RGD Reference Report - Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue.

Authors: Thiede, MA  Rodan, GA 
Citation: Thiede MA and Rodan GA, Science 1988 Oct 14;242(4876):278-80.
RGD ID: 729903
Pubmed: PMID:3175653   (View Abstract at PubMed)

A survey of rat tissues by RNA analysis, aimed at uncovering the physiological function of the parathyroid hormone-like peptide (PTH-LP) associated with hypercalcemia of malignancy, revealed the presence of a 1.5-kilobase messenger RNA encoding this peptide in lactating mammary glands. PTH-LP messenger RNA is expressed in mammary tissue only during lactation; it appears and disappears rapidly (2 to 4 hours) as a function of the sucking stimulus. The identity of this messenger RNA was confirmed by cloning the rat PTH-LP complementary DNA, which predicts a peptide with strong similarity to the human homolog. Moreover, extracts from lactating mammary tissue stimulated parathyroid hormone-dependent adenylate cyclase. These findings suggest that PTH-LP plays a physiological role in lactation, possibly as a hormone for the mobilization or transfer (or both) of calcium to the milk.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PthlhRatadenylate cyclase-activating G protein-coupled receptor signaling pathway  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PthlhRathormone activity  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pthlh  (parathyroid hormone-like hormone)


Additional Information