Ntrk1 (neurotrophic receptor tyrosine kinase 1) - Rat Genome Database

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Gene: Ntrk1 (neurotrophic receptor tyrosine kinase 1) Rattus norvegicus
Symbol: Ntrk1
Name: neurotrophic receptor tyrosine kinase 1
RGD ID: 620144
Description: Enables several functions, including GPI-linked ephrin receptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Involved in several processes, including cellular response to nicotine; detection of stimulus involved in sensory perception of pain; and nervous system development. Acts upstream of or within cellular response to growth factor stimulus. Located in several cellular components, including cell surface; endosome; and neuronal cell body. Part of protein-containing complex. Used to study Parkinsonism; glaucoma; and myofascial pain syndrome. Biomarker of several diseases, including colitis; diabetic neuropathy; glaucoma; periodontitis; and retinal detachment. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1); PARTICIPATES IN apoptotic cell death pathway; endocytosis pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: high affinity nerve growth factor receptor; neurotrophic tyrosine kinase, receptor, type 1; p140-TrkA; slow nerve growth factor receptor; Trk; trk precursor; trk-A; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82175,534,844 - 175,551,664 (-)NCBIGRCr8
mRatBN7.22173,236,961 - 173,253,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,236,963 - 173,253,770 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,385,200 - 180,401,999 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,407,539 - 178,424,344 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02172,997,036 - 173,013,812 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,143,568 - 187,160,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,143,568 - 187,160,373 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,548,566 - 206,565,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42179,838,740 - 179,855,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12179,788,845 - 179,805,651 (-)NCBI
Celera2167,186,754 - 167,203,558 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Alcohol-Related Disorders  (IEP)
Alcoholic Intoxication  (ISO)
Alzheimer's disease  (ISO)
asthma  (IEP,ISO)
atopic dermatitis  (ISO)
bipolar disorder  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (IEP)
diabetic neuropathy  (IEP)
endometriosis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
familial medullary thyroid carcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glaucoma  (IDA,IEP)
Hereditary Neoplastic Syndromes  (ISO)
hereditary sensory neuropathy  (ISO,ISS)
hereditary sensory neuropathy type 4  (ISO)
high grade glioma  (ISO)
Hirschsprung's disease  (ISO)
Hyperalgesia  (IMP)
immunodeficiency 42  (ISO)
intellectual disability  (ISO)
Lewy body dementia  (ISO)
Lung Injury  (ISO)
lymphoproliferative syndrome  (ISO)
MHC class II deficiency  (ISO)
myofascial pain syndrome  (IMP)
Neuralgia  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
obstructive sleep apnea  (ISO)
Optic Nerve Injuries  (IDA)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
parathyroid carcinoma  (ISO)
Parkinsonism  (IDA)
periodontitis  (IEP)
Primary Ovarian Failure  (ISO)
primary ovarian insufficiency  (ISO)
psychotic disorder  (ISO)
pulmonary sarcoidosis  (ISO)
retinal detachment  (IEP)
Retrograde Degeneration  (IEP)
rhinitis  (ISO)
schizophrenia  (ISO)
severe congenital neutropenia 3  (ISO)
severe congenital neutropenia 5  (ISO)
Spinal Cord Injuries  (IEP)
X-linked lymphoproliferative syndrome 1  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
Butylparaben  (EXP)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichlorine  (EXP)
dieldrin  (EXP,ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxycycline  (EXP)
echinacoside  (EXP,ISO)
endrin  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
ganglioside GM1  (EXP)
genistein  (ISO)
graphite  (EXP)
inulin  (ISO)
ketamine  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
menadione  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
nickel atom  (EXP)
nicotine  (ISO)
nocodazole  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propiconazole  (EXP)
pyrazinecarboxamide  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP)
rac-lactic acid  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
thimerosal  (ISO)
toluene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon guidance  (IMP)
axonogenesis involved in innervation  (ISO,ISS)
B cell differentiation  (ISO)
