CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: carbotricyclic compound
Accession: CHEBI:38032
browse the term
Definition: A carbopolyclic compound comprising of three carbocyclic rings.
Synonyms: related_synonym: carbotricyclic compounds
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Ephx1
epoxide hydrolase 1
increases metabolic processing
ISO
EPHX1 protein mutant form results in increased metabolism of 9,10-epoxy-9,10-dihydrophenanthrene
CTD
PMID:26838043
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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Abca13
ATP binding cassette subfamily A member 13
affects response to substance
ISO
ABCA13 gene SNP affects the susceptibility to Colchicine
CTD
PMID:25622337
NCBI chr14:83,873,397...84,376,138
Ensembl chr14:83,873,940...84,375,075
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Abcb11
ATP binding cassette subfamily B member 11
affects localization
EXP
Colchicine affects the localization of ABCB11 protein
CTD
PMID:12702492 PMID:15304119
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
affects transport increases export increases expression multiple interactions decreases response to substance
ISO
ABCB1 protein affects the transport of Colchicine ABCB1 protein results in increased export of Colchicine Colchicine results in increased expression of ABCB1; Colchicine results in increased expression of ABCB1 mRNA [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine; Colchicine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form] ABCB1 protein results in decreased susceptibility to Colchicine
CTD
PMID:7905786 PMID:11792417 PMID:12711602 PMID:15112361 PMID:15342794 PMID:15725475 PMID:16007523 PMID:24759273 More...
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc1
ATP binding cassette subfamily C member 1
decreases response to substance
ISO
ABCC1 protein results in decreased susceptibility to Colchicine
CTD
PMID:12067707
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions
EXP
[Colchicine co-treated with JTE 013] inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]
CTD
PMID:31300867
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
affects localization
EXP
Colchicine affects the localization of ABCC3 protein
CTD
PMID:12702492
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc4
ATP binding cassette subfamily C member 4
multiple interactions
ISO
Colchicine inhibits the reaction [Acetaminophen results in increased expression of ABCC4 protein]
CTD
PMID:18468992
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Ace
angiotensin I converting enzyme
multiple interactions decreases activity decreases expression
EXP
carvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Quercetin inhibits the reaction [Colchicine results in decreased activity of ACE protein]; resveratrol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Rivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein]
CTD
PMID:17135773 PMID:17652827 PMID:18980205 PMID:18992766
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ace2
angiotensin converting enzyme 2
decreases expression
EXP ISO
Colchicine results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Ache
acetylcholinesterase
increases activity multiple interactions
ISO
Colchicine results in increased activity of ACHE protein amyloid beta-protein (25-35) inhibits the reaction [Colchicine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Colchicine results in increased activity of ACHE protein]
CTD
PMID:33617922
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP ISO
Colchicine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD
PMID:14726149 PMID:22446813 PMID:37573684
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Ahr
aryl hydrocarbon receptor
decreases activity
ISO EXP
Colchicine results in decreased activity of AHR protein
CTD
PMID:16611024
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Aif1
allograft inflammatory factor 1
decreases expression
EXP
Colchicine results in decreased expression of AIF1 mRNA
CTD
PMID:20624997
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Ak1
adenylate kinase 1
decreases expression
EXP
Colchicine results in decreased expression of AK1 mRNA
CTD
PMID:20624997
NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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Alb
albumin
affects expression multiple interactions
ISO EXP
Colchicine affects the expression of ALB protein Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ALB protein]
CTD
PMID:8574231 PMID:23146695
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein]
CTD
PMID:37573684
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Apln
apelin
decreases expression
EXP
Colchicine results in decreased expression of APLN mRNA
CTD
PMID:20624997
NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391
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Arg1
arginase 1
multiple interactions
EXP
Colchicine promotes the reaction [Uric Acid results in increased expression of ARG1 protein]
CTD
PMID:33894285
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Atxn1
ataxin 1
decreases expression
ISO
Colchicine results in decreased expression of ATXN1 mRNA
CTD
PMID:24211769
NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
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Aurkb
aurora kinase B
increases expression
ISO
Colchicine results in increased expression of AURKB mRNA
CTD
PMID:21472861
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Avp
arginine vasopressin
decreases transport
EXP
Colchicine results in decreased transport of AVP protein
CTD
PMID:2453250
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
Colchicine results in increased expression of BAX protein dihydroactinidiolide inhibits the reaction [Colchicine results in increased expression of BAX protein]
CTD
PMID:22342440 PMID:33617922 PMID:33684465
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
EXP ISO
Colchicine inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA] dihydroactinidiolide inhibits the reaction [Colchicine results in decreased expression of BCL2 protein]
CTD
PMID:22342440 PMID:22446813 PMID:33617922 PMID:33684465
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions
EXP
[Diethylnitrosamine co-treated with Colchicine] results in decreased expression of BCL2L1 protein
CTD
PMID:11749691
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bdnf
brain-derived neurotrophic factor
decreases transport
EXP
Colchicine results in decreased transport of BDNF protein
CTD
PMID:21310905
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Blm
BLM RecQ like helicase
decreases expression
ISO
Colchicine results in decreased expression of BLM mRNA
CTD
PMID:24211769
NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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Btg1
BTG anti-proliferation factor 1
decreases expression
ISO
Colchicine results in decreased expression of BTG1 mRNA
CTD
PMID:24211769
NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
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Btg2
BTG anti-proliferation factor 2
decreases expression
ISO
Colchicine results in decreased expression of BTG2 mRNA
CTD
PMID:24211769
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Btg3
BTG anti-proliferation factor 3
decreases expression
ISO
Colchicine results in decreased expression of BTG3 mRNA
CTD
PMID:24211769
NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
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C3
complement C3
increases expression
EXP
Colchicine results in increased expression of C3 mRNA
CTD
PMID:20624997
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Capn1
calpain 1
decreases expression
EXP
Colchicine results in decreased expression of CAPN1 mRNA
CTD
PMID:18255150
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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Casp3
caspase 3
multiple interactions increases expression increases cleavage increases activity
EXP ISO
alsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; alvocidib inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; Lithium inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; SB 216763 inhibits the reaction [Colchicine results in increased activity of CASP3 protein] Colchicine results in increased expression of CASP3 protein dihydroactinidiolide inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; dihydroactinidiolide inhibits the reaction [Colchicine results in increased expression of CASP3 protein] Colchicine results in increased cleavage of CASP3 protein Colchicine results in increased expression of CASP3 mRNA
CTD
PMID:12941380 PMID:15005753 PMID:16478524 PMID:18255150 PMID:19815060 PMID:20300959 PMID:20624997 PMID:22342440 PMID:33617922 PMID:33684465 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases expression
EXP
Colchicine results in increased expression of CASP8 mRNA
CTD
PMID:18255150
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity
ISO
Colchicine results in increased activity of CASP9 protein
CTD
PMID:22342440
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
increases expression
EXP
Colchicine results in increased expression of CAT mRNA
CTD
PMID:18255150
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccdc51
coiled-coil domain containing 51
decreases expression
ISO
Colchicine results in decreased expression of CCDC51 mRNA
CTD
PMID:24211769
NCBI chr 8:109,722,595...109,741,478
Ensembl chr 8:109,722,557...109,741,472
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Ccl2
C-C motif chemokine ligand 2
increases expression
EXP
Colchicine results in increased expression of CCL2 mRNA
CTD
PMID:3119359 PMID:20624997
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccnb1
cyclin B1
increases expression
ISO
Colchicine results in increased expression of CCNB1 mRNA; Colchicine results in increased expression of CCNB1 protein
CTD
PMID:21472861 PMID:27769712
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnd1
cyclin D1
increases expression
ISO EXP
Colchicine results in increased expression of CCND1 protein Colchicine results in increased expression of CCND1 mRNA
CTD
PMID:16495211 PMID:18255150
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccne2
cyclin E2
decreases expression
ISO
Colchicine results in decreased expression of CCNE2 mRNA
CTD
PMID:24211769
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cd14
CD14 molecule
increases expression
EXP
Colchicine results in increased expression of CD14 mRNA
CTD
PMID:20624997
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd44
CD44 molecule
increases expression
EXP
Colchicine results in increased expression of CD44 mRNA
CTD
PMID:20624997
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cd59b
CD59b molecule
increases mutagenesis
ISO
Colchicine results in increased mutagenesis of CD59 protein
CTD
PMID:17045307
NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
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Cdc25a
cell division cycle 25A
decreases expression
ISO
Colchicine results in decreased expression of CDC25A mRNA
CTD
PMID:24211769
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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Cdc6
cell division cycle 6
decreases expression
ISO
Colchicine results in decreased expression of CDC6 mRNA
CTD
PMID:24211769
NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
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Cdh1
cadherin 1
affects activity
ISO
Colchicine affects the activity of CDH1 protein
CTD
PMID:10413674
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdk2
cyclin dependent kinase 2
increases expression
EXP
Colchicine results in increased expression of CDK2 mRNA
CTD
PMID:18255150
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk5
cyclin-dependent kinase 5
increases expression multiple interactions
EXP
Colchicine results in increased expression of CDK5 protein alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein]
CTD
PMID:12941380
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression decreases expression
EXP ISO
Colchicine results in increased expression of CDKN1A mRNA Colchicine results in increased expression of CDKN1A protein Colchicine results in decreased expression of CDKN1A mRNA
CTD
PMID:20624997 PMID:24211769 PMID:27358234
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn3
cyclin-dependent kinase inhibitor 3
decreases expression
EXP
Colchicine results in decreased expression of CDKN3 mRNA
CTD
PMID:20624997
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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Celf2
CUGBP, Elav-like family member 2
multiple interactions increases expression
ISO
2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased expression of CELF2 mRNA]
CTD
PMID:11478917
NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333
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Chaf1a
chromatin assembly factor 1 subunit A
decreases expression
ISO
Colchicine results in decreased expression of CHAF1A mRNA
CTD
PMID:24211769
NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
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Chaf1b
chromatin assembly factor 1 subunit B
decreases expression
ISO
Colchicine results in decreased expression of CHAF1B mRNA
CTD
PMID:24211769
NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070
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Cldn1
claudin 1
decreases expression
ISO
Colchicine results in decreased expression of CLDN1 mRNA
CTD
PMID:33002524
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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Cln8
CLN8, transmembrane ER and ERGIC protein
decreases expression
ISO
Colchicine results in decreased expression of CLN8 mRNA
CTD
PMID:24211769
NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774
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Coa7
cytochrome c oxidase assembly factor 7
decreases expression
ISO
Colchicine results in decreased expression of COA7 mRNA
CTD
PMID:24211769
NCBI chr 5:123,069,356...123,080,942
Ensembl chr 5:123,069,371...123,080,199
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Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
CTD
PMID:37573684
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col3a1
collagen type III alpha 1 chain
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased secretion of COL3A1 protein]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]
CTD
PMID:37573684
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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Cp
ceruloplasmin
increases expression
EXP
Colchicine results in increased expression of CP mRNA
CTD
PMID:20624997
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Cpt2
carnitine palmitoyltransferase 2
decreases expression
ISO
Colchicine results in decreased expression of CPT2 mRNA
CTD
PMID:24211769
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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Crh
corticotropin releasing hormone
decreases expression increases expression
EXP
Colchicine results in decreased expression of CRH protein Colchicine results in increased expression of CRH mRNA
CTD
PMID:1850078 PMID:2453250
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Csf2
colony stimulating factor 2
multiple interactions
ISO
Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Colchicine inhibits the reaction [Quercetin results in increased secretion of CSF2 protein]
CTD
PMID:18346843
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Cxcl1
C-X-C motif chemokine ligand 1
increases expression
EXP
Colchicine results in increased expression of CXCL1 mRNA
CTD
PMID:3119359
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO EXP
Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
CTD
PMID:16611024
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects metabolic processing
ISO
CYP3A4 protein affects the metabolism of Colchicine
CTD
PMID:15914514 PMID:16007523
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Colchicine results in increased expression of DDIT3 protein
CTD
PMID:27358234
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Ddit4
DNA-damage-inducible transcript 4
decreases expression
ISO
Colchicine results in decreased expression of DDIT4 mRNA
CTD
PMID:24211769
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Drd3
dopamine receptor D3
decreases expression
EXP
Colchicine results in decreased expression of DRD3 mRNA
CTD
PMID:7878047
NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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Dusp14
dual specificity phosphatase 14
decreases expression
ISO
Colchicine results in decreased expression of DUSP14 mRNA
CTD
PMID:24211769
NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329
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E2f1
E2F transcription factor 1
decreases expression
ISO
Colchicine results in decreased expression of E2F1 mRNA
CTD
PMID:24211769
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Ednrb
endothelin receptor type B
increases expression
EXP
Colchicine results in increased expression of EDNRB mRNA
CTD
PMID:20624997
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Enc1
ectodermal-neural cortex 1
decreases expression
ISO
Colchicine results in decreased expression of ENC1 mRNA
CTD
PMID:24211769
NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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Eprs1
glutamyl-prolyl-tRNA synthetase 1
increases expression
EXP
Colchicine results in increased expression of EPRS1 mRNA
CTD
PMID:20624997
NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
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Esm1
endothelial cell-specific molecule 1
decreases expression
EXP
Colchicine results in decreased expression of ESM1 mRNA
CTD
PMID:20624997
NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
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Esr1
estrogen receptor 1
multiple interactions
ISO
Colchicine binds to and results in decreased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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F2
coagulation factor II, thrombin
affects activity
ISO
Colchicine affects the activity of F2 protein
CTD
PMID:8574231
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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F3
coagulation factor III, tissue factor
increases expression
EXP
Colchicine results in increased expression of F3 mRNA
CTD
PMID:20624997
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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Fas
Fas cell surface death receptor
increases expression decreases expression
ISO
Colchicine results in increased expression of FAS mRNA Colchicine results in decreased expression of FAS protein
CTD
PMID:10675359
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fcgr2b
Fc gamma receptor 2B
increases expression
EXP
Colchicine results in increased expression of FCGR2B mRNA
CTD
PMID:20624997
NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
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Fdxr
ferredoxin reductase
decreases expression
ISO
Colchicine results in decreased expression of FDXR mRNA
CTD
PMID:24211769
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
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Fgf2
fibroblast growth factor 2
affects expression
EXP
Colchicine affects the expression of FGF2 protein
CTD
PMID:7714246
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Fn1
fibronectin 1
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]
CTD
PMID:37573684
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
EXP
Colchicine results in increased expression of and affects the localization of FOS protein Colchicine results in increased expression of FOS mRNA
CTD
PMID:3119359 PMID:7537689
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Foxj2
forkhead box J2
decreases expression
ISO
Colchicine results in decreased expression of FOXJ2 mRNA
CTD
PMID:24211769
NCBI chr 4:156,047,043...156,073,540
Ensembl chr 4:156,046,969...156,073,518
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Fzd1
frizzled class receptor 1
decreases expression
ISO
Colchicine results in decreased expression of FZD1 mRNA
CTD
PMID:24211769
NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643 Ensembl chr 4:29,310,091...29,312,643
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
EXP
Colchicine results in increased expression of GADD45A mRNA
CTD
PMID:20624997
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gadd45b
growth arrest and DNA-damage-inducible, beta
increases expression
EXP
Colchicine results in increased expression of GADD45B mRNA
CTD
PMID:20624997
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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Gadd45g
growth arrest and DNA-damage-inducible, gamma
increases expression
EXP
Colchicine results in increased expression of GADD45G mRNA
CTD
PMID:20624997
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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Gas7
growth arrest specific 7
decreases expression
EXP
Colchicine results in decreased expression of GAS7 mRNA
CTD
PMID:20624997
NCBI chr10:52,152,718...52,383,283
Ensembl chr10:52,152,493...52,383,276
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Gch1
GTP cyclohydrolase 1
decreases expression
ISO
Colchicine results in decreased expression of GCH1 mRNA
CTD
PMID:24211769
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
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Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]
CTD
PMID:37573684
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]
CTD
PMID:37573684
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Gdf15
growth differentiation factor 15
decreases expression
ISO
Colchicine results in decreased expression of GDF15 mRNA
CTD
PMID:24211769
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Gja1
gap junction protein, alpha 1
multiple interactions
EXP
Colchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]
CTD
PMID:8824497
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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Got1
glutamic-oxaloacetic transaminase 1
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of GOT1 protein]
CTD
PMID:37573684
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
CTD
PMID:37573684
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx1
glutathione peroxidase 1
increases expression
EXP
Colchicine results in increased expression of GPX1 mRNA
CTD
PMID:18255150
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
decreases expression
ISO
Colchicine results in decreased expression of GRIN1 mRNA
CTD
PMID:34748853
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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Grpel1
GrpE-like 1, mitochondrial
decreases expression
ISO
Colchicine results in decreased expression of GRPEL1 mRNA
CTD
PMID:24211769
NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
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Gsk3b
glycogen synthase kinase 3 beta
decreases expression
EXP
Colchicine results in decreased expression of GSK3B mRNA
CTD
PMID:18255150
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Gsr
glutathione-disulfide reductase
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein]
CTD
PMID:37573684
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Hal
histidine ammonia lyase
decreases expression
EXP
Colchicine results in decreased expression of HAL mRNA
CTD
PMID:32741898
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
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Hmox1
heme oxygenase 1
increases expression multiple interactions affects expression
EXP ISO
Colchicine results in increased expression of HMOX1 mRNA [dihydroactinidiolide co-treated with Colchicine] results in increased expression of HMOX1 mRNA Colchicine affects the expression of HMOX1 mRNA
CTD
PMID:20624997 PMID:22954530 PMID:33617922
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
Colchicine results in increased expression of HSPA5 protein
CTD
PMID:27358234
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Icam1
intercellular adhesion molecule 1
increases expression
EXP
Colchicine results in increased expression of ICAM1 mRNA
CTD
PMID:20624997
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Id3
inhibitor of DNA binding 3
decreases expression
ISO
Colchicine results in decreased expression of ID3 mRNA
CTD
PMID:24211769
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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Ifng
interferon gamma
multiple interactions
ISO
[Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]
CTD
PMID:29594315 PMID:37573684
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
increases phosphorylation affects response to substance multiple interactions
ISO
Colchicine results in increased phosphorylation of IKBKB protein IKBKB protein affects the susceptibility to Colchicine Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD
PMID:17029595 PMID:20159942
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Il10
interleukin 10
multiple interactions
EXP
[Colchicine co-treated with Uric Acid] results in increased expression of IL10 protein
CTD
PMID:33894285
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1a
interleukin 1 alpha
multiple interactions
ISO
Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]
CTD
PMID:11154858
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
increases expression multiple interactions decreases expression
EXP ISO
Colchicine results in increased expression of IL1B mRNA Colchicine inhibits the reaction [Uric Acid results in increased expression of IL1B protein] Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein] Colchicine results in increased expression of IL1B protein Colchicine results in decreased expression of IL1B mRNA
CTD
PMID:20624997 PMID:29594315 PMID:33002524 PMID:33894285 PMID:34453961 PMID:37573684 More...
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
decreases expression multiple interactions
ISO
Colchicine results in decreased expression of IL2 protein [Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA
CTD
PMID:1553933 PMID:29594315
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il6
interleukin 6
increases expression multiple interactions decreases expression
EXP ISO
Colchicine results in increased expression of IL6 mRNA Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] Colchicine results in increased expression of IL6 protein Colchicine results in decreased expression of IL6 mRNA Colchicine inhibits the reaction [Ethanol results in increased expression of IL6 protein]
CTD
PMID:20624997 PMID:22446813 PMID:33002524 PMID:34453961 PMID:37573684
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Inha
inhibin subunit alpha
decreases expression
EXP
Colchicine results in decreased expression of INHA mRNA
CTD
PMID:20624997
NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
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Ins1
insulin 1
multiple interactions
EXP
Colchicine inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]
CTD
PMID:19070612
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Ints15
integrator complex subunit 15
decreases expression
ISO
Colchicine results in decreased expression of INTS15 mRNA
CTD
PMID:24211769
NCBI chr12:11,245,045...11,260,170
Ensembl chr12:11,245,842...11,260,166
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Isg20l2
interferon stimulated exonuclease gene 20-like 2
decreases expression
ISO
Colchicine results in decreased expression of ISG20L2 mRNA
CTD
PMID:24211769
NCBI chr 2:173,396,780...173,407,102
Ensembl chr 2:173,396,780...173,406,614
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Jak2
Janus kinase 2
multiple interactions
EXP
Colchicine promotes the reaction [Uric Acid results in increased phosphorylation of JAK2 protein]
CTD
PMID:33894285
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation multiple interactions increases activity
ISO EXP
Colchicine results in increased phosphorylation of JUN protein 3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased phosphorylation of JUN protein]; Colchicine results in increased expression of and results in increased phosphorylation of JUN protein TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein] 3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased activity of JUN protein]; Colchicine results in increased phosphorylation of and results in increased localization of JUN protein
CTD
PMID:12221076 PMID:16478524
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Kif20a
kinesin family member 20A
decreases expression
ISO
Colchicine results in decreased expression of KIF20A mRNA
CTD
PMID:24211769
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
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Klf6
KLF transcription factor 6
increases expression
ISO
Colchicine results in increased expression of KLF6 mRNA
CTD
PMID:24211769
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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Krt18
keratin 18
decreases expression
ISO
Colchicine results in decreased expression of KRT18 protein
CTD
PMID:11259854
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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Ldha
lactate dehydrogenase A
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of LDHA protein]
CTD
PMID:37573684
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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Lhx2
LIM homeobox 2
decreases expression
ISO
Colchicine results in decreased expression of LHX2 mRNA
CTD
PMID:24211769
NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908
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Lpo
lactoperoxidase
decreases expression
ISO
Colchicine results in decreased expression of LPO mRNA
CTD
PMID:34748853
NCBI chr10:72,606,950...72,626,220
Ensembl chr10:72,606,944...72,626,535
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Lrp2
LDL receptor related protein 2
affects localization
EXP
Colchicine affects the localization of LRP2 protein
CTD
PMID:25588984
NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
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Lrrc47
leucine rich repeat containing 47
decreases expression
ISO
Colchicine results in decreased expression of LRRC47 mRNA
CTD
PMID:24211769
NCBI chr 5:164,570,539...164,580,174
Ensembl chr 5:164,570,435...164,580,174
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Map2
microtubule-associated protein 2
decreases expression
ISO
Colchicine results in decreased expression of MAP2 mRNA
CTD
PMID:34748853
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Mapk8
mitogen-activated protein kinase 8
increases phosphorylation multiple interactions
ISO
Colchicine results in increased phosphorylation of MAPK8 protein TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein]
CTD
PMID:12221076
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
increases phosphorylation multiple interactions
ISO
Colchicine results in increased phosphorylation of MAPK9 protein TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein]
CTD
PMID:12221076
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mapt
microtubule-associated protein tau
decreases expression
ISO
Colchicine results in decreased expression of MAPT protein
CTD
PMID:16930453
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mcm10
minichromosome maintenance 10 replication initiation factor
decreases expression
ISO
Colchicine results in decreased expression of MCM10 mRNA
CTD
PMID:24211769
NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
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Mgmt
O-6-methylguanine-DNA methyltransferase
multiple interactions
ISO
[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine
CTD
PMID:11792417
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Mir130b
microRNA 130b
decreases expression
ISO
Colchicine results in decreased expression of MIR130B
CTD
PMID:35134991
NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244
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Mir185
microRNA 185
decreases expression
ISO
Colchicine results in decreased expression of MIR185
CTD
PMID:35134991
NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
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Mir190b
microRNA 190b
increases expression
ISO
Colchicine results in increased expression of MIR190B
CTD
PMID:35134991
NCBI chr 2:175,514,800...175,514,877
Ensembl chr 2:175,514,800...175,514,877
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Mir20a
microRNA 20a
decreases expression
ISO
Colchicine results in decreased expression of MIR20A
CTD
PMID:35134991
NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
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Mir9-3
microRNA 9-3
decreases expression
ISO
Colchicine results in decreased expression of MIR9-3
CTD
PMID:35134991
NCBI chr 1:133,440,049...133,440,138
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Mirlet7d
microRNA let-7d
decreases expression
ISO
Colchicine results in decreased expression of MIRLET7D
CTD
PMID:35134991
NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
Colchicine results in decreased expression of MMP9 mRNA
CTD
PMID:33684465
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
multiple interactions
EXP
Colchicine inhibits the reaction [Ethanol results in increased activity of MPO protein]
CTD
PMID:22446813
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mrm2
mitochondrial rRNA methyltransferase 2
decreases expression
ISO
Colchicine results in decreased expression of MRM2 mRNA
CTD
PMID:24211769
NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118
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Msh6
mutS homolog 6
decreases expression
ISO
Colchicine results in decreased expression of MSH6 mRNA
CTD
PMID:24211769
NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
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Mtor
mechanistic target of rapamycin kinase
decreases expression
ISO
Colchicine results in decreased expression of MTOR mRNA
CTD
PMID:34748853
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Myc
MYC proto-oncogene, bHLH transcription factor
increases expression
EXP
Colchicine results in increased expression of MYC mRNA
CTD
PMID:3119359 PMID:20624997
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Myt1
myelin transcription factor 1
increases phosphorylation
ISO
Colchicine results in increased phosphorylation of MYT1 protein
CTD
PMID:16611024
NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341
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Nbn
nibrin
increases expression
EXP
Colchicine results in increased expression of NBN mRNA
CTD
PMID:20624997
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
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Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]
CTD
PMID:25257666
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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Ndufs4
NADH:ubiquinone oxidoreductase subunit S4
affects response to substance
ISO
NDUFS4 protein affects the susceptibility to Colchicine
CTD
PMID:21383081
NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
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Nfatc4
nuclear factor of activated T-cells 4
decreases localization
ISO
Colchicine results in decreased localization of NFATC4 protein
CTD
PMID:17044076
NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
[dihydroactinidiolide co-treated with Colchicine] results in increased expression of NFE2L2 mRNA Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA]
CTD
PMID:33617922 PMID:37573684
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia
NFKB inhibitor alpha
increases phosphorylation multiple interactions
ISO EXP
Colchicine results in increased phosphorylation of NFKBIA protein Colchicine inhibits the reaction [Uric Acid results in decreased expression of NFKBIA protein] Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD
PMID:17029595 PMID:33894285
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos1
nitric oxide synthase 1
increases expression
EXP
Colchicine results in increased expression of NOS1 protein
CTD
PMID:7537689
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Colchicine inhibits the reaction [Uric Acid results in increased expression of NOS2 protein]
CTD
PMID:23146695 PMID:33894285
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nptx1
neuronal pentraxin 1
increases expression
EXP
Colchicine results in increased expression of NPTX1 mRNA
CTD
PMID:18255150
NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Colchicine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD
PMID:25257666
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions increases degradation increases activity
ISO
Colchicine results in decreased localization of and results in decreased activity of NR3C1 protein Colchicine results in increased degradation of NR3C1 protein Colchicine results in increased activity of NR3C1 protein
CTD
PMID:15744361 PMID:20448266
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nts
neurotensin
increases expression
EXP
Colchicine results in increased expression of NTS mRNA
CTD
PMID:1850078
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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Ocln
occludin
decreases expression
ISO
Colchicine results in decreased expression of OCLN mRNA
CTD
PMID:33002524
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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Odc1
ornithine decarboxylase 1
multiple interactions increases expression
ISO EXP
Colchicine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] Colchicine results in increased expression of ODC1 mRNA
CTD
PMID:3119359 PMID:9270009
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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Olig2
oligodendrocyte transcription factor 2
decreases expression
ISO
Colchicine results in decreased expression of OLIG2 mRNA
CTD
PMID:34748853
NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152
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Orai3
ORAI calcium release-activated calcium modulator 3
decreases expression
ISO
Colchicine results in decreased expression of ORAI3 mRNA
CTD
PMID:24211769
NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052
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Palb2
partner and localizer of BRCA2
decreases expression
ISO
Colchicine results in decreased expression of PALB2 mRNA
CTD
PMID:24211769
NCBI chr 1:176,665,076...176,689,053
Ensembl chr 1:176,665,076...176,688,990
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
Colchicine results in increased cleavage of PARP1 protein
CTD
PMID:33684465
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pawr
pro-apoptotic WT1 regulator
increases expression multiple interactions
EXP
Colchicine results in increased expression of PAWR protein alvocidib inhibits the reaction [Colchicine results in increased expression of PAWR protein]
CTD
PMID:12941380
NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
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Pax6
paired box 6
multiple interactions
ISO
Colchicine promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA]
CTD
PMID:32949729
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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Pelo
pelota mRNA surveillance and ribosome rescue factor
decreases expression
ISO
Colchicine results in decreased expression of PELO mRNA
CTD
PMID:24211769
NCBI chr 2:46,797,853...46,799,621
Ensembl chr 2:46,797,853...46,799,746
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Phlda3
pleckstrin homology-like domain, family A, member 3
decreases expression
ISO
Colchicine results in decreased expression of PHLDA3 mRNA
CTD
PMID:24211769
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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Pidd1
p53-induced death domain protein 1
decreases expression
ISO
Colchicine results in decreased expression of PIDD1 mRNA
CTD
PMID:24211769
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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Plagl1
PLAG1 like zinc finger 1
increases expression
EXP
Colchicine results in increased expression of PLAGL1 mRNA
CTD
PMID:20624997
NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228
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Plat
plasminogen activator, tissue type
increases expression
EXP
Colchicine results in increased expression of PLAT mRNA
CTD
PMID:20624997
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plaur
plasminogen activator, urokinase receptor
increases expression
EXP
Colchicine results in increased expression of PLAUR mRNA
CTD
PMID:20624997
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Plekhf1
pleckstrin homology and FYVE domain containing 1
decreases expression
ISO
Colchicine results in decreased expression of PLEKHF1 mRNA
CTD
PMID:24211769
NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820
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Plxnb2
plexin B2
decreases expression
ISO
Colchicine results in decreased expression of PLXNB2 mRNA
CTD
PMID:24211769
NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330
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Pomc
proopiomelanocortin
increases secretion
EXP
Colchicine results in increased secretion of POMC protein
CTD
PMID:2453250
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
decreases expression
ISO
Colchicine results in decreased expression of PPM1D mRNA
CTD
PMID:24211769
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
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Ppp1ca
protein phosphatase 1 catalytic subunit alpha
increases expression
ISO
Colchicine results in increased expression of PPP1CA protein
CTD
PMID:16495211
NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
EXP
Colchicine results in increased expression of PPP1R15A mRNA
CTD
PMID:20624997
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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Prkab1
protein kinase AMP-activated non-catalytic subunit beta 1
decreases expression
ISO
Colchicine results in decreased expression of PRKAB1 mRNA
CTD
PMID:24211769
NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
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Psmc3ip
PSMC3 interacting protein
decreases expression
ISO
Colchicine results in decreased expression of PSMC3IP mRNA
CTD
PMID:24211769
NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]
CTD
PMID:37573684
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptk2b
protein tyrosine kinase 2 beta
multiple interactions increases phosphorylation
ISO
2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein]
CTD
PMID:11478917
NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
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Ptp4a1
protein tyrosine phosphatase 4A1
decreases expression
ISO
Colchicine results in decreased expression of PTP4A1 mRNA
CTD
PMID:24211769
NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
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Pus3
pseudouridine synthase 3
decreases expression
ISO
Colchicine results in decreased expression of PUS3 mRNA
CTD
PMID:24211769
NCBI chr 8:33,910,461...33,918,716
Ensembl chr 8:33,911,357...33,918,714
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Rad51c
RAD51 paralog C
decreases expression
ISO
Colchicine results in decreased expression of RAD51C mRNA
CTD
PMID:24211769
NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
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Ralbp1
ralA binding protein 1
multiple interactions affects transport
ISO
Colchicine inhibits the reaction [RALBP1 protein affects the transport of Leukotriene C4] RALBP1 protein affects the transport of Colchicine
CTD
PMID:15386349
NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707
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Rap2b
RAP2B, member of RAS oncogene family
decreases expression
ISO
Colchicine results in decreased expression of RAP2B mRNA
CTD
PMID:24211769
NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069
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Rassf1
Ras association domain family member 1
increases expression
EXP
Colchicine results in increased expression of RASSF1 mRNA
CTD
PMID:20624997
NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
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Rb1
RB transcriptional corepressor 1
multiple interactions
ISO
Colchicine results in decreased phosphorylation of and results in decreased activity of RB1 protein
CTD
PMID:16495211
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rbm34
RNA binding motif protein 34
decreases expression
ISO
Colchicine results in decreased expression of RBM34 mRNA
CTD
PMID:24211769
NCBI chr19:54,936,516...54,956,810
Ensembl chr19:54,936,531...54,956,715
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
Colchicine inhibits the reaction [Uric Acid results in increased phosphorylation of RELA protein]
CTD
PMID:33894285
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rfc1
replication factor C subunit 1
decreases expression
ISO
Colchicine results in decreased expression of RFC1 mRNA
CTD
PMID:24211769
NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370
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Rgs16
regulator of G-protein signaling 16
decreases expression
ISO
Colchicine results in decreased expression of RGS16 mRNA
CTD
PMID:24211769
NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
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Rnf113a1
ring finger protein 113A1
decreases expression
ISO
Colchicine results in decreased expression of RNF113A mRNA
CTD
PMID:24211769
NCBI chr X:116,427,941...116,429,164
Ensembl chr X:116,427,684...116,433,762
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Rnf19b
ring finger protein 19B
decreases expression
ISO
Colchicine results in decreased expression of RNF19B mRNA
CTD
PMID:24211769
NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380
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S100a8
S100 calcium binding protein A8
increases expression
EXP
Colchicine results in increased expression of S100A8 mRNA
CTD
PMID:20624997
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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S100a9
S100 calcium binding protein A9
increases expression
EXP
Colchicine results in increased expression of S100A9 mRNA
CTD
PMID:20624997
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Sac3d1
SAC3 domain containing 1
decreases expression
ISO
Colchicine results in decreased expression of SAC3D1 mRNA
CTD
PMID:24211769
NCBI chr 1:203,414,184...203,416,563
Ensembl chr 1:203,414,187...203,416,604
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Sct
secretin
multiple interactions
EXP
Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; Colchicine inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]
CTD
PMID:22194894
NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658
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Sdc1
syndecan 1
decreases expression
ISO
Colchicine results in decreased expression of SDC1 mRNA
CTD
PMID:24211769
NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
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Sdhaf1
succinate dehydrogenase complex assembly factor 1
decreases expression
ISO
Colchicine results in decreased expression of SDHAF1 mRNA
CTD
PMID:24211769
NCBI chr 1:85,576,207...85,577,156
Ensembl chr 1:85,576,041...85,577,366 Ensembl chr 1:85,576,041...85,577,366
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Sele
selectin E
increases expression
EXP
Colchicine results in increased expression of SELE mRNA
CTD
PMID:20624997
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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Serpina6
serpin family A member 6
decreases transport
EXP
Colchicine results in decreased transport of SERPINA6 protein
CTD
PMID:16700006
NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349
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Serpine1
serpin family E member 1
increases expression
EXP
Colchicine results in increased expression of SERPINE1 mRNA
CTD
PMID:20624997
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Sesn1
sestrin 1
increases expression decreases expression
EXP ISO
Colchicine results in increased expression of SESN1 mRNA Colchicine results in decreased expression of SESN1 mRNA
CTD
PMID:20624997 PMID:24211769
NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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Sgk1
serum/glucocorticoid regulated kinase 1
decreases expression
ISO
Colchicine results in decreased expression of SGK1 mRNA
CTD
PMID:24211769
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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Shank2
SH3 and multiple ankyrin repeat domains 2
decreases expression
ISO
Colchicine results in decreased expression of SHANK2 mRNA
CTD
PMID:34748853
NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
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Slbp
stem-loop histone mRNA binding protein
decreases expression
ISO
Colchicine results in decreased expression of SLBP mRNA
CTD
PMID:24211769
NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906
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Slc1a5
solute carrier family 1 member 5
decreases expression
ISO
Colchicine results in decreased expression of SLC1A5 mRNA
CTD
PMID:24211769
NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
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Slc6a4
solute carrier family 6 member 4
decreases expression
ISO
Colchicine results in decreased expression of SLC6A4 mRNA
CTD
PMID:34748853
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Sod1
superoxide dismutase 1
multiple interactions
ISO
Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]
CTD
PMID:37573684
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Spon1
spondin 1
increases expression
EXP
Colchicine results in increased expression of SPON1 mRNA
CTD
PMID:20624997
NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
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Sptan1
spectrin, alpha, non-erythrocytic 1
multiple interactions increases cleavage
ISO
3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased cleavage of SPTAN1 protein]
CTD
PMID:16478524
NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
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Srxn1
sulfiredoxin 1
increases expression
ISO
Colchicine results in increased expression of SRXN1 protein
CTD
PMID:27358234
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
Colchicine deficiency results in decreased activity of and affects the localization of STAT1 protein
CTD
PMID:28086195
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
multiple interactions
EXP
Colchicine promotes the reaction [Uric Acid results in increased phosphorylation of STAT3 protein]
CTD
PMID:33894285
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tat
tyrosine aminotransferase
multiple interactions decreases expression
ISO
pyrazolanthrone inhibits the reaction [Colchicine results in decreased expression of TAT mRNA]
CTD
PMID:15744361
NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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Tbc1d4
TBC1 domain family, member 4
multiple interactions affects phosphorylation
EXP
Colchicine inhibits the reaction [Oligomycins results in increased phosphorylation of TBC1D4 protein] Colchicine affects the phosphorylation of TBC1D4 protein
CTD
PMID:18063688
NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265
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Tfpi2
tissue factor pathway inhibitor 2
increases expression
EXP
Colchicine results in increased expression of TFPI2 mRNA
CTD
PMID:20624997
NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
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Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]
CTD
PMID:14726149 PMID:22446813 PMID:23146695
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Thbd
thrombomodulin
increases expression
EXP
Colchicine results in increased expression of THBD mRNA
CTD
PMID:20624997
NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
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Thbs1
thrombospondin 1
increases expression
EXP
Colchicine results in increased expression of THBS1 mRNA
CTD
PMID:20624997
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
Colchicine binds to and results in decreased activity of THRA protein
CTD
PMID:25752796
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Thrb
thyroid hormone receptor beta
multiple interactions
ISO
Colchicine binds to and results in decreased activity of THRB protein
CTD
PMID:25752796
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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Tigar
TP53 induced glycolysis regulatory phosphatase
decreases expression
ISO
Colchicine results in decreased expression of TIGAR mRNA
CTD
PMID:24211769
NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Colchicine results in increased expression of TIMP1 mRNA
CTD
PMID:20624997
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tipin
timeless interacting protein
decreases expression
ISO
Colchicine results in decreased expression of TIPIN mRNA
CTD
PMID:24211769
NCBI chr 8:64,780,813...64,801,358
Ensembl chr 8:64,780,828...64,801,352
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Tjp1
tight junction protein 1
decreases expression
ISO
Colchicine results in decreased expression of TJP1 mRNA
CTD
PMID:33002524
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tmem185b
transmembrane protein 185B
decreases expression
ISO
Colchicine results in decreased expression of TMEM185B mRNA
CTD
PMID:24211769
NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858
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Tnf
tumor necrosis factor
decreases expression multiple interactions increases expression
ISO EXP
Colchicine results in decreased expression of TNF protein Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] Colchicine results in increased expression of TNF protein Colchicine results in decreased expression of TNF mRNA Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TNF protein]
CTD
PMID:1553933 PMID:11154858 PMID:22446813 PMID:23146695 PMID:33002524 PMID:34453961 PMID:37573684 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf1a
TNF receptor superfamily member 1A
affects response to substance
ISO
TNFRSF1A protein affects the susceptibility to Colchicine
CTD
PMID:20159942
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Tnfsf9
TNF superfamily member 9
decreases expression
ISO
Colchicine results in decreased expression of TNFSF9 mRNA
CTD
PMID:24211769
NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
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Tnni3
troponin I3, cardiac type
increases expression
EXP
Colchicine results in increased expression of TNNI3 protein
CTD
PMID:20624997
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Top3a
DNA topoisomerase III alpha
decreases expression
ISO
Colchicine results in decreased expression of TOP3A mRNA
CTD
PMID:24211769
NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559
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Tor1a
torsin family 1, member A
decreases expression
ISO
Colchicine results in decreased expression of TOR1A mRNA
CTD
PMID:24211769
NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691
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Tp53
tumor protein p53
multiple interactions
ISO
TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein]; TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein]; TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein]
CTD
PMID:12221076
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpd52l1
TPD52 like 1
increases expression
EXP
Colchicine results in increased expression of TPD52L1 mRNA
CTD
PMID:20624997
NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109
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Traf2
Tnf receptor-associated factor 2
affects response to substance
ISO
TRAF2 protein affects the susceptibility to Colchicine
CTD
PMID:20159942
NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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Triap1
TP53 regulated inhibitor of apoptosis 1
decreases expression
ISO
Colchicine results in decreased expression of TRIAP1 mRNA
CTD
PMID:24211769
NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
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Trim26
tripartite motif-containing 26
decreases expression
ISO
Colchicine results in decreased expression of TRIM26 mRNA
CTD
PMID:24211769
NCBI chr20:1,708,297...1,731,176
Ensembl chr20:1,709,788...1,731,120
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Trim32
tripartite motif-containing 32
decreases expression
ISO
Colchicine results in decreased expression of TRIM32 mRNA
CTD
PMID:24211769
NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018
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Trim38
tripartite motif containing 38
decreases expression
ISO
Colchicine results in decreased expression of TRIM38 mRNA
CTD
PMID:24211769
NCBI chr17:41,351,857...41,365,021
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Tuba1b
tubulin, alpha 1B
decreases expression
EXP
Colchicine results in decreased expression of TUBA1B mRNA
CTD
PMID:20624997
NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186
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Tuba4a
tubulin, alpha 4A
decreases expression
EXP
Colchicine results in decreased expression of TUBA4A mRNA
CTD
PMID:20624997
NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918
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Tubb4b
tubulin, beta 4B class IVb
decreases expression
EXP
Colchicine results in decreased expression of TUBB4B mRNA
CTD
PMID:20624997
NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296
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Tubb5
tubulin, beta 5 class I
decreases expression
EXP
Colchicine results in decreased expression of TUBB5 mRNA
CTD
PMID:20624997
NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
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Tubg1
tubulin, gamma 1
decreases expression
EXP
Colchicine results in decreased expression of TUBG1 mRNA
CTD
PMID:20624997
NCBI chr10:86,052,845...86,059,436
Ensembl chr10:86,052,743...86,059,433
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Utp3
UTP3, small subunit processome component
decreases expression
ISO
Colchicine results in decreased expression of UTP3 mRNA
CTD
PMID:24211769
NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396
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Vcam1
vascular cell adhesion molecule 1
increases expression multiple interactions
EXP ISO
Colchicine results in increased expression of VCAM1 mRNA Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]; Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
CTD
PMID:11154858 PMID:20624997
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vip
vasoactive intestinal peptide
increases expression
EXP
Colchicine results in increased expression of VIP mRNA; Colchicine results in increased expression of VIP protein
CTD
PMID:1850078 PMID:8837219
NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
decreases expression
ISO
Colchicine results in decreased expression of XPC mRNA
CTD
PMID:24211769
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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Zbtb24
zinc finger and BTB domain containing 24
decreases expression
ISO
Colchicine results in decreased expression of ZBTB24 mRNA
CTD
PMID:24211769
NCBI chr20:44,943,302...44,965,329
Ensembl chr20:44,947,297...44,963,963
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Zfp202
zinc finger protein 202
decreases expression
ISO
Colchicine results in decreased expression of ZNF202 mRNA
CTD
PMID:24211769
NCBI chr 8:40,542,665...40,567,397
Ensembl chr 8:40,542,701...40,563,118
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Zfp36l1
zinc finger protein 36, C3H type-like 1
decreases expression
ISO
Colchicine results in decreased expression of ZFP36L1 mRNA
CTD
PMID:24211769
NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
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Zfp94
zinc finger protein 94
decreases expression
ISO
Colchicine results in decreased expression of ZNF45 mRNA
CTD
PMID:24211769
NCBI chr 1:79,858,188...79,879,702
Ensembl chr 1:79,859,180...79,879,612
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Esr1
estrogen receptor 1
multiple interactions
ISO
1-amino-2,4-dibromoanthraquinone binds to and results in increased activity of ESR1 protein
CTD
PMID:20707409
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Hras
HRas proto-oncogene, GTPase
increases mutagenesis
ISO
1-amino-2,4-dibromoanthraquinone results in increased mutagenesis of HRAS gene
CTD
PMID:11560247
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
1-amino-2,4-dibromoanthraquinone results in increased activity of NFE2L2 protein
CTD
PMID:30203046
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
1-amino-2,4-dibromoanthraquinone results in increased activity of NR1I3 protein
CTD
PMID:30203046
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
1-hydroxy-1-norresistomycin results in increased expression of BAX protein
CTD
PMID:29596799
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Casp3
caspase 3
increases expression
ISO
1-hydroxy-1-norresistomycin results in increased expression of CASP3 mRNA; 1-hydroxy-1-norresistomycin results in increased expression of CASP3 protein
CTD
PMID:29596799
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases expression
ISO
1-hydroxy-1-norresistomycin results in increased expression of CASP9 mRNA; 1-hydroxy-1-norresistomycin results in increased expression of CASP9 protein
CTD
PMID:29596799
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
1-hydroxy-1-norresistomycin results in increased expression of CDKN1A mRNA; 1-hydroxy-1-norresistomycin results in increased expression of CDKN1A protein
CTD
PMID:29596799
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
1-hydroxy-1-norresistomycin results in decreased expression of MMP2 mRNA; 1-hydroxy-1-norresistomycin results in decreased expression of MMP2 protein
CTD
PMID:29596799
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
1-hydroxy-1-norresistomycin results in decreased expression of MMP9 mRNA; 1-hydroxy-1-norresistomycin results in decreased expression of MMP9 protein
CTD
PMID:29596799
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Smim10l2a
small integral membrane protein 10 like 2A
increases expression
ISO
1-hydroxy-1-norresistomycin results in increased expression of SMIM10L2A mRNA
CTD
PMID:29596799
NCBI chr X:134,151,325...134,154,647
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Tnf
tumor necrosis factor
decreases expression
ISO
1-hydroxy-1-norresistomycin results in decreased expression of TNF mRNA
CTD
PMID:29596799
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
increases expression
ISO
1-hydroxy-1-norresistomycin results in increased expression of TP53 mRNA; 1-hydroxy-1-norresistomycin results in increased expression of TP53 protein
CTD
PMID:29596799
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
1-hydroxyanthraquinone results in decreased activity of CYP1A2 protein
CTD
PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Ahr
aryl hydrocarbon receptor
affects binding
EXP
1-methylfluorene binds to AHR protein
CTD
PMID:3024361
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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A2m
alpha-2-macroglobulin
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of A2M mRNA
CTD
PMID:17690111
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Ahr
aryl hydrocarbon receptor
increases activity multiple interactions
EXP
1-methylphenanthrene results in increased activity of AHR protein [1-methylphenanthrene results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA
CTD
PMID:11339718 PMID:17941746
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Aldob
aldolase, fructose-bisphosphate B
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of ALDOB mRNA
CTD
PMID:17690111
NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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Amacr
alpha-methylacyl-CoA racemase
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of AMACR mRNA
CTD
PMID:17690111
NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
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Apoc3
apolipoprotein C3
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of APOC3 mRNA
CTD
PMID:17690111
NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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Ar
androgen receptor
multiple interactions
EXP
1-methylphenanthrene inhibits the reaction [Metribolone binds to AR protein]
CTD
PMID:3695475
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CDKN1A mRNA
CTD
PMID:17690111
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Ceacam6
CEA cell adhesion molecule 6
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CEACAM6 mRNA
CTD
PMID:17690111
NCBI chr 1:80,416,531...80,434,668
Ensembl chr 1:80,416,531...80,434,668
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression affects expression multiple interactions
EXP ISO
1-methylphenanthrene results in increased expression of CYP1A1 protein 1-methylphenanthrene affects the expression of CYP1A1 mRNA 1-methylphenanthrene affects the reaction [Benzo(a)pyrene affects the expression of CYP1A1 mRNA]; [1-methylphenanthrene results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CYP1A1 mRNA
CTD
PMID:11339718 PMID:17690111 PMID:17941746 PMID:27099206
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
affects expression multiple interactions
EXP
1-methylphenanthrene affects the expression of CYP1B1 mRNA 1-methylphenanthrene affects the reaction [Benzo(a)pyrene affects the expression of CYP1B1 mRNA]
CTD
PMID:27099206
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Ece1
endothelin converting enzyme 1
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of ECE1 mRNA
CTD
PMID:17690111
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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G6pd
glucose-6-phosphate dehydrogenase
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of G6PD mRNA
CTD
PMID:17690111
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of GADD45A mRNA
CTD
PMID:17690111
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gck
glucokinase
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of GCK mRNA
CTD
PMID:17690111
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of HIF1A mRNA
CTD
PMID:17690111
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Igf1
insulin-like growth factor 1
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGF1 mRNA
CTD
PMID:17690111
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Igfbp1
insulin-like growth factor binding protein 1
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGFBP1 mRNA
CTD
PMID:17690111
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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Klf6
KLF transcription factor 6
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of KLF6 mRNA
CTD
PMID:17690111
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of MCL1 mRNA
CTD
PMID:17690111
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Mt1-ps3
metallothionein 1, pseudogene 3
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of MT1E mRNA
CTD
PMID:17690111
NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
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Sat1
spermidine/spermine N1-acetyl transferase 1
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SAT1 mRNA
CTD
PMID:17690111
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SERPINA3 mRNA
CTD
PMID:17690111
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Spp1
secreted phosphoprotein 1
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SPP1 mRNA
CTD
PMID:17690111
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Tp53
tumor protein p53
increases phosphorylation
EXP
1-methylphenanthrene results in increased phosphorylation of TP53 protein
CTD
PMID:17941746
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Xrcc1
X-ray repair cross complementing 1
multiple interactions
ISO
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of XRCC1 mRNA
CTD
PMID:17690111
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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Aaas
aladin WD repeat nucleoporin
increases expression
ISO
2-Acetylaminofluorene results in increased expression of AAAS mRNA
CTD
PMID:21607683
NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961
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Abcb1a
ATP binding cassette subfamily B member 1A
decreases expression increases expression multiple interactions increases activity
ISO EXP
2-Acetylaminofluorene results in decreased expression of ABCB1 mRNA 2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1A mRNA lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1A mRNA] 2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1 protein Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 protein] 2-Acetylaminofluorene results in increased activity of ABCB1 protein [2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA; [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA; [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]
CTD
PMID:11170838 PMID:11960367 PMID:12387747 PMID:17303067 PMID:17669244 PMID:21784091 PMID:22213190 More...
