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Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes . |
Al-Gayyar MM, etal., Diabetologia. 2011 Mar;54(3):669-80. Epub 2010 Dec 7.
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2. |
Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons. |
Allard S, etal., Neurobiol Aging. 2018 Jul;67:10-20. doi: 10.1016/j.neurobiolaging.2018.03.002. Epub 2018 Mar 9.
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3. |
Chronic and acute models of retinal neurodegeneration TrkA activity are neuroprotective whereas p75NTR activity is neurotoxic through a paracrine mechanism. |
Bai Y, etal., J Biol Chem. 2010 Dec 10;285(50):39392-400. Epub 2010 Oct 13.
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4. |
Targeted silencing of TrkA expression in rat forebrain neurons via the p75 receptor. |
Berhanu DA and Rush RA, Neuroscience. 2008 Jun 2;153(4):1115-25. Epub 2008 Mar 22.
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5. |
Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal. |
Bruns MB and Miller MW, J Neurochem. 2007 Mar;100(5):1155-68.
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6. |
Treadmill exercise improves cognitive function and facilitates nerve growth factor signaling by activating mitogen-activated protein kinase/extracellular signal-regulated kinase1/2 in the streptozotocin-induced diabetic rat hippocampus. |
Chae CH, etal., Neuroscience. 2009 Dec 29;164(4):1665-73. Epub 2009 Oct 2.
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7. |
Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures. |
Conti G, etal., Neurosci Res. 2009 Oct;65(2):201-9. Epub 2009 Jul 9.
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8. |
Gender differences in neurotrophin and glutamate receptor expression in cholinergic nucleus basalis neurons during the progression of Alzheimer's disease. |
Counts SE, etal., J Chem Neuroanat. 2011 Oct;42(2):111-7. Epub 2011 Mar 17.
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9. |
SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. |
Cozza A, etal., J Alzheimers Dis. 2008 Sep;15(1):61-70.
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10. |
Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer. |
Dang C, etal., J Gastroenterol Hepatol. 2006 May;21(5):850-8.
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11. |
Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. |
Dmitrieva VG, etal., Cell Mol Neurobiol. 2010 Jan;30(1):71-9. Epub 2009 Jul 25.
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12. |
Increased cutaneous NGF and CGRP-labelled trkA-positive intra-epidermal nerve fibres in rat diabetic skin. |
Evans L, etal., Neurosci Lett. 2011 Oct 25.
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13. |
Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. |
Formaggio E, etal., Neuroscience. 2010 Mar 17;166(2):580-9. Epub 2010 Jan 4.
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14. |
Anti-NGF treatment reduces bone resorption in periodontitis. |
Gaspersic R, etal., J Dent Res. 2010 May;89(5):515-20. Epub 2010 Mar 3.
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15. |
Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay. |
Gassei K, etal., Reproduction. 2008 Oct;136(4):459-69. Epub 2008 Jul 25.
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16. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
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17. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
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18. |
Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. |
Goldbart AD, etal., Pediatr Res. 2007 Oct;62(4):489-94.
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19. |
Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion. |
Hajebrahimi Z, etal., Neurosci Lett. 2008 Aug 29;441(3):261-6. Epub 2008 Jun 21.
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20. |
Involvement of NGF in the rat model of persistent muscle pain associated with taut band. |
Hayashi K, etal., J Pain. 2011 Oct;12(10):1059-68. Epub 2011 Jun 30.
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21. |
Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. |
Herbst R, etal., Development 2002 Dec;129(23):5449-60.
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22. |
Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. |
Hisata S, etal., J Cell Biol. 2007 Aug 27;178(5):843-60.
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23. |
Alterations in neurotrophin and neurotrophin-receptor localization in Hirschsprung's disease. |
Hoehner JC, etal., J Pediatr Surg. 1996 Nov;31(11):1524-9.
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24. |
Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis. |
Huehne K, etal., Neuromuscul Disord. 2008 Feb;18(2):159-66. Epub 2008 Feb 20.
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25. |
TrkA pathway(s) is involved in regulation of TRPM7 expression in hippocampal neurons subjected to ischemic-reperfusion and oxygen-glucose deprivation. |
Jiang H, etal., Brain Res Bull. 2008 May 15;76(1-2):124-30. Epub 2008 Feb 12.
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26. |
Molecular kinetics of nerve growth factor receptor trafficking and activation. |
Jullien J, etal., J Biol Chem 2002 Oct 11;277(41):38700-8.
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27. |
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. |
Lazaridis I, etal., PLoS Biol. 2011 Apr;9(4):e1001051. doi: 10.1371/journal.pbio.1001051. Epub 2011 Apr 26.
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28. |
Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells. |
Lebrun-Julien F, etal., Mol Cell Neurosci. 2009 Apr;40(4):410-20. Epub 2008 Dec 25.