behavioral response to formalin induced pain  (ISO)
cell differentiation  (IEA)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to growth factor stimulus  (IDA)
cellular response to nerve growth factor stimulus  (IBA,IDA,ISO)
cellular response to nicotine  (IDA)
circadian rhythm  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
ephrin receptor signaling pathway  (IEA)
innervation  (ISO)
learning or memory  (IMP)
mechanoreceptor differentiation  (ISO)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of cellular process  (IDA)
negative regulation of neuron apoptotic process  (IMP,ISO)
nerve growth factor signaling pathway  (IBA,IDA,IEA,ISO)
nervous system development  (IEA,ISO)
neuron apoptotic process  (ISO)
neuron development  (ISO)
neuron projection development  (ISO)
neurotrophin TRK receptor signaling pathway  (ISO,ISS)
olfactory nerve development  (IEP)
positive regulation of angiogenesis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,ISO,ISS)
positive regulation of neuron projection development  (IBA,IEA,ISO,ISS)
positive regulation of programmed cell death  (IDA)
positive regulation of protein phosphorylation  (IDA)
positive regulation of Ras protein signal transduction  (ISO,ISS)
positive regulation of synapse assembly  (ISO)
positive regulation of synaptic transmission, glutamatergic  (IMP)
programmed cell death involved in cell development  (IDA)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IEA)
response to activity  (IDA)
response to axon injury  (IEP)
response to electrical stimulus  (IDA)
response to ethanol  (IEP)
response to hydrostatic pressure  (IEP)
response to nicotine  (IDA)
response to nutrient levels  (IDA)
response to xenobiotic stimulus  (IDA)
Sertoli cell development  (IMP)
spermatogenesis  (IEP)
sympathetic nervous system development  (ISO,ISS)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes . Al-Gayyar MM, etal., Diabetologia. 2011 Mar;54(3):669-80. Epub 2010 Dec 7.
2. Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons. Allard S, etal., Neurobiol Aging. 2018 Jul;67:10-20. doi: 10.1016/j.neurobiolaging.2018.03.002. Epub 2018 Mar 9.
3. Chronic and acute models of retinal neurodegeneration TrkA activity are neuroprotective whereas p75NTR activity is neurotoxic through a paracrine mechanism. Bai Y, etal., J Biol Chem. 2010 Dec 10;285(50):39392-400. Epub 2010 Oct 13.
4. Targeted silencing of TrkA expression in rat forebrain neurons via the p75 receptor. Berhanu DA and Rush RA, Neuroscience. 2008 Jun 2;153(4):1115-25. Epub 2008 Mar 22.
5. Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal. Bruns MB and Miller MW, J Neurochem. 2007 Mar;100(5):1155-68.
6. Localization of nerve growth factor (NGF) receptors in the mitochondrial compartment: characterization and putative role. Carito V, etal., Biochim Biophys Acta. 2012 Feb;1820(2):96-103. doi: 10.1016/j.bbagen.2011.10.015. Epub 2011 Nov 21.
7. Treadmill exercise improves cognitive function and facilitates nerve growth factor signaling by activating mitogen-activated protein kinase/extracellular signal-regulated kinase1/2 in the streptozotocin-induced diabetic rat hippocampus. Chae CH, etal., Neuroscience. 2009 Dec 29;164(4):1665-73. Epub 2009 Oct 2.
8. Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures. Conti G, etal., Neurosci Res. 2009 Oct;65(2):201-9. Epub 2009 Jul 9.
9. Gender differences in neurotrophin and glutamate receptor expression in cholinergic nucleus basalis neurons during the progression of Alzheimer's disease. Counts SE, etal., J Chem Neuroanat. 2011 Oct;42(2):111-7. Epub 2011 Mar 17.
10. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. Cozza A, etal., J Alzheimers Dis. 2008 Sep;15(1):61-70.
11. Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer. Dang C, etal., J Gastroenterol Hepatol. 2006 May;21(5):850-8.
12. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Dmitrieva VG, etal., Cell Mol Neurobiol. 2010 Jan;30(1):71-9. Epub 2009 Jul 25.
13. Increased cutaneous NGF and CGRP-labelled trkA-positive intra-epidermal nerve fibres in rat diabetic skin. Evans L, etal., Neurosci Lett. 2011 Oct 25.
14. Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. Formaggio E, etal., Neuroscience. 2010 Mar 17;166(2):580-9. Epub 2010 Jan 4.
15. Anti-NGF treatment reduces bone resorption in periodontitis. Gaspersic R, etal., J Dent Res. 2010 May;89(5):515-20. Epub 2010 Mar 3.
16. Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay. Gassei K, etal., Reproduction. 2008 Oct;136(4):459-69. Epub 2008 Jul 25.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. Goldbart AD, etal., Pediatr Res. 2007 Oct;62(4):489-94.
20. Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion. Hajebrahimi Z, etal., Neurosci Lett. 2008 Aug 29;441(3):261-6. Epub 2008 Jun 21.
21. Involvement of NGF in the rat model of persistent muscle pain associated with taut band. Hayashi K, etal., J Pain. 2011 Oct;12(10):1059-68. Epub 2011 Jun 30.
22. Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Herbst R, etal., Development 2002 Dec;129(23):5449-60.
23. Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. Hisata S, etal., J Cell Biol. 2007 Aug 27;178(5):843-60.
24. Alterations in neurotrophin and neurotrophin-receptor localization in Hirschsprung's disease. Hoehner JC, etal., J Pediatr Surg. 1996 Nov;31(11):1524-9.
25. Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis. Huehne K, etal., Neuromuscul Disord. 2008 Feb;18(2):159-66. Epub 2008 Feb 20.
26. TrkA pathway(s) is involved in regulation of TRPM7 expression in hippocampal neurons subjected to ischemic-reperfusion and oxygen-glucose deprivation. Jiang H, etal., Brain Res Bull. 2008 May 15;76(1-2):124-30. Epub 2008 Feb 12.
27. Molecular kinetics of nerve growth factor receptor trafficking and activation. Jullien J, etal., J Biol Chem 2002 Oct 11;277(41):38700-8.
28. Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. Lazaridis I, etal., PLoS Biol. 2011 Apr;9(4):e1001051. doi: 10.1371/journal.pbio.1001051. Epub 2011 Apr 26.
29. Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells. Lebrun-Julien F, etal., Mol Cell Neurosci. 2009 Apr;40(4):410-20. Epub 2008 Dec 25.
30. Neonatal tissue damage facilitates nociceptive synaptic input to the developing superficial dorsal horn via NGF-dependent mechanisms. Li J and Baccei ML, Pain. 2011 Aug;152(8):1846-55. Epub 2011 May 6.
31. GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. Li X, etal., Mol Biol Cell. 2015 Dec 1;26(24):4412-26. doi: 10.1091/mbc.E15-02-0087. Epub 2015 Oct 7.
32. Effect of amyloid peptides on the increase in TrkA receptor expression induced by nicotine in vitro and in vivo. Li XD, etal., J Mol Neurosci. 2005;27(3):325-36.
33. Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis. Li Y, etal., Reprod Biol Endocrinol. 2011 Mar 8;9:30.
34. Novel neurotrophic tyrosine kinase receptor type 1 gene mutation associated with congenital insensitivity to pain with anhidrosis. Lin YP, etal., J Child Neurol. 2010 Dec;25(12):1548-51. Epub 2010 Jul 20.
35. A high soy diet enhances neurotropin receptor and Bcl-XL gene expression in the brains of ovariectomized female rats. Lovekamp-Swan T, etal., Brain Res. 2007 Jul 23;1159:54-66. Epub 2007 May 26.
36. Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA. MacDonald JI, etal., J Biol Chem. 2000 Jun 16;275(24):18225-33.
37. Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3. MacDonald JI, etal., J Mol Neurosci. 1999 Aug-Oct;13(1-2):141-58.
38. Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats. Manni L, etal., Diabetologia. 2011 Jul;54(7):1900-8. Epub 2011 Mar 23.
39. A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. Marler KJ, etal., J Neurosci. 2008 Nov 26;28(48):12700-12. doi: 10.1523/JNEUROSCI.1915-08.2008.
40. Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation. Matrone C, etal., Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11358-63. doi: 10.1073/pnas.0904998106. Epub 2009 Jun 19.
41. The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Meakin SO, etal., Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2374-8.
42. The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain. Miller R, etal., Brain Res 2002 Sep 20;950(1-2):137-47.
43. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):101-13. doi: 10.1002/neu.20009.
44. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):114-26. doi: 10.1002/neu.20010.
45. Differential regulation of the expression of neurotrophin receptors in rat extraocular motoneurons after lesion. Morcuende S, etal., J Comp Neurol. 2011 Aug 15;519(12):2335-52. doi: 10.1002/cne.22630.
46. Impaired glucose tolerance and insulinopenia in the GK-rat causes peripheral neuropathy. Murakawa Y, etal., Diabetes Metab Res Rev. 2002 Nov-Dec;18(6):473-83.
47. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
48. NGF/TrkA-mediated Kidins220/ARMS signaling activated in the allergic airway challenge in mice. Ni X, etal., Ann Allergy Asthma Immunol. 2010 Oct;105(4):299-306.
49. Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nikoletopoulou V, etal., Nature. 2010 Sep 2;467(7311):59-63. doi: 10.1038/nature09336.
50. Ultrastructural localization of the neurotrophin receptor (TrkA) in cultured rat pheochromocytoma PC12 Cells: three-dimensional image analysis by high voltage electron microscopy. Nishida T, etal., Biomed Res. 2007 Jun;28(3):161-7.
51. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
52. [Changes of nerve growth factor and its receptors in the lung tissues in asthmatic rats and their effects on the airway inflammation]. Ouyang RY, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Dec;30(6):660-5.
53. Expression of beta-nerve growth factor and its receptor in rat seminiferous epithelium: specific function at the onset of meiosis. Parvinen M, etal., J Cell Biol. 1992 May;117(3):629-41. doi: 10.1083/jcb.117.3.629.
54. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
55. Colitis elicits differential changes in the expression levels of receptor tyrosine kinase TrkA and TrkB in colonic afferent neurons: a possible involvement of axonal transport. Qiao LY and Grider JR, Pain. 2010 Oct;151(1):117-27. Epub 2010 Jul 16.
56. Differential up-regulation of neurotrophin receptors and functional activity of neurotrophins on peripheral blood eosinophils of patients with allergic rhinitis, atopic dermatitis and nonatopic subjects. Raap U, etal., Clin Exp Allergy. 2008 Sep;38(9):1493-8. Epub 2008 Jul 17.
57. Gangliosides activate Trk receptors by inducing the release of neurotrophins. Rabin SJ, etal., J Biol Chem 2002 Dec 20;277(51):49466-72.
58. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
59. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
60. Neurotrophin system activation in bronchoalveolar lavage fluid immune cells in pulmonary sarcoidosis. Ricci A, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Oct;22(3):186-94.
61. Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. Robinson KN, etal., J Biol Chem. 2005 Jan 7;280(1):225-35. Epub 2004 Oct 28.
62. Sequential expression of Trks A, B, and C in the regenerating olfactory neuroepithelium. Roskams AJ, etal., J Neurosci. 1996 Feb 15;16(4):1294-307.
63. Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions. Ross GM, etal., Eur J Neurosci. 1998 Mar;10(3):890-8.
64. Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation. Rotthier A, etal., Brain. 2009 Oct;132(Pt 10):2699-711. Epub 2009 Aug 3.
65. Age-related regional differences in cardiac nerve growth factor expression. Saygili E, etal., Age (Dordr). 2012 Jun;34(3):659-67. doi: 10.1007/s11357-011-9262-0. Epub 2011 May 11.
66. Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma. Sposato V, etal., Neurosci Lett. 2008 Nov 28;446(1):20-4. Epub 2008 Sep 18.
67. Nerve growth factor helps protect retina in experimental retinal detachment. Sun X, etal., Ophthalmologica. 2008;222(1):58-61. Epub 2007 Dec 19.
68. Skoura - a genetic island for congenital insensitivity to pain and anhidrosis among Moroccan Jews, as determined by a novel mutation in the NTRK1 gene. Suriu C, etal., Clin Genet. 2009 Mar;75(3):230-6.
69. Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas. Suzuki T, etal., J Natl Cancer Inst. 1993 Mar 3;85(5):377-84.
70. Effects of high-affinity nerve growth factor receptor inhibitors on symptoms in the NC/Nga mouse atopic dermatitis model. Takano N, etal., Br J Dermatol. 2007 Feb;156(2):241-6.
71. Chronic antipsychotic treatment: protracted decreases in phospho-TrkA levels in the rat hippocampus. Terry AV Jr, etal., Int J Neuropsychopharmacol. 2010 Jul;13(6):799-805. Epub 2010 Jan 11.
72. Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats. Terry AV Jr, etal., Physiol Behav. 2011 Feb 1;102(2):149-57. Epub 2010 Nov 6.
73. Presence of nerve growth factor and TrkA expression in the SVZ of EAE rats: evidence for a possible functional significance. Triaca V, etal., Exp Neurol. 2005 Jan;191(1):53-64.
74. Novel NTRK1 mutations cause hereditary sensory and autonomic neuropathy type IV: demonstration of a founder mutation in the Turkish population. Tuysuz B, etal., Neurogenetics. 2008 May;9(2):119-25. Epub 2008 Mar 6.