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
increases expression multiple interactions
EXP
2-Acetylaminofluorene results in increased expression of ABCB1B mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1B protein [2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased expression of ABCB1B mRNA; lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]
CTD
PMID:11020383 PMID:11170838 PMID:12801967 PMID:17070881 PMID:22084566
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcc1
ATP binding cassette subfamily C member 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of ABCC1 mRNA
CTD
PMID:12801967 PMID:17669244
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc10
ATP binding cassette subfamily C member 10
increases expression
ISO
2-Acetylaminofluorene results in increased expression of ABCC10 mRNA
CTD
PMID:12566991
NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178
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Abcc2
ATP binding cassette subfamily C member 2
increases expression multiple interactions
ISO
2-Acetylaminofluorene results in increased expression of ABCC2 mRNA 2-Acetylaminofluorene results in increased expression of ABCC2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC2 protein NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]
CTD
PMID:10691972 PMID:16381673 PMID:16426233
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
ISO EXP
2-Acetylaminofluorene results in increased expression of ABCC3 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC3 protein
CTD
PMID:10691972 PMID:12801967
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcg2
ATP binding cassette subfamily G member 2
increases expression increases activity multiple interactions
ISO EXP
2-Acetylaminofluorene results in increased expression of ABCG2 mRNA 2-Acetylaminofluorene results in increased activity of ABCG2 protein 2-Acetylaminofluorene results in increased expression of ABCG2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCG2 protein NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]
CTD
PMID:12819005 PMID:16381673 PMID:17538966 PMID:17669244 PMID:27475308
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Acaa2
acetyl-CoA acyltransferase 2
multiple interactions
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ACAA2 mRNA
CTD
PMID:14656948
NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
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Acmsd
aminocarboxymuconate semialdehyde decarboxylase
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of ACMSD mRNA
CTD
PMID:17070881
NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
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Acot9
acyl-CoA thioesterase 9
increases expression
EXP
2-Acetylaminofluorene results in increased expression of ACOT9 mRNA
CTD
PMID:21784091
NCBI chr X:40,073,197...40,123,573
Ensembl chr X:40,064,810...40,123,559
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Acsl3
acyl-CoA synthetase long-chain family member 3
increases expression
EXP
2-Acetylaminofluorene results in increased expression of ACSL3 mRNA
CTD
PMID:17070881
NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
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Aen
apoptosis enhancing nuclease
increases expression
ISO EXP
2-Acetylaminofluorene results in increased expression of AEN mRNA
CTD
PMID:17070881 PMID:21607683 PMID:22584684
NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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Afp
alpha-fetoprotein
multiple interactions increases expression
EXP
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP protein; [2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of AFP protein 2-Acetylaminofluorene results in increased expression of AFP mRNA; 2-Acetylaminofluorene results in increased expression of AFP protein
CTD
PMID:6187438 PMID:11350689 PMID:11813887 PMID:15133858 PMID:17538966
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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Ahr
aryl hydrocarbon receptor
increases expression
ISO
2-Acetylaminofluorene results in increased expression of AHR mRNA
CTD
PMID:25224404
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ak1
adenylate kinase 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of AK1 mRNA
CTD
PMID:17317680
NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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Akr1b1
aldo-keto reductase family 1 member B1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of AKR1B1 mRNA
CTD
PMID:17317680
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr1b10
aldo-keto reductase family 1 member B10
multiple interactions increases expression
EXP ISO
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AKR1B10 mRNA 2-Acetylaminofluorene results in increased expression of AKR1B10 mRNA
CTD
PMID:14656948 PMID:26198647
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akr7a3
aldo-keto reductase family 7 member A3
increases expression
EXP
2-Acetylaminofluorene results in increased expression of AKR7A3 mRNA
CTD
PMID:17070881
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; [2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA 2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD
PMID:11960367 PMID:17303067
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb
albumin
multiple interactions increases expression
EXP
[2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of ALB protein 2-Acetylaminofluorene results in increased expression of ALB protein
CTD
PMID:6187438 PMID:15133858
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of ALDH1A1 mRNA; 2-Acetylaminofluorene results in increased expression of ALDH1A1 protein
CTD
PMID:17070881 PMID:22584684 PMID:33211169
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh1a3
aldehyde dehydrogenase 1 family, member A3
increases expression
EXP
2-Acetylaminofluorene results in increased expression of ALDH1A3 mRNA
CTD
PMID:22584684
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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Aldh3a1
aldehyde dehydrogenase 3 family, member A1
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA]
CTD
PMID:17317680
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Tocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein]
CTD
PMID:15548946 PMID:15554553
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Anapc11
anaphase promoting complex subunit 11
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of ANAPC11 mRNA
CTD
PMID:22584684
NCBI chr10:105,875,209...105,886,307
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Anxa3
annexin A3
increases expression multiple interactions
ISO EXP
2-Acetylaminofluorene results in increased expression of ANXA3 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA] [Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of ANXA3 mRNA
CTD
PMID:17317680 PMID:18071240
NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
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Anxa8
annexin A8
increases expression
ISO
2-Acetylaminofluorene results in increased expression of ANXA8 mRNA
CTD
PMID:17317680
NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043
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Aox1
aldehyde oxidase 1
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of AOX1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AOX1 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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Apoa2
apolipoprotein A2
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of APOA2 mRNA
CTD
PMID:17070881
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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Apoa4
apolipoprotein A4
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of APOA4 mRNA
CTD
PMID:17070881
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Apoc3
apolipoprotein C3
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of APOC3 mRNA
CTD
PMID:17070881
NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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Apod
apolipoprotein D
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of APOD mRNA
CTD
PMID:20713471
NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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Aqp5
aquaporin 5
increases expression
EXP
2-Acetylaminofluorene results in increased expression of AQP5 mRNA
CTD
PMID:17187413
NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
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Areg
amphiregulin
increases expression multiple interactions
ISO
2-Acetylaminofluorene results in increased expression of AREG mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA]
CTD
PMID:17317680
NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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Asgr1
asialoglycoprotein receptor 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of ASGR1 mRNA
CTD
PMID:17187413
NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
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Atp6v1d
ATPase H+ transporting V1 subunit D
increases expression
EXP
2-Acetylaminofluorene results in increased expression of ATP6V1D mRNA
CTD
PMID:17070881
NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases expression
ISO EXP
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA] 2-Acetylaminofluorene results in increased expression of BAX mRNA [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]
CTD
PMID:11915028 PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684 More...
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions increases expression
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein] 2-Acetylaminofluorene results in increased expression of BCL2 mRNA
CTD
PMID:11915028 PMID:19167416 PMID:22213190
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions increases expression
EXP ISO
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein] 2-Acetylaminofluorene results in increased expression of BCL2L1 mRNA
CTD
PMID:11915028 PMID:21607683
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Birc5
baculoviral IAP repeat-containing 5
increases expression
EXP
2-Acetylaminofluorene results in increased expression of BIRC5 mRNA
CTD
PMID:19167416 PMID:22213190
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Brca1
BRCA1, DNA repair associated
increases expression
EXP
2-Acetylaminofluorene results in increased expression of BRCA1 mRNA
CTD
PMID:19167416
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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Btg2
BTG anti-proliferation factor 2
increases expression
EXP ISO
2-Acetylaminofluorene results in increased expression of BTG2 mRNA
CTD
PMID:17070881 PMID:21607683
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Bzw1
basic leucine zipper and W2 domains 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of BZW1 mRNA
CTD
PMID:17317680
NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
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C4bpa
complement component 4 binding protein, alpha
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of C4BPA mRNA
CTD
PMID:16510358
NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
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C6
complement C6
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of C6 mRNA
CTD
PMID:22584684
NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275
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C7
complement C7
increases expression
EXP
2-Acetylaminofluorene results in increased expression of C7 mRNA
CTD
PMID:17070881
NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
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Cacna2d1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CACNA2D1 mRNA
CTD
PMID:17187413
NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
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Cadm1
cell adhesion molecule 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CADM1 protein
CTD
PMID:17326163
NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
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Car2
carbonic anhydrase 2
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CAR2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAR2 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Casp3
caspase 3
multiple interactions increases expression increases activity
EXP
2-Acetylaminofluorene inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased cleavage of CASP3 protein]; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP3 protein]
CTD
PMID:12907702 PMID:23665045 PMID:26364502
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
multiple interactions increases activity
EXP
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein]
CTD
PMID:23665045
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
increases activity increases expression multiple interactions
EXP
2-Acetylaminofluorene results in increased activity of CASP9 protein 2-Acetylaminofluorene results in increased expression of CASP9 protein Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP9 protein]
CTD
PMID:23665045 PMID:26364502
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions decreases activity decreases expression
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of CAT protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of CAT protein]
CTD
PMID:17761372 PMID:23665045 PMID:26364502
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cavin3
caveolae associated protein 3
multiple interactions
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAVIN3 mRNA
CTD
PMID:14656948
NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
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Cblc
Cbl proto-oncogene C
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CBLC mRNA
CTD
PMID:17070881
NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755
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Cbr1
carbonyl reductase 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of CBR1 mRNA
CTD
PMID:21607683
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cck
cholecystokinin
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of CCK mRNA
CTD
PMID:22584684
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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Ccl2
C-C motif chemokine ligand 2
affects expression
EXP
2-Acetylaminofluorene affects the expression of CCL2 mRNA; 2-Acetylaminofluorene affects the expression of CCL2 protein
CTD
PMID:25051504
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl7
C-C motif chemokine ligand 7
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CCL7 protein
CTD
PMID:25051504
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Ccn2
cellular communication network factor 2
increases expression multiple interactions
EXP
2-Acetylaminofluorene results in increased expression of CCN2 mRNA; 2-Acetylaminofluorene results in increased expression of CCN2 protein Iloprost inhibits the reaction [2-Acetylaminofluorene results in increased expression of CCN2 mRNA]
CTD
PMID:15940639
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Ccna2
cyclin A2
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of CCNA2 protein
CTD
PMID:15158336
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
decreases expression increases expression
EXP
2-Acetylaminofluorene results in decreased expression of CCNB1 protein 2-Acetylaminofluorene results in increased expression of CCNB1 mRNA
CTD
PMID:15158336 PMID:22584684
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnb2
cyclin B2
increases expression multiple interactions
ISO EXP
2-Acetylaminofluorene results in increased expression of CCNB2 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA]
CTD
PMID:17317680 PMID:19167416 PMID:22584684
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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Ccnd1
cyclin D1
multiple interactions increases expression
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA] 2-Acetylaminofluorene results in increased expression of CCND1 mRNA
CTD
PMID:14633663 PMID:22584684
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccne1
cyclin E1
multiple interactions decreases activity
EXP
2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA] 2-Acetylaminofluorene results in decreased activity of CCNE1 protein
CTD
PMID:10708481 PMID:14633663
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Ccng1
cyclin G1
decreases expression increases expression
EXP ISO
2-Acetylaminofluorene results in decreased expression of CCNG1 mRNA 2-Acetylaminofluorene results in increased expression of CCNG1 mRNA
CTD
PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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Cd276
Cd276 molecule
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CD276 mRNA
CTD
PMID:17070881 PMID:21784091
NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
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Cd44
CD44 molecule
increases expression
EXP IEP
2-Acetylaminofluorene results in increased expression of CD44 mRNA; 2-Acetylaminofluorene results in increased expression of CD44 protein 2-Fluorenylacetamide increases CD44 mRNA in liver, and protein in liver and serum
CTD RGD
PMID:17187413 PMID:22584684 PMID:33211169 PMID:31966914
RGD:25823185
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cdc37
cell division cycle 37, HSP90 cochaperone
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 protein
CTD
PMID:16317707
NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
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Cdca3
cell division cycle associated 3
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CDCA3 mRNA
CTD
PMID:22584684
NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
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Cdh13
cadherin 13
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CDH13 mRNA
CTD
PMID:21784091
NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459
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Cdh22
cadherin 22
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CDH22 mRNA
CTD
PMID:17187413
NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588
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Cdh3
cadherin 3
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CDH3 mRNA
CTD
PMID:17187413
NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
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Cdk1
cyclin-dependent kinase 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CDK1 mRNA
CTD
PMID:19167416 PMID:22584684
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdk2
cyclin dependent kinase 2
multiple interactions decreases activity
EXP
2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; 2-Acetylaminofluorene results in decreased localization of and results in decreased phosphorylation of and results in decreased activity of CDK2 protein 2-Acetylaminofluorene results in decreased activity of CDK2 protein
CTD
PMID:10708481 PMID:15158336
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk4
cyclin-dependent kinase 4
increases activity
EXP
2-Acetylaminofluorene results in increased activity of CDK4 protein
CTD
PMID:15158336
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
EXP ISO
2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of CDKN1A protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; pioglitazone inhibits the reaction [2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]] 2-Acetylaminofluorene results in increased expression of CDKN1A mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA] 2-Acetylaminofluorene results in increased expression of CDKN1A mRNA; 2-Acetylaminofluorene results in increased expression of CDKN1A protein
CTD
PMID:10708481 PMID:11003613 PMID:14633663 PMID:17070881 PMID:17317680 PMID:17582756 PMID:19167416 PMID:21607683 PMID:22213190 PMID:22584684 More...
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
EXP
2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]; Pioglitazone inhibits the reaction [2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]]
CTD
PMID:17582756
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
multiple interactions increases expression increases methylation
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A protein 2-Acetylaminofluorene results in increased expression of CDKN2A mRNA 2-Acetylaminofluorene results in increased methylation of CDKN2A gene; 2-Acetylaminofluorene results in increased methylation of CDKN2A promoter
CTD
PMID:16317707 PMID:18204080 PMID:19167416 PMID:20188851 PMID:22213190
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Cdkn2b
cyclin-dependent kinase inhibitor 2B
increases expression
ISO EXP
2-Acetylaminofluorene results in increased expression of CDKN2B mRNA
CTD
PMID:17317680 PMID:22213190
NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
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Cdkn2c
cyclin-dependent kinase inhibitor 2C
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CDKN2C mRNA
CTD
PMID:22584684
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
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Cdkn3
cyclin-dependent kinase inhibitor 3
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CDKN3 mRNA
CTD
PMID:22213190 PMID:22584684
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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Cebpa
CCAAT/enhancer binding protein alpha
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of CEBPA protein
CTD
PMID:20188851 PMID:21785164
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Cebpb
CCAAT/enhancer binding protein beta
multiple interactions decreases expression
EXP
2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter] 2-Acetylaminofluorene results in decreased expression of CEBPB protein
CTD
PMID:21785164
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Ces2e
carboxylesterase 2E
increases expression
ISO
2-Acetylaminofluorene results in increased expression of CES2E mRNA
CTD
PMID:21607683
NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856
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Ces3a
carboxylesterase 3a
increases expression
ISO
2-Acetylaminofluorene results in increased expression of CES3 mRNA
CTD
PMID:20713471
NCBI chr19:32,992,386...33,000,562
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Ckmt1
creatine kinase, mitochondrial 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of CKMT1 mRNA
CTD
PMID:17317680
NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758
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Cldn4
claudin 4
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CLDN4 mRNA
CTD
PMID:17187413
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
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Cldn7
claudin 7
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CLDN7 mRNA
CTD
PMID:17187413
NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171
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Clu
clusterin
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CLU mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CLU mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Cmas
cytidine monophosphate N-acetylneuraminic acid synthetase
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CMAS protein
CTD
PMID:6331524
NCBI chr 4:175,718,808...175,737,128
Ensembl chr 4:175,718,808...175,737,125
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Col17a1
collagen type XVII alpha 1 chain
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA]
CTD
PMID:17317680
NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632
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Commd3
COMM domain containing 3
increases expression
ISO
2-Acetylaminofluorene results in increased expression of COMMD3 mRNA
CTD
PMID:17317680
NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177
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Coq6
coenzyme Q6 monooxygenase
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of COQ6 mRNA
CTD
PMID:16158176
NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657
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Cpq
carboxypeptidase Q
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of CPQ mRNA
CTD
PMID:17070881
NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546
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Cps1
carbamoyl-phosphate synthase 1
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of CPS1 protein
CTD
PMID:11813887
NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
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Crebbp
CREB binding protein
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of CREBBP mRNA
CTD
PMID:22213190
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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Cryab
crystallin, alpha B
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CRYAB mRNA
CTD
PMID:17070881
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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Cryl1
crystallin, lambda 1
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CRYL1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CRYL1 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997
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Csta
cystatin A
affects expression
ISO
2-Acetylaminofluorene affects the expression of CSTA mRNA
CTD
PMID:27825931
NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488
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Cx3cl1
C-X3-C motif chemokine ligand 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CX3CL1 mRNA
CTD
PMID:17187413
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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Cxcl1
C-X-C motif chemokine ligand 1
affects expression
EXP
2-Acetylaminofluorene affects the expression of CXCL1 protein
CTD
PMID:25051504
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl10
C-X-C motif chemokine ligand 10
affects expression
EXP
2-Acetylaminofluorene affects the expression of CXCL10 protein
CTD
PMID:25051504
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl12
C-X-C motif chemokine ligand 12
multiple interactions increases expression
EXP
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCL12 protein 2-Acetylaminofluorene results in increased expression of CXCL12 mRNA; 2-Acetylaminofluorene results in increased expression of CXCL12 protein
CTD
PMID:12626097 PMID:15579440
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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Cxcl2
C-X-C motif chemokine ligand 2
affects expression
EXP
2-Acetylaminofluorene affects the expression of CXCL2 protein
CTD
PMID:25051504
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cxcr4
C-X-C motif chemokine receptor 4
increases expression multiple interactions
EXP
2-Acetylaminofluorene results in increased expression of CXCR4 mRNA [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCR4 protein
CTD
PMID:12626097 PMID:15579440
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases hydrolysis multiple interactions increases expression
ISO EXP
CYP1A1 results in increased hydrolysis of 2-Acetylaminofluorene 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA] 2-Acetylaminofluorene analog results in increased expression of CYP1A1 protein; 2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP1A1 protein
CTD
PMID:2334931 PMID:10445401 PMID:11888708 PMID:15916741 PMID:20713471 PMID:25224404 More...
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects metabolic processing increases expression decreases expression multiple interactions increases hydrolysis increases activity
ISO EXP
CYP1A2 protein affects the metabolism of 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of CYP1A2 protein 2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA 2-Acetylaminofluorene analog results in decreased expression of CYP1A2 protein; 2-Acetylaminofluorene results in decreased expression of CYP1A2 protein NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA] CYP1A2 results in increased hydrolysis of 2-Acetylaminofluorene CYP1A2 protein results in increased activity of 2-Acetylaminofluorene
CTD
PMID:2334931 PMID:2655891 PMID:15450435 PMID:15916741 PMID:16381673 PMID:28245158 More...
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression multiple interactions
ISO
2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA]
CTD
PMID:17317680 PMID:20713471
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of CYP2A22 mRNA
CTD
PMID:21607683
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
decreases expression increases expression
EXP
2-Acetylaminofluorene analog results in decreased expression of CYP2B1 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B1 protein 2-Acetylaminofluorene results in increased expression of CYP2B1 protein
CTD
PMID:10445401 PMID:15916741
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
decreases expression
EXP
2-Acetylaminofluorene analog results in decreased expression of CYP2B2 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B2 protein
CTD
PMID:15916741
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2c13
cytochrome P450, family 2, subfamily c, polypeptide 13
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CYP2C13 mRNA
CTD
PMID:17070881
NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions increases expression
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CYP2E1 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] 2-Acetylaminofluorene analog results in increased expression of CYP2E1 protein; 2-Acetylaminofluorene results in increased expression of CYP2E1 protein
CTD
PMID:14656948 PMID:15916741 PMID:16158176 PMID:17393424 PMID:23665045
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CYP3A2 protein
CTD
PMID:10445401
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression multiple interactions
EXP
2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 protein [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP3A23-3A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP3A23-3A1 mRNA; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]; Trabectedin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]
CTD
PMID:12504080 PMID:14656948 PMID:16158176
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp4f5
cytochrome P450, family 4, subfamily f, polypeptide 5
increases expression
EXP
2-Acetylaminofluorene results in increased expression of CYP4F5 mRNA
CTD
PMID:17070881
NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Dap
death-associated protein
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of DAP mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of DAP mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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Ddah1
dimethylarginine dimethylaminohydrolase 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of DDAH1 mRNA
CTD
PMID:17070881
NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
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Ddit4l
DNA-damage-inducible transcript 4-like
increases expression
ISO
2-Acetylaminofluorene results in increased expression of DDIT4L mRNA
CTD
PMID:21607683
NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
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Ddr1
discoidin domain receptor tyrosine kinase 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of DDR1 mRNA
CTD
PMID:17187413
NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
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Des
desmin
increases expression
EXP
2-Acetylaminofluorene results in increased expression of DES mRNA
CTD
PMID:17187413
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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Dhodh
dihydroorotate dehydrogenase (quinone)
decreases activity
EXP
2-Acetylaminofluorene results in decreased activity of DHODH protein
CTD
PMID:6331524
NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
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Dlk1
delta like non-canonical Notch ligand 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of DLK1 mRNA; 2-Acetylaminofluorene results in increased expression of DLK1 protein
CTD
PMID:15567716 PMID:17187413 PMID:17538966
NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
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Dmp1
dentin matrix acidic phosphoprotein 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of DMP1 mRNA
CTD
PMID:17317680
NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323
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E2f1
E2F transcription factor 1
decreases expression increases expression
EXP
2-Acetylaminofluorene results in decreased expression of E2F1 protein 2-Acetylaminofluorene results in increased expression of E2F1 mRNA
CTD
PMID:15158336 PMID:19167416 PMID:22213190
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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E2f3
E2F transcription factor 3
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of E2F3 protein
CTD
PMID:15158336 PMID:19167416
NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
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E2f4
E2F transcription factor 4
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of E2F4 protein
CTD
PMID:15158336
NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806
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Eda2r
ectodysplasin A2 receptor
increases expression
ISO
2-Acetylaminofluorene results in increased expression of EDA2R mRNA
CTD
PMID:21607683
NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268
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Egf
epidermal growth factor
decreases localization multiple interactions
EXP
2-Acetylaminofluorene results in decreased localization of EGF protein 2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein]
CTD
PMID:10900465
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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Egfr
epidermal growth factor receptor
multiple interactions decreases expression
EXP
2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein] 2-Acetylaminofluorene results in decreased expression of EGFR mRNA
CTD
PMID:10900465 PMID:22213190
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Egr1
early growth response 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of EGR1 mRNA
CTD
PMID:19167416
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Ei24
EI24, autophagy associated transmembrane protein
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA]
CTD
PMID:17317680
NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
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Emp2
epithelial membrane protein 2
increases expression
ISO
2-Acetylaminofluorene results in increased expression of EMP2 mRNA
CTD
PMID:21607683
NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733
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Enc1
ectodermal-neural cortex 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of ENC1 mRNA
CTD
PMID:21607683
NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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Eno1
enolase 1
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of ENO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ENO1 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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Epcam
epithelial cell adhesion molecule
increases expression
EXP
2-Acetylaminofluorene results in increased expression of EPCAM mRNA
CTD
PMID:17070881 PMID:17187413
NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
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Epha1
Eph receptor A1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of EPHA1 mRNA
CTD
PMID:17317680
NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846
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Ephx1
epoxide hydrolase 1
increases expression
EXP ISO
2-Acetylaminofluorene results in increased expression of EPHX1 mRNA
CTD
PMID:17070881 PMID:17317680 PMID:21607683
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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Erbb2
erb-b2 receptor tyrosine kinase 2
increases expression
EXP
2-Acetylaminofluorene results in increased expression of ERBB2 protein
CTD
PMID:11350689
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Esr1
estrogen receptor 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of ESR1 mRNA
CTD
PMID:19167416
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Exoc4
exocyst complex component 4
increases expression
ISO
2-Acetylaminofluorene results in increased expression of EXOC4 mRNA
CTD
PMID:21607683
NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723
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Fam110a
family with sequence similarity 110, member A
increases expression
ISO
2-Acetylaminofluorene results in increased expression of FAM110A mRNA
CTD
PMID:21607683
NCBI chr 3:140,474,484...140,485,074
Ensembl chr 3:140,474,249...140,485,093
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Fas
Fas cell surface death receptor
increases expression
EXP
2-Acetylaminofluorene results in increased expression of FAS mRNA
CTD
PMID:17070881 PMID:22584684
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fbxw9
F-box and WD repeat domain containing 9
increases expression
ISO
2-Acetylaminofluorene results in increased expression of FBXW9 mRNA
CTD
PMID:21607683
NCBI chr19:23,090,534...23,097,439
Ensembl chr19:23,090,534...23,097,439
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Fhit
fragile histidine triad diadenosine triphosphatase
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of FHIT mRNA
CTD
PMID:17070881
NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
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Flt3
Fms related receptor tyrosine kinase 3
affects expression
EXP
2-Acetylaminofluorene affects the expression of FLT3 mRNA
CTD
PMID:18031378
NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474
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Fn1
fibronectin 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of FN1 mRNA
CTD
PMID:15940639
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein]
CTD
PMID:17696247
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fth1
ferritin heavy chain 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of FTH1 protein
CTD
PMID:21785164
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G6pc1
glucose-6-phosphatase catalytic subunit 1
multiple interactions
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein]
CTD
PMID:15554553
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Gaa
alpha glucosidase
increases expression
ISO
2-Acetylaminofluorene results in increased expression of GAA mRNA
CTD
PMID:17317680
NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836
G
Gas2l3
growth arrest-specific 2 like 3
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of GAS2L3 mRNA
CTD
PMID:20713471
NCBI chr 7:23,803,578...23,836,816
Ensembl chr 7:23,806,310...23,836,411
G
Gcgr
glucagon receptor
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCGR mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCGR mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression multiple interactions
ISO EXP
2-Acetylaminofluorene results in increased expression of GCLC mRNA [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA
CTD
PMID:14656948 PMID:16158176 PMID:16426233
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLM mRNA
CTD
PMID:16158176
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gdf15
growth differentiation factor 15
increases expression
ISO
2-Acetylaminofluorene results in increased expression of GDF15 mRNA
CTD
PMID:21607683
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
G
Ggt1
gamma-glutamyltransferase 1
increases expression multiple interactions
EXP
2-Acetylaminofluorene results in increased expression of GGT1 mRNA [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]
CTD
PMID:15554553 PMID:17187413
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
G
Gja1
gap junction protein, alpha 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of GJA1 mRNA; 2-Acetylaminofluorene results in increased expression of GJA1 protein
CTD
PMID:15133858 PMID:17187413
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
G
Gjb1
gap junction protein, beta 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of GJB1 mRNA
CTD
PMID:2559087
NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925
G
Gjb2
gap junction protein, beta 2
increases expression
EXP
2-Acetylaminofluorene results in increased expression of GJB2 mRNA
CTD
PMID:22213190
NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
G
Glrx3
glutaredoxin 3
increases expression
ISO
2-Acetylaminofluorene results in increased expression of GLRX3 mRNA
CTD
PMID:17317680
NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
G
Gpc3
glypican 3
increases expression
EXP
2-Acetylaminofluorene results in increased expression of GPC3 mRNA
CTD
PMID:17187413
NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798
G
Gpx2
glutathione peroxidase 2
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GPX2 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
G
Gria3
glutamate ionotropic receptor AMPA type subunit 3
increases expression
EXP ISO
2-Acetylaminofluorene results in increased expression of GRIA3 mRNA
CTD
PMID:17070881 PMID:21607683
NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096
G
Grina
glutamate ionotropic receptor NMDA type subunit associated protein 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of GRINA mRNA
CTD
PMID:21607683
NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366
G
Gsr
glutathione-disulfide reductase
multiple interactions decreases activity decreases expression
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSR mRNA; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of GSR protein]
CTD
PMID:16158176 PMID:23665045 PMID:26364502
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gss
glutathione synthetase
increases expression
ISO
2-Acetylaminofluorene results in increased expression of GSS mRNA
CTD
PMID:17317680
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
G
Gsta2
glutathione S-transferase alpha 2
multiple interactions increases expression
EXP ISO
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTA2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTA2 mRNA 2-Acetylaminofluorene results in increased expression of GSTA2 mRNA
CTD
PMID:14656948 PMID:16158176 PMID:17317680
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
G
Gsta5
glutathione S-transferase alpha 5
increases expression
ISO
2-Acetylaminofluorene results in increased expression of GSTA1 mRNA
CTD
PMID:17317680
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
G
Gstm1
glutathione S-transferase mu 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of GSTM1 mRNA
CTD
PMID:17070881
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstp1
glutathione S-transferase pi 1
multiple interactions increases expression
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein] 2-Acetylaminofluorene results in increased expression of GSTP1 mRNA; 2-Acetylaminofluorene results in increased expression of GSTP1 protein
CTD
PMID:12497209 PMID:12781041 PMID:12907702 PMID:15554553 PMID:17393424 PMID:18271918 PMID:21785164 PMID:22213190 More...
