Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ntrk1 (neurotrophic receptor tyrosine kinase 1) Rattus norvegicus
Analyze
Symbol: Ntrk1
Name: neurotrophic receptor tyrosine kinase 1
Description: Exhibits several functions, including GPI-linked ephrin receptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and regulation of programmed cell death. Localizes to several cellular components, including the dendrite; endosome; and neuronal cell body. Used to study glaucoma and myofascial pain syndrome. Biomarker of several diseases, including colitis; diabetic neuropathy; glaucoma; periodontitis; and retinal detachment. Human ortholog(s) of this gene implicated in Alzheimer's disease; familial medullary thyroid carcinoma; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1); PARTICIPATES IN apoptotic cell death pathway; endocytosis pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: high affinity nerve growth factor receptor; neurotrophic tyrosine kinase, receptor, type 1; p140-TrkA; slow nerve growth factor receptor; Trk; trk precursor; trk-A; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A
Orthologs:
Homo sapiens (human) : NTRK1 (neurotrophic receptor tyrosine kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Ntrk1 (neurotrophic tyrosine kinase, receptor, type 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Canis lupus familiaris (dog) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)
Sus scrofa (pig) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Chlorocebus sabaeus (African green monkey) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02187,143,568 - 187,160,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,143,568 - 187,160,373 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,548,566 - 206,565,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42179,838,740 - 179,855,545 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12179,788,845 - 179,805,651 (-)NCBI
Celera2167,186,754 - 167,203,558 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ntrk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620144
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.