Ethanol results in increased susceptibility to [Ceruletide results in increased expression of PTHLH mRNA] more ... CTD PMID:22280800 ceruletide affects response to substance ISO RGD:3441 6480464 PTHLH protein affects the susceptibility to Ceruletide CTD PMID:22280800 ceruletide increases expression ISO RGD:3441 6480464 Ceruletide results in increased expression of PTHLH mRNA, Ceruletide results in increased expression of PTHLH protein CTD PMID:22280800 ceruletide multiple interactions EXP 6480464 PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein] more ... CTD PMID:25035110 ceruletide increases expression EXP 6480464 Ceruletide results in increased expression of PTHLH mRNA, Ceruletide results in increased expression of PTHLH protein CTD PMID:22280800 , PMID:25035110 chloroethene increases response to substance EXP 6480464 PTHLH gene polymorphism results in increased susceptibility to Vinyl Chloride CTD PMID:12807761 chloropicrin affects expression ISO RGD:736996 6480464 chloropicrin affects the expression of PTHLH mRNA CTD PMID:26352163 chloropicrin decreases expression ISO RGD:736996 6480464 chloropicrin results in decreased expression of PTHLH mRNA CTD PMID:28476498 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of PTHLH mRNA CTD PMID:23125180 cisplatin multiple interactions ISO RGD:736996 6480464 Cisplatin promotes the reaction [jinfukang results in decreased expression of PTHLH mRNA], jinfukang promotes the reaction [Cisplatin results in decreased expression of PTHLH mRNA] CTD PMID:27392435 copper atom multiple interactions ISO RGD:736996 6480464 [NSC 689534 binds to Copper] which results in increased expression of PTHLH mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:736996 6480464 [NSC 689534 binds to Copper] which results in increased expression of PTHLH mRNA CTD PMID:20971185 crocidolite asbestos increases expression ISO RGD:736996 6480464 Asbestos, Crocidolite results in increased expression of PTHLH mRNA CTD PMID:18687144 curcumin multiple interactions ISO RGD:736996 6480464 Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein] CTD PMID:15129424 cyclosporin A increases expression ISO RGD:736996 6480464 Cyclosporine results in increased expression of PTHLH mRNA CTD PMID:25562108 cyclosporin A decreases expression ISO RGD:736996 6480464 Cyclosporine results in decreased expression of PTHLH mRNA CTD PMID:27989131 dexamethasone decreases expression ISO RGD:736996 6480464 Dexamethasone results in decreased expression of PTHLH mRNA CTD PMID:16278781 , PMID:27608943 dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PTHLH mRNA CTD PMID:29950665 enalapril multiple interactions ISO RGD:3441 6480464 Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA], Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 ethanol increases expression EXP 6480464 Ethanol results in increased expression of PTHLH mRNA, Ethanol results in increased expression of PTHLH protein CTD PMID:22280800 ethanol multiple interactions ISO RGD:736996 6480464 [[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of PTHLH mRNA CTD PMID:29432896 ethanol affects response to substance ISO RGD:3441 6480464 PTHLH protein affects the susceptibility to Ethanol CTD PMID:22280800 ethanol multiple interactions ISO RGD:3441 6480464 Ethanol results in increased susceptibility to [Ceruletide results in increased expression of PTHLH mRNA] more ... CTD PMID:22280800 ethanol increases expression ISO RGD:3441 6480464 Ethanol results in increased expression of PTHLH mRNA, Ethanol results in increased expression of PTHLH protein CTD PMID:22280800 folic acid multiple interactions ISO RGD:3441 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] more ... CTD PMID:15728788 folic acid increases expression ISO RGD:3441 6480464 Folic Acid results in increased expression of