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gtse1
G-2 and S-phase expressed 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of GTSE1 mRNA
CTD
PMID:21607683
NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806
G
H2ax
H2A.X variant histone
increases expression increases phosphorylation
EXP ISO
2-Acetylaminofluorene results in increased expression of H2AX protein 2-Acetylaminofluorene results in increased phosphorylation of H2AX protein
CTD
PMID:26338220 PMID:34510228
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of HADHA mRNA
CTD
PMID:16158176
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
G
Hamp
hepcidin antimicrobial peptide
multiple interactions decreases expression
EXP
2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter] 2-Acetylaminofluorene results in decreased expression of HAMP mRNA
CTD
PMID:21785164
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
G
Hebp2
heme binding protein 2
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA]
CTD
PMID:17317680
NCBI chr 1:13,194,982...13,201,777
Ensembl chr 1:13,194,982...13,201,777
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA; beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA]
CTD
PMID:20435455
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmox1
heme oxygenase 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of HMOX1 mRNA
CTD
PMID:22584684
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hras
HRas proto-oncogene, GTPase
increases expression
EXP
2-Acetylaminofluorene results in increased expression of HRAS protein
CTD
PMID:11350689
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
G
Hsd17b6
hydroxysteroid (17-beta) dehydrogenase 6
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of HSD17B6 mRNA
CTD
PMID:17070881
NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425
G
Ica1
islet cell autoantigen 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of ICA1 mRNA
CTD
PMID:21784091
NCBI chr 4:36,656,475...36,804,705
Ensembl chr 4:36,656,475...36,804,298
G
Id1
inhibitor of DNA binding 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of ID1 mRNA
CTD
PMID:15120964
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
G
Ifna1
interferon, alpha 1
multiple interactions
EXP
IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA]
CTD
PMID:14633663
NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
G
Ifna2
interferon alpha 2
multiple interactions
EXP
IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein]
CTD
PMID:11915028 PMID:15368444
NCBI chr 5:103,258,617...103,259,195
G
Ifng
interferon gamma
multiple interactions
EXP
2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein]
CTD
PMID:14736494
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Igf2
insulin-like growth factor 2
increases expression
EXP
2-Acetylaminofluorene results in increased expression of IGF2 mRNA
CTD
PMID:22213190
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
G
Igfals
insulin-like growth factor binding protein, acid labile subunit
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of IGFALS mRNA
CTD
PMID:21607683
NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
G
Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
increases activity
ISO
2-Acetylaminofluorene results in increased activity of IKBKB protein
CTD
PMID:11960367
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
G
Il10
interleukin 10
affects expression
EXP
2-Acetylaminofluorene affects the expression of IL10 protein
CTD
PMID:25051504
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il12b
interleukin 12B
increases expression
EXP
2-Acetylaminofluorene results in increased expression of IL12B protein
CTD
PMID:25051504
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
G
Il1b
interleukin 1 beta
multiple interactions affects expression increases expression
ISO EXP
2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] 2-Acetylaminofluorene affects the expression of IL1B mRNA 2-Acetylaminofluorene results in increased expression of IL1B protein
CTD
PMID:14670622 PMID:25051504
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2ra
interleukin 2 receptor subunit alpha
increases expression
EXP
2-Acetylaminofluorene results in increased expression of IL2RA mRNA
CTD
PMID:17070881
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
G
Il33
interleukin 33
increases expression
ISO
2-Acetylaminofluorene results in increased expression of IL33 mRNA
CTD
PMID:17317680
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
G
Il5
interleukin 5
increases expression
EXP
2-Acetylaminofluorene results in increased expression of IL5 protein
CTD
PMID:25051504
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Il6
interleukin 6
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of IL6 protein
CTD
PMID:25051504
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Itgb4
integrin subunit beta 4
increases expression
ISO
2-Acetylaminofluorene results in increased expression of ITGB4 mRNA
CTD
PMID:17317680
NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein]
CTD
PMID:17696247
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Kdm6a
lysine demethylase 6A
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of KDM6A mRNA
CTD
PMID:22213190
NCBI chr X:4,337,466...4,477,100
Ensembl chr X:4,337,750...4,477,062
G
Kif11
kinesin family member 11
increases expression
EXP
2-Acetylaminofluorene results in increased expression of KIF11 mRNA
CTD
PMID:22584684
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
G
Kit
KIT proto-oncogene receptor tyrosine kinase
increases expression
EXP
2-Acetylaminofluorene results in increased expression of KIT protein
CTD
PMID:15133858
NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
G
Krt14
keratin 14
increases expression
EXP
2-Acetylaminofluorene results in increased expression of KRT14 protein
CTD
PMID:33211169
NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799
G
Krt15
keratin 15
increases expression multiple interactions
ISO
2-Acetylaminofluorene results in increased expression of KRT15 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA]
CTD
PMID:17317680
NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799
G
Krt19
keratin 19
increases expression multiple interactions
EXP
2-Acetylaminofluorene results in increased expression of KRT19 mRNA; 2-Acetylaminofluorene results in increased expression of KRT19 protein [Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of KRT19 protein
CTD
PMID:15133858 PMID:17187413 PMID:17661067
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
G
Krt20
keratin 20
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of KRT20 mRNA
CTD
PMID:17317680
NCBI chr10:84,384,790...84,394,125
Ensembl chr10:84,384,802...84,394,107
G
Krt23
keratin 23
multiple interactions increases expression
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA]
CTD
PMID:17317680
NCBI chr10:84,434,445...84,450,773
Ensembl chr10:84,434,380...84,450,983
G
Krt4
keratin 4
increases expression multiple interactions
ISO
2-Acetylaminofluorene results in increased expression of KRT4 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA]
CTD
PMID:17317680
NCBI chr 7:133,046,067...133,052,027
Ensembl chr 7:133,046,515...133,052,019
G
Krt8
keratin 8
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of KRT8 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of KRT8 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
G
Lep
leptin
increases expression
EXP
2-Acetylaminofluorene results in increased expression of LEP protein
CTD
PMID:25051504
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Lig4
DNA ligase 4
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of LIG4 mRNA
CTD
PMID:19167416
NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
G
Ly6d
lymphocyte antigen 6 family member D
increases expression
ISO
2-Acetylaminofluorene results in increased expression of LY6D mRNA
CTD
PMID:17317680
NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733
G
Ly6e
lymphocyte antigen 6 family member E
increases expression
ISO
2-Acetylaminofluorene results in increased expression of LY6E mRNA
CTD
PMID:21607683
NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
G
Lypd3
Ly6/Plaur domain containing 3
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA]
CTD
PMID:17317680
NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901
G
Lzic
leucine zipper and CTNNBIP1 domain containing
increases expression
ISO
2-Acetylaminofluorene results in increased expression of LZIC mRNA
CTD
PMID:21607683
NCBI chr 5:159,928,260...159,941,512
Ensembl chr 5:159,920,439...159,939,685
G
Mal
mal, T-cell differentiation protein
increases expression
ISO
2-Acetylaminofluorene results in increased expression of MAL mRNA
CTD
PMID:17317680
NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP
2-Acetylaminofluorene affects the phosphorylation of and affects the activity of MAPK8 protein
CTD
PMID:17546627
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mat1a
methionine adenosyltransferase 1A
affects acetylation decreases expression affects methylation
EXP
2-Acetylaminofluorene affects the acetylation of MAT1A exon; 2-Acetylaminofluorene affects the acetylation of MAT1A promoter 2-Acetylaminofluorene results in decreased expression of MAT1A mRNA 2-Acetylaminofluorene affects the methylation of MAT1A exon; 2-Acetylaminofluorene affects the methylation of MAT1A promoter
CTD
PMID:22213190
NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274
G
Matn2
matrilin 2
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MATN2 mRNA; 2-Acetylaminofluorene results in increased expression of MATN2 protein
CTD
PMID:17513098
NCBI chr 7:65,494,996...65,644,613
Ensembl chr 7:65,494,834...65,645,113
G
Mbl2
mannose binding lectin 2
increases expression
ISO
2-Acetylaminofluorene results in increased expression of MBL2 mRNA
CTD
PMID:21607683
NCBI chr 1:228,016,439...228,024,736
G
Mdm2
MDM2 proto-oncogene
multiple interactions increases expression
EXP ISO
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein 2-Acetylaminofluorene results in increased expression of MDM2 mRNA; 2-Acetylaminofluorene results in increased expression of MDM2 protein
CTD
PMID:11003613 PMID:19167416 PMID:21607683 PMID:22213190 PMID:22584684
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Meg3
maternally expressed 3
decreases expression multiple interactions
ISO
2-Acetylaminofluorene results in decreased expression of MEG3 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA]
CTD
PMID:17317680
NCBI chr 6:128,491,808...128,524,010
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Mgmt
O-6-methylguanine-DNA methyltransferase
increases expression decreases expression
EXP
2-Acetylaminofluorene results in increased expression of MGMT mRNA 2-Acetylaminofluorene results in decreased expression of MGMT mRNA
CTD
PMID:17070881 PMID:22213190
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Mgst2
microsomal glutathione S-transferase 2
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MGST2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MGST2 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
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Mir106b
microRNA 106b
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR106B mRNA
CTD
PMID:19167416
NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425
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Mir125b1
microRNA 125b-1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of MIR125B-1 mRNA
CTD
PMID:19167416
NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052
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Mir130b
microRNA 130b
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR130B mRNA
CTD
PMID:19167416
NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244
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Mir132
microRNA 132
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR132 mRNA
CTD
PMID:19167416
NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
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Mir146b
microRNA 146b
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR146B mRNA
CTD
PMID:19167416
NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525
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Mir155
microRNA 155
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR155 mRNA
CTD
PMID:19167416
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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Mir17
microRNA 17
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR17; 2-Acetylaminofluorene results in increased expression of MIR17 mRNA
CTD
PMID:19167416 PMID:20188851
NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712
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Mir181b2
microRNA 181b-2
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR181B-2 mRNA
CTD
PMID:19167416
NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035
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Mir181c
microRNA 181c
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of MIR181C mRNA
CTD
PMID:19167416
NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628
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Mir185
microRNA 185
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR185 mRNA
CTD
PMID:19167416
NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
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Mir18a
microRNA 18a
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR18A; 2-Acetylaminofluorene results in increased expression of MIR18A mRNA
CTD
PMID:19167416 PMID:20188851
NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
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Mir200a
microRNA 200a
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR200A mRNA
CTD
PMID:19167416 PMID:22584684
NCBI chr 5:166,648,494...166,648,582
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Mir200b
microRNA 200b
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR200B mRNA
CTD
PMID:19167416 PMID:22584684
NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366
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Mir200c
microRNA 200c
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR200C mRNA
CTD
PMID:19167416
NCBI chr 4:157,523,679...157,523,747
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Mir202
microRNA 202
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of MIR202 mRNA
CTD
PMID:19167416
NCBI chr 1:194,754,730...194,754,801
Ensembl chr 1:194,754,730...194,754,801
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Mir204
microRNA 204
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of MIR204 mRNA
CTD
PMID:19167416
NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040
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Mir205
microRNA 205
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR205 mRNA
CTD
PMID:19167416
NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985
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Mir20a
microRNA 20a
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR20A; 2-Acetylaminofluorene results in increased expression of MIR20A mRNA
CTD
PMID:19167416 PMID:20188851
NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
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Mir21
microRNA 21
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR21 mRNA
CTD
PMID:19167416
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Mir214
microRNA 214
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR214 mRNA
CTD
PMID:19167416
NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481
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Mir22
microRNA 22
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR22 mRNA
CTD
PMID:22213190
NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
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Mir221
microRNA 221
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR221 mRNA
CTD
PMID:19167416
NCBI chr X:3,429,465...3,429,573
Ensembl chr X:3,429,465...3,429,573
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Mir293
microRNA 293
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR293 mRNA
CTD
PMID:19167416
NCBI chr 1:65,963,050...65,963,121
Ensembl chr 1:65,963,050...65,963,121
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Mir31
microRNA 31
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR31; 2-Acetylaminofluorene results in increased expression of MIR31 mRNA
CTD
PMID:19167416 PMID:20188851
NCBI chr 5:103,599,038...103,599,143
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Mir34a
microRNA 34a
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR34A mRNA
CTD
PMID:19167416 PMID:22584684
NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
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Mir3545
microRNA 3545
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of MIR203 mRNA
CTD
PMID:22584684
NCBI chr 6:131,199,542...131,199,656
Ensembl chr 6:131,199,542...131,199,656
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Mir410
microRNA 410
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of MIR410 mRNA
CTD
PMID:19167416
NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434
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Mir429
microRNA 429
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR429 mRNA
CTD
PMID:19167416 PMID:22584684
NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543
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Mir490
microRNA 490
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of MIR490 mRNA
CTD
PMID:19167416
NCBI chr 4:65,047,548...65,047,631
Ensembl chr 4:65,047,548...65,047,631
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Mir93
microRNA 93
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR93; 2-Acetylaminofluorene results in increased expression of MIR93 mRNA
CTD
PMID:19167416 PMID:20188851
NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
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Mir96
microRNA 96
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIR96 mRNA
CTD
PMID:19167416
NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
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Mir99a
microRNA 99a
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of MIR99A mRNA
CTD
PMID:19167416 PMID:22584684
NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523
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Mirlet7b
microRNA let-7b
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIRLET7B mRNA
CTD
PMID:19167416
NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
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Mirlet7c1
microRNA let-7c-1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIRLET7C-1 mRNA
CTD
PMID:19167416
NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265
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Mirlet7i
microRNA let-7i
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MIRLET7I mRNA
CTD
PMID:19167416
NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571
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Mki67
marker of proliferation Ki-67
multiple interactions increases expression
EXP ISO
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein] 2-Acetylaminofluorene results in increased expression of MKI67 mRNA
CTD
PMID:15565650 PMID:17317680 PMID:17393424 PMID:23665045 PMID:26338220
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mmp2
matrix metallopeptidase 2
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MMP2 mRNA
CTD
PMID:18678246
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MMP9 mRNA
CTD
PMID:18678246
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mt1
metallothionein 1
multiple interactions increases expression
EXP
Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MT1A protein]
CTD
PMID:15565650
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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Mthfr
methylenetetrahydrofolate reductase
decreases expression decreases methylation
EXP
2-Acetylaminofluorene results in decreased expression of MTHFR mRNA 2-Acetylaminofluorene results in decreased methylation of MTHFR promoter
CTD
PMID:22213190
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Muc1
mucin 1, cell surface associated
increases expression
EXP
2-Acetylaminofluorene results in increased expression of MUC1 mRNA
CTD
PMID:17187413
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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Mybl1
MYB proto-oncogene like 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of MYBL1 mRNA
CTD
PMID:21607683
NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions increases mutagenesis increases expression
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein] 2-Acetylaminofluorene results in increased mutagenesis of MYC gene 2-Acetylaminofluorene results in increased expression of MYC protein
CTD
PMID:11350689 PMID:17696247 PMID:19167416 PMID:20188851
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nampt
nicotinamide phosphoribosyltransferase
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of NAMPT mRNA
CTD
PMID:22584684
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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Nat1
N-acetyltransferase 1
increases activity
ISO
NAT1 protein results in increased activity of 2-Acetylaminofluorene
CTD
PMID:15450435
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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Nat2
N-acetyltransferase 2
increases activity
ISO
NAT2 protein results in increased activity of 2-Acetylaminofluorene
CTD
PMID:15450435
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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Nek6
NIMA-related kinase 6
increases expression
EXP
2-Acetylaminofluorene results in increased expression of NEK6 mRNA
CTD
PMID:22584684
NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression increases activity
ISO
2-Acetylaminofluorene results in increased expression of NFE2L2 mRNA 2-Acetylaminofluorene results in increased activity of NFE2L2 protein
CTD
PMID:21607683 PMID:30114225
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions increases localization
ISO
[RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA] 2-Acetylaminofluorene results in increased localization of NFKB1 protein Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of NFKB1 protein]
CTD
PMID:11960367 PMID:17303067
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
multiple interactions
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein; Acetylcysteine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein]; S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein]
CTD
PMID:18404532
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nfkbib
NFKB inhibitor beta
multiple interactions increases degradation
EXP
[2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased degradation of NFKBIB protein 2-Acetylaminofluorene results in increased degradation of NFKBIB protein
CTD
PMID:11020383
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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Ninj1
ninjurin 1
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of NINJ1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NINJ1 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nos2
nitric oxide synthase 2
multiple interactions increases expression
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of NOS2 protein]
CTD
PMID:23665045 PMID:26364502
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
increases expression multiple interactions
ISO
2-Acetylaminofluorene results in increased expression of NOS3 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA]
CTD
PMID:17317680
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Notch1
notch receptor 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of NOTCH1 mRNA
CTD
PMID:21607683
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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Nprl2
NPR2-like, GATOR1 complex subunit
increases expression
ISO
2-Acetylaminofluorene results in increased expression of NPRL2 mRNA
CTD
PMID:17317680
NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO EXP
2-Acetylaminofluorene results in increased expression of NQO1 mRNA
CTD
PMID:21607683 PMID:22213190
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases expression multiple interactions
ISO EXP
2-Acetylaminofluorene results in increased expression of NR1I2 mRNA NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA] NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A11 mRNA]
CTD
PMID:12504080 PMID:16381673
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nudcd2
NudC domain containing 2
increases expression
ISO
2-Acetylaminofluorene results in increased expression of NUDCD2 mRNA
CTD
PMID:21607683
NCBI chr10:25,163,247...25,168,738
Ensembl chr10:25,163,220...25,168,738
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Nudt7
nudix hydrolase 7
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of NUDT7 mRNA
CTD
PMID:21607683
NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081
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Nupr1
nuclear protein 1, transcriptional regulator
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of NUPR1 mRNA
CTD
PMID:17070881 PMID:22584684
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Nusap1
nucleolar and spindle associated protein 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of NUSAP1 mRNA
CTD
PMID:22584684
NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
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Ociad2
OCIA domain containing 2
increases expression
ISO
2-Acetylaminofluorene results in increased expression of OCIAD2 mRNA
CTD
PMID:17317680
NCBI chr14:34,873,668...34,889,276
Ensembl chr14:34,873,820...34,889,265
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Olfm1
olfactomedin 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of OLFM1 mRNA
CTD
PMID:20713471
NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239
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Osm
oncostatin M
increases expression
EXP
2-Acetylaminofluorene results in increased expression of OSM mRNA
CTD
PMID:15743783 PMID:18678246
NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
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Osmr
oncostatin M receptor
increases expression
EXP
2-Acetylaminofluorene results in increased expression of OSMR mRNA
CTD
PMID:15743783
NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
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Padi2
peptidyl arginine deiminase 2
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA]
CTD
PMID:17317680
NCBI chr 5:153,209,053...153,251,632
Ensembl chr 5:153,209,053...153,251,632
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Pck1
phosphoenolpyruvate carboxykinase 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of PCK1 mRNA
CTD
PMID:16510358
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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Pcna
proliferating cell nuclear antigen
multiple interactions increases expression
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]
CTD
PMID:16352317 PMID:17393424 PMID:19167416 PMID:23665045 PMID:26364502
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pdia3
protein disulfide isomerase family A, member 3
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PDIA3 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PDIA3 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
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Pecam1
platelet and endothelial cell adhesion molecule 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of PECAM1 mRNA
CTD
PMID:17187413
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
G
Perp
p53 apoptosis effector related to PMP22
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA]
CTD
PMID:17317680
NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
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Phlda3
pleckstrin homology-like domain, family A, member 3
increases expression
ISO EXP
2-Acetylaminofluorene results in increased expression of PHLDA3 mRNA
CTD
PMID:17070881 PMID:21607683 PMID:22584684
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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Phyh
phytanoyl-CoA 2-hydroxylase
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of PHYH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of PHYH mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
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Piga
phosphatidylinositol glycan anchor biosynthesis, class A
increases mutagenesis
EXP
2-Acetylaminofluorene results in increased mutagenesis of PIGA
CTD
PMID:22923490
NCBI chr X:30,043,033...30,055,861
Ensembl chr X:30,042,343...30,055,804
G
Pkd1
polycystin 1, transient receptor potential channel interacting
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of PKD1 mRNA
CTD
PMID:22584684
NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128
G
Pkm
pyruvate kinase M1/2
increases expression
EXP
2-Acetylaminofluorene results in increased expression of PKM mRNA; 2-Acetylaminofluorene results in increased expression of PKM protein
CTD
PMID:17538966
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Pkp1
plakophilin 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of PKP1 mRNA
CTD
PMID:17317680
NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465
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Plk2
polo-like kinase 2
increases expression
ISO
2-Acetylaminofluorene results in increased expression of PLK2 mRNA
CTD
PMID:21607683
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression multiple interactions
ISO EXP
2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA]
CTD
PMID:17317680 PMID:19167416
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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Polk
DNA polymerase kappa
increases expression
ISO
2-Acetylaminofluorene results in increased expression of POLK mRNA
CTD
PMID:21607683
NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313
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Por
cytochrome p450 oxidoreductase
increases expression
EXP
2-Acetylaminofluorene results in increased expression of POR mRNA
CTD
PMID:15089088
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Prc1
protein regulator of cytokinesis 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of PRC1 mRNA
CTD
PMID:19167416
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
G
Prkch
protein kinase C, eta
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PRKCH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PRKCH mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
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Prom1
prominin 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of PROM1 mRNA
CTD
PMID:17187413
NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
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Prox1
prospero homeobox 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of PROX1 mRNA
CTD
PMID:22213190
NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
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Psmd10
proteasome 26S subunit, non-ATPase 10
increases expression multiple interactions
EXP
2-Acetylaminofluorene results in increased expression of PSMD10 protein RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein]
CTD
PMID:16448463
NCBI chr X:104,656,809...104,665,122
Ensembl chr X:104,656,812...104,665,097
G
Psrc1
proline and serine rich coiled-coil 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of PSRC1 mRNA
CTD
PMID:21607683
NCBI chr 2:196,022,361...196,026,874
Ensembl chr 2:196,022,361...196,026,874
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Pten
phosphatase and tensin homolog
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of PTEN protein
CTD
PMID:19167416
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
G
Ptgr1
prostaglandin reductase 1
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PTGR1 mRNA
CTD
PMID:16158176
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PTGS2 protein]
CTD
PMID:23665045 PMID:26364502
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Ptn
pleiotrophin
increases expression
EXP
2-Acetylaminofluorene results in increased expression of PTN mRNA
CTD
PMID:12057922
NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456
G
Ptp4a3
protein tyrosine phosphatase 4A3
increases expression
ISO
2-Acetylaminofluorene results in increased expression of PTP4A3 mRNA
CTD
PMID:17317680
NCBI chr 7:105,650,640...105,660,921
Ensembl chr 7:105,628,029...105,660,919
G
Ptprc
protein tyrosine phosphatase, receptor type, C
increases expression
EXP
2-Acetylaminofluorene results in increased expression of PTPRC mRNA
CTD
PMID:17187413
NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
G
Pttg1
PTTG1 regulator of sister chromatid separation, securin
increases expression
EXP
2-Acetylaminofluorene results in increased expression of PTTG1 mRNA
CTD
PMID:19167416
NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
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Pvt1
Pvt1 oncogene
increases expression
ISO
2-Acetylaminofluorene results in increased expression of PVT1 mRNA
CTD
PMID:21607683
NCBI chr 7:93,656,528...93,879,938
G
Rac1
Rac family small GTPase 1
increases activity multiple interactions
ISO
2-Acetylaminofluorene results in increased activity of RAC1 protein [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA
CTD
PMID:11960367
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
G
Rassf1
Ras association domain family member 1
increases methylation
EXP
2-Acetylaminofluorene results in increased methylation of RASSF1 promoter
CTD
PMID:20188851
NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
G
Rb1
RB transcriptional corepressor 1
affects phosphorylation multiple interactions
EXP
2-Acetylaminofluorene affects the phosphorylation of RB1 protein 2-Acetylaminofluorene results in increased expression of and results in increased phosphorylation of RB1 protein; RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein]
CTD
PMID:15158336 PMID:16448463
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
G
Rbx1
ring-box 1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of RBX1 mRNA
CTD
PMID:17317680
NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051
G
Rela
RELA proto-oncogene, NF-kB subunit
increases activity increases expression multiple interactions increases localization
ISO EXP
2-Acetylaminofluorene results in increased activity of RELA protein 2-Acetylaminofluorene results in increased expression of RELA protein geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of RELA protein]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA] 2-Acetylaminofluorene results in increased localization of RELA protein [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA] 2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of RELA protein]
CTD
PMID:11020383 PMID:11960367 PMID:14670622 PMID:17303067 PMID:26364502
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Rgn
regucalcin
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of RGN mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of RGN mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450
G
Rgs2
regulator of G-protein signaling 2
increases expression
EXP
2-Acetylaminofluorene results in increased expression of RGS2 mRNA
CTD
PMID:22584684
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
G
Rhbdf2
rhomboid 5 homolog 2
increases expression
ISO
2-Acetylaminofluorene results in increased expression of RHBDF2 mRNA
CTD
PMID:21607683
NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283
G
Rhob
ras homolog family member B
increases expression
EXP
2-Acetylaminofluorene results in increased expression of RHOB mRNA
CTD
PMID:22584684
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
G
Rhobtb2
Rho-related BTB domain containing 2
increases expression
EXP
2-Acetylaminofluorene results in increased expression of RHOBTB2 mRNA
CTD
PMID:17070881
NCBI chr15:44,868,251...44,888,436
Ensembl chr15:44,870,376...44,888,651
G
Ripk1
receptor interacting serine/threonine kinase 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of RIPK1 mRNA
CTD
PMID:22584684
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
G
Ripk3
receptor-interacting serine-threonine kinase 3
increases expression
ISO
2-Acetylaminofluorene results in increased expression of RIPK3 mRNA
CTD
PMID:17317680
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
G
Ripk4
receptor-interacting serine-threonine kinase 4
increases expression
ISO
2-Acetylaminofluorene results in increased expression of RIPK4 mRNA
CTD
PMID:21607683
NCBI chr11:37,122,555...37,144,799
Ensembl chr11:37,122,565...37,144,799
G
Ros1
ROS proto-oncogene 1 , receptor tyrosine kinase
increases expression
EXP
2-Acetylaminofluorene results in increased expression of ROS1 mRNA
CTD
PMID:17187413
NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865
G
Rplp0
ribosomal protein lateral stalk subunit P0
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of RPLP0 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of RPLP0 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
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Rprm
reprimo, TP53 dependent G2 arrest mediator homolog
multiple interactions increases expression decreases expression
ISO EXP
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA] 2-Acetylaminofluorene results in increased expression of RPRM mRNA 2-Acetylaminofluorene results in decreased expression of RPRM mRNA
CTD
PMID:17317680 PMID:19167416 PMID:22584684
NCBI chr 3:38,539,581...38,540,998
Ensembl chr 3:38,539,581...38,540,998
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Rps27l
ribosomal protein S27-like
increases expression
ISO
2-Acetylaminofluorene results in increased expression of RPS27L mRNA
CTD
PMID:17317680
NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418
G
Rrm1
ribonucleotide reductase catalytic subunit M1
increases expression
ISO
2-Acetylaminofluorene results in increased expression of RRM1 mRNA
CTD
PMID:17317680
NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
G
Rrm2b
ribonucleotide reductase regulatory TP53 inducible subunit M2B
increases expression
ISO
2-Acetylaminofluorene results in increased expression of RRM2B mRNA
CTD
PMID:21704725
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
G
Rsad2
radical S-adenosyl methionine domain containing 2
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of RSAD2 mRNA
CTD
PMID:20713471
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
G
S100a11
S100 calcium binding protein A11
increases expression
ISO
2-Acetylaminofluorene results in increased expression of S100A11 mRNA
CTD
PMID:17317680
NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044
G
S100a14
S100 calcium binding protein A14
increases expression
ISO
2-Acetylaminofluorene results in increased expression of S100A14 mRNA
CTD
PMID:17317680
NCBI chr 2:176,008,395...176,010,423
Ensembl chr 2:176,008,395...176,010,423
G
Scarb2
scavenger receptor class B, member 2
increases expression
ISO
2-Acetylaminofluorene results in increased expression of SCARB2 mRNA
CTD
PMID:17317680
NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813
G
Scpep1
serine carboxypeptidase 1
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SCPEP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SCPEP1 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr10:73,703,275...73,732,892
Ensembl chr10:73,703,278...73,732,850
G
Sctr
secretin receptor
increases expression
EXP
2-Acetylaminofluorene results in increased expression of SCTR mRNA
CTD
PMID:17187413
NCBI chr13:31,127,781...31,190,162
Ensembl chr13:31,127,858...31,180,189
G
Serpina7
serpin family A member 7
increases expression
EXP
2-Acetylaminofluorene results in increased expression of SERPINA7 mRNA
CTD
PMID:17070881
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
G
Serpinb5
serpin family B member 5
increases expression multiple interactions
ISO
2-Acetylaminofluorene results in increased expression of SERPINB5 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]
CTD
PMID:17317680
NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
G
Serpinf1
serpin family F member 1
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of SERPINF1 mRNA
CTD
PMID:21607683
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
G
Sesn2
sestrin 2
increases expression
ISO
2-Acetylaminofluorene results in increased expression of SESN2 mRNA
CTD
PMID:21607683
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
G
Sfn
stratifin
increases expression
EXP
2-Acetylaminofluorene results in increased expression of SFN mRNA
CTD
PMID:19167416 PMID:22213190
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
G
Sirt1
sirtuin 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of SIRT1 protein
CTD
PMID:19167416
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
G
Slc15a5
solute carrier family 15, member 5
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of SLC15A5 mRNA
CTD
PMID:21607683
NCBI chr 4:170,878,021...170,971,620
Ensembl chr 4:170,878,021...170,971,620
G
Slc16a10
solute carrier family 16 member 10
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of SLC16A10 mRNA
CTD
PMID:17070881
NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
G
Slc25a4
solute carrier family 25 member 4
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA]
CTD
PMID:17317680
NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
G
Slc2a8
solute carrier family 2 member 8
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA]
CTD
PMID:17317680
NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464
G
Slc40a1
solute carrier family 40 member 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of SLC40A1 mRNA
CTD
PMID:21785164
NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
G
Slco1a4
solute carrier organic anion transporter family, member 1a4
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1A4 mRNA
CTD
PMID:16158176
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
G
Slco1b2
solute carrier organic anion transporter family member 1B2
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1B2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SLCO1B2 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
G
Smad2
SMAD family member 2
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein]
CTD
PMID:15368444
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
G
Smad3
SMAD family member 3
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein]
CTD
PMID:15368444
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
G
Smad4
SMAD family member 4
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of SMAD4 mRNA
CTD
PMID:22213190
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
G
Smo
smoothened, frizzled class receptor
increases expression
EXP
2-Acetylaminofluorene results in increased expression of SMO mRNA
CTD
PMID:17187413
NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
G
Sncg
synuclein, gamma
increases expression
EXP
2-Acetylaminofluorene results in increased expression of SNCG mRNA
CTD
PMID:22213190
NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368
G
Sntg2
syntrophin, gamma 2
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of SNTG2 mRNA
CTD
PMID:21607683
NCBI chr 6:46,801,893...47,003,390
Ensembl chr 6:46,801,377...47,003,372
G
Socs1
suppressor of cytokine signaling 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of SOCS1 mRNA
CTD
PMID:22213190
NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
G
Sod1
superoxide dismutase 1
multiple interactions
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of SOD1 protein
CTD
PMID:17761372
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sod2
superoxide dismutase 2
multiple interactions
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein; O-(Chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein]
CTD
PMID:17761372
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Sox4
SRY-box transcription factor 4
increases expression
EXP
2-Acetylaminofluorene results in increased expression of SOX4 mRNA
CTD
PMID:22584684
NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665
G
Spg7
SPG7 matrix AAA peptidase subunit, paraplegin
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SPG7 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SPG7 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr19:51,117,088...51,151,228
Ensembl chr19:51,117,057...51,150,484
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Spink1
serine peptidase inhibitor, Kazal type 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of SPINK1 mRNA
CTD
PMID:17070881
NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
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Sprr1a
small proline-rich protein 1A
increases expression
ISO
2-Acetylaminofluorene results in increased expression of SPRR1A mRNA
CTD
PMID:17317680
NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063
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Sprr2f
small proline rich protein 2F
increases expression multiple interactions
ISO
2-Acetylaminofluorene results in increased expression of SPRR2F mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA]
CTD
PMID:17317680
NCBI chr 2:177,989,974...177,990,204
Ensembl chr 2:177,989,974...177,990,204
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Sptlc2
serine palmitoyltransferase, long chain base subunit 2
increases expression
ISO
2-Acetylaminofluorene results in increased expression of SPTLC2 mRNA
CTD
PMID:17317680
NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542
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Sst
somatostatin
increases expression
EXP
2-Acetylaminofluorene results in increased expression of SST protein
CTD
PMID:16534498
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
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St3gal3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of ST3GAL3 mRNA
CTD
PMID:21607683
NCBI chr 5:131,470,348...131,670,794
Ensembl chr 5:131,470,348...131,670,810
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St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
increases expression
EXP
2-Acetylaminofluorene results in increased expression of ST3GAL5 protein
CTD
PMID:6331524
NCBI chr 4:104,134,613...104,192,558
Ensembl chr 4:104,134,613...104,192,558
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Stat3
signal transducer and activator of transcription 3
multiple interactions
EXP
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein; Dexamethasone inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein]
CTD
PMID:12957465
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Steap3
STEAP3 metalloreductase
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of STEAP3 mRNA
CTD
PMID:22584684
NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519
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Stmn1
stathmin 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of STMN1 mRNA
CTD
PMID:22584684
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
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Sugct
succinylCoA:glutarate-CoA transferase
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of SUGCT mRNA
CTD
PMID:17070881
NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376
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Sulf2
sulfatase 2
increases expression
EXP ISO
2-Acetylaminofluorene results in increased expression of SULF2 mRNA
CTD
PMID:17070881 PMID:21607683
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
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Sult1c2a
sulfotransferase family 1C member 2A
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of SULT1C2 mRNA
CTD
PMID:21607683
NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734
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Sult1e1
sulfotransferase family 1E member 1
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SULT1E1 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
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Sult2a1
sulfotransferase family 2A member 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of SULT2A1 mRNA
CTD
PMID:17070881
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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Taldo1
transaldolase 1
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TALDO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TALDO1 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
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Tceal9
transcription elongation factor A like 9
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TCEAL9 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TCEAL9 mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr X:99,245,645...99,247,720
Ensembl chr X:99,228,458...99,247,763
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Tes
testin LIM domain protein
increases expression
EXP
2-Acetylaminofluorene results in increased expression of TES mRNA
CTD
PMID:21784091
NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829
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Tf
transferrin
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of TF mRNA
CTD
PMID:16510358
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tff1
trefoil factor 1
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TFF1 mRNA]
CTD
PMID:17317680
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Tff3
trefoil factor 3
increases expression
EXP
2-Acetylaminofluorene results in increased expression of TFF3 mRNA
CTD
PMID:22213190
NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054
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Tfrc
transferrin receptor
increases expression
EXP
2-Acetylaminofluorene results in increased expression of TFRC mRNA
CTD
PMID:21785164
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tgfb1
transforming growth factor, beta 1
multiple interactions increases expression
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein] 2-Acetylaminofluorene results in increased expression of TGFB1 mRNA
CTD
PMID:15368444 PMID:15940639
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Thrb
thyroid hormone receptor beta
increases activity
ISO
2-Acetylaminofluorene results in increased activity of THRB protein
CTD
PMID:31077750
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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Thy1
Thy-1 cell surface antigen
increases expression
EXP
2-Acetylaminofluorene results in increased expression of THY1 protein
CTD
PMID:17576600
NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
2-Acetylaminofluorene results in increased expression of TIMP1 mRNA
CTD
PMID:18678246
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tkt
transketolase
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TKT mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TKT mRNA
CTD
PMID:14656948 PMID:16158176
NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
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Tmem134
transmembrane protein 134
increases expression
ISO
2-Acetylaminofluorene results in increased expression of TMEM134 mRNA
CTD
PMID:17317680
NCBI chr 1:201,419,225...201,424,778
Ensembl chr 1:201,419,264...201,431,411
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Tmem184c
transmembrane protein 184C
increases expression
EXP
2-Acetylaminofluorene results in increased expression of TMEM184C mRNA
CTD
PMID:21784091
NCBI chr19:30,345,183...30,361,275
Ensembl chr19:30,345,290...30,361,269
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Tmem43
transmembrane protein 43
increases expression
ISO
2-Acetylaminofluorene results in increased expression of TMEM43 mRNA
CTD
PMID:21607683
NCBI chr 4:123,977,680...123,992,823
Ensembl chr 4:123,977,625...123,992,825
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Tnf
tumor necrosis factor
multiple interactions increases expression
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TNF protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]
CTD
PMID:18271918 PMID:23665045 PMID:25051504
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf10b
TNF receptor superfamily member 10b
increases expression
ISO
2-Acetylaminofluorene results in increased expression of TNFRSF10B mRNA
CTD
PMID:21607683
NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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Top2a
DNA topoisomerase II alpha
increases expression
EXP
2-Acetylaminofluorene results in increased expression of TOP2A mRNA
CTD
PMID:22584684
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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Tp53
tumor protein p53
increases expression decreases expression increases response to substance multiple interactions
EXP ISO
2-Acetylaminofluorene results in increased expression of TP53 protein 2-Acetylaminofluorene results in increased expression of TRP53 protein 2-Acetylaminofluorene results in decreased expression of TP53 protein TRP53 protein modified form results in increased susceptibility to 2-Acetylaminofluorene TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of CYP4F15 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TFF1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TUBA1C mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of UBE2C mRNA] [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TP53 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; Vanadium promotes the reaction [2-Acetylaminofluorene results in increased expression of TP53 protein]
CTD
PMID:7728945 PMID:9667752 PMID:10708481 PMID:11003613 PMID:11915028 PMID:12888115 PMID:14633663 PMID:15565650 PMID:17317680 PMID:19167416 PMID:23665045 More...