75. Local administration of a synthetic cell-penetrating peptide antagonizing TrkA function suppresses inflammatory pain in rats. Ueda K, etal., J Pharmacol Sci. 2010;112(4):438-43. Epub 2010 Mar 30.
76. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ and Strack S, Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24.
77. Dual association of a TRKA polymorphism with schizophrenia. Van Schijndel JE, etal., Psychiatr Genet. 2011 Jun;21(3):125-31.
78. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. Wan J, etal., J Neurosci. 2008 Sep 3;28(36):9002-12. doi: 10.1523/JNEUROSCI.0767-08.2008.
79. Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling. Wang T, etal., Acta Pharmacol Sin. 2010 Jul;31(7):765-74. doi: 10.1038/aps.2010.69. Epub 2010 Jun 28.
80. Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum. Wang ZY, etal., Neuroscience. 2010 Jan 20;165(2):485-91. doi: 10.1016/j.neuroscience.2009.10.045.
81. Guiding adult Mammalian sensory axons during regeneration. Webber CA, etal., J Neuropathol Exp Neurol. 2008 Mar;67(3):212-22.
82. [A study on expressions of nerve growth factor and its receptor tyrosine kinase receptor A in lung bronchiolar epithelial cells of chronic obstructive pulmonary disease patients]. Xiao Y and Xu YJ, Zhonghua Jie He He Hu Xi Za Zhi. 2011 Jan;34(1):34-8.
83. Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor. Yano H, etal., J Neurosci Res. 2000 Feb 1;59(3):356-64.
84. Nerve growth factor applied onto the olfactory epithelium alleviates degenerative changes of the olfactory receptor neurons following axotomy. Yasuno H, etal., Brain Res. 2000 Dec 22;887(1):53-62.
85. Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth. Zhang Y, etal., J Biol Chem. 2009 May 1;284(18):12469-79. Epub 2009 Mar 5.
Additional References at PubMed
PMID:1281417   PMID:2927393   PMID:7854358   PMID:8325889   PMID:8815902   PMID:9856458   PMID:10207144   PMID:10808049   PMID:10908605   PMID:11244088   PMID:11248116   PMID:11251075  
PMID:11551509   PMID:11731452   PMID:11750876   PMID:11877420   PMID:11927634   PMID:12151805   PMID:12471037   PMID:12810599   PMID:12849738   PMID:12858046   PMID:12882321   PMID:12882335  
PMID:12909622   PMID:12911749   PMID:12944916   PMID:14622124   PMID:14698082   PMID:15240558   PMID:15262992   PMID:15282267   PMID:15376326   PMID:15459109   PMID:15488758   PMID:15533302  
PMID:15737746   PMID:15753086   PMID:15834419   PMID:15911341   PMID:16118792   PMID:16195402   PMID:16195501   PMID:16207814   PMID:16219032   PMID:16246731   PMID:16284401   PMID:16306406  
PMID:16597733   PMID:16644033   PMID:16729028   PMID:16738245   PMID:16819522   PMID:16860569   PMID:17020011   PMID:17072373   PMID:17196528   PMID:17202489   PMID:17215105   PMID:17215246  
PMID:17380122   PMID:17506493   PMID:17548467   PMID:17640889   PMID:17700442   PMID:17822405   PMID:17952852   PMID:17967490   PMID:18174161   PMID:18187921   PMID:18191823   PMID:18299325  
PMID:18337399   PMID:18419753   PMID:18751719   PMID:18957307   PMID:19162192   PMID:19403809   PMID:19533291   PMID:19565663   PMID:19585233   PMID:19607811   PMID:19701634   PMID:19762468  
PMID:19818769   PMID:20209132   PMID:20333299   PMID:21150695   PMID:21151572   PMID:21187090   PMID:21199218   PMID:21295348   PMID:21312342   PMID:21411748   PMID:21429296   PMID:22028877  
PMID:22073361   PMID:22384148   PMID:22419059   PMID:22496904   PMID:23100034   PMID:23115187   PMID:23158009   PMID:23228124   PMID:23382219   PMID:23589303   PMID:23615109   PMID:23749991  
PMID:23785138   PMID:23809594   PMID:23821557   PMID:23928917   PMID:24006492   PMID:24040018   PMID:24198040   PMID:24265310   PMID:24270184   PMID:24316227   PMID:24480438   PMID:24484474  
PMID:24613359   PMID:24760869   PMID:24872407   PMID:25545984   PMID:25644424   PMID:25662281   PMID:25708205   PMID:26588713   PMID:26642930   PMID:27334657   PMID:27445338   PMID:27655914  
PMID:27830679   PMID:28197073   PMID:28758954   PMID:28877995   PMID:29325876   PMID:29450621   PMID:30308237   PMID:30592331   PMID:31113619   PMID:31440771   PMID:31831796   PMID:31875259  
PMID:32024191   PMID:33043964   PMID:33125501   PMID:34943971   PMID:36575400  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82175,534,844 - 175,551,664 (-)NCBIGRCr8