PTHLH mRNA, Folic Acid results in increased expression of PTHLH protein CTD PMID:11532093 , PMID:15728788 folic acid multiple interactions EXP 6480464 PTHLH protein inhibits the reaction [Folic Acid results in increased expression of BAX protein], PTHLH protein inhibits the reaction [Folic Acid results in increased expression of BCL2 protein] CTD PMID:16672315 formaldehyde increases expression ISO RGD:3441 6480464 Formaldehyde results in increased expression of PTHLH mRNA CTD PMID:18499655 geldanamycin multiple interactions ISO RGD:736996 6480464 [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA, [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA CTD PMID:12724357 gentamycin multiple interactions ISO RGD:3441 6480464 Losartan inhibits the reaction [Gentamicins results in increased expression of PTHLH protein] CTD PMID:15728788 gentamycin increases expression ISO RGD:3441 6480464 Gentamicins results in increased expression of PTHLH protein CTD PMID:15728788 L-ascorbic acid decreases expression ISO RGD:3441 6480464 Ascorbic Acid results in decreased expression of PTHLH mRNA CTD PMID:15372504 lead diacetate multiple interactions ISO RGD:3441 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of PTHLH protein CTD PMID:23604592 lead(0) multiple interactions ISO RGD:3441 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of PTHLH protein CTD PMID:23604592 lead(2+) multiple interactions ISO RGD:3441 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of PTHLH protein CTD PMID:23604592 leflunomide increases expression ISO RGD:736996 6480464 leflunomide results in increased expression of PTHLH mRNA CTD PMID:28988120 losartan multiple interactions ISO RGD:3441 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA] more ... CTD PMID:15728788 manganese(II) chloride increases expression ISO RGD:3441 6480464 manganese chloride results in increased expression of PTHLH mRNA CTD PMID:28801915 mercury dichloride increases expression ISO RGD:3441 6480464 Mercuric Chloride results in increased expression of PTHLH mRNA CTD PMID:16507785 methotrexate increases expression ISO RGD:736996 6480464 Methotrexate results in increased expression of PTHLH mRNA CTD PMID:24449571 methylmercury chloride increases expression ISO RGD:736996 6480464 methylmercuric chloride results in increased expression of PTHLH mRNA CTD PMID:28001369 nitrofen decreases expression ISO RGD:3441 6480464 nitrofen results in decreased expression of PTHLH mRNA, nitrofen results in decreased expression of PTHLH protein CTD PMID:19855984 paracetamol increases expression ISO RGD:736996 6480464 Acetaminophen results in increased expression of PTHLH mRNA CTD PMID:29067470 pentane-2,3-dione decreases expression ISO RGD:736996 6480464 2, 3-pentanedione results in decreased expression of PTHLH mRNA CTD PMID:30710127 phenylephrine increases expression ISO RGD:3441 6480464 Phenylephrine results in increased expression of PTHLH mRNA, Phenylephrine results in increased expression of PTHLH protein CTD PMID:19910689 phenylephrine multiple interactions ISO RGD:3441 6480464 PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein] more ... CTD PMID:19910689 phorbol 13-acetate 12-myristate increases secretion ISO RGD:3441 6480464 Tetradecanoylphorbol Acetate results in increased secretion of PTHLH protein CTD PMID:7946399 potassium chromate decreases expression ISO RGD:736996 6480464 potassium chromate(VI) results in decreased expression of PTHLH mRNA CTD PMID:22714537 progesterone multiple interactions ISO RGD:736996 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of PTHLH mRNA CTD PMID:17404688 progesterone decreases expression ISO RGD:3441 6480464 Progesterone results in decreased expression of PTHLH mRNA CTD PMID:21770760 progesterone increases expression ISO RGD:736996 6480464 Progesterone