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53inp1
tumor protein p53 inducible nuclear protein 1
multiple interactions increases expression
EXP ISO
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of TRP53INP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TRP53INP1 mRNA 2-Acetylaminofluorene results in increased expression of TP53INP1 mRNA 2-Acetylaminofluorene results in increased expression of TRP53INP1 mRNA
CTD
PMID:14656948 PMID:16158176 PMID:21607683 PMID:22584684
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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Tp73
tumor protein p73
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of TP73 mRNA
CTD
PMID:22213190
NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
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Trpm2
transient receptor potential cation channel, subfamily M, member 2
multiple interactions
EXP
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNA
CTD
PMID:16158176
NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
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Tsc22d1
TSC22 domain family, member 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of TSC22D1 mRNA
CTD
PMID:15089088
NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
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Tshb
thyroid stimulating hormone subunit beta
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA]
CTD
PMID:17317680
NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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Ttr
transthyretin
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA]
CTD
PMID:17317680
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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Tuba1c
tubulin, alpha 1C
multiple interactions
ISO
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TUBA1C mRNA]
CTD
PMID:17317680
NCBI chr 7:130,192,050...130,199,655
Ensembl chr 7:130,192,016...130,199,647 Ensembl chr X:130,192,016...130,199,647
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Tubb4b
tubulin, beta 4B class IVb
increases expression
ISO EXP
2-Acetylaminofluorene results in increased expression of TUBB4B mRNA
CTD
PMID:21607683 PMID:22584684
NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296
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Tubb5
tubulin, beta 5 class I
increases expression
EXP
2-Acetylaminofluorene results in increased expression of TUBB5 mRNA
CTD
PMID:22584684
NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
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Tubb6
tubulin, beta 6 class V
increases expression
ISO
2-Acetylaminofluorene results in increased expression of TUBB6 mRNA
CTD
PMID:21607683
NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418
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Ube2c
ubiquitin-conjugating enzyme E2C
increases expression multiple interactions
ISO EXP
2-Acetylaminofluorene results in increased expression of UBE2C mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of UBE2C mRNA]
CTD
PMID:17317680 PMID:22584684
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of 2-Acetylaminofluorene analog
CTD
PMID:11375903
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Vcam1
vascular cell adhesion molecule 1
increases expression
ISO EXP
2-Acetylaminofluorene results in increased expression of VCAM1 mRNA 2-Acetylaminofluorene results in increased expression of VCAM1 protein
CTD
PMID:21607683 PMID:25051504
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vegfa
vascular endothelial growth factor A
decreases expression multiple interactions increases expression
EXP
2-Acetylaminofluorene results in decreased expression of VEGFA mRNA geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of VEGFA protein]
CTD
PMID:22213190 PMID:25051504 PMID:26364502
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Wee1
WEE1 G2 checkpoint kinase
increases expression
EXP
2-Acetylaminofluorene results in increased expression of WEE1 mRNA
CTD
PMID:22584684
NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
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Wwox
WW domain-containing oxidoreductase
decreases expression
ISO
2-Acetylaminofluorene results in decreased expression of WWOX mRNA
CTD
PMID:21607683
NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391
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Xdh
xanthine dehydrogenase
increases activity multiple interactions
EXP
2-Acetylaminofluorene results in increased activity of XDH protein Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
CTD
PMID:23665045
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
decreases response to substance
ISO
XPC protein results in decreased susceptibility to 2-Acetylaminofluorene
CTD
PMID:23153559
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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Zeb1
zinc finger E-box binding homeobox 1
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of ZEB1 protein
CTD
PMID:19167416
NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
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Zeb2
zinc finger E-box binding homeobox 2
decreases expression
EXP
2-Acetylaminofluorene results in decreased expression of ZEB2 protein
CTD
PMID:19167416
NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157
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Zmat3
zinc finger, matrin type 3
multiple interactions increases expression
ISO EXP
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA] 2-Acetylaminofluorene results in increased expression of ZMAT3 mRNA
CTD
PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684
NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863
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Esr1
estrogen receptor 1
multiple interactions
ISO
2-aminoanthraquinone binds to and results in increased activity of ESR1 protein
CTD
PMID:20707409
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases chemical synthesis multiple interactions
ISO
CYP1A2 protein results in increased chemical synthesis of 2-hydroxychrysophanol [CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CTD
PMID:29698620
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases chemical synthesis
ISO
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol CYP3A4 protein results in increased chemical synthesis of 2-hydroxychrysophanol
CTD
PMID:29698620
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Alb
albumin
affects binding
ISO
Alizarin Red S binds to ALB protein
CTD
PMID:18968587
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Abi3bp
ABI family member 3 binding protein
increases expression
ISO
3-nitrobenzanthrone results in increased expression of ABI3BP mRNA
CTD
PMID:34036453
NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of ADAMTS1 mRNA
CTD
PMID:34036453
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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Adgra2
adhesion G protein-coupled receptor A2
increases expression
ISO
3-nitrobenzanthrone results in increased expression of ADGRA2 mRNA
CTD
PMID:34036453
NCBI chr16:64,932,964...64,971,433
Ensembl chr16:64,933,315...64,971,483
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Adm2
adrenomedullin 2
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of ADM2 mRNA
CTD
PMID:34036453
NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
3-nitrobenzanthrone binds to and results in increased activity of AHR protein
CTD
PMID:28186253
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Akr1c1
aldo-keto reductase family 1, member C1
multiple interactions increases reduction
ISO
[AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone
CTD
PMID:30406992
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
G
Akr1c2
aldo-keto reductase family 1, member C2
multiple interactions increases reduction
ISO
[AKR1C2 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [AKR1C2 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone
CTD
PMID:30406992
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
increases reduction multiple interactions
ISO
AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone [AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone
CTD
PMID:30406992
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
3-nitrobenzanthrone results in increased expression of and results in increased phosphorylation of AKT1 protein; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of AKT1 protein]
CTD
PMID:34036453
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Ang
angiogenin
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of ANG mRNA
CTD
PMID:34036453
NCBI chr15:24,312,711...24,323,361
G
Apoe
apolipoprotein E
increases expression
ISO
3-nitrobenzanthrone results in increased expression of APOE mRNA
CTD
PMID:34036453
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
G
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of ARAP2 mRNA
CTD
PMID:34036453
NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154
G
Areg
amphiregulin
increases expression
ISO
3-nitrobenzanthrone results in increased expression of AREG mRNA
CTD
PMID:34036453
NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
G
Bicc1
BicC family RNA binding protein 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of BICC1 mRNA
CTD
PMID:34036453
NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776
G
Bmp4
bone morphogenetic protein 4
increases expression
ISO
3-nitrobenzanthrone results in increased expression of BMP4 mRNA
CTD
PMID:34036453
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
G
Bmper
BMP-binding endothelial regulator
increases expression
ISO
3-nitrobenzanthrone results in increased expression of BMPER mRNA
CTD
PMID:34036453
NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256
G
Bnc2
basonuclin zinc finger protein 2
increases expression
ISO
3-nitrobenzanthrone results in increased expression of BNC2 mRNA
CTD
PMID:34036453
NCBI chr 5:98,679,071...99,016,044
Ensembl chr 5:98,687,410...99,079,426
G
Btg1
BTG anti-proliferation factor 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of BTG1 mRNA
CTD
PMID:34036453
NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
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Cav1
caveolin 1
increases expression
ISO
3-nitrobenzanthrone results in increased expression of CAV1 mRNA
CTD
PMID:34036453
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
G
Ccbe1
collagen and calcium binding EGF domains 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of CCBE1 mRNA
CTD
PMID:34036453
NCBI chr18:59,579,851...59,823,977
Ensembl chr18:59,580,768...59,824,400
G
Cd24
CD24 molecule
increases expression
ISO
3-nitrobenzanthrone results in increased expression of CD24 mRNA
CTD
PMID:34036453
NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
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Cd34
CD34 molecule
affects expression
ISO
3-nitrobenzanthrone affects the expression of CD34 mRNA
CTD
PMID:34036453
NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832
G
Cdh1
cadherin 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of CDH1 mRNA; 3-nitrobenzanthrone results in decreased expression of CDH1 protein
CTD
PMID:34036453
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cdk14
cyclin-dependent kinase 14
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of CDK14 mRNA
CTD
PMID:34036453
NCBI chr 4:28,666,416...29,258,865
Ensembl chr 4:28,666,843...29,258,861
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
3-nitrobenzanthrone results in increased expression of CDKN1A protein
CTD
PMID:25230394
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Chrdl1
chordin-like 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of CHRDL1 mRNA
CTD
PMID:34036453
NCBI chr X:106,889,125...106,992,937
Ensembl chr X:106,889,125...106,992,921
G
Cldn3
claudin 3
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of CLDN3 mRNA
CTD
PMID:34036453
NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
G
Col18a1
collagen type XVIII alpha 1 chain
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of COL18A1 mRNA
CTD
PMID:34036453
NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
G
Col5a2
collagen type V alpha 2 chain
increases expression
ISO
3-nitrobenzanthrone results in increased expression of COL5A2 mRNA
CTD
PMID:34036453
NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154
G
Col6a1
collagen type VI alpha 1 chain
affects expression
ISO
3-nitrobenzanthrone affects the expression of COL6A1 mRNA
CTD
PMID:34036453
NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
G
Ctnnb1
catenin beta 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of CTNNB1 mRNA
CTD
PMID:34036453
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
G
Cxcl14
C-X-C motif chemokine ligand 14
increases expression
ISO
3-nitrobenzanthrone results in increased expression of CXCL14 mRNA
CTD
PMID:19879285
NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
G
Cxcr4
C-X-C motif chemokine receptor 4
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of CXCR4 mRNA
CTD
PMID:34036453
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases expression
ISO
CYP1A1 protein affects the reaction [3-nitrobenzanthrone results in increased abundance of Reactive Oxygen Species] 3-nitrobenzanthrone results in increased expression of CYP1A1 mRNA
CTD
PMID:17477947 PMID:25230394
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
3-nitrobenzanthrone results in increased expression of CYP1B1 mRNA
CTD
PMID:34036453
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Ddr2
discoidin domain receptor tyrosine kinase 2
affects expression
ISO
3-nitrobenzanthrone affects the expression of DDR2 mRNA
CTD
PMID:34036453
NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
G
Dsc2
desmocollin 2
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of DSC2 mRNA
CTD
PMID:34036453
NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392
G
Ecm1
extracellular matrix protein 1
affects expression
ISO
3-nitrobenzanthrone affects the expression of ECM1 mRNA
CTD
PMID:34036453
NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
G
Epcam
epithelial cell adhesion molecule
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of EPCAM mRNA
CTD
PMID:34036453
NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
G
Eps8l1
EPS8-like 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of EPS8L1 mRNA
CTD
PMID:34036453
NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524
G
Erbb2
erb-b2 receptor tyrosine kinase 2
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of ERBB2 mRNA
CTD
PMID:34036453
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
G
Ereg
epiregulin
increases expression multiple interactions
ISO
3-nitrobenzanthrone results in increased expression of EREG mRNA; 3-nitrobenzanthrone results in increased expression of EREG protein EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of SOX9 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of TWIST2 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of AKT1 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]
CTD
PMID:34036453
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
G
Etv4
ETS variant transcription factor 4
increases expression
ISO
3-nitrobenzanthrone results in increased expression of ETV4 mRNA
CTD
PMID:34036453
NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974
G
F11r
F11 receptor
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of F11R mRNA
CTD
PMID:34036453
NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
G
Fbln1
fibulin 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of FBLN1 mRNA
CTD
PMID:34036453
NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075
G
Fbln5
fibulin 5
increases expression
ISO
3-nitrobenzanthrone results in increased expression of FBLN5 mRNA
CTD
PMID:34036453
NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755
G
Fgf18
fibroblast growth factor 18
affects expression
ISO
3-nitrobenzanthrone affects the expression of FGF18 mRNA
CTD
PMID:34036453
NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
G
Fgf2
fibroblast growth factor 2
increases expression
ISO
3-nitrobenzanthrone results in increased expression of FGF2 mRNA
CTD
PMID:34036453
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Fgf9
fibroblast growth factor 9
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of FGF9 mRNA
CTD
PMID:34036453
NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
G
Fgfr2
fibroblast growth factor receptor 2
increases expression
ISO
3-nitrobenzanthrone results in increased expression of FGFR2 mRNA
CTD
PMID:34036453
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
G
Flt4
Fms related receptor tyrosine kinase 4
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of FLT4 mRNA
CTD
PMID:34036453
NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
G
Foxo4
forkhead box O4
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of FOXO4 mRNA
CTD
PMID:34036453
NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115
G
Fst
follistatin
increases expression
ISO
3-nitrobenzanthrone results in increased expression of FST mRNA
CTD
PMID:34036453
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
G
Gdf6
growth differentiation factor 6
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of GDF6 mRNA
CTD
PMID:34036453
NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567
G
Grem1
gremlin 1, DAN family BMP antagonist
increases expression
ISO
3-nitrobenzanthrone results in increased expression of GREM1 mRNA
CTD
PMID:34036453
NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
G
Hipk2
homeodomain interacting protein kinase 2
increases expression
ISO
3-nitrobenzanthrone results in increased expression of HIPK2 mRNA
CTD
PMID:34036453
NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
G
Hoxb3
homeo box B3
increases expression
ISO
3-nitrobenzanthrone results in increased expression of HOXB3 mRNA
CTD
PMID:34036453
NCBI chr10:81,258,739...81,314,134
Ensembl chr10:81,299,357...81,313,107
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
multiple interactions
ISO
[NAT2 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene; [SULT1A1 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene
CTD
PMID:17483118
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
G
Id2
inhibitor of DNA binding 2
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of ID2 mRNA
CTD
PMID:34036453
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
G
Igfbp4
insulin-like growth factor binding protein 4
increases expression
ISO
3-nitrobenzanthrone results in increased expression of IGFBP4 mRNA
CTD
PMID:34036453
NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
G
Il15
interleukin 15
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of IL15 mRNA
CTD
PMID:34036453
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
G
Il18
interleukin 18
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of IL18 mRNA
CTD
PMID:34036453
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
affects expression
ISO
3-nitrobenzanthrone affects the expression of IL1B mRNA
CTD
PMID:34036453
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
increases expression increases secretion multiple interactions
ISO
3-nitrobenzanthrone results in increased expression of IL6 mRNA 3-nitrobenzanthrone results in increased secretion of IL6 protein IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]
CTD
PMID:34036453
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Inhba
inhibin subunit beta A
increases expression
ISO
3-nitrobenzanthrone results in increased expression of INHBA mRNA
CTD
PMID:34036453
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
G
Irf6
interferon regulatory factor 6
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of IRF6 mRNA
CTD
PMID:34036453
NCBI chr13:104,672,179...104,691,386
Ensembl chr13:104,672,179...104,691,386
G
Isl1
ISL LIM homeobox 1
affects expression
ISO
3-nitrobenzanthrone affects the expression of ISL1 mRNA
CTD
PMID:34036453
NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584
G
Itga1
integrin subunit alpha 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of ITGA1 mRNA
CTD
PMID:34036453
NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
G
Itgb1bp1
integrin subunit beta 1 binding protein 1
increases expression
ISO
3-nitrobenzanthrone results in increased expression of ITGB1BP1 mRNA
CTD
PMID:34036453
NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
G
Itgb3
integrin subunit beta 3
affects expression
ISO
3-nitrobenzanthrone affects the expression of ITGB3 mRNA
CTD
PMID:34036453
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
G
Itm2a
integral membrane protein 2A
affects expression
ISO
3-nitrobenzanthrone affects the expression of ITM2A mRNA
CTD
PMID:34036453
NCBI chr X:72,486,383...72,492,344
Ensembl chr X:72,486,381...72,492,363
G
Jam2
junctional adhesion molecule 2
affects expression
ISO
3-nitrobenzanthrone affects the expression of JAM2 mRNA
CTD
PMID:34036453
NCBI chr11:23,830,820...23,880,071
Ensembl chr11:23,831,106...23,880,063
G
Jcad
junctional cadherin 5 associated
increases expression
ISO
3-nitrobenzanthrone results in increased expression of JCAD mRNA
CTD
PMID:34036453
NCBI chr17:53,089,382...53,130,996
Ensembl chr17:53,089,382...53,130,967
G
Krt7
keratin 7
affects expression
ISO
3-nitrobenzanthrone affects the expression of KRT7 mRNA
CTD
PMID:34036453
NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
G
Lad1
ladinin 1
increases expression
ISO
3-nitrobenzanthrone results in increased expression of LAD1 mRNA
CTD
PMID:34036453
NCBI chr13:47,249,605...47,263,967
Ensembl chr13:47,249,605...47,263,967
G
Llgl2
LLGL scribble cell polarity complex component 2
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of LLGL2 mRNA
CTD
PMID:34036453
NCBI chr10:101,050,978...101,086,527
Ensembl chr10:101,051,408...101,086,525
G
Lum
lumican
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of LUM mRNA
CTD
PMID:34036453
NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation multiple interactions
ISO
3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]
CTD
PMID:34036453
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation multiple interactions
ISO
3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]
CTD
PMID:34036453
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Met
MET proto-oncogene, receptor tyrosine kinase
increases expression
ISO
3-nitrobenzanthrone results in increased expression of MET mRNA; 3-nitrobenzanthrone results in increased expression of MET protein
CTD
PMID:34036453
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
G
Mmp2
matrix metallopeptidase 2
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of MMP2 mRNA
CTD
PMID:34036453
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Myo1d
myosin ID
affects expression
ISO
3-nitrobenzanthrone affects the expression of MYO1D mRNA
CTD
PMID:34036453
NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349
G
Myo5c
myosin VC
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of MYO5C mRNA
CTD
PMID:34036453
NCBI chr 8:75,989,497...76,066,485
Ensembl chr 8:75,989,528...76,066,483
G
Nat1
N-acetyltransferase 1
multiple interactions increases activity
ISO
[NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone NAT1 protein results in increased activity of 3-nitrobenzanthrone
CTD
PMID:15805261 PMID:20545351
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
G
Nat2
N-acetyltransferase 2
multiple interactions increases response to substance increases activity
ISO
[NAT2 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] NAT2 protein results in increased susceptibility to 3-nitrobenzanthrone NAT2 protein results in increased activity of 3-nitrobenzanthrone
CTD
PMID:15805261 PMID:17483118 PMID:20545351
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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Ndrg1
N-myc downstream regulated 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of NDRG1 mRNA
CTD
PMID:34036453
NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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Nf1
neurofibromin 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of NF1 mRNA
CTD
PMID:34036453
NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
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Nfe2l2
NFE2 like bZIP transcription factor 2
affects metabolic processing multiple interactions affects response to substance
ISO
NFE2L2 protein affects the metabolism of 3-nitrobenzanthrone [NFE2L2 protein affects the metabolism of 3-nitrobenzanthrone] which affects the abundance of 3-aminobenzanthrone NFE2L2 protein affects the susceptibility to 3-nitrobenzanthrone
CTD
PMID:31746589
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression increases reduction multiple interactions affects binding increases metabolic processing increases activity
ISO
3-nitrobenzanthrone results in increased expression of NQO1 mRNA NQO1 protein results in increased reduction of 3-nitrobenzanthrone [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [NQO1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [NQO1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone 3-nitrobenzanthrone binds to NQO1 protein NQO1 protein results in increased metabolism of 3-nitrobenzanthrone NQO1 protein results in increased activity of 3-nitrobenzanthrone
CTD
PMID:15805261 PMID:20545351 PMID:25230394 PMID:28922594 PMID:30406992
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression
ISO
3-nitrobenzanthrone results in increased expression of NR4A1 mRNA
CTD
PMID:34036453
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nrp1
neuropilin 1
increases expression
ISO
3-nitrobenzanthrone results in increased expression of NRP1 mRNA
CTD
PMID:34036453
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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Nrp2
neuropilin 2
affects expression
ISO
3-nitrobenzanthrone affects the expression of NRP2 mRNA
CTD
PMID:34036453
NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958
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Oas1a
2'-5' oligoadenylate synthetase 1A
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of OAS1 mRNA
CTD
PMID:34036453
NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
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Pdpn
podoplanin
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of PDPN mRNA
CTD
PMID:34036453
NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
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Pkn1
protein kinase N1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of PKN1 mRNA
CTD
PMID:34036453
NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107
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Plxnd1
plexin D1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of PLXND1 mRNA
CTD
PMID:34036453
NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244
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Pmp22
peripheral myelin protein 22
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of PMP22 mRNA
CTD
PMID:34036453
NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
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Por
cytochrome p450 oxidoreductase
multiple interactions
ISO
[POR protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; POR protein results in increased activity of and results in increased reduction of 3-nitrobenzanthrone
CTD
PMID:20545351
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Ppfibp2
PPFIA binding protein 2
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of PPFIBP2 mRNA
CTD
PMID:34036453
NCBI chr 1:161,504,774...161,687,339
Ensembl chr 1:161,504,890...161,655,212
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Ppl
periplakin
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of PPL mRNA
CTD
PMID:34036453
NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575
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Ptx3
pentraxin 3
increases expression
ISO
3-nitrobenzanthrone results in increased expression of PTX3 mRNA
CTD
PMID:34036453
NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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Pycard
PYD and CARD domain containing
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of PYCARD mRNA
CTD
PMID:34036453
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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Ramp2
receptor activity modifying protein 2
increases expression
ISO
3-nitrobenzanthrone results in increased expression of RAMP2 mRNA
CTD
PMID:34036453
NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
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RT1-Hb-ps1
RT1 class II, locus Hb, pseudogene 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of HLA-DPB1 mRNA
CTD
PMID:34036453
NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618
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Sema3e
semaphorin 3E
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of SEMA3E mRNA
CTD
PMID:34036453
NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229
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Sfrp1
secreted frizzled-related protein 1
increases expression
ISO
3-nitrobenzanthrone results in increased expression of SFRP1 mRNA
CTD
PMID:34036453
NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286
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Slc37a1
solute carrier family 37 member 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of SLC37A1 mRNA
CTD
PMID:34036453
NCBI chr20:9,360,501...9,433,895
Ensembl chr20:9,378,836...9,433,892
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Slit2
slit guidance ligand 2
increases expression
ISO
3-nitrobenzanthrone results in increased expression of SLIT2 mRNA
CTD
PMID:34036453
NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948
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Snai2
snail family transcriptional repressor 2
increases expression
ISO
3-nitrobenzanthrone results in increased expression of SNAI2 mRNA; 3-nitrobenzanthrone results in increased expression of SNAI2 protein
CTD
PMID:34036453
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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Snai3
snail family transcriptional repressor 3
increases expression
ISO
3-nitrobenzanthrone results in increased expression of SNAI3 mRNA
CTD
PMID:34036453
NCBI chr19:50,516,771...50,529,295
Ensembl chr19:50,516,771...50,523,486
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Sox9
SRY-box transcription factor 9
increases expression multiple interactions
ISO
3-nitrobenzanthrone results in increased expression of SOX9 mRNA; 3-nitrobenzanthrone results in increased expression of SOX9 protein EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of SOX9 protein]
CTD
PMID:34036453
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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Spint1
serine peptidase inhibitor, Kunitz type 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of SPINT1 mRNA
CTD
PMID:34036453
NCBI chr 3:106,231,082...106,244,121
Ensembl chr 3:106,231,444...106,244,119
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Spock3
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of SPOCK3 mRNA
CTD
PMID:34036453
NCBI chr16:26,382,895...26,815,943
Ensembl chr16:26,383,383...26,815,205
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Srf
serum response factor
increases expression
ISO
3-nitrobenzanthrone results in increased expression of SRF mRNA
CTD
PMID:34036453
NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
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Srgn
serglycin
increases expression
ISO
3-nitrobenzanthrone results in increased expression of SRGN mRNA
CTD
PMID:34036453
NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406
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Stat1
signal transducer and activator of transcription 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of STAT1 mRNA
CTD
PMID:34036453
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
increases phosphorylation multiple interactions
ISO
3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]
CTD
PMID:34036453
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Sulf1
sulfatase 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of SULF1 mRNA
CTD
PMID:34036453
NCBI chr 5:6,362,894...6,526,174
Ensembl chr 5:6,362,911...6,525,584
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Sult1a1
sulfotransferase family 1A member 1
multiple interactions increases activity increases response to substance
ISO
[NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [SULT1A1 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene SULT1A1 protein results in increased activity of 3-nitrobenzanthrone SULT1A1 protein results in increased susceptibility to 3-nitrobenzanthrone
CTD
PMID:15805261 PMID:17483118 PMID:20545351
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Syne1
spectrin repeat containing nuclear envelope protein 1
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of SYNE1 mRNA
CTD
PMID:34036453
NCBI chr 1:41,512,146...41,983,382
Ensembl chr 1:41,512,030...41,983,322
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Tcf4
transcription factor 4
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of TCF4 mRNA
CTD
PMID:34036453
NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
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Thbs1
thrombospondin 1
increases expression
ISO
3-nitrobenzanthrone results in increased expression of THBS1 mRNA
CTD
PMID:34036453
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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Thbs2
thrombospondin 2
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of THBS2 mRNA
CTD
PMID:34036453
NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
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Timp4
TIMP metallopeptidase inhibitor 4
affects expression
ISO
3-nitrobenzanthrone affects the expression of TIMP4 mRNA
CTD
PMID:34036453
NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558
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Tjp3
tight junction protein 3
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of TJP3 mRNA
CTD
PMID:34036453
NCBI chr 7:8,427,650...8,446,279
Ensembl chr 7:8,432,811...8,446,279
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Tnc
tenascin C
increases expression
ISO
3-nitrobenzanthrone results in increased expression of TNC mRNA
CTD
PMID:34036453
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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Tnfsf12
TNF superfamily member 12
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of TNFSF12 mRNA
CTD
PMID:34036453
NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
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Tns1
tensin 1
affects expression
ISO
3-nitrobenzanthrone affects the expression of TNS1 mRNA
CTD
PMID:34036453
NCBI chr 9:75,491,886...75,702,853
Ensembl chr 9:75,495,814...75,703,225
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Tom1l1
target of myb1 like 1 membrane trafficking protein
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of TOM1L1 mRNA
CTD
PMID:34036453
NCBI chr10:75,464,577...75,508,304
Ensembl chr10:75,464,577...75,508,250
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Tp53
tumor protein p53
decreases expression increases mutagenesis increases expression
ISO
3-nitrobenzanthrone results in decreased expression of TP53 mRNA; 3-nitrobenzanthrone results in decreased expression of TP53 protein 3-nitrobenzanthrone results in increased mutagenesis of TP53 gene 3-nitrobenzanthrone results in increased expression of TRP53 protein
CTD
PMID:18765419 PMID:25230394 PMID:34036453
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Twist1
twist family bHLH transcription factor 1
increases expression affects expression
ISO
3-nitrobenzanthrone results in increased expression of TWIST1 protein 3-nitrobenzanthrone affects the expression of TWIST1 mRNA
CTD
PMID:34036453
NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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Twist2
twist family bHLH transcription factor 2
multiple interactions increases expression
ISO
EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of TWIST2 protein] 3-nitrobenzanthrone results in increased expression of TWIST2 mRNA; 3-nitrobenzanthrone results in increased expression of TWIST2 protein
CTD
PMID:34036453
NCBI chr 9:92,374,740...92,419,222
Ensembl chr 9:92,374,574...92,419,222
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Vamp8
vesicle-associated membrane protein 8
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of VAMP8 mRNA
CTD
PMID:34036453
NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897
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Zeb1
zinc finger E-box binding homeobox 1
increases expression
ISO
3-nitrobenzanthrone results in increased expression of ZEB1 mRNA
CTD
PMID:34036453
NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
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Zeb2
zinc finger E-box binding homeobox 2
decreases expression
ISO
3-nitrobenzanthrone results in decreased expression of ZEB2 mRNA
CTD
PMID:34036453
NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157
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Ahr
aryl hydrocarbon receptor
affects binding
EXP
3-nitroperylene binds to AHR protein
CTD
PMID:6329540
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Abcb1b
ATP-binding cassette, sub-family B member 1B
increases expression
EXP
4-acetylaminofluorene results in increased expression of ABCB1B mRNA
CTD
PMID:17070881
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
G
Acmsd
aminocarboxymuconate semialdehyde decarboxylase
increases expression
EXP
4-acetylaminofluorene results in increased expression of ACMSD mRNA
CTD
PMID:17070881
NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
G
Acsl3
acyl-CoA synthetase long-chain family member 3
increases expression
EXP
4-acetylaminofluorene results in increased expression of ACSL3 mRNA
CTD
PMID:17070881
NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
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Aen
apoptosis enhancing nuclease
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of AEN mRNA
CTD
PMID:17070881
NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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Akr7a3
aldo-keto reductase family 7 member A3
increases expression
EXP
4-acetylaminofluorene results in increased expression of AKR7A3 mRNA
CTD
PMID:17070881
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
4-acetylaminofluorene results in increased expression of ALDH1A1 mRNA
CTD
PMID:17070881
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Apoa2
apolipoprotein A2
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of APOA2 mRNA
CTD
PMID:17070881
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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Apoa4
apolipoprotein A4
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of APOA4 mRNA
CTD
PMID:17070881
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Apoc3
apolipoprotein C3
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of APOC3 mRNA
CTD
PMID:17070881
NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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Atp6v1d
ATPase H+ transporting V1 subunit D
increases expression
EXP
4-acetylaminofluorene results in increased expression of ATP6V1D mRNA
CTD
PMID:17070881
NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303
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Bax
BCL2 associated X, apoptosis regulator
increases expression
EXP
4-acetylaminofluorene results in increased expression of BAX mRNA
CTD
PMID:17070881
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Btg2
BTG anti-proliferation factor 2
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of BTG2 mRNA
CTD
PMID:17070881
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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C7
complement C7
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of C7 mRNA
CTD
PMID:17070881
NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
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Cblc
Cbl proto-oncogene C
increases expression
EXP
4-acetylaminofluorene results in increased expression of CBLC mRNA
CTD
PMID:17070881
NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755
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Ccng1
cyclin G1
increases expression
EXP
4-acetylaminofluorene results in increased expression of CCNG1 mRNA
CTD
PMID:17070881
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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Cd276
Cd276 molecule
increases expression
EXP
4-acetylaminofluorene results in increased expression of CD276 mRNA
CTD
PMID:17070881
NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of CDKN1A mRNA
CTD
PMID:17070881
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cpq
carboxypeptidase Q
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of CPQ mRNA
CTD
PMID:17070881
NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546
G
Cryab
crystallin, alpha B
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of CRYAB mRNA
CTD
PMID:17070881
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
G
Cyp2c13
cytochrome P450, family 2, subfamily c, polypeptide 13
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of CYP2C13 mRNA
CTD
PMID:17070881
NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
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Cyp4f5
cytochrome P450, family 4, subfamily f, polypeptide 5
increases expression
EXP
4-acetylaminofluorene results in increased expression of CYP4F5 mRNA
CTD
PMID:17070881
NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978
G
Ddah1
dimethylarginine dimethylaminohydrolase 1
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of DDAH1 mRNA
CTD
PMID:17070881
NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
G
Epcam
epithelial cell adhesion molecule
increases expression
EXP
4-acetylaminofluorene results in increased expression of EPCAM mRNA
CTD
PMID:17070881
NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
G
Ephx1
epoxide hydrolase 1
increases expression
EXP
4-acetylaminofluorene results in increased expression of EPHX1 mRNA
CTD
PMID:17070881
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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Fas
Fas cell surface death receptor
increases expression decreases expression
EXP
4-acetylaminofluorene results in increased expression of FAS mRNA 4-acetylaminofluorene results in decreased expression of FAS mRNA
CTD
PMID:17070881
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fhit
fragile histidine triad diadenosine triphosphatase
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of FHIT mRNA
CTD
PMID:17070881
NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
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Gria3
glutamate ionotropic receptor AMPA type subunit 3
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of GRIA3 mRNA
CTD
PMID:17070881
NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096
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Gstm1
glutathione S-transferase mu 1
increases expression
EXP
4-acetylaminofluorene results in increased expression of GSTM1 mRNA
CTD
PMID:17070881
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Hsd17b6
hydroxysteroid (17-beta) dehydrogenase 6
increases expression
EXP
4-acetylaminofluorene results in increased expression of HSD17B6 mRNA
CTD
PMID:17070881
NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425
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Il2ra
interleukin 2 receptor subunit alpha
increases expression
EXP
4-acetylaminofluorene results in increased expression of IL2RA mRNA
CTD
PMID:17070881
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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Mgmt
O-6-methylguanine-DNA methyltransferase
increases expression
EXP
4-acetylaminofluorene results in increased expression of MGMT mRNA
CTD
PMID:17070881
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
EXP
4-acetylaminofluorene results in increased expression of NUPR1 mRNA
CTD
PMID:17070881
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Phlda3
pleckstrin homology-like domain, family A, member 3
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of PHLDA3 mRNA
CTD
PMID:17070881
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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Por
cytochrome p450 oxidoreductase
increases expression
EXP
4-acetylaminofluorene results in increased expression of POR mRNA
CTD
PMID:15089088
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Rhobtb2
Rho-related BTB domain containing 2
increases expression
EXP
4-acetylaminofluorene results in increased expression of RHOBTB2 mRNA
CTD
PMID:17070881
NCBI chr15:44,868,251...44,888,436
Ensembl chr15:44,870,376...44,888,651
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Serpina7
serpin family A member 7
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of SERPINA7 mRNA
CTD
PMID:17070881
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
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Slc16a10
solute carrier family 16 member 10
increases expression
EXP
4-acetylaminofluorene results in increased expression of SLC16A10 mRNA
CTD
PMID:17070881
NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
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Spink1
serine peptidase inhibitor, Kazal type 1
increases expression
EXP
4-acetylaminofluorene results in increased expression of SPINK1 mRNA
CTD
PMID:17070881
NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
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Sugct
succinylCoA:glutarate-CoA transferase
increases expression
EXP
4-acetylaminofluorene results in increased expression of SUGCT mRNA
CTD
PMID:17070881
NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376
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Sulf2
sulfatase 2
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of SULF2 mRNA
CTD
PMID:17070881
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
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Sult2a1
sulfotransferase family 2A member 1
increases expression
EXP
4-acetylaminofluorene results in increased expression of SULT2A1 mRNA
CTD
PMID:17070881
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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Tsc22d1
TSC22 domain family, member 1
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of TSC22D1 mRNA
CTD
PMID:15089088
NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
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Zmat3
zinc finger, matrin type 3
decreases expression
EXP
4-acetylaminofluorene results in decreased expression of ZMAT3 mRNA
CTD
PMID:17070881
NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863
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Oprm1
opioid receptor, mu 1
multiple interactions
ISO
[7-benzylidenenaltrexone binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate); [7-benzylidenenaltrexone binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP
CTD
PMID:11413242
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
7-nitrobenzanthracene binds to and results in increased activity of AHR protein
CTD
PMID:28186253
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
7-nitrobenzanthracene results in increased expression of CYP1A1 mRNA
CTD
PMID:12107646
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO
7-nitrobenzanthracene results in increased expression of CYP1A2 mRNA
CTD
PMID:12107646
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
9,10-anthraquinone analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein
CTD
PMID:26915975
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
9,10-anthraquinone analog results in increased expression of BAD protein
CTD
PMID:26915975
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
9,10-anthraquinone analog results in increased expression of BAX mRNA; 9,10-anthraquinone analog results in increased expression of BAX protein
CTD
PMID:26915975
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
9,10-anthraquinone analog results in decreased expression of BCL2 mRNA; 9,10-anthraquinone analog results in decreased expression of BCL2 protein
CTD
PMID:26915975
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
9,10-anthraquinone analog results in decreased expression of BCL2L1 protein
CTD
PMID:26915975
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bcl2l11
Bcl2-like 11
increases expression
ISO
9,10-anthraquinone analog results in increased expression of BCL2L11 protein
CTD
PMID:26915975
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Casp3
caspase 3
increases activity increases expression
ISO
9,10-anthraquinone analog results in increased activity of CASP3 protein 9,10-anthraquinone analog results in increased expression of CASP3 mRNA
CTD
PMID:26915975
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity
ISO
9,10-anthraquinone analog results in increased activity of CASP9 protein
CTD
PMID:26915975
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccl5
C-C motif chemokine ligand 5
increases expression
ISO
9,10-anthraquinone results in increased expression of CCL5 mRNA
CTD
PMID:23333790
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccnd1
cyclin D1
decreases expression
ISO
9,10-anthraquinone analog results in decreased expression of CCND1 protein
CTD
PMID:26915975
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd2
cyclin D2
decreases expression
ISO
9,10-anthraquinone analog results in decreased expression of CCND2 protein
CTD
PMID:26915975
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
9,10-anthraquinone analog results in decreased expression of PTGS2 mRNA; 9,10-anthraquinone analog results in decreased expression of PTGS2 protein
CTD
PMID:26915975
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ephx1
epoxide hydrolase 1
increases metabolic processing
ISO
EPHX1 protein mutant form results in increased metabolism of 9,10-epoxy-9,10-dihydrophenanthrene
CTD
PMID:26838043
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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Akr1a1
aldo-keto reductase family 1 member A1
multiple interactions
ISO
AKR1A1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone
CTD
PMID:21910479
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
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Akr1b1
aldo-keto reductase family 1 member B1
increases reduction multiple interactions
ISO
AKR1B1 protein results in increased reduction of 9,10-phenanthrenequinone AKR1B1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone
CTD
PMID:10510318 PMID:21910479
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr1b10
aldo-keto reductase family 1 member B10
increases metabolic processing increases expression
ISO
AKR1B10 protein results in increased metabolism of 9,10-phenanthrenequinone 9,10-phenanthrenequinone results in increased expression of AKR1B10 mRNA
CTD
PMID:24813866
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akr1c1
aldo-keto reductase family 1, member C1
increases metabolic processing multiple interactions increases reduction
ISO
AKR1C1 protein results in increased metabolism of 9,10-phenanthrenequinone AKR1C1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone AKR1C1 protein results in increased reduction of 9,10-phenanthrenequinone
CTD
PMID:17950253 PMID:21851338 PMID:21910479 PMID:23261716
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
increases metabolic processing increases reduction multiple interactions
ISO
AKR1C2 protein results in increased metabolism of 9,10-phenanthrenequinone AKR1C2 protein results in increased reduction of 9,10-phenanthrenequinone AKR1C2 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone
CTD
PMID:17950253 PMID:21851338 PMID:21910479 PMID:23261716
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
increases metabolic processing increases expression increases reduction multiple interactions
ISO
AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone 9,10-phenanthrenequinone results in increased expression of AKR1C3 protein AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone [AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; AKR1C3 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]; Indomethacin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]; N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]
CTD
PMID:17950253 PMID:19442656 PMID:21851338 PMID:21910479 PMID:23261716 PMID:29108775 More...
