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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pthlh
Name: parathyroid hormone-like hormone
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pthlhincreases expressionEXP 6480464CTDFolic Acid results in increased expression of PTHLH mRNA; Folic Acid results in increased expression of PTHLH proteinPMID:11532093 PMID:15728788
Pthlhmultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]; [Folic Acid results in increased activity of MAPK1 protein] which results in increased expression of PTHLH protein; [Folic Acid results in increased activity of MAPK3 protein] which results in increased expression of PTHLH protein; AGT protein promotes the reaction [Folic Acid results in increased expression of PTHLH protein]; CREB1 protein promotes the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]; PTHLH protein promotes the reaction [Folic Acid results in increased expression of AGT protein]; quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]PMID:15728788
Pthlhdecreases expressionISOPthlh (Mus musculus)6480464CTDFolic Acid results in decreased expression of PTHLH mRNAPMID:25629700
Pthlhmultiple interactionsISOPthlh (Mus musculus)6480464CTDFolic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of PTHLH mRNA]; PTHLH protein inhibits the reaction [Folic Acid results in increased expression of BAX protein]; PTHLH protein inhibits the reaction [Folic Acid results in increased expression of BCL2 protein]PMID:16672315 PMID:22206623
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