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29. |
Neonatal tissue damage facilitates nociceptive synaptic input to the developing superficial dorsal horn via NGF-dependent mechanisms. |
Li J and Baccei ML, Pain. 2011 Aug;152(8):1846-55. Epub 2011 May 6.
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30. |
GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. |
Li X, etal., Mol Biol Cell. 2015 Dec 1;26(24):4412-26. doi: 10.1091/mbc.E15-02-0087. Epub 2015 Oct 7.
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31. |
Effect of amyloid peptides on the increase in TrkA receptor expression induced by nicotine in vitro and in vivo. |
Li XD, etal., J Mol Neurosci. 2005;27(3):325-36.
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32. |
Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis. |
Li Y, etal., Reprod Biol Endocrinol. 2011 Mar 8;9:30.
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33. |
Novel neurotrophic tyrosine kinase receptor type 1 gene mutation associated with congenital insensitivity to pain with anhidrosis. |
Lin YP, etal., J Child Neurol. 2010 Dec;25(12):1548-51. Epub 2010 Jul 20.
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34. |
A high soy diet enhances neurotropin receptor and Bcl-XL gene expression in the brains of ovariectomized female rats. |
Lovekamp-Swan T, etal., Brain Res. 2007 Jul 23;1159:54-66. Epub 2007 May 26.
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35. |
Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA. |
MacDonald JI, etal., J Biol Chem. 2000 Jun 16;275(24):18225-33.
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36. |
Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3. |
MacDonald JI, etal., J Mol Neurosci. 1999 Aug-Oct;13(1-2):141-58.
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37. |
Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats. |
Manni L, etal., Diabetologia. 2011 Jul;54(7):1900-8. Epub 2011 Mar 23.
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38. |
A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. |
Marler KJ, etal., J Neurosci. 2008 Nov 26;28(48):12700-12. doi: 10.1523/JNEUROSCI.1915-08.2008.
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39. |
Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation. |
Matrone C, etal., Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11358-63. doi: 10.1073/pnas.0904998106. Epub 2009 Jun 19.
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40. |
The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. |
Meakin SO, etal., Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2374-8.
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41. |
The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain. |
Miller R, etal., Brain Res 2002 Sep 20;950(1-2):137-47.
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42. |
Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure. |
Moore DB, etal., J Neurobiol. 2004 Jul;60(1):101-13. doi: 10.1002/neu.20009.
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43. |
Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure. |
Moore DB, etal., J Neurobiol. 2004 Jul;60(1):114-26. doi: 10.1002/neu.20010.
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44. |
Differential regulation of the expression of neurotrophin receptors in rat extraocular motoneurons after lesion. |
Morcuende S, etal., J Comp Neurol. 2011 Aug 15;519(12):2335-52. doi: 10.1002/cne.22630.
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45. |
Impaired glucose tolerance and insulinopenia in the GK-rat causes peripheral neuropathy. |
Murakawa Y, etal., Diabetes Metab Res Rev. 2002 Nov-Dec;18(6):473-83.
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46. |
Electronic Transfer of LocusLink and RefSeq Data |
NCBI rat LocusLink and RefSeq merged data July 26, 2002
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47. |
NGF/TrkA-mediated Kidins220/ARMS signaling activated in the allergic airway challenge in mice. |
Ni X, etal., Ann Allergy Asthma Immunol. 2010 Oct;105(4):299-306.
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48. |
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. |
Nikoletopoulou V, etal., Nature. 2010 Sep 2;467(7311):59-63. doi: 10.1038/nature09336.
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49. |
Ultrastructural localization of the neurotrophin receptor (TrkA) in cultured rat pheochromocytoma PC12 Cells: three-dimensional image analysis by high voltage electron microscopy. |
Nishida T, etal., Biomed Res. 2007 Jun;28(3):161-7.
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50. |
OMIM Disease Annotation Pipeline |
OMIM Disease Annotation Pipeline
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51. |
[Changes of nerve growth factor and its receptors in the lung tissues in asthmatic rats and their effects on the airway inflammation]. |
Ouyang RY, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Dec;30(6):660-5.
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52. |
KEGG Annotation Import Pipeline |
Pipeline to import KEGG annotations from KEGG into RGD
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53. |
Colitis elicits differential changes in the expression levels of receptor tyrosine kinase TrkA and TrkB in colonic afferent neurons: a possible involvement of axonal transport. |
Qiao LY and Grider JR, Pain. 2010 Oct;151(1):117-27. Epub 2010 Jul 16.
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54. |
Differential up-regulation of neurotrophin receptors and functional activity of neurotrophins on peripheral blood eosinophils of patients with allergic rhinitis, atopic dermatitis and nonatopic subjects. |
Raap U, etal., Clin Exp Allergy. 2008 Sep;38(9):1493-8. Epub 2008 Jul 17.
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55. |
Gangliosides activate Trk receptors by inducing the release of neurotrophins. |
Rabin SJ, etal., J Biol Chem 2002 Dec 20;277(51):49466-72.