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Akr7a2
aldo-keto reductase family 7, member A2
increases reduction multiple interactions affects reduction
ISO
AKR7A2 protein results in increased reduction of 9,10-phenanthrenequinone AKR7A2 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone 9,10-phenanthrenequinone affects the reduction of AKR7A5 protein
CTD
PMID:10510318 PMID:12604212 PMID:21910479
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
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Akr7a3
aldo-keto reductase family 7 member A3
increases reduction multiple interactions
EXP ISO
AKR7A3 protein results in increased reduction of 9,10-phenanthrenequinone AKR7A3 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone
CTD
PMID:19168568 PMID:21910479
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
9,10-phenanthrenequinone results in increased expression of BAX protein
CTD
PMID:29108775
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bbc3
Bcl-2 binding component 3
increases expression
ISO
9,10-phenanthrenequinone results in increased expression of BBC3 protein
CTD
PMID:29108775
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
9,10-phenanthrenequinone results in decreased expression of BCL2 protein
CTD
PMID:29108775
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
increases activity multiple interactions
ISO
9,10-phenanthrenequinone results in increased activity of CASP3 protein Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in increased activity of CASP3 protein]
CTD
PMID:25289770 PMID:29108775
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity multiple interactions
ISO
9,10-phenanthrenequinone results in increased activity of CASP9 protein Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in increased activity of CASP9 protein]
CTD
PMID:29108775
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions increases activity
ISO
CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein] 9,10-phenanthrenequinone results in increased activity of CAT protein
CTD
PMID:32493877 PMID:34391839
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cbr1
carbonyl reductase 1
increases metabolic processing multiple interactions
ISO
CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone [CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone]
CTD
PMID:21910479 PMID:23295225 PMID:29108775
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cbr3
carbonyl reductase 3
increases metabolic processing
ISO
CBR3 protein results in increased metabolism of 9,10-phenanthrenequinone
CTD
PMID:19061875
NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
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Ccl11
C-C motif chemokine ligand 11
increases expression
ISO
9,10-phenanthrenequinone results in increased expression of CCL11 protein
CTD
PMID:15669044
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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Cldn5
claudin 5
multiple interactions decreases expression
ISO
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 protein]; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine promotes the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 protein]; 9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein]; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein]
CTD
PMID:34391839
NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
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Dcxr
dicarbonyl and L-xylulose reductase
multiple interactions increases metabolic processing
ISO
9,10-phenanthrenequinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; [CBR2 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; [DCXR protein results in increased metabolism of 9,10-phenanthrenequinone] which results in increased chemical synthesis of Hydroxyl Radical
CTD
PMID:21910479 PMID:28595002
NCBI chr10:106,006,404...106,008,293
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Dhrs11
dehydrogenase/reductase 11
increases reduction
ISO
DHRS11 protein results in increased reduction of 9,10-phenanthrenequinone
CTD
PMID:30926317
NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
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Dhrs7
dehydrogenase/reductase 7
increases reduction
ISO
DHRS7 protein results in increased reduction of 9,10-phenanthrenequinone
CTD
PMID:24246760
NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
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Egfr
epidermal growth factor receptor
multiple interactions increases phosphorylation
ISO
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of EGFR protein]; catalase-polyethylene glycol inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of EGFR protein]
CTD
PMID:32493877
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Hmox1
heme oxygenase 1
multiple interactions decreases expression
ISO
1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of HMOX1 protein]
CTD
PMID:15629867
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il5
interleukin 5
increases expression
ISO
9,10-phenanthrenequinone results in increased expression of IL5 protein
CTD
PMID:15669044
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation multiple interactions
ISO
9,10-phenanthrenequinone results in increased phosphorylation of MAPK1 protein 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK1 protein]; catalase-polyethylene glycol inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK1 protein]
CTD
PMID:32493877
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions increases phosphorylation
ISO
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK3 protein]; catalase-polyethylene glycol inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK3 protein]
CTD
PMID:32493877
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mmp2
matrix metallopeptidase 2
increases secretion increases expression
ISO
9,10-phenanthrenequinone results in increased secretion of MMP2 protein 9,10-phenanthrenequinone results in increased expression of MMP2 mRNA
CTD
PMID:24813866
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Nfe2l2
NFE2 like bZIP transcription factor 2
affects localization
ISO
9,10-phenanthrenequinone affects the localization of NFE2L2 protein
CTD
PMID:29108775
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nos2
nitric oxide synthase 2
increases expression
ISO
9,10-phenanthrenequinone results in increased expression of NOS2 protein
CTD
PMID:34391839
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
decreases expression
ISO
9,10-phenanthrenequinone results in decreased expression of NOS3 protein
CTD
PMID:34391839
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions increases expression increases metabolic processing increases response to substance
ISO
[NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; Acetylcysteine inhibits the reaction [NQO1 protein results in increased susceptibility to 9,10-phenanthrenequinone]; NQO1 protein promotes the reaction [Acetylcysteine results in decreased susceptibility to 9,10-phenanthrenequinone] 9,10-phenanthrenequinone results in increased expression of NQO1 protein NQO1 protein results in increased metabolism of 9,10-phenanthrenequinone
CTD
PMID:21910479 PMID:22925602 PMID:29108775
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
9,10-phenanthrenequinone results in increased expression of PMAIP1 protein
CTD
PMID:29108775
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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Prdx1
peroxiredoxin 1
multiple interactions
ISO
9,10-phenanthrenequinone promotes the reaction [PRDX1 protein binds to PRDX1 protein]
CTD
PMID:32493877
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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Ptpn1
protein tyrosine phosphatase, non-receptor type 1
multiple interactions
ISO
[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]
CTD
PMID:32493877
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
G
Sod1
superoxide dismutase 1
multiple interactions decreases expression
ISO
1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of SOD1 protein]
CTD
PMID:15629867
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Top2a
DNA topoisomerase II alpha
multiple interactions
ISO
9,10-phenanthrenequinone binds to and results in decreased activity of TOP2A protein
CTD
PMID:22218491
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
G
Tp53
tumor protein p53
affects localization
ISO
9,10-phenanthrenequinone affects the localization of TP53 protein
CTD
PMID:29108775
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Alb
albumin
affects binding
ISO
9-anthroic acid binds to ALB protein
CTD
PMID:16404478
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Cftr
CF transmembrane conductance regulator
decreases activity increases activity
ISO
9-anthroic acid results in decreased activity of CFTR protein 9-anthroic acid results in increased activity of CFTR protein mutant form
CTD
PMID:15290302
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
9-nitroanthracene binds to and results in increased activity of AHR protein
CTD
PMID:28186253
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Ano1
anoctamin 1
multiple interactions
ISO
9-phenanthrol inhibits the reaction [Calcium results in increased activity of ANO1 protein]
CTD
PMID:25573456
NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
G
Ar
androgen receptor
multiple interactions
EXP ISO
9-phenanthrol inhibits the reaction [Metribolone binds to AR protein] 9-phenanthrol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:3695475 PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
C3
complement C3
increases expression
ISO
9-phenanthrol results in increased expression of C3 mRNA
CTD
PMID:22989670
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases abundance multiple interactions
ISO
CYP1A1 protein results in increased abundance of 9-phenanthrol [CYP1A1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CTD
PMID:27137136
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions increases abundance
ISO
[CYP1A2 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol CYP1A2 protein results in increased abundance of 9-phenanthrol
CTD
PMID:27137136
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases abundance multiple interactions
ISO
CYP1B1 protein results in increased abundance of 9-phenanthrol [CYP1B1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CTD
PMID:27137136
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
multiple interactions increases abundance
ISO
[CYP2A13 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol CYP2A13 protein results in increased abundance of 9-phenanthrol
CTD
PMID:27137136
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
G
Esr1
estrogen receptor 1
multiple interactions
ISO
9-phenanthrol binds to and results in decreased activity of ESR1 protein
CTD
PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
affects binding multiple interactions
ISO
ESR2 protein binds to 9-phenanthrol 9-phenanthrol inhibits the reaction [ESR2 protein binds to Estradiol]
CTD
PMID:22989670
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Fth1
ferritin heavy chain 1
multiple interactions
ISO
9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of FTH1 mRNA]
CTD
PMID:27246103
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
G
Gcg
glucagon
multiple interactions
EXP
9-phenanthrol inhibits the reaction [[GCG protein co-treated with Glucose] results in increased secretion of INS1 protein]
CTD
PMID:29098165
NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929
G
Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of ICAM1 protein]
CTD
PMID:28214884
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Ins1
insulin 1
multiple interactions increases secretion
EXP
9-phenanthrol inhibits the reaction [[GCG protein co-treated with Glucose] results in increased secretion of INS1 protein]; 9-phenanthrol inhibits the reaction [Glucose results in increased secretion of INS1 protein] 9-phenanthrol results in increased secretion of INS1 protein
CTD
PMID:29098165
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
G
Jag1
jagged canonical Notch ligand 1
decreases expression
ISO
9-phenanthrol results in decreased expression of JAG1 mRNA
CTD
PMID:22989670
NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
G
Nfatc1
nuclear factor of activated T-cells 1
multiple interactions
ISO
9-phenanthrol inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein]
CTD
PMID:27246103
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:27246103
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
9-phenanthrol binds to and affects the activity of NR1I2 protein 9-phenanthrol binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nrip1
nuclear receptor interacting protein 1
increases expression
ISO
9-phenanthrol results in increased expression of NRIP1 mRNA
CTD
PMID:22989670
NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
9-phenanthrol binds to and affects the activity of PPARG protein 9-phenanthrol binds to and results in increased activity of PPARG protein
CTD
PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Scn5a
sodium voltage-gated channel alpha subunit 5
decreases activity
ISO
9-phenanthrol results in decreased activity of SCN5A protein mutant form
CTD
PMID:30153324
NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
G
Sele
selectin E
multiple interactions
ISO
9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of SELE protein]
CTD
PMID:28214884
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
G
Thra
thyroid hormone receptor alpha
multiple interactions
ISO
9-phenanthrol binds to and results in increased activity of THRA protein
CTD
PMID:33049310
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
G
Thrb
thyroid hormone receptor beta
multiple interactions
ISO
9-phenanthrol binds to and results in increased activity of THRB protein
CTD
PMID:33049310
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
G
Trpm4
transient receptor potential cation channel, subfamily M, member 4
multiple interactions decreases activity
ISO
9-phenanthrol inhibits the reaction [Arsenic Trioxide results in increased expression of TRPM4 protein]; 9-phenanthrol inhibits the reaction [Glutamic Acid results in increased activity of TRPM4 protein]; 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased expression of TRPM4 protein] 9-phenanthrol results in decreased activity of TRPM4 protein
CTD
PMID:25047048 PMID:28214884 PMID:31054354 PMID:34335274
NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
G
Trpm5
transient receptor potential cation channel, subfamily M, member 5
decreases activity
ISO
9-phenanthrol results in decreased activity of TRPM5 protein
CTD
PMID:18297105
NCBI chr 1:198,254,956...198,277,824
Ensembl chr 1:198,255,723...198,277,654
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of VCAM1 protein]
CTD
PMID:28214884
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
[acenaphthene co-treated with anthracene co-treated with 1,12-benzoperylene co-treated with 1,2,5,6-dibenzanthracene co-treated with fluorene co-treated with naphthalene co-treated with phenanthrene] results in increased activity of AHR protein; [acenaphthene co-treated with Benzo(a)pyrene] results in increased activity of AHR protein
CTD
PMID:17665671
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases activity multiple interactions
ISO
acenaphthene results in increased activity of CYP1A2 protein [acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA
CTD
PMID:7750161 PMID:8001243
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases oxidation multiple interactions
ISO
CYP1B1 protein results in increased oxidation of acenaphthene [CYP1B1 protein results in increased oxidation of acenaphthene] which results in increased chemical synthesis of acenaphthene-1-ol
CTD
PMID:25642975
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
multiple interactions increases oxidation
ISO
[CYP2A13 protein results in increased oxidation of acenaphthene] which results in increased chemical synthesis of acenaphthene-1-ol
CTD
PMID:25642975
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
acenaphthene results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
decreases activity
ISO
Acenaphthenes analog results in decreased activity of CYP11B2 protein
CTD
PMID:16246562
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
G
Mtnr1a
melatonin receptor 1A
affects binding
ISO
Acenaphthenes analog binds to MTNR1A protein
CTD
PMID:11063602
NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919
G
Mtnr1b
melatonin receptor 1B
affects binding
ISO
Acenaphthenes analog binds to MTNR1B protein
CTD
PMID:11063602
NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
G
Dhrs11
dehydrogenase/reductase 11
increases reduction
ISO
DHRS11 protein results in increased reduction of acenaphthenequinone
CTD
PMID:30926317
NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
acenaphthenequinone affects the localization of and results in increased expression of NFKB1 protein
CTD
PMID:17082565
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
ISO
[acenaphthenequinone results in increased chemical synthesis of Reactive Oxygen Species] which affects the expression of PTGS2 protein; Acetylcysteine inhibits the reaction [acenaphthenequinone results in increased expression of PTGS2 protein]; BAY 11-7085 inhibits the reaction [acenaphthenequinone results in increased expression of PTGS2 protein]
CTD
PMID:17082565
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases expression
ISO
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein]; acenaphthenequinone affects the localization of and results in increased expression of RELA protein; Acetylcysteine inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein]
CTD
PMID:17082565 PMID:17925309
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
acenaphthylene results in increased expression of CYP1A1 mRNA; acenaphthylene results in increased expression of CYP1A1 protein
CTD
PMID:10190573
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression increases oxidation multiple interactions increases activity
ISO
acenaphthylene results in increased expression of CYP1A2 mRNA; acenaphthylene results in increased expression of CYP1A2 protein CYP1A2 protein results in increased oxidation of acenaphthylene [acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA acenaphthylene results in increased activity of CYP1A2 protein
CTD
PMID:7750161 PMID:8001243 PMID:10977129 PMID:25642975
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression increases oxidation
ISO
acenaphthylene results in increased expression of CYP1B1 mRNA CYP1B1 protein results in increased oxidation of acenaphthylene
CTD
PMID:10402558 PMID:25642975
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
increases oxidation
ISO
CYP2A13 protein results in increased oxidation of acenaphthylene; CYP2A13 protein results in increased oxidation of acenaphthylene metabolite
CTD
PMID:25642975
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases oxidation
ISO
CYP3A4 protein results in increased oxidation of acenaphthylene
CTD
PMID:25642975
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
acenaphthylene results in increased cleavage of PARP1 protein
CTD
PMID:21132278
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity multiple interactions
ISO
alizarin results in decreased activity of CYP1A1 protein alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]
CTD
PMID:12379470 PMID:37515497
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
alizarin results in decreased activity of CYP1A2 protein
CTD
PMID:12379470 PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
alizarin results in decreased activity of CYP1B1 protein
CTD
PMID:12379470
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
alizarin results in decreased activity of CYP2E1 protein
CTD
PMID:12379470
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Esr1
estrogen receptor 1
multiple interactions
ISO
alizarin binds to and results in increased activity of ESR1 protein
CTD
PMID:20707409
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
H2ax
H2A.X variant histone
multiple interactions
ISO
alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]
CTD
PMID:37515497
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]
CTD
PMID:33421718
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]
CTD
PMID:33421718
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
multiple interactions
ISO
alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein]
CTD
PMID:33421718
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
G
Nat1
N-acetyltransferase 1
decreases activity
ISO
alizarin results in decreased activity of NAT1 protein
CTD
PMID:34783865
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases glucuronidation
ISO
UGT1A1 protein results in increased glucuronidation of alizarin
CTD
PMID:14557274
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of alizarin
CTD
PMID:14557274
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt2b15
UDP glucuronosyltransferase family 2 member B15
increases metabolic processing
EXP
UGT2B15 protein results in increased metabolism of alizarin
CTD
PMID:7574722
NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
G
Adipoq
adiponectin, C1Q and collagen domain containing
multiple interactions
ISO
aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in decreased expression of ADIPOQ mRNA]
CTD
PMID:22645054
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
G
Akr1b10
aldo-keto reductase family 1 member B10
decreases activity
ISO
aloe emodin results in decreased activity of AKR1B10 protein
CTD
PMID:35065925
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
G
Akr1c3
aldo-keto reductase family 1, member C3
decreases activity
ISO
aloe emodin results in decreased activity of AKR1C3 protein
CTD
PMID:35065925
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
G
Atf3
activating transcription factor 3
increases expression
ISO
aloe emodin results in increased expression of ATF3 mRNA
CTD
PMID:22210228
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
aloe emodin results in increased expression of BAX protein
CTD
PMID:19928967
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
aloe emodin results in decreased expression of BCL2 mRNA; aloe emodin results in decreased expression of BCL2 protein
CTD
PMID:19928967 PMID:22210228
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp3
caspase 3
increases activity multiple interactions increases cleavage increases expression
ISO
aloe emodin results in increased activity of CASP3 protein [Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form] aloe emodin results in increased cleavage of CASP3 protein
CTD
PMID:19928967 PMID:22210228
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
increases activity multiple interactions increases expression
ISO
aloe emodin results in increased activity of CASP8 protein [Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]
CTD
PMID:19928967
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
increases activity increases expression multiple interactions
ISO
aloe emodin results in increased activity of CASP9 protein aloe emodin results in increased expression of CASP9 protein modified form [Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]
CTD
PMID:19928967
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cbr1
carbonyl reductase 1
decreases activity
ISO
aloe emodin results in decreased activity of CBR1 protein
CTD
PMID:35065925
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cycs
cytochrome c, somatic
increases expression
ISO
aloe emodin results in increased expression of CYCS protein
CTD
PMID:19928967
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
aloe emodin results in decreased activity of CYP1A1 protein
CTD
PMID:27633141
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
aloe emodin results in decreased activity of CYP1A2 protein
CTD
PMID:27633141 PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
aloe emodin results in decreased activity of CYP1B1 protein
CTD
PMID:27633141
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions increases chemical synthesis
ISO
[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin CYP2B6 protein results in increased chemical synthesis of aloe emodin
CTD
PMID:29698620
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
aloe emodin results in decreased activity of CYP2C19 protein
CTD
PMID:33438235
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases chemical synthesis multiple interactions
ISO
CYP3A4 protein results in increased chemical synthesis of aloe emodin [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CTD
PMID:29698620
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
aloe emodin results in increased expression of DDIT3 mRNA; aloe emodin results in increased expression of DDIT3 protein
CTD
PMID:22210228
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
increases phosphorylation
ISO
aloe emodin results in increased phosphorylation of EIF2S1 protein
CTD
PMID:22210228
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Fabp4
fatty acid binding protein 4
multiple interactions
ISO
aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of FABP4 mRNA]
CTD
PMID:22645054
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
G
Fadd
Fas associated via death domain
multiple interactions
ISO
aloe emodin results in increased expression of and affects the localization of FADD protein
CTD
PMID:19928967
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
G
Fas
Fas cell surface death receptor
increases expression
ISO
aloe emodin results in increased expression of FAS protein
CTD
PMID:19928967
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
increases expression
ISO
aloe emodin results in increased expression of FASLG protein
CTD
PMID:19928967
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
aloe emodin results in increased expression of HSPA5 mRNA; aloe emodin results in increased expression of HSPA5 protein
CTD
PMID:22210228
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Lpl
lipoprotein lipase
multiple interactions
ISO
aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA]
CTD
PMID:22645054
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Nat1
N-acetyltransferase 1
multiple interactions decreases expression
ISO
aloe emodin results in decreased expression of and results in decreased activity of NAT1 protein aloe emodin results in decreased expression of NAT1 mRNA
CTD
PMID:16314733
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]
CTD
PMID:19352036
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of PPARG mRNA]
CTD
PMID:22645054
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]
CTD
PMID:19352036
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Retn
resistin
multiple interactions
ISO
aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of RETN mRNA]
CTD
PMID:22645054
NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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Sult1a1
sulfotransferase family 1A member 1
decreases activity
ISO
aloe emodin results in decreased activity of SULT1A1 protein
CTD
PMID:27633141
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
G
Sult1e1
sulfotransferase family 1E member 1
decreases activity
ISO
aloe emodin results in decreased activity of SULT1E1 protein
CTD
PMID:27633141
NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
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Tnf
tumor necrosis factor
multiple interactions increases expression
ISO
aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TNF mRNA] aloe emodin results in increased expression of TNF protein
CTD
PMID:19928967 PMID:22645054
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfrsf1a
TNF receptor superfamily member 1A
increases expression
ISO
aloe emodin results in increased expression of TNFRSF1A protein
CTD
PMID:19928967
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
G
Tnfrsf1b
TNF receptor superfamily member 1B
increases expression
ISO
aloe emodin results in increased expression of TNFRSF1B protein
CTD
PMID:19928967
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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Tp53
tumor protein p53
increases expression
ISO
aloe emodin results in increased expression of TP53 protein
CTD
PMID:19928967
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Tradd
TNFRSF1A-associated via death domain
multiple interactions
ISO
aloe emodin results in increased expression of and affects the localization of TRADD protein
CTD
PMID:19928967
NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
G
Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of aloe emodin
CTD
PMID:24854283
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Xbp1
X-box binding protein 1
increases splicing
ISO
aloe emodin results in increased splicing of XBP1 mRNA
CTD
PMID:22210228
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
G
Top2a
DNA topoisomerase II alpha
decreases activity
ISO
altertoxin I results in decreased activity of TOP2A protein
CTD
PMID:27682608
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
G
Aadat
aminoadipate aminotransferase
affects expression
EXP
Amitriptyline affects the expression of AADAT mRNA
CTD
PMID:18355885
NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
G
Abat
4-aminobutyrate aminotransferase
decreases expression
EXP
Amitriptyline results in decreased expression of ABAT mRNA
CTD
PMID:21820738
NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
G
Abcb11
ATP binding cassette subfamily B member 11
decreases expression
EXP
Amitriptyline results in decreased expression of ABCB11 mRNA
CTD
PMID:27765674
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
G
Abcb1a
ATP binding cassette subfamily B member 1A
affects transport increases transport affects expression
ISO EXP
ABCB1A protein affects the transport of Amitriptyline ABCB1A protein results in increased transport of Amitriptyline; ABCB1A protein results in increased transport of Amitriptyline metabolite Amitriptyline affects the expression of ABCB1 mRNA
CTD
PMID:10700657 PMID:12082591 PMID:18355885
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcd2
ATP binding cassette subfamily D member 2
decreases expression
EXP
Amitriptyline results in decreased expression of ABCD2 mRNA
CTD
PMID:22341215
NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
G
Abcg5
ATP binding cassette subfamily G member 5
decreases expression
EXP
Amitriptyline results in decreased expression of ABCG5 mRNA
CTD
PMID:27765674
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
G
Abcg8
ATP binding cassette subfamily G member 8
decreases expression
EXP
Amitriptyline results in decreased expression of ABCG8 mRNA
CTD
PMID:27765674
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
G
Ace2
angiotensin converting enzyme 2
increases expression
ISO
Amitriptyline results in increased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
G
Ache
acetylcholinesterase
decreases expression increases activity
EXP ISO
Amitriptyline results in decreased expression of ACHE mRNA Amitriptyline results in increased activity of ACHE protein
CTD
PMID:21820738 PMID:29614332
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
affects expression
EXP
Amitriptyline affects the expression of ALDH1A1 mRNA
CTD
PMID:18355885
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
G
Ankrd1
ankyrin repeat domain 1
increases expression
EXP
Amitriptyline results in increased expression of ANKRD1 mRNA
CTD
PMID:22341215
NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
G
Ano3
anoctamin 3
decreases expression
EXP
Amitriptyline results in decreased expression of ANO3 mRNA
CTD
PMID:22341215
NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154
G
Ap1s1
adaptor related protein complex 1 subunit sigma 1
decreases expression
ISO
Amitriptyline results in decreased expression of AP1S1 mRNA
CTD
PMID:17175557 PMID:17567588
NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
G
Apoa4
apolipoprotein A4
affects expression
EXP
Amitriptyline affects the expression of APOA4 mRNA
CTD
PMID:18355885
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
G
Arg1
arginase 1
increases expression
EXP
Amitriptyline results in increased expression of ARG1 mRNA
CTD
PMID:22341215
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
G
Asah1
N-acylsphingosine amidohydrolase 1
increases expression
ISO
Amitriptyline results in increased expression of ASAH1 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
G
Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Amitriptyline results in increased expression of ASNS mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
G
Atf3
activating transcription factor 3
increases expression
EXP
Amitriptyline results in increased expression of ATF3 mRNA
CTD
PMID:22341215
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]
CTD
PMID:19135049
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
CTD
PMID:19135049
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bhmt
betaine-homocysteine S-methyltransferase
affects expression
EXP
Amitriptyline affects the expression of BHMT mRNA
CTD
PMID:18355885
NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
G
C1qa
complement C1q A chain
increases expression
EXP
Amitriptyline results in increased expression of C1QA mRNA
CTD
PMID:22341215
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
G
C1qc
complement C1q C chain
increases expression
EXP
Amitriptyline results in increased expression of C1QC mRNA
CTD
PMID:22341215
NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
G
Cacna2d1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
increases expression
EXP
Amitriptyline results in increased expression of CACNA2D1 mRNA
CTD
PMID:22341215
NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
G
Casp1
caspase 1
multiple interactions
ISO
Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein]
CTD
PMID:28633109
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Casp3
caspase 3
multiple interactions increases expression increases activity
EXP
Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] Amitriptyline results in increased expression of CASP3 mRNA Amitriptyline results in increased activity of CASP3 protein
CTD
PMID:16717317 PMID:19135049 PMID:19815060
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casr
calcium-sensing receptor
decreases expression
EXP
Amitriptyline results in decreased expression of CASR mRNA
CTD
PMID:22341215
NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
G
Cat
catalase
decreases expression
ISO
Amitriptyline results in decreased expression of CAT protein
CTD
PMID:1937386
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Cd74
CD74 molecule
increases expression
EXP
Amitriptyline results in increased expression of CD74 mRNA
CTD
PMID:22341215
NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
G
Cdkn2c
cyclin-dependent kinase inhibitor 2C
affects expression
EXP
Amitriptyline affects the expression of CDKN2C mRNA
CTD
PMID:18355885
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
G
Ces2h
carboxylesterase 2H
affects expression
EXP
Amitriptyline affects the expression of CES2 mRNA
CTD
PMID:18355885
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
G
Chat
choline O-acetyltransferase
increases expression
EXP
Amitriptyline results in increased expression of CHAT mRNA
CTD
PMID:21820738
NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
G
Chrna3
cholinergic receptor nicotinic alpha 3 subunit
decreases expression
EXP
Amitriptyline results in decreased expression of CHRNA3 mRNA
CTD
PMID:22341215
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
G
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
decreases expression increases response to substance
EXP ISO
Amitriptyline results in decreased expression of CHRNB2 mRNA CHRNB2 protein results in increased susceptibility to Amitriptyline
CTD
PMID:21820738 PMID:21905669
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
G
Cmtm6
CKLF-like MARVEL transmembrane domain containing 6
affects expression
EXP
Amitriptyline affects the expression of CMTM6 mRNA
CTD
PMID:18355885
NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033
G
Cpne4
copine 4
decreases expression
EXP
Amitriptyline results in decreased expression of CPNE4 mRNA
CTD
PMID:22341215
NCBI chr 8:105,177,376...105,653,075
Ensembl chr 8:105,177,376...105,653,068
G
Cpped1
calcineurin-like phosphoesterase domain containing 1
affects expression
EXP
Amitriptyline affects the expression of CPPED1 mRNA
CTD
PMID:18355885
NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054
G
Crem
cAMP responsive element modulator
affects expression
EXP
Amitriptyline affects the expression of CREM mRNA
CTD
PMID:18355885
NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
G
Csrp3
cysteine and glycine rich protein 3
increases expression
EXP
Amitriptyline results in increased expression of CSRP3 mRNA
CTD
PMID:22341215
NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
G
Cybb
cytochrome b-245 beta chain
multiple interactions
ISO
Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]; Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein]
CTD
PMID:28633109
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases metabolic processing multiple interactions
ISO
Amitriptyline results in increased metabolism of CYP1A2 protein; CYP1A2 protein results in increased metabolism of Amitriptyline [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CTD
PMID:18359012 PMID:23397584 PMID:27320963
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
affects expression
EXP
Amitriptyline affects the expression of CYP2A1 mRNA
CTD
PMID:18355885
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Amitriptyline results in increased expression of CYP2B1 mRNA
CTD
PMID:10945841
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2b15
cytochrome P450, family 2, subfamily b, polypeptide 15
affects expression
EXP
Amitriptyline affects the expression of CYP2B15 mRNA
CTD
PMID:18355885
NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
G
Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
Amitriptyline results in increased expression of CYP2B2 mRNA
CTD
PMID:10945841
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases metabolic processing
ISO
CYP2B6 protein results in increased metabolism of Amitriptyline
CTD
PMID:27320963
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions increases metabolic processing
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline CYP2C19 protein results in increased metabolism of Amitriptyline
CTD
PMID:23397584 PMID:27320963
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity multiple interactions increases metabolic processing
ISO
Amitriptyline results in decreased activity of CYP2D6 protein [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline Amitriptyline results in increased metabolism of CYP2D6 protein; CYP2D6 protein results in increased metabolism of Amitriptyline
CTD
PMID:16044105 PMID:18359012 PMID:18359183 PMID:23397584 PMID:27320963
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases metabolic processing multiple interactions
ISO
Amitriptyline results in increased metabolism of CYP3A4 protein [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CTD
PMID:18359012 PMID:23397584
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression affects expression
EXP
Amitriptyline results in increased expression of CYP3A23-3A1 mRNA Amitriptyline affects the expression of CYP3A23-3A1 mRNA
CTD
PMID:10945841 PMID:18355885
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases metabolic processing
ISO
Amitriptyline results in increased metabolism of CYP3A5 protein
CTD
PMID:18359012
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp4f4
cytochrome P450, family 4, subfamily f, polypeptide 4
affects expression
EXP
Amitriptyline affects the expression of CYP4F2 mRNA
CTD
PMID:18355885
NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506
G
Dcaf8
DDB1 and CUL4 associated factor 8
affects expression
EXP
Amitriptyline affects the expression of DCAF8 mRNA
CTD
PMID:18355885
NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726
G
Depp1
DEPP autophagy regulator 1
increases expression
ISO
Amitriptyline results in increased expression of DEPP1 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Des
desmin
multiple interactions
ISO
Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein]
CTD
PMID:23024785
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
G
Dnmt1
DNA methyltransferase 1
decreases activity
EXP
Amitriptyline results in decreased activity of DNMT1 protein Amitriptyline decreases activity of Dnmt1 protein in astrocyte nucleus
CTD RGD
PMID:19924110 PMID:22880885
RGD:9588218
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Drd1
dopamine receptor D1
increases expression
EXP
Amitriptyline results in increased expression of DRD1 mRNA
CTD
PMID:16499906
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Drd3
dopamine receptor D3
increases expression
EXP
Amitriptyline results in increased expression of DRD3 mRNA
CTD
PMID:21820738
NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
G
Ecel1
endothelin converting enzyme-like 1
increases expression
EXP
Amitriptyline results in increased expression of ECEL1 mRNA
CTD
PMID:22341215
NCBI chr 9:87,819,516...87,829,154
Ensembl chr 9:87,816,718...87,826,675
G
Eif4b
eukaryotic translation initiation factor 4B
affects expression
EXP
Amitriptyline affects the expression of EIF4B mRNA
CTD
PMID:18355885
NCBI chr 7:133,206,637...133,228,436
G
Ephx1
epoxide hydrolase 1
affects expression
EXP
Amitriptyline affects the expression of EPHX1 mRNA
CTD
PMID:18355885
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
G
Erp29
endoplasmic reticulum protein 29
affects expression
EXP
Amitriptyline affects the expression of ERP29 mRNA
CTD
PMID:18355885
NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
G
Fabp1
fatty acid binding protein 1
increases expression
ISO
Amitriptyline results in increased expression of FABP1 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
G
Flrt3
fibronectin leucine rich transmembrane protein 3
increases expression
EXP
Amitriptyline results in increased expression of FLRT3 mRNA
CTD
PMID:22341215
NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841
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Fmo3
flavin containing dimethylaniline monoxygenase 3
increases metabolic processing
ISO
FMO3 protein results in increased metabolism of Amitriptyline
CTD
PMID:27320963
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
G
Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Amitriptyline results in increased expression of FNDC4 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
increases expression decreases expression
EXP
Amitriptyline results in increased expression of GABRA1 mRNA Amitriptyline results in decreased expression of GABRA1 mRNA
CTD
PMID:21820738 PMID:22341215
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
G
Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
increases expression
EXP
Amitriptyline results in increased expression of GABRA2 mRNA
CTD
PMID:21820738
NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
G
Gabra4
gamma-aminobutyric acid type A receptor subunit alpha 4
increases expression
EXP
Amitriptyline results in increased expression of GABRA4 mRNA
CTD
PMID:21820738
NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
G
Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
increases expression
EXP
Amitriptyline results in increased expression of GABRB3 mRNA
CTD
PMID:21820738
NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
EXP
Amitriptyline results in increased expression of GADD45A mRNA
CTD
PMID:22341215
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gal
galanin and GMAP prepropeptide
increases expression
EXP
Amitriptyline results in increased expression of GAL mRNA
CTD
PMID:22341215
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
G
Gckr
glucokinase regulator
affects expression
EXP
Amitriptyline affects the expression of GCKR mRNA
CTD
PMID:18355885
NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
G
Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression
ISO
Amitriptyline results in increased expression of GDPD3 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
G
Gfap
glial fibrillary acidic protein
increases expression
EXP
Amitriptyline results in increased expression of GFAP mRNA
CTD
PMID:22954530
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Gls2
glutaminase 2
affects expression
EXP
Amitriptyline affects the expression of GLS2 mRNA
CTD
PMID:18355885
NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426
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Got2
glutamic-oxaloacetic transaminase 2
affects expression
EXP
Amitriptyline affects the expression of GOT2 mRNA
CTD
PMID:18355885
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
G
Grb14
growth factor receptor bound protein 14
affects expression
EXP
Amitriptyline affects the expression of GRB14 mRNA
CTD
PMID:18355885
NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
G
Grik1
glutamate ionotropic receptor kainate type subunit 1
decreases expression
EXP
Amitriptyline results in decreased expression of GRIK1 mRNA
CTD
PMID:22341215
NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
G
Gstp1
glutathione S-transferase pi 1
decreases activity
ISO
Amitriptyline results in decreased activity of GSTP1 protein
CTD
PMID:15094841
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Hal
histidine ammonia lyase
affects expression
EXP
Amitriptyline affects the expression of HAL mRNA
CTD
PMID:18355885
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
G
Hmgb2
high mobility group box 2
affects expression
EXP
Amitriptyline affects the expression of HMGB2 mRNA
CTD
PMID:18355885
NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
Amitriptyline results in increased expression of HMGCS1 mRNA
CTD
PMID:16324787
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
G
Hoxd1
homeo box D1
decreases expression
EXP
Amitriptyline results in decreased expression of HOXD1 mRNA
CTD
PMID:22341215
NCBI chr 3:59,665,629...59,667,769
Ensembl chr 3:59,665,629...59,667,769
G
Hpn
hepsin
increases expression
ISO
Amitriptyline results in increased expression of HPN mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
G
Hpse
heparanase
decreases expression
EXP
Amitriptyline results in decreased expression of HPSE mRNA
CTD
PMID:22341215
NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
G
Hs3st2
heparan sulfate-glucosamine 3-sulfotransferase 2
decreases expression
EXP
Amitriptyline results in decreased expression of HS3ST2 mRNA
CTD
PMID:22341215
NCBI chr 1:175,956,161...176,077,400
Ensembl chr 1:175,956,157...176,077,399
G
Htr1a
5-hydroxytryptamine receptor 1A
increases expression
EXP
Amitriptyline results in increased expression of HTR1A protein
CTD
PMID:1589591
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
G
Htr1d
5-hydroxytryptamine receptor 1D
decreases expression
EXP
Amitriptyline results in decreased expression of HTR1D mRNA
CTD
PMID:22341215
NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619
G
Htr2c
5-hydroxytryptamine receptor 2C
affects binding
ISO
Amitriptyline binds to HTR2C protein
CTD
PMID:18083778
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
G
Il1b
interleukin 1 beta
multiple interactions
ISO
Amitriptyline inhibits the reaction [7-ketocholesterol results in increased expression of IL1B protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased expression of IL1B protein]
CTD
PMID:28633109
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il33
interleukin 33
affects expression
EXP
Amitriptyline affects the expression of IL33 mRNA
CTD
PMID:18355885
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
G
Inhbe
inhibin subunit beta E
increases expression
ISO
Amitriptyline results in increased expression of INHBE mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
G
Itgb6
integrin subunit beta 6
decreases expression
EXP
Amitriptyline results in decreased expression of ITGB6 mRNA
CTD
PMID:22341215
NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
G
Kcna4
potassium voltage-gated channel subfamily A member 4
decreases expression
EXP
Amitriptyline results in decreased expression of KCNA4 mRNA
CTD
PMID:22341215
NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions
ISO
Amitriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD
PMID:19583963 PMID:21158687
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kcnn2
potassium calcium-activated channel subfamily N member 2
decreases activity
EXP
Amitriptyline results in decreased activity of KCNN2 protein
CTD
PMID:10915830
NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
G
Kcns1
potassium voltage-gated channel, modifier subfamily S, member 1
decreases expression
EXP
Amitriptyline results in decreased expression of KCNS1 mRNA
CTD
PMID:22341215
NCBI chr 3:152,835,642...152,843,032
Ensembl chr 3:152,835,644...152,842,960
G
Kcns3
potassium voltage-gated channel, modifier subfamily S, member 3
decreases expression
EXP
Amitriptyline results in decreased expression of KCNS3 mRNA
CTD
PMID:22341215
NCBI chr 6:33,808,314...33,865,018
Ensembl chr 6:33,808,216...33,865,125
G
Lox
lysyl oxidase
affects expression
EXP
Amitriptyline affects the expression of LOX mRNA
CTD
PMID:18355885
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
G
Lss
lanosterol synthase
increases expression
ISO
Amitriptyline results in increased expression of LSS mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
G
Macroh2a1
macroH2A.1 histone
affects expression
EXP
Amitriptyline affects the expression of MACROH2A1 mRNA
CTD
PMID:18355885
NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072
G
Manba
mannosidase beta
affects expression
EXP
Amitriptyline affects the expression of MANBA mRNA
CTD
PMID:18355885
NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983
G
Maoa
monoamine oxidase A
affects expression
EXP
Amitriptyline affects the expression of MAOA mRNA
CTD
PMID:21820738
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
G
Mlx
MAX dimerization protein MLX
affects expression
EXP
Amitriptyline affects the expression of MLX mRNA
CTD
PMID:18355885
NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350
G
Mmp16
matrix metallopeptidase 16
increases expression
EXP
Amitriptyline results in increased expression of MMP16 mRNA
CTD
PMID:22341215
NCBI chr 5:31,312,280...31,556,276
Ensembl chr 5:31,312,280...31,548,388
G
Mrps18b
mitochondrial ribosomal protein S18B
affects expression
EXP
Amitriptyline affects the expression of MRPS18B mRNA
CTD
PMID:18355885
NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260
G
Msmo1
methylsterol monooxygenase 1
affects expression
EXP
Amitriptyline affects the expression of MSMO1 mRNA
CTD
PMID:18355885
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
G
Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein]
CTD
PMID:28633109
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
G
Nmb
neuromedin B
decreases expression
EXP
Amitriptyline results in decreased expression of NMB mRNA
CTD
PMID:22341215
NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190
G
Nmur1
neuromedin U receptor 1
decreases expression
EXP
Amitriptyline results in decreased expression of NMUR1 mRNA
CTD
PMID:21820738
NCBI chr 9:87,033,231...87,038,070
Ensembl chr 9:87,033,279...87,036,684
G
Nog
noggin
decreases expression
EXP
Amitriptyline results in decreased expression of NOG mRNA
CTD
PMID:22341215
NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
G
Nphs2
NPHS2 stomatin family member, podocin
multiple interactions
ISO
Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]
CTD
PMID:23024785
NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
G
Npy
neuropeptide Y
increases expression
EXP
Amitriptyline results in increased expression of NPY mRNA
CTD
PMID:22341215
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Npy5r
neuropeptide Y receptor Y5
increases expression
EXP
Amitriptyline results in increased expression of NPY5R mRNA
CTD
PMID:21820738
NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382
G
Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Amitriptyline results in increased expression of NR0B2 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects response to substance
ISO
NR3C1 protein affects the susceptibility to Amitriptyline
CTD
PMID:11226678
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Nr3c2
nuclear receptor subfamily 3, group C, member 2
increases expression
EXP
Amitriptyline results in increased expression of NR3C2 mRNA
CTD
PMID:12393271
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
G
Nrep
neuronal regeneration related protein
affects expression
EXP
Amitriptyline affects the expression of NREP mRNA
CTD
PMID:18355885
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
G
Ntng1
netrin G1
decreases expression
EXP
Amitriptyline results in decreased expression of NTNG1 mRNA
CTD
PMID:22341215
NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997
G
Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Amitriptyline results in increased expression of NUPR1 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
G
Oaf
out at first homolog
affects expression
EXP
Amitriptyline affects the expression of OAF mRNA
CTD
PMID:18355885
NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
