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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pthlh
Name: parathyroid hormone-like hormone
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pthlhdecreases expressionISOPTHLH (Homo sapiens)6480464CTDCalcitriol results in decreased expression of PTHLH mRNA; Calcitriol results in decreased expression of PTHLH proteinPMID:16002434 PMID:16243370
Pthlhincreases degradationISOPTHLH (Homo sapiens)6480464CTDCalcitriol results in increased degradation of PTHLH proteinPMID:21664243
Pthlhmultiple interactionsISOPTHLH (Homo sapiens)6480464CTDalitretinoin promotes the reaction [Calcitriol results in decreased expression of PTHLH mRNA]; Calcitriol results in decreased expression of and results in decreased stability of PTHLH mRNA; VDR mutant form inhibits the reaction [Calcitriol results in decreased expression of PTHLH mRNA]PMID:16243370 PMID:21664243
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