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56. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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57. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
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58. |
Neurotrophin system activation in bronchoalveolar lavage fluid immune cells in pulmonary sarcoidosis. |
Ricci A, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Oct;22(3):186-94.
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59. |
Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. |
Robinson KN, etal., J Biol Chem. 2005 Jan 7;280(1):225-35. Epub 2004 Oct 28.
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60. |
Sequential expression of Trks A, B, and C in the regenerating olfactory neuroepithelium. |
Roskams AJ, etal., J Neurosci. 1996 Feb 15;16(4):1294-307.
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61. |
Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions. |
Ross GM, etal., Eur J Neurosci. 1998 Mar;10(3):890-8.
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62. |
Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation. |
Rotthier A, etal., Brain. 2009 Oct;132(Pt 10):2699-711. Epub 2009 Aug 3.
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63. |
Age-related regional differences in cardiac nerve growth factor expression. |
Saygili E, etal., Age (Dordr). 2012 Jun;34(3):659-67. doi: 10.1007/s11357-011-9262-0. Epub 2011 May 11.
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64. |
Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma. |
Sposato V, etal., Neurosci Lett. 2008 Nov 28;446(1):20-4. Epub 2008 Sep 18.
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65. |
Nerve growth factor helps protect retina in experimental retinal detachment. |
Sun X, etal., Ophthalmologica. 2008;222(1):58-61. Epub 2007 Dec 19.
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66. |
Skoura - a genetic island for congenital insensitivity to pain and anhidrosis among Moroccan Jews, as determined by a novel mutation in the NTRK1 gene. |
Suriu C, etal., Clin Genet. 2009 Mar;75(3):230-6.
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Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas. |
Suzuki T, etal., J Natl Cancer Inst. 1993 Mar 3;85(5):377-84.
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68. |
Effects of high-affinity nerve growth factor receptor inhibitors on symptoms in the NC/Nga mouse atopic dermatitis model. |
Takano N, etal., Br J Dermatol. 2007 Feb;156(2):241-6.
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69. |
Chronic antipsychotic treatment: protracted decreases in phospho-TrkA levels in the rat hippocampus. |
Terry AV Jr, etal., Int J Neuropsychopharmacol. 2010 Jul;13(6):799-805. Epub 2010 Jan 11.
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70. |
Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats. |
Terry AV Jr, etal., Physiol Behav. 2011 Feb 1;102(2):149-57. Epub 2010 Nov 6.
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71. |
Presence of nerve growth factor and TrkA expression in the SVZ of EAE rats: evidence for a possible functional significance. |
Triaca V, etal., Exp Neurol. 2005 Jan;191(1):53-64.
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72. |
Novel NTRK1 mutations cause hereditary sensory and autonomic neuropathy type IV: demonstration of a founder mutation in the Turkish population. |
Tuysuz B, etal., Neurogenetics. 2008 May;9(2):119-25. Epub 2008 Mar 6.
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73. |
Local administration of a synthetic cell-penetrating peptide antagonizing TrkA function suppresses inflammatory pain in rats. |
Ueda K, etal., J Pharmacol Sci. 2010;112(4):438-43. Epub 2010 Mar 30.
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74. |
The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. |
Van Kanegan MJ and Strack S, Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24.
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75. |
Dual association of a TRKA polymorphism with schizophrenia. |
Van Schijndel JE, etal., Psychiatr Genet. 2011 Jun;21(3):125-31.
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76. |
Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. |
Wan J, etal., J Neurosci. 2008 Sep 3;28(36):9002-12. doi: 10.1523/JNEUROSCI.0767-08.2008.
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77. |
Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling. |
Wang T, etal., Acta Pharmacol Sin. 2010 Jul;31(7):765-74. doi: 10.1038/aps.2010.69. Epub 2010 Jun 28.
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78. |
Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum. |
Wang ZY, etal., Neuroscience. 2010 Jan 20;165(2):485-91. doi: 10.1016/j.neuroscience.2009.10.045.
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79. |
Guiding adult Mammalian sensory axons during regeneration. |
Webber CA, etal., J Neuropathol Exp Neurol. 2008 Mar;67(3):212-22.
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80. |
[A study on expressions of nerve growth factor and its receptor tyrosine kinase receptor A in lung bronchiolar epithelial cells of chronic obstructive pulmonary disease patients]. |
Xiao Y and Xu YJ, Zhonghua Jie He He Hu Xi Za Zhi. 2011 Jan;34(1):34-8.
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81. |
Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor. |
Yano H, etal., J Neurosci Res. 2000 Feb 1;59(3):356-64.
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82. |
Nerve growth factor applied onto the olfactory epithelium alleviates degenerative changes of the olfactory receptor neurons following axotomy. |
Yasuno H, etal., Brain Res. 2000 Dec 22;887(1):53-62.
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83. |
Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth. |
Zhang Y, etal., J Biol Chem. 2009 May 1;284(18):12469-79. Epub 2009 Mar 5.
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