G
Patj
PATJ, crumbs cell polarity complex component
decreases expression
EXP
Amitriptyline results in decreased expression of PATJ mRNA
CTD
PMID:22341215
NCBI chr 5:113,061,985...113,364,807
Ensembl chr 5:113,062,118...113,364,807
G
Pc
pyruvate carboxylase
affects expression
EXP
Amitriptyline affects the expression of PC mRNA
CTD
PMID:18355885
NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
G
Pecr
peroxisomal trans-2-enoyl-CoA reductase
affects expression
EXP
Amitriptyline affects the expression of PECR mRNA
CTD
PMID:18355885
NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
G
Phyh
phytanoyl-CoA 2-hydroxylase
increases expression
ISO
Amitriptyline results in increased expression of PHYH mRNA
CTD
PMID:15342952
NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
G
Plcd4
phospholipase C, delta 4
decreases expression
EXP
Amitriptyline results in decreased expression of PLCD4 mRNA
CTD
PMID:22341215
NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
G
Plpp4
phospholipid phosphatase 4
decreases expression
EXP
Amitriptyline results in decreased expression of PLPP4 mRNA
CTD
PMID:22341215
NCBI chr 1:183,829,794...183,959,319
Ensembl chr 1:183,830,409...183,959,319
G
Por
cytochrome p450 oxidoreductase
affects expression
EXP
Amitriptyline affects the expression of POR mRNA
CTD
PMID:18355885
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Prokr1
prokineticin receptor 1
decreases expression
EXP
Amitriptyline results in decreased expression of PROKR1 mRNA
CTD
PMID:21820738
NCBI chr 4:120,022,301...120,033,367
Ensembl chr 4:120,021,747...120,033,379
G
Pycard
PYD and CARD domain containing
multiple interactions
ISO
Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein]
CTD
PMID:28633109
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
G
Rasd1
ras related dexamethasone induced 1
increases expression
EXP
Amitriptyline results in increased expression of RASD1 mRNA
CTD
PMID:22341215
NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186
G
Rbl2
RB transcriptional corepressor like 2
affects expression
EXP
Amitriptyline affects the expression of RBL2 mRNA
CTD
PMID:18355885
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
G
Reg3b
regenerating family member 3 beta
increases expression
EXP
Amitriptyline results in increased expression of REG3B mRNA
CTD
PMID:22341215
NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
G
Rnf112
ring finger protein 112
decreases expression
EXP
Amitriptyline results in decreased expression of RNF112 mRNA
CTD
PMID:22341215
NCBI chr10:46,121,146...46,126,691
Ensembl chr10:46,121,148...46,126,699
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RT1-Da
RT1 class II, locus Da
increases expression
EXP
Amitriptyline results in increased expression of RT1-DA mRNA
CTD
PMID:22341215
NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
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RT1-Db1
RT1 class II, locus Db1
increases expression
EXP
Amitriptyline results in increased expression of RT1-DB1 mRNA
CTD
PMID:22341215
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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RT1-S3
RT1 class Ib, locus S3
affects expression
EXP
Amitriptyline affects the expression of RT1-S3 mRNA
CTD
PMID:18355885
NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
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Scd
stearoyl-CoA desaturase
increases expression
ISO
Amitriptyline results in increased expression of SCD mRNA
CTD
PMID:16324787
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Scn11a
sodium voltage-gated channel alpha subunit 11
decreases expression
EXP
Amitriptyline results in decreased expression of SCN11A mRNA
CTD
PMID:22341215
NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044
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Sema6a
semaphorin 6A
increases expression
EXP
Amitriptyline results in increased expression of SEMA6A mRNA
CTD
PMID:22341215
NCBI chr18:40,050,623...40,171,954
Ensembl chr18:40,050,624...40,171,954
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Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
increases expression
ISO
Amitriptyline results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Sh3gl3
SH3 domain containing GRB2 like 3, endophilin A3
affects expression
EXP
Amitriptyline affects the expression of SH3GL3 mRNA
CTD
PMID:18355885
NCBI chr 1:136,124,500...136,255,669
Ensembl chr 1:136,124,499...136,255,584
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Slc22a1
solute carrier family 22 member 1
multiple interactions decreases activity
ISO
Amitriptyline inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] Amitriptyline results in decreased activity of SLC22A1 protein
CTD
PMID:30189235 PMID:31364238
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a2
solute carrier family 22 member 2
multiple interactions decreases activity
ISO
Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] Amitriptyline results in decreased activity of SLC22A2 protein
CTD
PMID:21599003 PMID:23770354 PMID:28629854 PMID:30189235 PMID:31364238
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a6
solute carrier family 22 member 6
multiple interactions
ISO
Amitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD
PMID:21561794
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
Amitriptyline results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium]
CTD
PMID:28629854
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Slc6a6
solute carrier family 6 member 6
affects expression
EXP
Amitriptyline affects the expression of SLC6A6 mRNA
CTD
PMID:18355885
NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
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Slco1a4
solute carrier organic anion transporter family, member 1a4
affects expression
EXP
Amitriptyline affects the expression of SLCO1A4 mRNA
CTD
PMID:18355885
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Smagp
small cell adhesion glycoprotein
increases expression
EXP
Amitriptyline results in increased expression of SMAGP mRNA
CTD
PMID:22341215
NCBI chr 7:131,720,260...131,738,711
Ensembl chr 7:131,718,740...131,738,691
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Smpd1
sphingomyelin phosphodiesterase 1
multiple interactions increases response to substance decreases activity
ISO
[Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein] which results in decreased abundance of Ceramides; Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein SMPD1 protein results in increased susceptibility to Amitriptyline Amitriptyline results in decreased activity of SMPD1 protein
CTD
PMID:23770692
NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
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Sod1
superoxide dismutase 1
increases expression
EXP
Amitriptyline results in increased expression of SOD1 mRNA
CTD
PMID:10721683
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sorl1
sortilin related receptor 1
decreases expression
EXP
Amitriptyline results in decreased expression of SORL1 mRNA
CTD
PMID:22341215
NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
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Sox11
SRY-box transcription factor 11
increases expression
EXP
Amitriptyline results in increased expression of SOX11 mRNA
CTD
PMID:22341215
NCBI chr 6:44,008,333...44,010,354
Ensembl chr 6:44,008,340...44,010,354
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Sprr1a
small proline-rich protein 1A
increases expression
EXP
Amitriptyline results in increased expression of SPRR1A mRNA
CTD
PMID:22341215
NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063
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Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
ISO
Amitriptyline results in increased cleavage of and results in increased activity of SREBF1 protein
CTD
PMID:16324787
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions
ISO
Amitriptyline results in increased cleavage of and results in increased activity of SREBF2 protein
CTD
PMID:16324787
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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Sstr1
somatostatin receptor 1
decreases expression
EXP
Amitriptyline results in decreased expression of SSTR1 mRNA
CTD
PMID:21820738
NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802
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St13
ST13, Hsp70 interacting protein
affects expression
EXP
Amitriptyline affects the expression of ST13 mRNA
CTD
PMID:18355885
NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945
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Stac2
SH3 and cysteine rich domain 2
increases expression
EXP
Amitriptyline results in increased expression of STAC2 mRNA
CTD
PMID:22341215
NCBI chr10:83,032,418...83,048,260
Ensembl chr10:83,032,417...83,048,260
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Stbd1
starch binding domain 1
affects expression
EXP
Amitriptyline affects the expression of STBD1 mRNA
CTD
PMID:18355885
NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443
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Stmn1
stathmin 1
affects expression
EXP
Amitriptyline affects the expression of STMN1 mRNA
CTD
PMID:18355885
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
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Stmn4
stathmin 4
increases expression
EXP
Amitriptyline results in increased expression of STMN4 mRNA
CTD
PMID:22341215
NCBI chr15:40,541,305...40,559,253
Ensembl chr15:40,541,357...40,559,253
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Tagln
transgelin
decreases expression
ISO
Amitriptyline results in decreased expression of TAGLN mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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Tex261
testis expressed 261
affects expression
EXP
Amitriptyline affects the expression of TEX261 mRNA
CTD
PMID:18355885
NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253
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Tgm1
transglutaminase 1
increases expression
EXP
Amitriptyline results in increased expression of TGM1 mRNA
CTD
PMID:22341215
NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523
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Timm10b
translocase of inner mitochondrial membrane 10B
affects expression
EXP
Amitriptyline affects the expression of TIMM10B mRNA
CTD
PMID:18355885
NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642
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Trh
thyrotropin releasing hormone
multiple interactions
ISO
Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein]
CTD
PMID:6455462
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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Trpv1
transient receptor potential cation channel, subfamily V, member 1
multiple interactions
EXP
Amitriptyline inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]
CTD
PMID:23264033
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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Tshb
thyroid stimulating hormone subunit beta
multiple interactions
ISO
Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein]
CTD
PMID:6455462
NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
affects expression
EXP
Amitriptyline affects the expression of UBA52 mRNA
CTD
PMID:18355885
NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
affects expression
EXP
Amitriptyline affects the expression of UGT1A1 mRNA
CTD
PMID:18355885
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2a1
UDP glucuronosyltransferase family 2 member A1
affects expression
EXP
Amitriptyline affects the expression of UGT2A1 mRNA
CTD
PMID:18355885
NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
affects expression
EXP
Amitriptyline affects the expression of UGT2B1 mRNA
CTD
PMID:18355885
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]
CTD
PMID:23024785
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Amitriptyline results in increased expression of WIPI1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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Adam8
ADAM metallopeptidase domain 8
increases expression
EXP
2-anthramine results in increased expression of ADAM8 mRNA
CTD
PMID:23038007
NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
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Aen
apoptosis enhancing nuclease
increases expression
EXP
2-anthramine results in increased expression of AEN mRNA
CTD
PMID:23038007
NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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Alb
albumin
decreases expression
EXP
2-anthramine results in decreased expression of ALB protein
CTD
PMID:31714650
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
2-anthramine results in increased expression of ALDH1A1 mRNA
CTD
PMID:23038007
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Anxa1
annexin A1
increases expression
EXP
2-anthramine results in increased expression of ANXA1 mRNA
CTD
PMID:23038007
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Ar
androgen receptor
multiple interactions
ISO
2-anthramine inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD
PMID:18324785
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atp6v1d
ATPase H+ transporting V1 subunit D
increases expression
EXP
2-anthramine results in increased expression of ATP6V1D mRNA
CTD
PMID:23038007
NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303
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Car2
carbonic anhydrase 2
increases expression
EXP
2-anthramine results in increased expression of CAR2 mRNA
CTD
PMID:23038007
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Ccng1
cyclin G1
increases expression
EXP
2-anthramine results in increased expression of CCNG1 mRNA
CTD
PMID:23038007
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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Cd46
CD46 molecule
increases expression
EXP
2-anthramine results in increased expression of CD46 mRNA
CTD
PMID:23038007
NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
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Cd93
CD93 molecule
increases expression
EXP
2-anthramine results in increased expression of CD93 mRNA
CTD
PMID:23038007
NCBI chr 3:135,891,859...135,898,378
Ensembl chr 3:135,891,859...135,898,378
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Cdh13
cadherin 13
increases expression
EXP
2-anthramine results in increased expression of CDH13 mRNA
CTD
PMID:23038007
NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
EXP
2-anthramine results in increased expression of CDKN1A mRNA
CTD
PMID:23038007
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1c
cyclin-dependent kinase inhibitor 1C
increases expression
EXP
2-anthramine results in increased expression of CDKN1C mRNA
CTD
PMID:23038007
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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Cyb5a
cytochrome b5 type A
multiple interactions
ISO
CYB5A protein promotes the reaction [CYP1A2 protein results in increased activity of 2-anthramine]
CTD
PMID:15728263
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions affects metabolic processing increases activity
ISO
CYB5A protein promotes the reaction [CYP1A2 protein results in increased activity of 2-anthramine] CYP1A2 protein affects the metabolism of 2-anthramine
CTD
PMID:2655891 PMID:15728263
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp4a8
cytochrome P450, family 4, subfamily a, polypeptide 8
decreases expression
EXP
2-anthramine results in decreased expression of CYP4A8 mRNA
CTD
PMID:23038007
NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
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Dcn
decorin
increases expression
EXP
2-anthramine results in increased expression of DCN mRNA
CTD
PMID:23038007
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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Ddit4
DNA-damage-inducible transcript 4
increases expression
EXP
2-anthramine results in increased expression of DDIT4 mRNA
CTD
PMID:23038007
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Dmbt1
deleted in malignant brain tumors 1
increases expression
EXP
2-anthramine results in increased expression of DMBT1 mRNA
CTD
PMID:23038007
NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
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Dph3
diphthamide biosynthesis 3
increases expression
EXP
2-anthramine results in increased expression of DPH3 mRNA
CTD
PMID:23038007
NCBI chr16:7,288,295...7,293,734
Ensembl chr16:7,282,705...7,291,265
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Fabp1
fatty acid binding protein 1
increases expression
EXP
2-anthramine results in increased expression of FABP1 mRNA
CTD
PMID:31714650
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fabp4
fatty acid binding protein 4
increases expression
EXP
2-anthramine results in increased expression of FABP4 mRNA
CTD
PMID:23038007
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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Fas
Fas cell surface death receptor
increases expression
EXP
2-anthramine results in increased expression of FAS mRNA
CTD
PMID:23038007
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G6pc1
glucose-6-phosphatase catalytic subunit 1
increases expression
EXP
2-anthramine results in increased expression of G6PC1 mRNA
CTD
PMID:23038007
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Gck
glucokinase
increases expression
EXP
2-anthramine results in increased expression of GCK mRNA
CTD
PMID:23038007
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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Gria3
glutamate ionotropic receptor AMPA type subunit 3
increases expression
EXP
2-anthramine results in increased expression of GRIA3 mRNA
CTD
PMID:23038007
NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096
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Gsta5
glutathione S-transferase alpha 5
increases expression
EXP
2-anthramine results in increased expression of GSTA5 mRNA
CTD
PMID:23038007
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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Havcr1
hepatitis A virus cellular receptor 1
increases expression
EXP
2-anthramine results in increased expression of HAVCR1 mRNA
CTD
PMID:31714650
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Hif1a
hypoxia inducible factor 1 subunit alpha
increases activity
ISO
2-anthramine results in increased activity of HIF1A protein
CTD
PMID:19502547
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Ifng
interferon gamma
multiple interactions
ISO
[2-anthramine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD
PMID:29594315
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Igfbp2
insulin-like growth factor binding protein 2
increases expression
EXP
2-anthramine results in increased expression of IGFBP2 mRNA
CTD
PMID:23038007
NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
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Il1b
interleukin 1 beta
decreases expression increases expression
ISO EXP
2-anthramine results in decreased expression of IL1B mRNA 2-anthramine results in increased expression of IL1B mRNA
CTD
PMID:29594315 PMID:31714650
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
multiple interactions
ISO
[2-anthramine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:29594315
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il7
interleukin 7
increases expression
EXP
2-anthramine results in increased expression of IL7 mRNA
CTD
PMID:31714650
NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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Jam3
junctional adhesion molecule 3
increases expression
EXP
2-anthramine results in increased expression of JAM3 mRNA
CTD
PMID:23038007
NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355
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Lama5
laminin subunit alpha 5
increases expression
EXP
2-anthramine results in increased expression of LAMA5 mRNA
CTD
PMID:23038007
NCBI chr 3:167,270,296...167,318,370
Ensembl chr 3:167,270,296...167,318,451
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Mgmt
O-6-methylguanine-DNA methyltransferase
increases expression
EXP
2-anthramine results in increased expression of MGMT mRNA
CTD
PMID:23038007
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Mmd2
monocyte to macrophage differentiation-associated 2
decreases expression
EXP
2-anthramine results in decreased expression of MMD2 mRNA
CTD
PMID:23038007
NCBI chr12:11,962,733...12,009,776
Ensembl chr12:11,962,757...12,009,773
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Nhej1
nonhomologous end-joining factor 1
increases expression
EXP
2-anthramine results in increased expression of NHEJ1 mRNA
CTD
PMID:23038007
NCBI chr 9:76,526,322...76,622,488
Ensembl chr 9:76,526,324...76,622,444
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Nrcam
neuronal cell adhesion molecule
increases expression
EXP
2-anthramine results in increased expression of NRCAM mRNA
CTD
PMID:23038007
NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
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Pln
phospholamban
increases expression
EXP
2-anthramine results in increased expression of PLN mRNA
CTD
PMID:23038007
NCBI chr20:32,629,537...32,639,559
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Rbp7
retinol binding protein 7
increases expression
EXP
2-anthramine results in increased expression of RBP7 mRNA
CTD
PMID:23038007
NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339
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Sgcb
sarcoglycan, beta
increases expression
EXP
2-anthramine results in increased expression of SGCB mRNA
CTD
PMID:23038007
NCBI chr14:34,563,614...34,578,614
Ensembl chr14:34,563,608...34,578,583
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Slc25a37
solute carrier family 25 member 37
increases expression
EXP
2-anthramine results in increased expression of SLC25A37 mRNA
CTD
PMID:23038007
NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
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Sox4
SRY-box transcription factor 4
increases expression
EXP
2-anthramine results in increased expression of SOX4 mRNA
CTD
PMID:23038007
NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665
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Spp1
secreted phosphoprotein 1
increases expression
EXP
2-anthramine results in increased expression of SPP1 mRNA
CTD
PMID:31714650
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Thyn1
thymocyte nuclear protein 1
increases expression
EXP
2-anthramine results in increased expression of THYN1 mRNA
CTD
PMID:23038007
NCBI chr 8:25,406,563...25,415,445
Ensembl chr 8:25,406,500...25,415,445
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Tnfrsf9
TNF receptor superfamily member 9
increases expression
EXP
2-anthramine results in increased expression of TNFRSF9 mRNA
CTD
PMID:23038007
NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
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Vxn
vexin
increases expression
EXP
2-anthramine results in increased expression of VXN mRNA
CTD
PMID:23038007
NCBI chr 5:9,659,213...9,684,684
Ensembl chr 5:9,659,213...9,684,684
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Acp2
acid phosphatase 2, lysosomal
multiple interactions affects expression
ISO
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of ACP2 protein anthracene affects the expression of ACP2 protein
CTD
PMID:28803881
NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680
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Ahr
aryl hydrocarbon receptor
multiple interactions affects binding increases activity affects localization
ISO EXP
2-oxohexyl isothiocyanate inhibits the reaction [anthracene affects the localization of AHR protein]; [acenaphthene co-treated with anthracene co-treated with 1,12-benzoperylene co-treated with 1,2,5,6-dibenzanthracene co-treated with fluorene co-treated with naphthalene co-treated with phenanthrene] results in increased activity of AHR protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; alyssin inhibits the reaction [anthracene affects the localization of AHR protein]; sulforaphane affects the reaction [anthracene affects the localization of AHR protein] anthracene binds to AHR protein anthracene results in increased activity of AHR protein
CTD
PMID:3024361 PMID:17665671 PMID:19362136 PMID:28710019 PMID:30980910
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ahrr
aryl-hydrocarbon receptor repressor
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHRR protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]
CTD
PMID:28710019 PMID:30980910
NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
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Ar
androgen receptor
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; anthracene inhibits the reaction [Androgens results in increased activity of AR protein]; anthracene inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD
PMID:18324785 PMID:28377212 PMID:30980910
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arnt
aryl hydrocarbon receptor nuclear translocator
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA
CTD
PMID:28710019
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions affects expression
ISO
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of BAX protein anthracene affects the expression of BAX protein
CTD
PMID:28803881
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Casp3
caspase 3
increases expression multiple interactions
ISO
anthracene results in increased expression of CASP3 protein [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CASP3 protein
CTD
PMID:28803881
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ccna2
cyclin A2
decreases expression multiple interactions
ISO
anthracene results in decreased expression of CCNA2 protein [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in decreased expression of CCNA2 protein
CTD
PMID:28803881
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnd1
cyclin D1
increases expression multiple interactions
ISO
anthracene results in increased expression of CCND1 protein [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CCND1 protein
CTD
PMID:28803881
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdk2
cyclin dependent kinase 2
increases expression multiple interactions
ISO
anthracene results in increased expression of CDK2 protein [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CDK2 protein
CTD
PMID:28803881
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Comt
catechol-O-methyltransferase
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein
CTD
PMID:28710019
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression multiple interactions
ISO
anthracene results in increased expression of CYP19A1 protein [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of CYP19A1 protein
CTD
PMID:28803881
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases expression increases activity
EXP ISO
anthracene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] anthracene results in increased expression of CYP1A1 mRNA [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]; alyssin inhibits the reaction [anthracene results in increased activity of CYP1A1 protein]; sulforaphane inhibits the reaction [anthracene results in increased activity of CYP1A1 protein]
CTD
PMID:15315710 PMID:19362136 PMID:21668866 PMID:28710019 PMID:30980910
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases activity affects binding multiple interactions
ISO
anthracene results in increased activity of CYP1A2 protein anthracene binds to CYP1A2 protein [acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA alyssin inhibits the reaction [anthracene results in increased activity of CYP1A2 protein]; sulforaphane inhibits the reaction [anthracene results in increased activity of CYP1A2 protein]
CTD
PMID:7750161 PMID:8001243 PMID:19362136 PMID:32278787
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
anthracene results in increased expression of CYP1B1 mRNA
CTD
PMID:21668866
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Esr1
estrogen receptor 1
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]
CTD
PMID:30980910
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Nfkb2
nuclear factor kappa B subunit 2
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of NFKB2 protein
CTD
PMID:30980910
NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
anthracene results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Tnf
tumor necrosis factor
multiple interactions
ISO
TNF protein promotes the reaction [anthracene results in increased expression of CXCL8 mRNA]
CTD
PMID:18434080
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Cat
catalase
multiple interactions
ISO
CAT protein inhibits the reaction [Anthralin results in increased expression of CXCL8 mRNA]
CTD
PMID:9628260
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccnb1
cyclin B1
increases expression
ISO
Anthralin results in increased expression of CCNB1 protein
CTD
PMID:20025956
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Chek1
checkpoint kinase 1
increases expression
ISO
Anthralin results in increased expression of CHEK1 protein
CTD
PMID:20025956
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Csf2
colony stimulating factor 2
increases expression
ISO
Anthralin results in increased expression of CSF2 mRNA
CTD
PMID:9628260
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
Anthralin results in decreased activity of CYP1A2 protein
CTD
PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
ISO
Anthralin results in increased expression of FOSL1 protein
CTD
PMID:20025956
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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Gstp1
glutathione S-transferase pi 1
multiple interactions
ISO
Anthralin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:23769903
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Hells
helicase, lymphoid specific
increases expression
ISO
Anthralin results in increased expression of HELLS protein
CTD
PMID:20025956
NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
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Il1a
interleukin 1 alpha
increases expression multiple interactions
ISO
Anthralin results in increased expression of IL1A mRNA; Anthralin results in increased expression of IL1A protein Plant Extracts inhibits the reaction [Anthralin results in increased expression of IL1A mRNA]; Plant Extracts inhibits the reaction [Anthralin results in increased expression of IL1A protein]
CTD
PMID:7665919 PMID:8435107
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1rl1
interleukin 1 receptor-like 1
increases expression
ISO
Anthralin results in increased expression of IL1RL1 protein
CTD
PMID:20025956
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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Il6
interleukin 6
increases expression
ISO
Anthralin results in increased expression of IL6 mRNA
CTD
PMID:9628260
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mcm3
minichromosome maintenance complex component 3
increases expression
ISO
Anthralin results in increased expression of MCM3 protein
CTD
PMID:20025956
NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
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Nup54
nucleoporin 54
increases expression
ISO
Anthralin results in increased expression of NUP54 protein
CTD
PMID:20025956
NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028
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Phex
phosphate regulating endopeptidase X-linked
increases expression
ISO
Anthralin results in increased expression of PHEX protein
CTD
PMID:20025956
NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469
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Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
increases expression
ISO
Anthralin results in increased expression of PIK3R5 protein
CTD
PMID:20025956
NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
Anthralin results in increased expression of PTGS2 mRNA
CTD
PMID:8989914
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rad51ap1
RAD51 associated protein 1
increases expression
ISO
Anthralin results in increased expression of RAD51AP1 protein
CTD
PMID:20025956
NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524
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Rif1
replication timing regulatory factor 1
increases expression
ISO
Anthralin results in increased expression of RIF1 protein
CTD
PMID:20025956
NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
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Slc2a1
solute carrier family 2 member 1
increases expression
ISO
Anthralin results in increased expression of SLC2A1 protein
CTD
PMID:20025956
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Stmn1
stathmin 1
increases expression
ISO
Anthralin results in increased expression of STMN1 protein
CTD
PMID:20025956
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
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Tfrc
transferrin receptor
increases expression
ISO
Anthralin results in increased expression of TFRC protein
CTD
PMID:20025956
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tgfb1
transforming growth factor, beta 1
increases expression
ISO
Anthralin results in increased expression of TGFB1 mRNA
CTD
PMID:8148055
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
increases expression
ISO
Anthralin results in increased expression of TNF mRNA; Anthralin results in increased expression of TNF protein
CTD
PMID:9628260
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
increases glucuronidation
ISO
UGT1A3 protein results in increased glucuronidation of Anthralin
CTD
PMID:15117964
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Vegfa
vascular endothelial growth factor A
increases expression
ISO
Anthralin results in increased expression of VEGFA protein
CTD
PMID:20025956
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Ar
androgen receptor
multiple interactions
EXP
Anthracenes analog inhibits the reaction [Metribolone binds to AR protein]
CTD
PMID:3695475
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions decreases response to substance
EXP
Anthracenes analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] GABRA1 protein mutant form results in decreased susceptibility to Anthracenes analog
CTD
PMID:18275132
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
EXP
Anthracenes analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:18275132
NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
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Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
EXP
Anthracenes analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:18275132
NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
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Top1
DNA topoisomerase I
decreases activity
ISO
Anthracenes results in decreased activity of TOP1 protein
CTD
PMID:7598737
NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
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Top2a
DNA topoisomerase II alpha
decreases activity
ISO
Anthracenes results in decreased activity of TOP2A protein
CTD
PMID:20561793
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
2,6-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:19269596
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Alb
albumin
affects binding
ISO
2,6-dihydroxyanthraquinone binds to ALB protein
CTD
PMID:16404478
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
2,6-dihydroxyanthraquinone results in increased expression of CYP1A1 mRNA
CTD
PMID:11502733
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
2,6-dihydroxyanthraquinone results in increased expression of CYP1B1 mRNA
CTD
PMID:11502733
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases glucuronidation
ISO
UGT1A1 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone
CTD
PMID:12756209 PMID:14557274
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone
CTD
PMID:14557274
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases glucuronidation
ISO
UGT1A1 protein results in increased glucuronidation of anthrarobin
CTD
PMID:14557274
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of anthrarobin
CTD
PMID:14557274
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions
ISO
aurantio-obtusin inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]
CTD
PMID:35101544
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Acsl4
acyl-CoA synthetase long-chain family member 4
increases expression
ISO
aurantio-obtusin results in increased expression of ACSL4 protein
CTD
PMID:35995123
NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
aurantio-obtusin results in increased expression of BAX protein
CTD
PMID:35995123
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
aurantio-obtusin results in decreased expression of BCL2 protein
CTD
PMID:35995123
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp1
caspase 1
increases expression
ISO
aurantio-obtusin results in increased expression of CASP1 mRNA
CTD
PMID:34718095
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
increases cleavage multiple interactions
ISO
aurantio-obtusin results in increased cleavage of CASP3 protein aurantio-obtusin results in increased expression of and results in increased cleavage of CASP3 protein
CTD
PMID:34718095 PMID:35995123
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
aurantio-obtusin results in increased expression of CCL2 mRNA
CTD
PMID:34718095
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Crebbp
CREB binding protein
increases phosphorylation
ISO
aurantio-obtusin results in increased phosphorylation of CREBBP protein
CTD
PMID:35995123
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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Gpt
glutamic--pyruvic transaminase
increases expression
ISO
aurantio-obtusin results in increased expression of GPT protein
CTD
PMID:34718095
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Hamp
hepcidin antimicrobial peptide
decreases expression
ISO
aurantio-obtusin results in decreased expression of HAMP mRNA
CTD
PMID:34718095
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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Il18
interleukin 18
increases expression
ISO
aurantio-obtusin results in increased expression of IL18 mRNA; aurantio-obtusin results in increased expression of IL18 protein
CTD
PMID:34718095
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
increases expression
ISO
aurantio-obtusin results in increased expression of IL1B mRNA; aurantio-obtusin results in increased expression of IL1B protein
CTD
PMID:34718095
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
increases expression
ISO
aurantio-obtusin results in increased expression of IL6 mRNA
CTD
PMID:34718095
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Kcnn4
potassium calcium-activated channel subfamily N member 4
increases expression
ISO
aurantio-obtusin results in increased expression of KCNN4 mRNA; aurantio-obtusin results in increased expression of KCNN4 protein
CTD
PMID:34718095
NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
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Nfkb1
nuclear factor kappa B subunit 1
decreases expression
ISO
aurantio-obtusin results in decreased expression of NFKB1 mRNA
CTD
PMID:34718095
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nlrp3
NLR family, pyrin domain containing 3
increases expression
ISO
aurantio-obtusin results in increased expression of NLRP3 mRNA; aurantio-obtusin results in increased expression of NLRP3 protein
CTD
PMID:34718095
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Rela
RELA proto-oncogene, NF-kB subunit
decreases expression
ISO
aurantio-obtusin results in decreased expression of RELA protein
CTD
PMID:34718095
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Slc22a6
solute carrier family 22 member 6
decreases activity
ISO
aurantio-obtusin results in decreased activity of SLC22A6 protein
CTD
PMID:29045746
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
decreases activity
ISO
aurantio-obtusin results in decreased activity of SLC22A8 protein
CTD
PMID:29045746
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Spn
sialophorin
increases expression
ISO
aurantio-obtusin results in increased expression of SPN mRNA
CTD
PMID:34718095
NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
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Tnf
tumor necrosis factor
increases expression
ISO
aurantio-obtusin results in increased expression of TNF mRNA
CTD
PMID:34718095
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Xpo1
exportin 1
decreases expression
ISO
aurantio-obtusin results in decreased expression of XPO1 mRNA
CTD
PMID:34718095
NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
azamulin results in decreased activity of CYP3A4 protein
CTD
PMID:15860655
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Kras
KRAS proto-oncogene, GTPase
increases mutagenesis
ISO
benz(j)aceanthrylene results in increased mutagenesis of KRAS gene
CTD
PMID:9659573
NCBI chr 4:178,185,418...178,218,484
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Ahr
aryl hydrocarbon receptor
increases activity
EXP
capoamycin results in increased activity of AHR protein
CTD
PMID:25500124
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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A2m
alpha-2-macroglobulin
decreases expression
ISO
salvin results in decreased expression of A2M protein
CTD
PMID:35926579
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Aacs
acetoacetyl-CoA synthetase
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of AACS mRNA]
CTD
PMID:35202923
NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954
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Abat
4-aminobutyrate aminotransferase
increases expression
ISO
salvin results in increased expression of ABAT protein
CTD
PMID:35926579
NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
G
Abca6
ATP binding cassette subfamily A member 6
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of ABCA6 mRNA]
CTD
PMID:35202923
NCBI chr10:95,142,805...95,212,087
Ensembl chr10:95,142,966...95,211,530
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Abhd11
abhydrolase domain containing 11
increases expression
ISO
salvin results in increased expression of ABHD11 protein
CTD
PMID:35926579
NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398
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Abi1
abl-interactor 1
increases expression
ISO
salvin results in increased expression of ABI1 protein
CTD
PMID:35926579
NCBI chr17:85,098,837...85,179,829
Ensembl chr17:85,098,550...85,179,792
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Acly
ATP citrate lyase
increases expression
ISO
salvin results in increased expression of ACLY protein
CTD
PMID:35926579
NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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Acss2
acyl-CoA synthetase short-chain family member 2
increases expression
ISO
salvin results in increased expression of ACSS2 protein
CTD
PMID:35926579
NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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Actn1
actinin, alpha 1
increases expression
ISO
salvin results in increased expression of ACTN1 protein
CTD
PMID:35926579
NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
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Adcy9
adenylate cyclase 9
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of ADCY9 mRNA]
CTD
PMID:35202923
NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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Adgre1
adhesion G protein-coupled receptor E1
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of ADGRE1 mRNA]
CTD
PMID:35202923
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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Adgre4
adhesion G protein-coupled receptor E4
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of ADGRE4 mRNA]
CTD
PMID:35202923
NCBI chr 9:9,758,106...9,901,908
Ensembl chr 9:9,760,355...9,900,760
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Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
increases expression
ISO
salvin results in increased expression of ADH1 protein
CTD
PMID:35926579
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
G
Aebp1
AE binding protein 1
decreases expression
ISO
salvin results in decreased expression of AEBP1 protein
CTD
PMID:35926579
NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877
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Agps
alkylglycerone phosphate synthase
decreases expression
ISO
salvin results in decreased expression of AGPS protein
CTD
PMID:35926579
NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830
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Ahsg
alpha-2-HS-glycoprotein
decreases expression
ISO
salvin results in decreased expression of AHSG protein
CTD
PMID:35926579
NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999
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Akt1
AKT serine/threonine kinase 1
increases phosphorylation decreases phosphorylation
ISO
salvin results in increased phosphorylation of AKT1 protein salvin results in decreased phosphorylation of AKT1 protein
CTD
PMID:25178877 PMID:25271104
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Alb
albumin
decreases expression
ISO
salvin results in decreased expression of ALB protein
CTD
PMID:35926579
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh1a3
aldehyde dehydrogenase 1 family, member A3
decreases expression
ISO
salvin results in decreased expression of ALDH1A3 protein
CTD
PMID:35926579
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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Apaf1
apoptotic peptidase activating factor 1
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein]
CTD
PMID:29854073
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
G
Apoa1
apolipoprotein A1
decreases expression
ISO
salvin results in decreased expression of APOA1 protein
CTD
PMID:35926579
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
G
Apoa4
apolipoprotein A4
decreases expression
ISO
salvin results in decreased expression of APOA4 protein
CTD
PMID:35926579
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Apoe
apolipoprotein E
decreases expression
ISO
salvin results in decreased expression of APOE protein
CTD
PMID:35926579
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Apoh
apolipoprotein H
decreases expression
ISO
salvin results in decreased expression of APOH protein
CTD
PMID:35926579
NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
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Asns
asparagine synthetase (glutamine-hydrolyzing)
decreases expression
ISO
salvin results in decreased expression of ASNS protein
CTD
PMID:35926579
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Aspa
aspartoacylase
decreases expression
ISO
salvin results in decreased expression of ASPA protein
CTD
PMID:35926579
NCBI chr10:57,891,704...57,945,267
Ensembl chr10:57,892,104...57,945,272
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Aspn
asporin
increases expression
ISO
salvin results in increased expression of ASPN protein
CTD
PMID:35926579
NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041
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Atp12a
ATPase H+/K+ transporting non-gastric alpha2 subunit
increases expression
ISO
salvin results in increased expression of ATP12A protein
CTD
PMID:35926579
NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229
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B2m
beta-2 microglobulin
increases expression
ISO
salvin results in increased expression of B2M protein
CTD
PMID:35926579
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Bad
BCL2-associated agonist of cell death
multiple interactions increases expression decreases phosphorylation
ISO
salvin promotes the reaction [arsenic trioxide results in decreased phosphorylation of BAD protein] salvin results in increased expression of BAD protein salvin results in decreased phosphorylation of BAD protein
CTD
PMID:23239002 PMID:28918123
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Basp1
brain abundant, membrane attached signal protein 1
decreases expression
ISO
salvin results in decreased expression of BASP1 protein
CTD
PMID:35926579
NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases expression
ISO
salvin inhibits the reaction [Paraquat results in increased expression of BAX protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein] salvin inhibits the reaction [sodium arsenite results in increased expression of BAX protein] salvin results in increased expression of BAX protein
CTD
PMID:26577515 PMID:26686574 PMID:28918123 PMID:29854073
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcas2
BCAS2, pre-mRNA processing factor
decreases expression
ISO
salvin results in decreased expression of BCAS2 protein
CTD
PMID:35926579
NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
EXP ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein] salvin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] salvin results in decreased expression of BCL2 protein Acetylcysteine inhibits the reaction [salvin results in decreased expression of BCL2 protein]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]
CTD
PMID:25446857 PMID:26577515 PMID:26686574 PMID:28918123 PMID:29854073 PMID:30707903 More...
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l2
Bcl2-like 2
multiple interactions
ISO
salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein]
CTD
PMID:24557422
NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
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Bmp5
bone morphogenetic protein 5
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of BMP5 mRNA]
CTD
PMID:35202923
NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925
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Bzw2
basic leucine zipper and W2 domains 2
decreases expression
ISO
salvin results in decreased expression of BZW2 protein
CTD
PMID:35926579
NCBI chr 6:52,828,069...52,888,599
Ensembl chr 6:52,827,661...52,888,628
G
C3
complement C3
decreases expression
ISO
salvin results in decreased expression of C3 protein
CTD
PMID:35926579
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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C4b
complement C4B
decreases expression
ISO
salvin results in decreased expression of C4B protein
CTD
PMID:35926579
NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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Camp
cathelicidin antimicrobial peptide
decreases expression
ISO
salvin results in decreased expression of CAMP protein
CTD
PMID:35926579
NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
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Car2
carbonic anhydrase 2
increases expression
ISO
salvin results in increased expression of CA2 protein
CTD
PMID:35926579
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Casp14
caspase 14
increases expression
ISO
salvin results in increased expression of CASP14 protein
CTD
PMID:35926579
NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
G
Casp3
caspase 3
multiple interactions increases cleavage
EXP ISO
salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein] salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein] salvin results in increased cleavage of CASP3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP3 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Acrylamide results in increased expression of CASP3 mRNA]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP3 protein]
CTD
PMID:24557422 PMID:25271104 PMID:25446857 PMID:26577515 PMID:26686574 PMID:28159594 PMID:28918123 PMID:29854073 PMID:30707903 PMID:31705926 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp6
caspase 6
decreases expression
ISO
salvin results in decreased expression of CASP6 protein
CTD
PMID:35926579
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp8
caspase 8
multiple interactions increases cleavage
ISO
Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein] salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein]
CTD
PMID:28918123 PMID:29854073
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity multiple interactions increases cleavage
ISO
salvin results in increased activity of CASP9 protein salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP9 protein] salvin results in increased cleavage of CASP9 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP9 protein]; salvin inhibits the reaction [Acrylamide results in increased expression of CASP9 mRNA]; salvin inhibits the reaction [Paraquat results in increased activity of CASP9 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]; salvin promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein]
CTD
PMID:23239002 PMID:26577515 PMID:26686574 PMID:28159594 PMID:28918123 PMID:29854073 More...