results in increased expression of PTHLH mRNA CTD PMID:18070364 , PMID:20864642 quercetin increases expression ISO RGD:736996 6480464 Quercetin results in increased expression of PTHLH mRNA CTD PMID:21632981 quinapril hydrochloride multiple interactions ISO RGD:3441 6480464 Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA], Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 rac-lactic acid decreases expression ISO RGD:736996 6480464 Lactic Acid results in decreased expression of PTHLH mRNA CTD PMID:30851411 silver atom increases expression EXP 6480464 Silver results in increased expression of PTHLH mRNA CTD PMID:27131904 silver(0) increases expression EXP 6480464 Silver results in increased expression of PTHLH mRNA CTD PMID:27131904 sodium arsenite multiple interactions ISO RGD:3441 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of PTHLH protein CTD PMID:23604592 Soman increases expression ISO RGD:3441 6480464 Soman results in increased expression of PTHLH mRNA CTD PMID:19281266 styrene increases response to substance EXP 6480464 PTHLH gene polymorphism results in increased susceptibility to Styrene CTD PMID:12807761 tamoxifen increases secretion ISO RGD:736996 6480464 Tamoxifen results in increased secretion of PTHLH protein CTD PMID:9790998 tamoxifen affects expression ISO RGD:736996 6480464 Tamoxifen affects the expression of PTHLH mRNA CTD PMID:14699072 telmisartan multiple interactions ISO RGD:3441 6480464 telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of PTHLH protein] CTD PMID:23750309 testosterone decreases expression EXP 6480464 Testosterone results in decreased expression of PTHLH protein CTD PMID:17676588 testosterone decreases expression ISO RGD:736996 6480464 Testosterone results in decreased expression of PTHLH protein CTD PMID:17676588 titanium dioxide decreases expression ISO RGD:3441 6480464 titanium dioxide results in decreased expression of PTHLH mRNA CTD PMID:30012374 titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PTHLH mRNA CTD PMID:29950665 trichostatin A increases expression ISO RGD:736996 6480464 trichostatin A results in increased expression of PTHLH mRNA CTD PMID:24935251 undecane increases expression ISO RGD:3441 6480464 undecane results in increased expression of PTHLH protein CTD PMID:17337753 valproic acid affects expression ISO RGD:736996 6480464 Valproic Acid affects the expression of PTHLH mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:736996 6480464 Valproic Acid results in increased expression of PTHLH mRNA CTD PMID:24935251 , PMID:28001369 vinclozolin decreases expression ISO RGD:3441 6480464 vinclozolin results in decreased expression of PTHLH mRNA CTD PMID:23869203 zoledronic acid affects response to substance ISO RGD:736996 6480464 PTHLH protein affects the susceptibility to zoledronic acid CTD PMID:16475708 zoledronic acid decreases expression ISO RGD:736996 6480464 zoledronic acid results in decreased expression of PTHLH mRNA CTD PMID:16278781 more ...
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO RGD:3441 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA PANTHER:PTN000425409 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO UniProtKB:P12272 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 bone mineralization NOT IMP MGI:MGI:2154515 2290270 (MGI:MGI:2153596, PMID:11606467) MGI MGI:MGI:2153596 , PMID:11606467 calcium ion homeostasis TAS 2290270 (MGI:MGI:5780847, PMID:19968565) MGI MGI:MGI:5780847 , PMID:19968565 endochondral ossification IMP MGI:MGI:2154515 2290270 (MGI:MGI:1352921, PMID:8895385) MGI MGI:MGI:1352921 , PMID:8895385 endoderm development IDA 2290270 (MGI:MGI:1326851, PMID:9921650) MGI MGI:MGI:1326851 , PMID:9921650 epithelial cell differentiation IMP MGI:MGI:2154515 2290270 (MGI:MGI:3042805, PMID:15162506) MGI MGI:MGI:3042805 , PMID:15162506 lung alveolus development IMP MGI:MGI:2154515 2290270 (MGI:MGI:3042805, PMID:15162506) MGI MGI:MGI:3042805 , PMID:15162506 magnesium ion homeostasis TAS 2290270 (MGI:MGI:5780847, PMID:19968565) MGI MGI:MGI:5780847 , PMID:19968565 mammary gland bud elongation IMP MGI:MGI:2154515 2290270 (MGI:MGI:1203302, PMID:9477327) MGI MGI:MGI:1203302 , PMID:9477327 negative regulation of chondrocyte development ISO UniProtKB:P12272 2290270 (MGI:MGI:85084, PMID:9008714) MGI MGI:MGI:85084 , PMID:9008714 negative regulation of chondrocyte differentiation ISO UniProtKB:P12272 2290270 (MGI:MGI:85084, PMID:9008714) MGI MGI:MGI:85084 , PMID:9008714 negative regulation of chondrocyte differentiation IMP MGI:MGI:2154515 2290270 (MGI:MGI:1352921, PMID:8895385) MGI MGI:MGI:1352921 , PMID:8895385 negative regulation of chondrocyte differentiation IDA 2290270 (MGI:MGI:3709778, PMID:17328886) MGI MGI:MGI:3709778 , PMID:17328886 negative regulation of chondrocyte differentiation IGI MGI:MGI:95728 2290270 (MGI:MGI:3709778, PMID:17328886) MGI MGI:MGI:3709778 , PMID:17328886 negative regulation of DNA-binding transcription factor activity IDA 2290270 (MGI:MGI:3709778, PMID:17328886) MGI MGI:MGI:3709778 , PMID:17328886 nipple sheath formation IMP MGI:MGI:2154515 2290270 (MGI:MGI:1203302, PMID:9477327) MGI MGI:MGI:1203302 , PMID:9477327 osteoblast development IMP MGI:MGI:2154515 2290270 (MGI:MGI:3624906, PMID:9832460) MGI MGI:MGI:3624906 , PMID:9832460 osteoblast development IBA MGI:MGI:97800 , PANTHER:PTN000425409 2290270 (PMID:21873635) GO_Central PMID:21873635 phosphate ion homeostasis TAS 2290270 (MGI:MGI:5780847, PMID:19968565) MGI MGI:MGI:5780847 , PMID:19968565 positive regulation of cell population proliferation IDA 2290270 (MGI:MGI:3709778, PMID:17328886) MGI MGI:MGI:3709778 , PMID:17328886 protein processing IDA 2290270 (MGI:MGI:3709778, PMID:17328886) MGI MGI:MGI:3709778 , PMID:17328886 regulation of gene expression ISO UniProtKB:P12272 2290270 (MGI:MGI:85084, PMID:9008714) MGI MGI:MGI:85084 , PMID:9008714 skeletal system development ISO UniProtKB:P12272 2290270 (MGI:MGI:85084, PMID:9008714) MGI MGI:MGI:85084 , PMID:9008714 skeletal system development IMP MGI:MGI:2154515 2290270 (MGI:MGI:2153596 more ... MGI MGI:MGI:2153596 more ... surfactant homeostasis IMP MGI:MGI:2154515 2290270 (MGI:MGI:3042805, PMID:15162506) MGI MGI:MGI:3042805 , PMID:15162506 Cellular Component cytoplasm IEA UniProtKB-KW:KW-0963 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cytosol ISO UniProtKB:P12272 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 extracellular region IEA UniProtKB-KW:KW-0964 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 extracellular region IEA InterPro:IPR001415 , InterPro:IPR003626 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 extracellular space TAS 2290270 (MGI:MGI:2153596, PMID:11606467) MGI MGI:MGI:2153596 , PMID:11606467 Golgi apparatus ISO UniProtKB:P12272 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 intracellular IDA 2290270 (MGI:MGI:1352921, PMID:8895385) MGI MGI:MGI:1352921 , PMID:8895385 nucleoplasm ISO UniProtKB:P12272 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus IEA UniProtKB-KW:KW-0539 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Molecular Function hormone activity TAS 2290270 (MGI:MGI:2153596, PMID:11606467) MGI MGI:MGI:2153596 , PMID:11606467 hormone activity IBA PANTHER:PTN000425409 , RGD:3441 2290270 (PMID:21873635) GO_Central PMID:21873635 hormone activity ISO RGD:3441 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 peptide hormone receptor binding ISO UniProtKB:P12272 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 peptide hormone receptor binding IBA PANTHER:PTN000425409 , UniProtKB:P12272 2290270 (PMID:21873635) GO_Central PMID:21873635
Gene-Chemical Interaction Annotations