mRatBN7.22173,236,961 - 173,253,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,236,963 - 173,253,770 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,385,200 - 180,401,999 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,407,539 - 178,424,344 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02172,997,036 - 173,013,812 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,143,568 - 187,160,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,143,568 - 187,160,373 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,548,566 - 206,565,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42179,838,740 - 179,855,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12179,788,845 - 179,805,651 (-)NCBI
Celera2167,186,754 - 167,203,558 (-)NCBICelera
Cytogenetic Map2q34NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381156,815,750 - 156,881,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,815,636 - 156,881,850 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,785,542 - 156,851,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,052,166 - 155,118,266 (+)NCBINCBI36Build 36hg18NCBI36
Build 341153,643,743 - 153,664,715NCBI
Celera1129,856,788 - 129,922,861 (+)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1128,143,945 - 128,209,968 (+)NCBIHuRef
CHM1_11158,181,737 - 158,247,825 (+)NCBICHM1_1
T2T-CHM13v2.01155,952,603 - 156,018,667 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39387,685,551 - 87,702,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl387,685,551 - 87,702,469 (-)EnsemblGRCm39 Ensembl
GRCm38387,778,244 - 87,795,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,778,244 - 87,795,162 (-)EnsemblGRCm38mm10GRCm38
MGSCv37387,582,166 - 87,599,084 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36387,864,171 - 87,881,089 (-)NCBIMGSCv36mm8
Celera387,816,061 - 87,832,981 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.62NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555452,929,704 - 2,947,579 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,929,704 - 2,947,579 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2192,962,864 - 92,984,198 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1192,697,515 - 92,718,687 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1136,007,476 - 136,047,355 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1741,140,931 - 41,159,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,140,879 - 41,159,288 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha740,627,981 - 40,646,334 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,003,176 - 41,021,761 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,003,175 - 41,037,050 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1740,785,455 - 40,803,799 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0740,838,471 - 40,856,834 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,121,978 - 41,140,332 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505826,971,788 - 26,991,308 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365806,002,120 - 6,021,709 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365806,002,168 - 6,021,690 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl493,219,516 - 93,255,981 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,219,509 - 93,237,944 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24101,791,572 - 101,810,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1206,987,903 - 7,027,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl206,987,905 - 7,008,670 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,276,759 - 6,297,741 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248851,989,138 - 2,005,577 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,989,027 - 2,005,474 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ntrk1
89 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000018961, ENSRNOT00000044046
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,254,996 - 173,255,140 (+)MAPPERmRatBN7.2
Rnor_6.02187,161,600 - 187,161,743NCBIRnor6.0
Rnor_5.02206,566,598 - 206,566,741UniSTSRnor5.0
RGSC_v3.42179,856,771 - 179,856,915RGDRGSC3.4
RGSC_v3.42179,856,772 - 179,856,915UniSTSRGSC3.4
RGSC_v3.12179,806,877 - 179,807,021RGD
Celera2167,204,785 - 167,204,918UniSTS
Cytogenetic Map2q34UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,254,993 - 173,255,208 (+)MAPPERmRatBN7.2
Rnor_6.02187,161,597 - 187,161,811NCBIRnor6.0
Rnor_5.02206,566,595 - 206,566,809UniSTSRnor5.0
RGSC_v3.42179,856,768 - 179,856,983RGDRGSC3.4
RGSC_v3.42179,856,769 - 179,856,983UniSTSRGSC3.4
RGSC_v3.12179,806,874 - 179,807,089RGD
Celera2167,204,782 - 167,204,986UniSTS