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
ISO
salvin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of CAT mRNA] salvin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
CTD
PMID:28159594 PMID:29854073
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cd14
CD14 molecule
multiple interactions
ISO
[salvin co-treated with Tretinoin] results in increased expression of CD14 protein; salvin promotes the reaction [Calcitriol results in increased expression of CD14 protein]
CTD
PMID:11504768
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd177
CD177 molecule
decreases expression
ISO
salvin results in decreased expression of CD177 protein
CTD
PMID:35926579
NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression multiple interactions
ISO
salvin results in increased expression of CDKN1B protein salvin promotes the reaction [arsenic trioxide results in increased expression of CDKN1B protein]
CTD
PMID:23239002
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cela1
chymotrypsin like elastase 1
decreases expression
ISO
salvin results in decreased expression of CELA1 protein
CTD
PMID:35926579
NCBI chr 7:131,773,161...131,786,300
Ensembl chr 7:131,742,002...131,786,285
G
Cela3b
chymotrypsin like elastase 3B
decreases expression
ISO
salvin results in decreased expression of CELA3B protein
CTD
PMID:35926579
NCBI chr 5:149,628,773...149,636,937
Ensembl chr 5:149,628,773...149,636,937
G
Chp2
calcineurin-like EF hand protein 2
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of CHP2 mRNA]
CTD
PMID:35202923
NCBI chr 1:176,757,945...176,772,443
Ensembl chr 1:176,757,876...176,772,139
G
Ckmt1
creatine kinase, mitochondrial 1
increases expression
ISO
salvin results in increased expression of CKMT1 protein
CTD
PMID:35926579
NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758
G
Clca1
chloride channel accessory 1
increases expression
ISO
salvin results in increased expression of CLCA1 protein
CTD
PMID:35926579
NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369
G
Clca4
chloride channel accessory 4
decreases expression
ISO
salvin results in decreased expression of CLCA4A protein
CTD
PMID:35926579
NCBI chr 2:233,883,625...233,904,993
Ensembl chr 2:233,883,851...233,903,089
G
Clec14a
C-type lectin domain containing 14A
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of CLEC14A mRNA]
CTD
PMID:35202923
NCBI chr 6:75,881,470...75,884,612
Ensembl chr 6:75,881,473...75,884,612
G
Clic5
chloride intracellular channel 5
increases expression
ISO
salvin results in increased expression of CLIC5 protein
CTD
PMID:35926579
NCBI chr 9:16,710,980...16,813,502
Ensembl chr 9:16,710,980...16,813,427
G
Clns1a
chloride nucleotide-sensitive channel 1A
increases expression
ISO
salvin results in increased expression of CLNS1A protein
CTD
PMID:35926579
NCBI chr 1:152,019,369...152,039,670
Ensembl chr 1:152,019,378...152,039,661
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Clu
clusterin
decreases expression
ISO
salvin results in decreased expression of CLU protein
CTD
PMID:35926579
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
G
Col18a1
collagen type XVIII alpha 1 chain
decreases expression
ISO
salvin results in decreased expression of COL18A1 protein
CTD
PMID:35926579
NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
G
Col6a3
collagen type VI alpha 3 chain
decreases expression
ISO
salvin results in decreased expression of COL6A3 protein
CTD
PMID:35926579
NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
G
Cox6a1
cytochrome c oxidase subunit 6A1
increases expression
ISO
salvin results in increased expression of COX6A1 protein
CTD
PMID:35926579
NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041
G
Cp
ceruloplasmin
decreases expression
ISO
salvin results in decreased expression of CP protein
CTD
PMID:35926579
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
G
Cpb1
carboxypeptidase B1
decreases expression
ISO
salvin results in decreased expression of CPB1 protein
CTD
PMID:35926579
NCBI chr 2:102,755,241...102,785,628
Ensembl chr 2:102,755,241...102,785,628
G
Cpox
coproporphyrinogen oxidase
increases expression
ISO
salvin results in increased expression of CPOX protein
CTD
PMID:35926579
NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
G
Cpsf7
cleavage and polyadenylation specific factor 7
decreases expression
ISO
salvin results in decreased expression of CPSF7 protein
CTD
PMID:35926579
NCBI chr 1:207,167,690...207,191,938
Ensembl chr 1:207,167,859...207,191,905
G
Crnkl1
crooked neck pre-mRNA splicing factor 1
decreases expression
ISO
salvin results in decreased expression of CRNKL1 protein
CTD
PMID:35926579
NCBI chr 3:133,338,593...133,354,329
Ensembl chr 3:133,337,039...133,354,302 Ensembl chr 6:133,337,039...133,354,302
G
Ctrb1
chymotrypsinogen B1
decreases expression
ISO
salvin results in decreased expression of CTRB1 protein
CTD
PMID:35926579
NCBI chr19:39,652,931...39,657,689
Ensembl chr19:39,652,933...39,657,688
G
Cybb
cytochrome b-245 beta chain
decreases expression
ISO
salvin results in decreased expression of CYBB protein
CTD
PMID:35926579
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
G
Cyp20a1
cytochrome P450, family 20, subfamily a, polypeptide 1
decreases expression
ISO
salvin results in decreased expression of CYP20A1 protein
CTD
PMID:35926579
NCBI chr 9:61,755,804...61,805,123
Ensembl chr 9:61,755,790...61,805,123
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of CYP2B10 mRNA]
CTD
PMID:35202923
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c66
cytochrome P450, family 2, subfamily c, polypeptide 66
decreases expression
ISO
salvin results in decreased expression of CYP2C66 protein
CTD
PMID:35926579
NCBI chr 1:237,078,517...237,169,841
Ensembl chr 1:237,078,517...237,169,650
G
Cyp51
cytochrome P450, family 51
decreases expression
ISO
salvin results in decreased expression of CYP51A1 protein
CTD
PMID:35926579
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of CYP7A1 mRNA]
CTD
PMID:35202923
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Dmbt1
deleted in malignant brain tumors 1
decreases expression
ISO
salvin results in decreased expression of DMBT1 protein
CTD
PMID:35926579
NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
G
Dnajc10
DnaJ heat shock protein family (Hsp40) member C10
decreases expression
ISO
salvin results in decreased expression of DNAJC10 protein
CTD
PMID:35926579
NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719
G
Dop1b
DOP1 leucine zipper like protein B
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of DOP1B mRNA]
CTD
PMID:35202923
NCBI chr11:33,024,376...33,125,931
Ensembl chr11:33,024,411...33,125,931
G
Dpep1
dipeptidase 1
decreases expression
ISO
salvin results in decreased expression of DPEP1 protein
CTD
PMID:35926579
NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
G
Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of EHHADH mRNA]
CTD
PMID:35202923
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
G
Elane
elastase, neutrophil expressed
decreases expression
ISO
salvin results in decreased expression of ELANE protein
CTD
PMID:35926579
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
G
Eno3
enolase 3
increases expression
ISO
salvin results in increased expression of ENO3 protein
CTD
PMID:35926579
NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
G
Fabp1
fatty acid binding protein 1
decreases expression
ISO
salvin results in decreased expression of FABP1 protein
CTD
PMID:35926579
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
G
Fabp5
fatty acid binding protein 5
decreases expression
ISO
salvin results in decreased expression of FABP5 protein
CTD
PMID:35926579
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
G
Fas
Fas cell surface death receptor
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of FAS protein]
CTD
PMID:29854073
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fbln2
fibulin 2
decreases expression
ISO
salvin results in decreased expression of FBLN2 protein
CTD
PMID:35926579
NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948
G
Fen1
flap structure-specific endonuclease 1
decreases expression
ISO
salvin results in decreased expression of FEN1 protein
CTD
PMID:35926579
NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
G
Fga
fibrinogen alpha chain
decreases expression
ISO
salvin results in decreased expression of FGA protein
CTD
PMID:35926579
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
G
Fgb
fibrinogen beta chain
decreases expression
ISO
salvin results in decreased expression of FGB protein
CTD
PMID:35926579
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
G
Fgf21
fibroblast growth factor 21
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of FGF21 mRNA]
CTD
PMID:35202923
NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
G
Fgg
fibrinogen gamma chain
decreases expression
ISO
salvin results in decreased expression of FGG protein
CTD
PMID:35926579
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
G
Fis1
fission, mitochondrial 1
multiple interactions
ISO
salvin inhibits the reaction [Oxidopamine results in increased expression of FIS1 protein]
CTD
PMID:31705926
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
G
Fmo2
flavin containing dimethylaniline monoxygenase 2
increases expression
ISO
salvin results in increased expression of FMO2 protein
CTD
PMID:35926579
NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
G
Fscn1
fascin actin-bundling protein 1
decreases expression
ISO
salvin results in decreased expression of FSCN1 protein
CTD
PMID:35926579
NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
G
Galnt12
polypeptide N-acetylgalactosaminyltransferase 12
decreases expression
ISO
salvin results in decreased expression of GALNT12 protein
CTD
PMID:35926579
NCBI chr 5:61,384,575...61,413,346
Ensembl chr 5:61,384,571...61,413,354
G
Galnt3
polypeptide N-acetylgalactosaminyltransferase 3
decreases expression
ISO
salvin results in decreased expression of GALNT3 protein
CTD
PMID:35926579
NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268
G
Garre1
granule associated Rac and RHOG effector 1
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of GARRE1 mRNA]
CTD
PMID:35202923
NCBI chr 1:86,862,121...86,939,725
Ensembl chr 1:86,862,121...86,939,687
G
Gc
GC, vitamin D binding protein
decreases expression
ISO
salvin results in decreased expression of GC protein
CTD
PMID:35926579
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression multiple interactions
ISO EXP
salvin results in increased expression of GCLC mRNA salvin results in increased expression of GCLC protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein]
CTD
PMID:18329808 PMID:25446857 PMID:26577515 PMID:26686574
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions increases expression
EXP ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein] salvin results in increased expression of GCLM protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of GCLM mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]
CTD
PMID:25446857 PMID:26577515 PMID:26686574 PMID:28159594
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
decreases expression
ISO
salvin results in decreased expression of GCNT3 protein
CTD
PMID:35926579
NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
G
Gfer
growth factor, augmenter of liver regeneration
increases expression
ISO
salvin results in increased expression of GFER protein
CTD
PMID:35926579
NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869
G
Ggh
gamma-glutamyl hydrolase
increases expression
ISO
salvin results in increased expression of GGH protein
CTD
PMID:35926579
NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787
G
Glod5
glyoxalase domain containing 5
increases expression
ISO
salvin results in increased expression of GLOD5 protein
CTD
PMID:35926579
NCBI chr X:14,473,994...14,488,797
Ensembl chr X:14,473,994...14,488,683
G
Gnl3
G protein nucleolar 3
decreases expression
ISO
salvin results in decreased expression of GNL3 protein
CTD
PMID:35926579
NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
CTD
PMID:29854073 PMID:35202923
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gpx1
glutathione peroxidase 1
multiple interactions
ISO
salvin inhibits the reaction [Acrylamide results in decreased expression of GPX1 mRNA]
CTD
PMID:28159594
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Grn
granulin precursor
decreases expression
ISO
salvin results in decreased expression of GRN protein
CTD
PMID:35926579
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
G
Gsdme
gasdermin E
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of GSDME mRNA]
CTD
PMID:35202923
NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
G
Gsr
glutathione-disulfide reductase
multiple interactions increases expression
EXP ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein] salvin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] salvin results in increased expression of GSR protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GSR protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein]
CTD
PMID:25446857 PMID:26577515 PMID:26686574 PMID:29854073
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gstp1
glutathione S-transferase pi 1
multiple interactions increases expression
EXP ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein] salvin results in increased expression of GSTP1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSTP1 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSTP1 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]; salvin results in increased expression of and results in increased activity of GSTP1 protein
CTD
PMID:25271104 PMID:26577515
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gtf2f1
general transcription factor IIF subunit 1
decreases expression
ISO
salvin results in decreased expression of GTF2F1 protein
CTD
PMID:35926579
NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
decreases expression
ISO
salvin results in decreased expression of HMGCS2 protein
CTD
PMID:35926579
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
G
Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO
salvin results in increased expression of HMOX1 mRNA; salvin results in increased expression of HMOX1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of HMOX1 protein]
CTD
PMID:18329808 PMID:23942037 PMID:26686574
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hnrnpa3
heterogeneous nuclear ribonucleoprotein A3
decreases expression
ISO
salvin results in decreased expression of HNRNPA3 protein
CTD
PMID:35926579
NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306
G
Hp
haptoglobin
decreases expression
ISO
salvin results in decreased expression of HP protein
CTD
PMID:35926579
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
G
Hpx
hemopexin
decreases expression
ISO
salvin results in decreased expression of HPX protein
CTD
PMID:35926579
NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328
G
Hsd17b6
hydroxysteroid (17-beta) dehydrogenase 6
decreases expression
ISO
salvin results in decreased expression of HSD17B6 protein
CTD
PMID:35926579
NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425
G
Id3
inhibitor of DNA binding 3
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of ID3 mRNA]
CTD
PMID:35202923
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
G
Ifng
interferon gamma
multiple interactions
ISO
salvin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
CTD
PMID:23942037
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Igfbp7
insulin-like growth factor binding protein 7
decreases expression
ISO
salvin results in decreased expression of IGFBP7 protein
CTD
PMID:35926579
NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
G
Igkvl-ps13
immunoglobulin kappa variable like, pseudogene 13
decreases expression
ISO
salvin results in decreased expression of IGKV1-133 protein
CTD
PMID:35926579
NCBI chr 4:96,968,574...96,969,477
G
Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
multiple interactions increases ubiquitination
ISO
PRKN protein affects the reaction [salvin results in increased ubiquitination of IKBKG protein]
CTD
PMID:31705926
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
G
Inhbe
inhibin subunit beta E
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of INHBE mRNA]
CTD
PMID:35202923
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
G
Inmt
indolethylamine N-methyltransferase
increases expression
ISO
salvin results in increased expression of INMT protein
CTD
PMID:35926579
NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
G
Ints3
integrator complex subunit 3
decreases expression
ISO
salvin results in decreased expression of INTS3 protein
CTD
PMID:35926579
NCBI chr 2:175,859,421...175,911,683
Ensembl chr 2:175,859,440...175,911,709
G
Itga2
integrin subunit alpha 2
decreases expression
ISO
salvin results in decreased expression of ITGA2 protein
CTD
PMID:35926579
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
G
Itgam
integrin subunit alpha M
multiple interactions decreases expression
ISO
[salvin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ITGAM protein; salvin promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; salvin promotes the reaction [Tretinoin results in increased expression of ITGAM protein] salvin results in decreased expression of ITGAM protein
CTD
PMID:11504768 PMID:35926579
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
G
Itgb2
integrin subunit beta 2
decreases expression
ISO
salvin results in decreased expression of ITGB2 protein
CTD
PMID:35926579
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
G
Klf12
KLF transcription factor 12
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of KLF12 mRNA]
CTD
PMID:35202923
NCBI chr15:76,628,778...77,062,000
Ensembl chr15:76,637,654...77,062,056
G
Kng1
kininogen 1
decreases expression
ISO
salvin results in decreased expression of KNG1 protein
CTD
PMID:35926579
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
G
Lamp2
lysosomal-associated membrane protein 2
decreases expression
ISO
salvin results in decreased expression of LAMP2 protein
CTD
PMID:35926579
NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522
G
Lcn2
lipocalin 2
decreases expression
ISO
salvin results in decreased expression of LCN2 protein
CTD
PMID:35926579
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
G
Lgals2
galectin 2
decreases expression
ISO
salvin results in decreased expression of LGALS2 protein
CTD
PMID:35926579
NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802
G
Lgals3bp
galectin 3 binding protein
decreases expression
ISO
salvin results in decreased expression of LGALS3BP protein
CTD
PMID:35926579
NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256
G
Lgals9
galectin 9
decreases expression
ISO
salvin results in decreased expression of LGALS9 protein
CTD
PMID:35926579
NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
G
Lgmn
legumain
decreases expression
ISO
salvin results in decreased expression of LGMN protein
CTD
PMID:35926579
NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
G
Ltf
lactotransferrin
decreases expression
ISO
salvin results in decreased expression of LTF protein
CTD
PMID:35926579
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
G
Luzp1
leucine zipper protein 1
decreases expression
ISO
salvin results in decreased expression of LUZP1 protein
CTD
PMID:35926579
NCBI chr 5:148,706,094...148,781,616
Ensembl chr 5:148,706,138...148,781,609
G
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
increases expression
ISO
salvin results in increased expression of LYVE1 protein
CTD
PMID:35926579
NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309
G
Lyz2
lysozyme 2
decreases expression
ISO
salvin results in decreased expression of LYZ2 protein
CTD
PMID:35926579
NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP ISO
salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein] salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]
CTD
PMID:25446857 PMID:29854073
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mapk9
mitogen-activated protein kinase 9
multiple interactions
EXP
salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK9 protein]
CTD
PMID:25446857
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
G
Marcksl1
MARCKS-like 1
decreases expression
ISO
salvin results in decreased expression of MARCKSL1 protein
CTD
PMID:35926579
NCBI chr 5:141,851,491...141,853,814
Ensembl chr 5:141,850,110...141,853,817
G
Mcm7
minichromosome maintenance complex component 7
decreases expression
ISO
salvin results in decreased expression of MCM7 protein
CTD
PMID:35926579
NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
G
Mfn2
mitofusin 2
multiple interactions
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of MFN2 protein]
CTD
PMID:31705926
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
G
Mov10
Mov10 RNA helicase
decreases expression
ISO
salvin results in decreased expression of MOV10 protein
CTD
PMID:35926579
NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083
G
Mpo
myeloperoxidase
decreases expression
ISO
salvin results in decreased expression of MPO protein
CTD
PMID:35926579
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Mpzl2
myelin protein zero-like 2
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of MPZL2 mRNA]
CTD
PMID:35202923
NCBI chr 8:45,348,285...45,359,298
Ensembl chr 8:45,348,285...45,359,298
G
Mrps31
mitochondrial ribosomal protein S31
decreases expression
ISO
salvin results in decreased expression of MRPS31 protein
CTD
PMID:35926579
NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654
G
Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation
ISO
salvin results in decreased phosphorylation of MTOR protein
CTD
PMID:25178877 PMID:28918123
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Mug1
murinoglobulin 1
decreases expression
ISO
salvin results in decreased expression of MUG1 protein
CTD
PMID:35926579
NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051
G
Mug2
murinoglobulin 2
decreases expression
ISO
salvin results in decreased expression of MUG2 protein
CTD
PMID:35926579
NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475
G
Mylip
myosin regulatory light chain interacting protein
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of MYLIP mRNA]
CTD
PMID:35202923
NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295
G
Myo1b
myosin Ib
decreases expression
ISO
salvin results in decreased expression of MYO1B protein
CTD
PMID:35926579
NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
G
Ndst1
N-deacetylase and N-sulfotransferase 1
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of NDST1 mRNA]
CTD
PMID:35202923
NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191
G
Ndufa12
NADH:ubiquinone oxidoreductase subunit A12
increases expression
ISO
salvin results in increased expression of NDUFA12 protein
CTD
PMID:35926579
NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315
G
Nelfb
negative elongation factor complex member B
decreases expression
ISO
salvin results in decreased expression of NELFB protein
CTD
PMID:35926579
NCBI chr 3:8,010,883...8,027,403
Ensembl chr 3:8,010,888...8,027,403
G
Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity multiple interactions
ISO
salvin results in increased activity of NFE2L2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased activity of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSTP1 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GSR protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of SOD2 protein]; salvin affects the localization of and results in increased activity of NFE2L2 protein; salvin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 mRNA]; salvin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 protein]
CTD
PMID:26577515 PMID:26686574 PMID:28159594
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
salvin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased phosphorylation of NFKBIA protein]; salvin results in increased phosphorylation of and results in increased degradation of NFKBIA protein
CTD
PMID:21375325 PMID:25271104 PMID:29854073
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nlrp12
NLR family, pyrin domain containing 12
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of NLRP12 mRNA]
CTD
PMID:35202923
NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
salvin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:21375325
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nox1
NADPH oxidase 1
decreases expression
ISO
salvin results in decreased expression of NOX1 protein
CTD
PMID:35926579
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression multiple interactions
ISO
salvin results in increased expression of NQO1 mRNA salvin results in increased expression of NQO1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of NQO1 mRNA]
CTD
PMID:18329808 PMID:26686574 PMID:28159594
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Nr3c2
nuclear receptor subfamily 3, group C, member 2
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of NR3C2 mRNA]
CTD
PMID:35202923
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
G
Nrdc
nardilysin convertase
decreases expression
ISO
salvin results in decreased expression of NRDC protein
CTD
PMID:35926579
NCBI chr 5:123,755,807...123,818,910
Ensembl chr 5:123,755,806...123,818,595
G
Oas1a
2'-5' oligoadenylate synthetase 1A
increases expression
ISO
salvin results in increased expression of OAS1G protein
CTD
PMID:35926579
NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
G
Opa1
OPA1, mitochondrial dynamin like GTPase
multiple interactions increases expression
ISO
OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PRKN protein affects the reaction [salvin results in increased expression of OPA1 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 protein]
CTD
PMID:31705926
NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
G
Orm1
orosomucoid 1
decreases expression
ISO
salvin results in decreased expression of ORM1 protein
CTD
PMID:35926579
NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases cleavage decreases expression
ISO EXP
Acetylcysteine inhibits the reaction [salvin results in increased cleavage of PARP1 protein]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein] salvin results in decreased expression of PARP1 protein
CTD
PMID:25446857 PMID:28918123 PMID:30707903 PMID:31705926
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pcbd2
pterin-4 alpha-carbinolamine dehydratase 2
increases expression
ISO
salvin results in increased expression of PCBD2 protein
CTD
PMID:35926579
NCBI chr17:8,845,161...8,896,343
Ensembl chr17:8,845,084...8,910,539
G
Pde5a
phosphodiesterase 5A
increases expression
ISO
salvin results in increased expression of PDE5A protein
CTD
PMID:35926579
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
G
Per2
period circadian regulator 2
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of PER2 mRNA]
CTD
PMID:35202923
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
G
Pgam5
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
decreases expression
ISO
salvin results in decreased expression of PGAM5 protein
CTD
PMID:35926579
NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420
G
Pglyrp1
peptidoglycan recognition protein 1
decreases expression
ISO
salvin results in decreased expression of PGLYRP1 protein
CTD
PMID:35926579
NCBI chr 1:78,531,815...78,537,001
Ensembl chr 1:78,531,815...78,537,001
G
Phgdh
phosphoglycerate dehydrogenase
decreases expression
ISO
salvin results in decreased expression of PHGDH protein
CTD
PMID:35926579
NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
G
Pink1
PTEN induced kinase 1
multiple interactions
ISO
PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PINK1 protein]
CTD
PMID:30707903
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
G
Plg
plasminogen
decreases expression
ISO
salvin results in decreased expression of PLG protein
CTD
PMID:35926579
NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
G
Plin2
perilipin 2
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of PLIN2 mRNA]
CTD
PMID:35202923
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
G
Plin4
perilipin 4
increases expression
ISO
salvin results in increased expression of PLIN4 protein
CTD
PMID:35926579
NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
G
Plpp1
phospholipid phosphatase 1
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of PLPP1 mRNA]
CTD
PMID:35202923
NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268
G
Pnlip
pancreatic lipase
decreases expression
ISO
salvin results in decreased expression of PNLIP protein
CTD
PMID:35926579
NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654
G
Pnliprp1
pancreatic lipase-related protein 1
decreases expression
ISO
salvin results in decreased expression of PNLIPRP1 protein
CTD
PMID:35926579
NCBI chr 1:257,867,885...257,883,514
Ensembl chr 1:257,867,885...257,883,514
G
Pparg
peroxisome proliferator-activated receptor gamma
increases activity
ISO
salvin results in increased activity of PPARG protein
CTD
PMID:20696231
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Prdx6
peroxiredoxin 6
increases expression
ISO
salvin results in increased expression of PRDX6 protein
CTD
PMID:35926579
NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
G
Prkn
parkin RBR E3 ubiquitin protein ligase
multiple interactions increases expression
ISO
PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PRKN protein affects the reaction [salvin results in increased expression of OPA1 protein]; PRKN protein affects the reaction [salvin results in increased expression of RELA protein]; PRKN protein affects the reaction [salvin results in increased ubiquitination of IKBKG protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein] salvin results in increased expression of PRKN protein
CTD
PMID:30707903 PMID:31705926
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
G
Prom1
prominin 1
decreases expression
ISO
salvin results in decreased expression of PROM1 protein
CTD
PMID:35926579
NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
G
Pten
phosphatase and tensin homolog
multiple interactions increases expression
ISO
salvin promotes the reaction [arsenic trioxide results in increased expression of PTEN mRNA] salvin results in increased expression of PTEN mRNA
CTD
PMID:23239002
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
G
Ptgds
prostaglandin D2 synthase
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of PTGDS mRNA]
CTD
PMID:35202923
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
salvin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:21375325
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Pvalb
parvalbumin
decreases expression
ISO
salvin results in decreased expression of PVALB protein
CTD
PMID:35926579
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
G
Pxdn
peroxidasin
decreases expression
ISO
salvin results in decreased expression of PXDN protein
CTD
PMID:35926579
NCBI chr 6:46,580,749...46,658,345
Ensembl chr 6:46,580,761...46,658,345
G
Qsox1
quiescin sulfhydryl oxidase 1
decreases expression
ISO
salvin results in decreased expression of QSOX1 protein
CTD
PMID:35926579
NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459
G
Rab11fip2
RAB11 family interacting protein 2
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of RAB11FIP2 mRNA]
CTD
PMID:35202923
NCBI chr 1:258,950,535...259,094,555
Ensembl chr 1:258,923,873...259,093,752
G
Rapgef5
Rap guanine nucleotide exchange factor 5
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of RAPGEF5 mRNA]
CTD
PMID:35202923
NCBI chr 6:138,445,184...138,679,943
Ensembl chr 6:138,437,991...138,679,936
G
Rara
retinoic acid receptor, alpha
multiple interactions
ISO
[Tetradecanoylphorbol Acetate co-treated with salvin] results in increased expression of RARA protein
CTD
PMID:11504768
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
G
Rbpms
RNA binding protein, mRNA processing factor
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of RBPMS mRNA]
CTD
PMID:35202923
NCBI chr16:58,239,370...58,395,424
Ensembl chr16:58,239,474...58,395,426
G
Rdh9
retinol dehydrogenase 9
decreases expression
ISO
salvin results in decreased expression of RDH9 protein
CTD
PMID:35926579
NCBI chr 7:63,642,305...63,645,149
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases expression affects localization
ISO
salvin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of and affects the localization of RELA protein] salvin results in increased expression of RELA protein salvin affects the localization of RELA protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin affects the localization of RELA protein]; PRKN protein affects the reaction [salvin results in increased expression of RELA protein]; salvin results in increased expression of and results in increased activity of RELA protein
CTD
PMID:21375325 PMID:25271104 PMID:29854073 PMID:31705926
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Rer1
retention in endoplasmic reticulum sorting receptor 1
increases expression
ISO
salvin results in increased expression of RER1 protein
CTD
PMID:35926579
NCBI chr 5:165,634,567...165,646,643
Ensembl chr 5:165,634,300...165,646,750
G
Rheb
Ras homolog, mTORC1 binding
decreases expression
ISO
salvin results in decreased expression of RHEB protein
CTD
PMID:35926579
NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
G
Rnase4
ribonuclease A family member 4
decreases expression
ISO
salvin results in decreased expression of RNASE4 protein
CTD
PMID:35926579
NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117
G
Rpa1
replication protein A1
decreases expression
ISO
salvin results in decreased expression of RPA1 protein
CTD
PMID:35926579
NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949
G
Rps21-ps1
ribosomal protein S21, pseudogene 1
increases expression
ISO
salvin results in increased expression of RPS21 protein
CTD
PMID:35926579
NCBI chr 5:153,387,133...153,387,476
Ensembl chr 5:153,387,176...153,387,427
G
Rxra
retinoid X receptor alpha
increases expression multiple interactions
ISO
salvin results in increased expression of RXRA protein Calcitriol promotes the reaction [salvin results in increased expression of RXRA protein]; Tretinoin promotes the reaction [salvin results in increased expression of RXRA protein]
CTD
PMID:11504768
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
G
S100a11
S100 calcium binding protein A11
decreases expression
ISO
salvin results in decreased expression of S100A11 protein
CTD
PMID:35926579
NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044
G
S100a8
S100 calcium binding protein A8
decreases expression
ISO
salvin results in decreased expression of S100A8 protein
CTD
PMID:35926579
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
G
S100a9
S100 calcium binding protein A9
decreases expression
ISO
salvin results in decreased expression of S100A9 protein
CTD
PMID:35926579
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
G
S100g
S100 calcium binding protein G
increases expression
ISO
salvin results in increased expression of S100G protein
CTD
PMID:35926579
NCBI chr X:31,705,853...31,708,422
Ensembl chr X:31,705,866...31,708,433
G
Sdc3
syndecan 3
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of SDC3 mRNA]
CTD
PMID:35202923
NCBI chr 5:142,965,659...142,998,390
Ensembl chr 5:142,965,591...142,996,480
G
Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
decreases expression
ISO
salvin results in decreased expression of SERPINA3N protein
CTD
PMID:35926579
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
G
Sgsm3
small G protein signaling modulator 3
decreases expression
ISO
salvin results in decreased expression of SGSM3 protein
CTD
PMID:35926579
NCBI chr 7:112,514,453...112,544,109
Ensembl chr 7:112,514,630...112,544,108
G
Shc1
SHC adaptor protein 1
multiple interactions increases expression decreases expression
ISO
salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SHC1 protein]; SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein] salvin results in increased expression of SHC1 mRNA
CTD
PMID:24557422
NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
G
Shmt2
serine hydroxymethyltransferase 2
decreases expression
ISO
salvin results in decreased expression of SHMT2 protein
CTD
PMID:35926579
NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236
G
Sik2
salt-inducible kinase 2
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of SIK2 mRNA]
CTD
PMID:35202923
NCBI chr 8:51,225,543...51,325,343
Ensembl chr 8:51,225,543...51,325,415
G
Sirt1
sirtuin 1
multiple interactions increases expression
ISO
Niacinamide inhibits the reaction [salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein] salvin results in increased expression of SIRT1 mRNA; salvin results in increased expression of SIRT1 protein
CTD
PMID:24557422
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Slc26a3
solute carrier family 26 member 3
increases expression
ISO
salvin results in increased expression of SLC26A3 protein
CTD
PMID:35926579
NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772
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Slc35a2
solute carrier family 35 member A2
increases expression
ISO
salvin results in increased expression of SLC35A2 protein
CTD
PMID:35926579
NCBI chr X:14,608,145...14,616,937
Ensembl chr X:14,608,055...14,616,678
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Sltm
SAFB-like, transcription modulator
decreases expression
ISO
salvin results in decreased expression of SLTM protein
CTD
PMID:35926579
NCBI chr 8:71,215,995...71,261,821
Ensembl chr 8:71,216,612...71,261,825
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Snw1
SNW domain containing 1
decreases expression
ISO
salvin results in decreased expression of SNW1 protein
CTD
PMID:35926579
NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
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Snx4
sorting nexin 4
decreases expression
ISO
salvin results in decreased expression of SNX4 protein
CTD
PMID:35926579
NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174
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Sod1
superoxide dismutase 1
multiple interactions
ISO EXP
salvin inhibits the reaction [Acrylamide results in decreased expression of SOD1 mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of SOD1 protein]
CTD
PMID:25446857 PMID:28159594
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
multiple interactions increases expression
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of SOD2 protein]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SOD2 protein]
CTD
PMID:24557422 PMID:26577515 PMID:26686574
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sorbs1
sorbin and SH3 domain containing 1
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in decreased expression of SORBS1 mRNA]
CTD
PMID:35202923
NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169
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Sparc
secreted protein acidic and cysteine rich
decreases expression
ISO
salvin results in decreased expression of SPARC protein
CTD
PMID:35926579
NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
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Sprr2a
small proline rich protein 2A
decreases expression
ISO
salvin results in decreased expression of SPRR2A protein
CTD
PMID:35926579
NCBI chr 2:177,815,964...177,816,236
Ensembl chr 2:177,815,964...177,816,236
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Stub1
STIP1 homology and U-box containing protein 1
decreases expression
ISO
salvin results in decreased expression of STUB1 protein
CTD
PMID:35926579
NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046
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Tbx3
T-box transcription factor 3
multiple interactions
ISO
salvin inhibits the reaction [sodium arsenite results in increased expression of TBX3 mRNA]
CTD
PMID:35202923
NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
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Tep1
telomerase associated protein 1
decreases expression
ISO
salvin results in decreased expression of TEP1 protein
CTD
PMID:35926579
NCBI chr15:24,045,876...24,093,526
Ensembl chr15:24,045,878...24,093,526
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Tf
transferrin
decreases expression
ISO
salvin results in decreased expression of TF protein
CTD
PMID:35926579
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tgm3
transglutaminase 3
increases expression
ISO
salvin results in increased expression of TGM3 protein
CTD
PMID:35926579
NCBI chr 3:117,228,661...117,264,078
Ensembl chr 3:117,228,661...117,264,075
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Th
tyrosine hydroxylase
multiple interactions
EXP
salvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein]
CTD
PMID:25446857
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tinagl1
tubulointerstitial nephritis antigen-like 1
increases expression
ISO
salvin results in increased expression of TINAGL1 protein
CTD
PMID:35926579
NCBI chr 5:142,513,710...142,523,730
Ensembl chr 5:142,513,714...142,523,720
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Tmed5
transmembrane p24 trafficking protein 5
decreases expression
ISO
salvin results in decreased expression of TMED5 protein
CTD
PMID:35926579
NCBI chr14:1,607,895...1,619,028
Ensembl chr14:1,607,819...1,628,426
G
Tmsb4x
thymosin beta 4, X-linked
decreases expression
ISO
salvin results in decreased expression of TMSB4X protein
CTD
PMID:35926579
NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667
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Tnf
tumor necrosis factor
multiple interactions
ISO
salvin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:21375325
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnxb
tenascin XB
increases expression
ISO
salvin results in increased expression of TNXB protein
CTD
PMID:35926579
G
Tsg101
tumor susceptibility 101
decreases expression
ISO
salvin results in decreased expression of TSG101 protein
CTD
PMID:35926579
NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554
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Tspan15
tetraspanin 15
increases expression
ISO
salvin results in increased expression of TSPAN15 protein
CTD
PMID:35926579
NCBI chr20:30,130,528...30,174,912
Ensembl chr20:30,130,530...30,174,930
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Txlna
taxilin alpha
decreases expression
ISO
salvin results in decreased expression of TXLNA protein
CTD
PMID:35926579
NCBI chr 5:141,969,337...141,985,054
Ensembl chr 5:141,969,346...141,984,583
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Tyr
tyrosinase
decreases expression
ISO
salvin results in decreased expression of TYR mRNA
CTD
PMID:21071833
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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Ubl4a
ubiquitin-like 4A
decreases expression
ISO
salvin results in decreased expression of UBL4A protein
CTD
PMID:35926579
NCBI chr X:152,151,242...152,154,094
Ensembl chr X:152,151,460...152,154,069
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Vdac1
voltage-dependent anion channel 1
multiple interactions
ISO
PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of and results in decreased ubiquitination of VDAC1 protein]
CTD
PMID:30707903
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Vdr
vitamin D receptor
multiple interactions increases expression
ISO
Calcitriol promotes the reaction [salvin results in increased expression of VDR protein]; Tetradecanoylphorbol Acetate promotes the reaction [salvin results in increased expression of VDR protein]; Tretinoin promotes the reaction [salvin results in increased expression of VDR protein]
CTD
PMID:11504768
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Vill
villin-like
decreases expression
ISO
salvin results in decreased expression of VILL protein
CTD
PMID:35926579
NCBI chr 8:118,776,718...118,794,983
Ensembl chr 8:118,776,742...118,794,983
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Wdr5
WD repeat domain 5
decreases expression
ISO
salvin results in decreased expression of WDR5 protein
CTD
PMID:35926579
NCBI chr 3:10,836,964...10,856,682
Ensembl chr 3:10,837,025...10,856,671
G
Wif1
Wnt inhibitory factor 1
decreases expression
ISO
salvin results in decreased expression of WIF1 protein
CTD
PMID:35926579
NCBI chr 7:56,548,060...56,618,364
Ensembl chr 7:56,548,053...56,618,360
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Zfp207
zinc finger protein 207
decreases expression
ISO
salvin results in decreased expression of ZFP207 protein; salvin results in decreased expression of ZNF207 protein
CTD
PMID:35926579
NCBI chr10:65,385,807...65,398,086
Ensembl chr10:65,385,740...65,397,386
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Esr1
estrogen receptor 1
multiple interactions
ISO
cedrol binds to and results in increased activity of ESR1 protein
CTD
PMID:27633901
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
multiple interactions
ISO
cedrol binds to and results in increased activity of ESR2 protein
CTD
PMID:27633901
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
danthron inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:19269596
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Aifm1
apoptosis inducing factor, mitochondria associated 1
multiple interactions increases expression
ISO
danthron affects the localization of and results in increased expression of AIFM1 protein danthron results in increased expression of AIFM1 mRNA
CTD
PMID:21126053
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Alb
albumin
affects binding
ISO
danthron binds to ALB protein
CTD
PMID:16404478
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Atf6
activating transcription factor 6
increases expression
ISO
danthron results in increased expression of ATF6 protein
CTD
PMID:21126053
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
danthron results in increased expression of BAX protein
CTD
PMID:21126053
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
danthron results in decreased expression of BCL2 protein
CTD
PMID:21126053
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
increases expression decreases expression
ISO
danthron results in increased expression of BCL2L1 protein danthron results in decreased expression of BCL2L1 protein
CTD
PMID:21126053
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
G
Bid
BH3 interacting domain death agonist
increases expression
ISO
danthron results in increased expression of BID protein
CTD
PMID:21126053
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
G
Birc2
baculoviral IAP repeat-containing 2
decreases expression
ISO
danthron results in decreased expression of BIRC2 protein
CTD
PMID:21126053
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
G
Birc3
baculoviral IAP repeat-containing 3
increases expression
ISO
danthron results in increased expression of BIRC3 protein
CTD
PMID:21126053
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
G
Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
danthron results in decreased expression of BIRC5 protein
CTD
PMID:21126053
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Casp3
caspase 3
multiple interactions increases expression
ISO
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP3 protein]; danthron results in increased activity of and results in increased expression of CASP3 protein danthron results in increased expression of CASP3 mRNA
CTD
PMID:21126053
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
multiple interactions increases expression
ISO
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein]; danthron results in increased activity of and results in increased expression of CASP8 protein danthron results in increased expression of CASP8 mRNA
CTD
PMID:21126053
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
multiple interactions increases expression
ISO
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP9 protein]; danthron results in increased activity of and results in increased expression of CASP9 protein danthron results in increased expression of CASP9 mRNA
CTD
PMID:21126053
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cycs
cytochrome c, somatic
multiple interactions
ISO
danthron affects the localization of and results in increased expression of CYCS protein
CTD
PMID:21126053
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
danthron results in decreased activity of CYP1A2 protein
CTD
PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
danthron results in increased expression of DDIT3 protein
CTD
PMID:21126053
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Diablo
diablo, IAP-binding mitochondrial protein
increases expression
ISO
danthron results in increased expression of DIABLO protein
CTD
PMID:21126053
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
G
Endog
endonuclease G
increases expression multiple interactions
ISO
danthron results in increased expression of ENDOG mRNA danthron affects the localization of and results in increased expression of ENDOG protein
CTD
PMID:21126053
NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
G
Fas
Fas cell surface death receptor
increases expression
ISO
danthron results in increased expression of FAS protein
CTD
PMID:21126053
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
increases expression
ISO
danthron results in increased expression of FASLG protein
CTD
PMID:21126053
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
G
Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
danthron results in increased expression of HSPA5 protein
CTD
PMID:21126053
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Sod1
superoxide dismutase 1
decreases expression
ISO
danthron results in decreased expression of SOD1 protein
CTD
PMID:21126053
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sod2
superoxide dismutase 2
decreases expression
ISO
danthron results in decreased expression of SOD2 protein
CTD
PMID:21126053
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Tnfsf10
TNF superfamily member 10
increases expression
ISO
danthron results in increased expression of TNFSF10 protein
CTD
PMID:21126053
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
G
Xiap
X-linked inhibitor of apoptosis
decreases expression
ISO
danthron results in decreased expression of XIAP protein
CTD
PMID:21126053
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
G
Abcb11
ATP binding cassette subfamily B member 11
decreases expression
EXP
chrysophanic acid results in decreased expression of ABCB11 mRNA; chrysophanic acid results in decreased expression of ABCB11 protein
CTD
PMID:28161596
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
G
Abcc2
ATP binding cassette subfamily C member 2
increases expression
EXP
chrysophanic acid results in increased expression of ABCC2 mRNA; chrysophanic acid results in increased expression of ABCC2 protein
CTD
PMID:28161596
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
G
Abcc4
ATP binding cassette subfamily C member 4
increases expression
EXP
chrysophanic acid results in increased expression of ABCC4 mRNA; chrysophanic acid results in increased expression of ABCC4 protein
CTD
PMID:28161596
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
chrysophanic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:19269596
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
chrysophanic acid results in decreased phosphorylation of AKT1 protein
CTD
PMID:30300626
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Bak1
BCL2-antagonist/killer 1
increases expression
ISO
chrysophanic acid results in increased expression of BAK1 protein
CTD
PMID:30300626
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
chrysophanic acid results in increased expression of BAX protein
CTD
PMID:30300626
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
chrysophanic acid results in decreased activity of CYP1A1 protein
CTD
PMID:27633141
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity multiple interactions increases metabolic processing
ISO
chrysophanic acid results in decreased activity of CYP1A2 protein [CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CTD
PMID:27633141 PMID:29698620 PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
chrysophanic acid results in decreased activity of CYP1B1 protein
CTD
PMID:27633141
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions increases metabolic processing
ISO
[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CTD
PMID:29698620
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases metabolic processing increases chemical synthesis multiple interactions
ISO
CYP3A4 protein results in increased metabolism of chrysophanic acid CYP3A4 protein results in increased chemical synthesis of chrysophanic acid metabolite [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol; [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CTD
PMID:29698620
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
increases expression
EXP
chrysophanic acid results in increased expression of CYP7A1 mRNA; chrysophanic acid results in increased expression of CYP7A1 protein
CTD
PMID:28161596
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
EXP
chrysophanic acid results in decreased expression of CYP8B1 mRNA; chrysophanic acid results in decreased expression of CYP8B1 protein
CTD
PMID:28161596
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
chrysophanic acid results in increased expression of DDIT3 protein
CTD
PMID:30300626
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases phosphorylation multiple interactions
ISO
chrysophanic acid results in increased phosphorylation of EIF2AK3 protein Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein]
CTD
PMID:30300626
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
G
Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
increases phosphorylation multiple interactions
ISO
chrysophanic acid results in increased phosphorylation of EIF2S1 protein Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]
CTD
PMID:30300626
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
G
Ern1
endoplasmic reticulum to nucleus signaling 1
increases expression
ISO
chrysophanic acid results in increased expression of ERN1 protein
CTD
PMID:30300626
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
chrysophanic acid results in decreased phosphorylation of MAPK1 protein
CTD
PMID:30300626
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk14
mitogen activated protein kinase 14
affects phosphorylation
ISO
chrysophanic acid affects the phosphorylation of MAPK14 protein
CTD
PMID:30300626
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
G
Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
chrysophanic acid results in decreased phosphorylation of MAPK3 protein
CTD
PMID:30300626
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mapk8
mitogen-activated protein kinase 8
affects phosphorylation
ISO
chrysophanic acid affects the phosphorylation of MAPK8 protein
CTD
PMID:30300626
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Pcna
proliferating cell nuclear antigen
decreases expression
ISO
chrysophanic acid results in decreased expression of PCNA protein
CTD
PMID:30300626
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Rps6
ribosomal protein S6
decreases phosphorylation
ISO
chrysophanic acid results in decreased phosphorylation of RPS6 protein
CTD
PMID:30300626
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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Rps6kb1
ribosomal protein S6 kinase B1
decreases phosphorylation
ISO
chrysophanic acid results in decreased phosphorylation of RPS6KB1 protein
CTD
PMID:30300626
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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Slc10a1