Cytogenetic Map2q34UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,242,538 - 173,242,743 (+)MAPPERmRatBN7.2
Rnor_6.02187,149,144 - 187,149,348NCBIRnor6.0
Rnor_5.02206,554,142 - 206,554,346UniSTSRnor5.0
RGSC_v3.42179,844,316 - 179,844,520UniSTSRGSC3.4
Celera2167,192,330 - 167,192,534UniSTS
Cytogenetic Map2q34UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 6 20 12 12 2 62 30 30 2
Below cutoff 1 8 20 12 13 12 7 8 12 5 8 8 7


RefSeq Acc Id: ENSRNOT00000018961   ⟹   ENSRNOP00000018961
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,236,963 - 173,253,770 (-)Ensembl
Rnor_6.0 Ensembl2187,143,568 - 187,160,373 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092760   ⟹   ENSRNOP00000076015
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,147,599 - 187,149,017 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092780   ⟹   ENSRNOP00000075951
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,247,148 - 173,253,610 (-)Ensembl
Rnor_6.0 Ensembl2187,154,102 - 187,160,215 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092860
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,147,564 - 187,148,886 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092935
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,147,564 - 187,148,886 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115670   ⟹   ENSRNOP00000079821
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,236,963 - 173,253,770 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119500   ⟹   ENSRNOP00000085208
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,236,963 - 173,253,709 (-)Ensembl
RefSeq Acc Id: NM_021589   ⟹   NP_067600
Rat AssemblyChrPosition (strand)Source
GRCr82175,534,844 - 175,551,649 (-)NCBI
mRatBN7.22173,236,963 - 173,253,770 (-)NCBI
Rnor_6.02187,143,568 - 187,160,373 (-)NCBI
Rnor_5.02206,548,566 - 206,565,385 (-)NCBI
RGSC_v3.42179,838,740 - 179,855,545 (-)RGD
Celera2167,186,754 - 167,203,558 (-)RGD
RefSeq Acc Id: XM_039103004   ⟹   XP_038958932
Rat AssemblyChrPosition (strand)Source
GRCr82175,534,844 - 175,551,664 (-)NCBI
mRatBN7.22173,236,961 - 173,253,806 (-)NCBI
RefSeq Acc Id: XM_063282427   ⟹   XP_063138497
Rat AssemblyChrPosition (strand)Source
GRCr82175,534,844 - 175,551,295 (-)NCBI
RefSeq Acc Id: NP_067600   ⟸   NM_021589
- Peptide Label: precursor
- UniProtKB: P35739 (UniProtKB/Swiss-Prot),   A6J617 (UniProtKB/TrEMBL),   A0A8I6A1S2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075951   ⟸   ENSRNOT00000092780
RefSeq Acc Id: ENSRNOP00000076015   ⟸   ENSRNOT00000092760
RefSeq Acc Id: ENSRNOP00000018961   ⟸   ENSRNOT00000018961
RefSeq Acc Id: XP_038958932   ⟸   XM_039103004
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A1S2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079821   ⟸   ENSRNOT00000115670
RefSeq Acc Id: ENSRNOP00000085208   ⟸   ENSRNOT00000119500
RefSeq Acc Id: XP_063138497   ⟸   XM_063282427
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35739-F1-model_v2 AlphaFold P35739 1-799 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620144 AgrOrtholog
BioCyc Gene G2FUF-52535 BioCyc
Ensembl Genes ENSRNOG00000013953 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023126 UniProtKB/Swiss-Prot
  ENSRNOG00060031729 UniProtKB/Swiss-Prot
  ENSRNOG00065029663 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018961.4 UniProtKB/Swiss-Prot
  ENSRNOT00000092780.2 UniProtKB/TrEMBL
  ENSRNOT00000115670.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119500.1 UniProtKB/TrEMBL
  ENSRNOT00055039763 UniProtKB/Swiss-Prot
  ENSRNOT00060054994 UniProtKB/Swiss-Prot
  ENSRNOT00065051271 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTRK_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_neurotrophic_rcpt_1 UniProtKB/Swiss-Prot
  Tyr_kinase_NGF_rcpt UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TPKR_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ntrk1 PhenoGen
  NTKRECEPTOR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013953 RatGTEx
  ENSRNOG00055023126 RatGTEx
  ENSRNOG00060031729 RatGTEx
  ENSRNOG00065029663 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A6J618_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Ntrk1  neurotrophic receptor tyrosine kinase 1  Ntrk1  neurotrophic tyrosine kinase, receptor, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ntrk1  neurotrophic tyrosine kinase, receptor, type 1    trk precursor  Name updated 1299863 APPROVED
2002-08-07 Ntrk1  trk precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein activated by GM1 ganglioside 727459