solute carrier family 10 member 1
decreases expression
EXP
chrysophanic acid results in decreased expression of SLC10A1 mRNA; chrysophanic acid results in decreased expression of SLC10A1 protein
CTD
PMID:28161596
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc22a6
solute carrier family 22 member 6
decreases activity
ISO
chrysophanic acid results in decreased activity of SLC22A6 protein
CTD
PMID:29045746
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
decreases activity
ISO
chrysophanic acid results in decreased activity of SLC22A8 protein
CTD
PMID:29045746
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Sult1a1
sulfotransferase family 1A member 1
decreases activity
ISO
chrysophanic acid results in decreased activity of SULT1A1 protein
CTD
PMID:27633141
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of chrysophanic acid
CTD
PMID:24854283
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases chemical synthesis
ISO
CYP2C19 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone
CTD
PMID:27989148
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases chemical synthesis
ISO
CYP3A4 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone
CTD
PMID:27989148
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
cyclobenzaprine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Ahr
aryl hydrocarbon receptor
multiple interactions increases activity
EXP
dibenzo(aj)anthracene binds to and results in increased activity of AHR protein; dibenzo(aj)anthracene inhibits the reaction [Benzo(a)pyrene binds to AHR protein] dibenzo(aj)anthracene results in increased activity of AHR protein
CTD
PMID:11525907 PMID:28104439 PMID:29471110
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
dibenzo(aj)anthracene results in increased expression of CYP1A1 protein
CTD
PMID:28104439
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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H2ax
H2A.X variant histone
increases phosphorylation
EXP
Disperse Blue 1 results in increased phosphorylation of H2AX protein
CTD
PMID:33211169
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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Krt14
keratin 14
increases expression
EXP
Disperse Blue 1 results in increased expression of KRT14 protein
CTD
PMID:33211169
NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799
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Abcb11
ATP binding cassette subfamily B member 11
increases expression multiple interactions affects activity decreases expression
EXP ISO
Emodin results in increased expression of ABCB11 mRNA; Emodin results in increased expression of ABCB11 protein 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside affects the reaction [[Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid]; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCB11 protein; [Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid dorsomorphin inhibits the reaction [Emodin results in decreased expression of ABCB11 mRNA]; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA] Emodin results in decreased expression of ABCB11 mRNA; Emodin results in decreased expression of ABCB11 protein
CTD
PMID:28161596 PMID:30517764 PMID:35753641
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions increases expression
ISO EXP
Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] Emodin results in increased expression of ABCB1A mRNA ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]
CTD
PMID:19549930 PMID:24380838
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
increases expression
EXP
Emodin results in increased expression of ABCB1B mRNA
CTD
PMID:19549930
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcb4
ATP binding cassette subfamily B member 4
decreases expression
EXP
Emodin results in decreased expression of ABCB4 mRNA
CTD
PMID:28161596
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc2
ATP binding cassette subfamily C member 2
increases expression multiple interactions decreases expression
EXP ISO
Emodin results in increased expression of ABCC2 mRNA [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC2 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC2 protein Emodin results in decreased expression of ABCC2 mRNA Emodin results in decreased expression of ABCC2 mRNA; Emodin results in decreased expression of ABCC2 protein
CTD
PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
increases expression multiple interactions decreases expression
EXP ISO
Emodin results in increased expression of ABCC3 mRNA [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC3 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC3 protein Emodin results in decreased expression of ABCC3 mRNA Emodin results in decreased expression of ABCC3 mRNA; Emodin results in decreased expression of ABCC3 protein
CTD
PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc4
ATP binding cassette subfamily C member 4
decreases expression multiple interactions
EXP ISO
Emodin results in decreased expression of ABCC4 mRNA; Emodin results in decreased expression of ABCC4 protein [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC4 protein Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC4 mRNA]
CTD
PMID:28161596 PMID:30517764 PMID:35753641
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Abcc6
ATP binding cassette subfamily C member 6
increases expression
EXP
Emodin results in increased expression of ABCC6 mRNA
CTD
PMID:19549930
NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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Acta1
actin, alpha 1, skeletal muscle
decreases expression
ISO
Emodin results in decreased expression of ACTA1 mRNA
CTD
PMID:16045814
NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
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Acta2
actin alpha 2, smooth muscle
decreases expression multiple interactions
EXP
Emodin results in decreased expression of ACTA2 protein 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
CTD
PMID:15288473 PMID:27989784
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Adgre1
adhesion G protein-coupled receptor E1
multiple interactions
ISO
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]
CTD
PMID:37023836
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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Agt
angiotensinogen
multiple interactions
EXP
Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]; Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein]
CTD
PMID:17886230
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
Emodin binds to and results in increased activity of AHR protein Emodin binds to and results in increased activity of AHR protein; Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:14644660 PMID:17869316
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akr1b10
aldo-keto reductase family 1 member B10
decreases activity
ISO
Emodin results in decreased activity of AKR1B10 protein
CTD
PMID:35065925
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akr1c3
aldo-keto reductase family 1, member C3
decreases activity
ISO
Emodin results in decreased activity of AKR1C3 protein
CTD
PMID:35065925
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Akr7a3
aldo-keto reductase family 7 member A3
decreases activity
ISO
Emodin results in decreased activity of AKR7A3 protein
CTD
PMID:35065925
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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Akt1
AKT serine/threonine kinase 1
multiple interactions decreases phosphorylation decreases expression
ISO EXP
[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein] Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein] Emodin results in decreased expression of AKT1 mRNA
CTD
PMID:15288473 PMID:16045814 PMID:17077332 PMID:23848338 PMID:27032576
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Ar
androgen receptor
multiple interactions
ISO
Emodin inhibits the reaction [cobaltous chloride results in increased expression of AR protein]
CTD
PMID:23212659
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arg2
arginase 2
decreases expression
ISO
Emodin results in decreased expression of ARG2 mRNA
CTD
PMID:21319176
NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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Arid3a
AT-rich interaction domain 3A
increases expression
ISO
Emodin results in increased expression of ARID3A mRNA
CTD
PMID:15612046
NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599
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Atm
ATM serine/threonine kinase
increases expression increases phosphorylation
ISO
Emodin results in increased expression of ATM mRNA Emodin results in increased phosphorylation of ATM protein
CTD
PMID:16045814 PMID:20855424
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Bag5
BAG cochaperone 5
decreases expression
ISO
Emodin results in decreased expression of BAG5 mRNA
CTD
PMID:16045814
NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970
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Bax
BCL2 associated X, apoptosis regulator
affects expression increases expression multiple interactions decreases expression
ISO EXP
Emodin affects the expression of BAX protein Emodin results in increased expression of BAX protein 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside promotes the reaction [Emodin results in increased expression of BAX protein] Emodin results in decreased expression of BAX protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; U 0126 affects the reaction [Emodin affects the expression of BAX protein]
CTD
PMID:19549930 PMID:27032576 PMID:35753641
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions affects expression
ISO EXP
Emodin results in decreased expression of BCL2 mRNA; Emodin results in decreased expression of BCL2 protein [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of BCL2 protein Emodin affects the expression of BCL2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; SB 203580 affects the reaction [Emodin affects the expression of BCL2 protein]; U 0126 affects the reaction [Emodin affects the expression of BCL2 protein]
CTD
PMID:19549930 PMID:23848338 PMID:27032576 PMID:35753641
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bfar
bifunctional apoptosis regulator
decreases expression
ISO
Emodin results in decreased expression of BFAR mRNA
CTD
PMID:16045814
NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038
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Bid
BH3 interacting domain death agonist
increases degradation multiple interactions
ISO
Emodin results in increased degradation of BID protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; SB 203580 promotes the reaction [Emodin results in increased degradation of BID protein]
CTD
PMID:27032576
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
Emodin results in decreased expression of BIRC5 mRNA; Emodin results in decreased expression of BIRC5 protein
CTD
PMID:23848338
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Canx
calnexin
decreases expression
ISO
Emodin results in decreased expression of CANX mRNA
CTD
PMID:16045814
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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Casp1
caspase 1
increases expression multiple interactions
ISO
Emodin results in increased expression of CASP1 mRNA Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]
CTD
PMID:15612046 PMID:37023836
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp12
caspase 12
decreases expression
ISO
Emodin results in decreased expression of CASP12 mRNA
CTD
PMID:21319176
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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Casp3
caspase 3
increases expression multiple interactions affects expression increases cleavage increases activity
ISO EXP
Emodin results in increased expression of CASP3 protein [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP3 protein; Emodin inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein] Emodin affects the expression of CASP3 protein modified form Emodin results in increased cleavage of CASP3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Emodin results in increased activity of CASP3 protein]; Emodin results in increased cleavage of and results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [Emodin results in increased cleavage of CASP3 protein]
CTD
PMID:19549930 PMID:23848338 PMID:25448808 PMID:27032576 PMID:34492313 PMID:34971761 PMID:35753641 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
multiple interactions increases activity
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]; U 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein]
CTD
PMID:27032576
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases expression multiple interactions
ISO EXP
Emodin results in increased expression of CASP9 mRNA [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP9 protein
CTD
PMID:21319176 PMID:35753641
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions affects expression
ISO EXP
Emodin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein] Emodin promotes the reaction [Cisplatin results in decreased activity of CAT protein] Emodin affects the expression of CAT protein
CTD
PMID:19549930 PMID:22271272 PMID:26139382
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cbr1
carbonyl reductase 1
decreases activity
ISO
Emodin results in decreased activity of CBR1 protein
CTD
PMID:35065925
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Ccl26
C-C motif chemokine ligand 26
multiple interactions
ISO
Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein]
CTD
PMID:37788752
NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335
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Ccnb2
cyclin B2
decreases expression
ISO
Emodin results in decreased expression of CCNB2 mRNA
CTD
PMID:16045814
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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Ccr3
C-C motif chemokine receptor 3
multiple interactions
ISO
Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein]
CTD
PMID:37788752
NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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Cdh1
cadherin 1
increases expression multiple interactions
EXP
Emodin results in increased expression of CDH1 protein 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]
CTD
PMID:27989784
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdk13
cyclin-dependent kinase 13
decreases expression
ISO
Emodin results in decreased expression of CDK13 mRNA
CTD
PMID:16045814
NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
Emodin results in decreased expression of CDK4 mRNA
CTD
PMID:16045814
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdkn1c
cyclin-dependent kinase inhibitor 1C
increases expression
ISO
Emodin results in increased expression of CDKN1C mRNA
CTD
PMID:21319176
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
decreases expression
ISO
Emodin results in decreased expression of CELSR3 mRNA
CTD
PMID:16045814
NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354
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Chia
chitinase, acidic
multiple interactions
ISO
Emodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA]
CTD
PMID:22484343
NCBI chr 2:193,614,374...193,656,532
Ensembl chr 2:193,614,114...193,656,533
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Cidec
cell death-inducing DFFA-like effector c
decreases expression
ISO
Emodin results in decreased expression of CIDEC mRNA
CTD
PMID:21319176
NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
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Col1a1
collagen type I alpha 1 chain
decreases expression
EXP
Emodin results in decreased expression of COL1A1 mRNA
CTD
PMID:15288473
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col1a2
collagen type I alpha 2 chain
multiple interactions
EXP
Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]
CTD
PMID:19474275
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Col3a1
collagen type III alpha 1 chain
decreases expression
EXP
Emodin results in decreased expression of COL3A1 mRNA
CTD
PMID:15288473
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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Cops5
COP9 signalosome subunit 5
multiple interactions
ISO
[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein
CTD
PMID:17077332
NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
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Csnk2a1
casein kinase 2 alpha 1
increases expression
ISO
Emodin results in increased expression of CSNK2A1 mRNA
CTD
PMID:21319176
NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
G
Csnk2b
casein kinase 2 beta
increases expression
ISO
Emodin results in increased expression of CSNK2B mRNA
CTD
PMID:21319176
NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133
G
Ctsd
cathepsin D
decreases expression
ISO
Emodin results in decreased expression of CTSD mRNA
CTD
PMID:16045814
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cxcl1
C-X-C motif chemokine ligand 1
multiple interactions
EXP
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]
CTD
PMID:18590720
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
G
Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
EXP
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA]
CTD
PMID:18590720
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cyld
CYLD lysine 63 deubiquitinase
increases expression
ISO
Emodin results in increased expression of CYLD mRNA
CTD
PMID:21319176
NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases activity increases expression
ISO
Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] Emodin results in decreased activity of CYP1A1 protein Emodin results in increased expression of CYP1A1 mRNA; Emodin results in increased expression of CYP1A1 protein
CTD
PMID:11502733 PMID:14644660 PMID:17012224 PMID:27633141
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions increases hydroxylation increases oxidation decreases activity
ISO
[CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite CYP1A2 protein results in increased hydroxylation of Emodin CYP1A2 protein results in increased oxidation of Emodin Emodin results in decreased activity of CYP1A2 protein
CTD
PMID:27633141 PMID:27989148 PMID:30672276 PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression decreases activity
ISO
Emodin results in increased expression of CYP1B1 mRNA; Emodin results in increased expression of CYP1B1 protein Emodin results in decreased activity of CYP1B1 protein
CTD
PMID:11502733 PMID:14990334 PMID:27633141
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression multiple interactions
EXP ISO
Emodin results in decreased expression of CYP27A1 mRNA [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP27A1 protein
CTD
PMID:28161596 PMID:30517764 PMID:35753641
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases oxidation decreases activity multiple interactions
ISO
CYP2C19 protein results in increased oxidation of Emodin Emodin results in decreased activity of CYP2C19 protein [CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CTD
PMID:27989148 PMID:33438235
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
Emodin results in decreased activity of CYP2D6 protein
CTD
PMID:33438235
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions decreases activity affects response to substance increases hydroxylation increases oxidation
ISO
[CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite Emodin results in decreased activity of CYP3A4 protein CYP3A4 protein affects the susceptibility to Emodin CYP3A4 protein results in increased hydroxylation of Emodin CYP3A4 protein results in increased oxidation of Emodin
CTD
PMID:27989148 PMID:30672276 PMID:33438235 PMID:34875353
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases hydroxylation
ISO
CYP3A5 protein results in increased hydroxylation of Emodin
CTD
PMID:30672276
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression multiple interactions
EXP
Emodin results in decreased expression of CYP7A1 mRNA; Emodin results in decreased expression of CYP7A1 protein [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP7A1 protein
CTD
PMID:28161596 PMID:35753641
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Cyp7b1
cytochrome P450 family 7 subfamily B member 1
decreases expression
ISO
Emodin results in decreased expression of CYP7B1 mRNA
CTD
PMID:30517764
NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
EXP
Emodin results in decreased expression of CYP8B1 mRNA; Emodin results in decreased expression of CYP8B1 protein
CTD
PMID:28161596
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
G
Dct
dopachrome tautomerase
decreases expression
ISO
Emodin results in decreased expression of DCT mRNA; Emodin results in decreased expression of DCT protein
CTD
PMID:26972667
NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
G
Ddit3
DNA-damage inducible transcript 3
increases expression
EXP
Emodin results in increased expression of DDIT3 protein
CTD
PMID:19549930
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Dhfr
dihydrofolate reductase
decreases expression
ISO
Emodin results in decreased expression of DHFR mRNA
CTD
PMID:16045814
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
G
Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
increases expression
ISO
Emodin results in increased expression of DNAJB1 mRNA
CTD
PMID:16045814
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
G
Dync1h1
dynein cytoplasmic 1 heavy chain 1
increases expression
ISO
Emodin results in increased expression of DYNC1H1 mRNA
CTD
PMID:21319176
NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
G
E2f5
E2F transcription factor 5
increases expression
ISO
Emodin results in increased expression of E2F5 mRNA
CTD
PMID:16045814
NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
G
Egr1
early growth response 1
multiple interactions
EXP
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA]
CTD
PMID:18590720
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Ei24
EI24, autophagy associated transmembrane protein
increases expression
ISO
Emodin results in increased expression of EI24 mRNA
CTD
PMID:16045814
NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
G
Eif2b1
eukaryotic translation initiation factor 2B subunit alpha
decreases expression
ISO
Emodin results in decreased expression of EIF2B1 mRNA
CTD
PMID:16045814
NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601
G
Esr1
estrogen receptor 1
increases activity
ISO
Emodin results in increased activity of ESR1 protein
CTD
PMID:19161236
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
increases activity
ISO
Emodin results in increased activity of ESR2 protein
CTD
PMID:19161236
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Fabp5
fatty acid binding protein 5
decreases expression
ISO
Emodin results in decreased expression of FABP5 mRNA
CTD
PMID:15612046
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
G
Fadd
Fas associated via death domain
increases expression
ISO
Emodin results in increased expression of FADD mRNA
CTD
PMID:21319176
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
G
Fas
Fas cell surface death receptor
multiple interactions decreases expression increases expression
ISO EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]; U 0126 promotes the reaction [Emodin results in increased expression of FAS protein] Emodin results in decreased expression of FAS protein
CTD
PMID:19549930 PMID:27032576
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Faslg
Fas ligand
multiple interactions increases expression
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]; SB 203580 promotes the reaction [Emodin results in increased expression of FASLG protein]; U 0126 promotes the reaction [Emodin results in increased expression of FASLG protein]
CTD
PMID:27032576
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
G
Fn1
fibronectin 1
decreases expression
EXP
Emodin results in decreased expression of FN1 mRNA
CTD
PMID:15288473
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
G
Foxo1
forkhead box O1
increases expression
ISO
Emodin results in increased expression of FOXO1 mRNA
CTD
PMID:16045814
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GADD45A mRNA]
CTD
PMID:30517764
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Gas2
growth arrest-specific 2
increases expression
ISO
Emodin results in increased expression of GAS2 mRNA
CTD
PMID:16045814
NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
EXP
Emodin results in increased expression of GCLC mRNA
CTD
PMID:34971761
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
EXP
Emodin results in increased expression of GCLM mRNA
CTD
PMID:34971761
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gcnt2
glucosaminyl (N-acetyl) transferase 2
increases expression
ISO
Emodin results in increased expression of GCNT2 mRNA
CTD
PMID:15612046
NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
G
Gfap
glial fibrillary acidic protein
multiple interactions
EXP
Emodin inhibits the reaction [Oxaliplatin results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein]
CTD
PMID:36184831
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Golga3
golgin A3
increases expression
ISO
Emodin results in increased expression of GOLGA3 mRNA
CTD
PMID:21319176
NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
[Emodin co-treated with 1-aminobenzotriazole] results in increased expression of GPT protein; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]
CTD
PMID:34492313 PMID:37023836
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gpx1
glutathione peroxidase 1
increases expression
ISO
Emodin results in increased expression of GPX1 mRNA
CTD
PMID:16045814
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Gpx2
glutathione peroxidase 2
multiple interactions
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPX2 mRNA]
CTD
PMID:30517764
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
G
Gsr
glutathione-disulfide reductase
multiple interactions
ISO
Emodin promotes the reaction [Cisplatin results in decreased activity of GSR protein]
CTD
PMID:22271272
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gstm5
glutathione S-transferase, mu 5
decreases expression
ISO
Emodin results in decreased expression of GSTM3 mRNA
CTD
PMID:16045814
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
G
Gstp1
glutathione S-transferase pi 1
multiple interactions
ISO
Emodin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]
CTD
PMID:15313406
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
H2ax
H2A.X variant histone
increases expression multiple interactions
ISO
Emodin results in increased expression of H2AX protein; Emodin results in increased expression of H2AX protein modified form TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
CTD
PMID:20855424 PMID:34492313 PMID:36893906
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Hacd3
3-hydroxyacyl-CoA dehydratase 3
decreases expression
ISO
Emodin results in decreased expression of HACD3 mRNA
CTD
PMID:16045814
NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
G
Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions
ISO
Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA]
CTD
PMID:21382473
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Hils1
histone linker H1 domain, spermatid-specific 1
increases expression
ISO
Emodin results in increased expression of H1F9 mRNA
CTD
PMID:21319176
NCBI chr10:79,913,525...79,914,321
Ensembl chr10:79,913,480...79,914,321
G
Hk2
hexokinase 2
increases expression
ISO
Emodin results in increased expression of HK2 mRNA
CTD
PMID:21319176
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
G
Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 protein] Emodin results in increased expression of HMOX1 mRNA
CTD
PMID:26139382 PMID:30517764 PMID:34875353
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hnf4a
hepatocyte nuclear factor 4, alpha
decreases expression affects glucuronidation
EXP ISO
Emodin results in decreased expression of HNF4A protein Emodin results in decreased expression of HNF4A mRNA; Emodin results in decreased expression of HNF4A protein HNF4A gene SNP affects the glucuronidation of Emodin
CTD
PMID:32538071
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
G
Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
EXP
Emodin results in increased expression of HSPA5 protein
CTD
PMID:19549930
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Icam1
intercellular adhesion molecule 1
multiple interactions
EXP
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ICAM1 protein]
CTD
PMID:18590720
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Igsf11
immunoglobulin superfamily, member 11
increases expression
ISO
Emodin results in increased expression of IGSF11 mRNA
CTD
PMID:21319176
NCBI chr11:61,733,139...61,884,059
Ensembl chr11:61,733,144...61,868,348
G
Il10
interleukin 10
multiple interactions
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL10 mRNA]
CTD
PMID:30517764
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il13
interleukin 13
multiple interactions
ISO
Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein]
CTD
PMID:22484343
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il15
interleukin 15
increases expression
ISO
Emodin results in increased expression of IL15 mRNA
CTD
PMID:15612046
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
G
Il18
interleukin 18
multiple interactions
ISO
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]
CTD
PMID:37023836
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
multiple interactions
ISO EXP
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL1B protein] Emodin inhibits the reaction [Oxaliplatin results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]
CTD
PMID:26139382 PMID:30517764 PMID:36184831 PMID:37023836
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il4
interleukin 4
multiple interactions
ISO
Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein]
CTD
PMID:22484343
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il5
interleukin 5
multiple interactions
ISO
Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein]
CTD
PMID:22484343
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Il6
interleukin 6
multiple interactions
EXP ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein] Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein] Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
CTD
PMID:18590720 PMID:23848338 PMID:26139382 PMID:30517764 PMID:37023836
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
decreases expression
ISO
Emodin results in decreased expression of ITPR1 mRNA
CTD
PMID:16045814
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
G
Jag1
jagged canonical Notch ligand 1
multiple interactions decreases expression
EXP
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein] Emodin results in decreased expression of JAG1 protein
CTD
PMID:27989784
NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
G
Jak1
Janus kinase 1
decreases phosphorylation multiple interactions
ISO
Emodin results in decreased phosphorylation of JAK1 protein Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]
CTD
PMID:23848338
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
G
Jak2
Janus kinase 2
decreases phosphorylation multiple interactions
ISO
Emodin results in decreased phosphorylation of JAK2 protein Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]
CTD
PMID:23848338
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
G
Jund
JunD proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein
CTD
PMID:17077332
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
G
Krt19
keratin 19
decreases expression
ISO
Emodin results in decreased expression of KRT19 mRNA
CTD
PMID:16045814
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
G
Laptm5
lysosomal protein transmembrane 5
increases expression
ISO
Emodin results in increased expression of LAPTM5 mRNA
CTD
PMID:15612046
NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
G
Lef1
lymphoid enhancer binding factor 1
decreases expression
ISO
Emodin results in decreased expression of LEF1 mRNA
CTD
PMID:15612046
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
G
Lrp1
LDL receptor related protein 1
multiple interactions
ISO
[Emodin co-treated with cobaltous chloride] results in increased expression of LRP1 protein
CTD
PMID:23212659
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
G
Macf1
microtubule-actin crosslinking factor 1
decreases expression
ISO
Emodin results in decreased expression of MACF1 mRNA
CTD
PMID:16045814
NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905
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Maob
monoamine oxidase B
decreases activity
EXP
Emodin results in decreased activity of MAOB protein
CTD
PMID:15120460
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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Map2k1
mitogen activated protein kinase kinase 1
multiple interactions
EXP
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]
CTD
PMID:15288473
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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Map2k2
mitogen activated protein kinase kinase 2
multiple interactions
EXP
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]
CTD
PMID:15288473
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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Mapk1
mitogen activated protein kinase 1
multiple interactions decreases phosphorylation increases phosphorylation
EXP ISO
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein] Emodin results in decreased phosphorylation of MAPK1 protein Emodin results in increased phosphorylation of MAPK1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]
CTD
PMID:15288473 PMID:26972667 PMID:27032576
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk10
mitogen activated protein kinase 10
increases expression
ISO
Emodin results in increased expression of MAPK10 mRNA
CTD
PMID:15612046
NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
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Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO
Acetylcysteine inhibits the reaction [Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]
CTD
PMID:14729614
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk3
mitogen activated protein kinase 3
multiple interactions decreases phosphorylation increases phosphorylation
EXP ISO
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] Emodin results in decreased phosphorylation of MAPK3 protein Emodin results in increased phosphorylation of MAPK3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]
CTD
PMID:15288473 PMID:26972667 PMID:27032576
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapt
microtubule-associated protein tau
decreases expression
ISO
Emodin results in decreased expression of MAPT mRNA
CTD
PMID:16045814
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression increases expression
ISO
Emodin results in decreased expression of MCL1 mRNA; Emodin results in decreased expression of MCL1 protein Emodin results in increased expression of MCL1 mRNA
CTD
PMID:21319176 PMID:23848338
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Melk
maternal embryonic leucine zipper kinase
decreases expression
ISO
Emodin results in decreased expression of MELK mRNA; Emodin results in decreased expression of MELK protein
CTD
PMID:36893906
NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937
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Mgmt
O-6-methylguanine-DNA methyltransferase
increases expression
EXP
Emodin results in increased expression of MGMT mRNA
CTD
PMID:19549930
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Mitf
melanocyte inducing transcription factor
decreases expression
ISO
Emodin results in decreased expression of MITF protein
CTD
PMID:26972667
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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Mpo
myeloperoxidase
multiple interactions
EXP
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein]
CTD
PMID:18590720
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
multiple interactions
ISO
Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]
CTD
PMID:22484343
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions affects expression
EXP
Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein] Emodin affects the expression of MYC protein
CTD
PMID:17886230 PMID:19549930
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Mylk
myosin light chain kinase
increases activity
EXP
Emodin results in increased activity of MYLK protein
CTD
PMID:15133857
NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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Ncoa2
nuclear receptor coactivator 2
increases expression
ISO
Emodin results in increased expression of NCOA2 mRNA
CTD
PMID:21319176
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions affects localization
ISO EXP
Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NFE2L2 protein]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of NFE2L2 mRNA] Emodin affects the localization of NFE2L2 protein [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein]
CTD
PMID:26139382 PMID:34971761
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
increases expression multiple interactions
EXP ISO
Emodin results in increased expression of NFKB1 protein Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]
CTD
PMID:19549930 PMID:37023836
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
increases expression multiple interactions
ISO
Emodin results in increased expression of NFKBIA mRNA Emodin inhibits the reaction [Ovalbumin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD
PMID:16045814 PMID:22484343
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nkx6-2
NK6 homeobox 2
increases expression
ISO
Emodin results in increased expression of NKX6-2 mRNA
CTD
PMID:15612046
NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]
CTD
PMID:37023836
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nos2
nitric oxide synthase 2
multiple interactions affects expression
EXP
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein] Emodin affects the expression of NOS2
CTD
PMID:18590720 PMID:23615023
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Notch1
notch receptor 1
decreases expression multiple interactions decreases response to substance
EXP
Emodin results in decreased expression of NOTCH1 protein 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein] NOTCH1 protein results in decreased susceptibility to Emodin
CTD
PMID:27989784
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression multiple interactions
ISO EXP
Emodin results in increased expression of NQO1 mRNA Emodin results in increased expression of and results in increased activity of NQO1 protein
CTD
PMID:34875353 PMID:34971761
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Emodin results in increased expression of NR0B2 mRNA
CTD
PMID:30517764
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nr1h3
nuclear receptor subfamily 1, group H, member 3
increases expression
ISO
Emodin results in increased expression of NR1H3 mRNA; Emodin results in increased expression of NR1H3 protein
CTD
PMID:26972667
NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
decreases expression
ISO
Emodin results in decreased expression of NR1H4 mRNA; Emodin results in decreased expression of NR1H4 protein
CTD
PMID:30517764
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Oma1
OMA1 zinc metallopeptidase
multiple interactions
EXP
Emodin inhibits the reaction [Hydrogen Peroxide results in increased expression of OMA1 protein]; Emodin inhibits the reaction [Oxidopamine results in increased expression of OMA1 protein]
CTD
PMID:34971761
NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980
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Parp1
poly (ADP-ribose) polymerase 1
increases activity increases cleavage multiple interactions
ISO
Emodin results in increased activity of PARP1 protein Emodin results in increased cleavage of PARP1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; [U 0126 co-treated with Emodin] results in increased cleavage of PARP1 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]
CTD
PMID:23848338 PMID:27032576 PMID:34492313 PMID:36893906
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein]
CTD
PMID:17886230
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pdcl
phosducin like
decreases expression
ISO
Emodin results in decreased expression of PDCL mRNA
CTD
PMID:16045814
NCBI chr 3:21,110,165...21,119,763
Ensembl chr 3:21,110,167...21,119,715
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Pdgfb
platelet derived growth factor subunit B
multiple interactions
EXP
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]
CTD
PMID:15288473
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pdgfrb
platelet derived growth factor receptor beta
multiple interactions decreases expression
EXP
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein] Emodin results in decreased expression of PDGFRB protein
CTD
PMID:15288473
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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Pecam1
platelet and endothelial cell adhesion molecule 1
decreases expression
ISO
Emodin results in decreased expression of PECAM1 protein
CTD
PMID:23848338
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Pik3c3
phosphatidylinositol 3-kinase, catalytic subunit type 3
increases expression
ISO
Emodin results in increased expression of PIK3C3 mRNA
CTD
PMID:16045814
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
affects expression
EXP
Emodin affects the expression of PIK3R1 protein
CTD
PMID:19549930
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Pkm
pyruvate kinase M1/2
affects localization decreases activity multiple interactions
EXP
Emodin affects the localization of PKM protein Emodin results in decreased activity of PKM protein [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which results in decreased activity of PKM protein; [Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein]
CTD
PMID:34971761
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression multiple interactions
ISO
Emodin results in increased expression of PPARG protein Emodin results in increased stability of and results in increased expression of PPARG mRNA
CTD
PMID:25448808
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
increases expression
ISO
Emodin results in increased expression of PPM1D mRNA
CTD
PMID:16045814
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
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Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
decreases expression
ISO
Emodin results in decreased expression of PPP1R1C mRNA
CTD
PMID:15612046
NCBI chr 3:64,616,700...64,719,696
Ensembl chr 3:64,616,700...64,724,104
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Prdx6
peroxiredoxin 6
increases expression
ISO
Emodin results in increased expression of PRDX6 mRNA
CTD
PMID:16045814
NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
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Prkca
protein kinase C, alpha
affects localization
EXP
Emodin affects the localization of PRKCA protein
CTD
PMID:15133857
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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Prkcd
protein kinase C, delta
decreases expression affects expression
ISO EXP
Emodin results in decreased expression of PRKCD mRNA Emodin affects the expression of PRKCD protein
CTD
PMID:16045814 PMID:19549930
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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Prm3
protamine 3
increases expression
ISO
Emodin results in increased expression of PRM3 mRNA
CTD
PMID:21319176
NCBI chr10:4,877,471...4,877,985
Ensembl chr10:4,877,471...4,877,985
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
Emodin inhibits the reaction [Oxaliplatin results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
CTD
PMID:36184831
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptk2
protein tyrosine kinase 2
affects expression
EXP
Emodin affects the expression of PTK2 protein
CTD
PMID:19549930
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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Ptpn6
protein tyrosine phosphatase, non-receptor type 6
increases expression multiple interactions
ISO
Emodin results in increased expression of PTPN6 protein PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]
CTD
PMID:23848338
NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
decreases expression multiple interactions
ISO EXP
Emodin results in decreased expression of RAF1 mRNA Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]
CTD
PMID:15288473 PMID:16045814
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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Rag1
recombination activating 1
decreases expression
ISO
Emodin results in decreased expression of RAG1 mRNA
CTD
PMID:15612046
NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291
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Rarb
retinoic acid receptor, beta
decreases expression
ISO
Emodin results in decreased expression of RARB mRNA
CTD
PMID:22609528
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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Rb1
RB transcriptional corepressor 1
decreases expression
ISO
Emodin results in decreased expression of RB1 mRNA
CTD
PMID:16045814
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rcn2
reticulocalbin 2
increases expression
ISO
Emodin results in increased expression of RCN2 mRNA
CTD
PMID:16045814
NCBI chr 8:56,449,206...56,466,253
Ensembl chr 8:56,449,206...56,466,251
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions decreases localization
EXP ISO
Emodin affects the expression of and affects the localization of RELA protein; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of RELA protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein] Emodin results in decreased localization of RELA protein Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]; Emodin inhibits the reaction [Ovalbumin affects the localization of RELA protein]
CTD
PMID:18590720 PMID:19549930 PMID:22484343 PMID:30517764 PMID:36184831 PMID:37023836 More...
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rhoa
ras homolog family member A
decreases expression
ISO
Emodin results in decreased expression of RHOA mRNA
CTD
PMID:16045814
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Rock1
Rho-associated coiled-coil containing protein kinase 1
decreases expression
ISO
Emodin results in decreased expression of ROCK1 mRNA
CTD
PMID:16045814
NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
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Rock2
Rho-associated coiled-coil containing protein kinase 2
decreases expression
ISO
Emodin results in decreased expression of ROCK2 mRNA
CTD
PMID:16045814
NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
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Sae1
SUMO1 activating enzyme subunit 1
decreases expression
ISO
Emodin results in decreased expression of SAE1 mRNA
CTD
PMID:16045814
NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
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Serpine1
serpin family E member 1
multiple interactions
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]
CTD
PMID:14534369
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slc10a1
solute carrier family 10 member 1
decreases expression multiple interactions
EXP ISO
Emodin results in decreased expression of SLC10A1 mRNA; Emodin results in decreased expression of SLC10A1 protein Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]
CTD
PMID:28161596 PMID:30517764
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc22a6
solute carrier family 22 member 6
decreases activity
ISO
Emodin results in decreased activity of SLC22A6 protein
CTD
PMID:29045746
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
decreases activity
ISO
Emodin results in decreased activity of SLC22A8 protein
CTD
PMID:29045746
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Slco1b2
solute carrier organic anion transporter family member 1B2
multiple interactions
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]
CTD
PMID:30517764
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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Smcp
sperm mitochondria-associated cysteine-rich protein
increases expression
ISO
Emodin results in increased expression of SMCP mRNA
CTD
PMID:21319176
NCBI chr 2:178,160,948...178,165,951
Ensembl chr 2:178,160,127...178,166,001
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Snu13
small nuclear ribonucleoprotein 13
decreases expression
ISO
Emodin results in decreased expression of SNU13 mRNA
CTD
PMID:15612046
NCBI chr 7:113,565,293...113,570,887
Ensembl chr 7:113,565,295...113,570,872 Ensembl chr 1:113,565,295...113,570,872
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Sod1
superoxide dismutase 1
multiple interactions
ISO
Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA]
CTD
PMID:21382473
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
multiple interactions affects activity
ISO EXP
Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA] Emodin affects the activity of SOD2 protein
CTD
PMID:21382473 PMID:23615023
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
decreases phosphorylation
ISO
Emodin results in decreased phosphorylation of SRC protein
CTD
PMID:23848338
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
increases expression
ISO
Emodin results in increased expression of ST8SIA1 mRNA
CTD
PMID:16045814
NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708
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Stat3
signal transducer and activator of transcription 3
affects localization multiple interactions
ISO
Emodin affects the localization of STAT3 protein Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein; pervanadate inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]
CTD
PMID:23848338
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stip1
stress-induced phosphoprotein 1
decreases expression
ISO
Emodin results in decreased expression of STIP1 mRNA
CTD
PMID:16045814
NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476
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Sult1a1
sulfotransferase family 1A member 1
decreases activity
ISO
Emodin results in decreased activity of SULT1A1 protein
CTD
PMID:27633141
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Supt20h
SPT20 homolog, SAGA complex component
increases expression
ISO
Emodin results in increased expression of SUPT20H mRNA
CTD
PMID:16045814
NCBI chr 2:138,897,316...138,930,493
Ensembl chr 2:138,897,416...138,930,495
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Taok3
TAO kinase 3
decreases expression
ISO
Emodin results in decreased expression of TAOK3 mRNA
CTD
PMID:16045814
NCBI chr12:39,312,354...39,473,656
Ensembl chr12:39,314,027...39,461,244
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Tbcc
tubulin folding cofactor C
decreases expression
ISO
Emodin results in decreased expression of TBCC mRNA
CTD
PMID:16045814
NCBI chr 9:14,098,855...14,100,043
Ensembl chr 9:14,098,868...14,100,042
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Tcfl5
transcription factor like 5
increases expression
ISO
Emodin results in increased expression of TCFL5 mRNA
CTD
PMID:15612046
NCBI chr 3:167,734,471...167,754,174
Ensembl chr 3:167,734,473...167,754,282
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Tgfb1
transforming growth factor, beta 1
multiple interactions decreases activity
EXP
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin results in decreased activity of TGFB1 protein]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]
CTD
PMID:15288473 PMID:19474275 PMID:27989784
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
multiple interactions
EXP ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein] Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of TNF protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]
CTD
PMID:14534369 PMID:15313406 PMID:18590720 PMID:26139382 PMID:36184831 PMID:37023836 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Top2a
DNA topoisomerase II alpha
multiple interactions increases activity
ISO
Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form] Emodin results in increased activity of TOP2A protein
CTD
PMID:20855424
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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Tp53
tumor protein p53
affects expression
EXP
Emodin affects the expression of TP53 protein
CTD
PMID:19549930
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp63
tumor protein p63
increases expression
ISO
Emodin results in increased expression of TRP63 mRNA
CTD
PMID:15612046
NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
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Traf2
Tnf receptor-associated factor 2
increases expression decreases expression
ISO
Emodin results in increased expression of TRAF2 mRNA Emodin results in decreased expression of TRAF2 mRNA
CTD
PMID:16045814 PMID:21319176
NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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Trpv2
transient receptor potential cation channel, subfamily V, member 2
increases expression
ISO
Emodin results in increased expression of TRPV2 mRNA
CTD
PMID:15612046
NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
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Tsga13
testis specific, 13
increases expression
ISO
Emodin results in increased expression of TSGA13 mRNA
CTD
PMID:21319176
NCBI chr 4:59,501,773...59,522,925
Ensembl chr 4:59,501,774...59,522,818
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Tubb3
tubulin, beta 3 class III
decreases expression
ISO
Emodin results in decreased expression of TUBB3 mRNA
CTD
PMID:16045814
NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
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Txn1
thioredoxin 1
multiple interactions
EXP
Emodin results in increased expression of and results in increased activity of TXN protein
CTD
PMID:34971761
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Txnl4b
thioredoxin-like 4B
decreases expression
ISO
Emodin results in decreased expression of TXNL4B mRNA
CTD
PMID:16045814
NCBI chr19:37,530,157...37,539,827
Ensembl chr19:37,530,152...37,538,521
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Txnrd1
thioredoxin reductase 1
decreases expression multiple interactions
ISO EXP
Emodin results in decreased expression of TXNRD1 mRNA Emodin results in increased expression of and results in increased activity of TXNRD1 protein
CTD
PMID:16045814 PMID:34971761
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Tyr
tyrosinase
decreases activity
ISO
Emodin results in decreased activity of TYR protein
CTD
PMID:26972667
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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Tyrp1
tyrosinase-related protein 1
decreases expression
ISO
Emodin results in decreased expression of TYRP1 mRNA; Emodin results in decreased expression of TYRP1 protein
CTD
PMID:26972667
NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
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Ube2i
ubiquitin-conjugating enzyme E2I
increases expression
ISO
Emodin results in increased expression of UBE2I mRNA
CTD
PMID:21319176
NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443 Ensembl chr10:69,701,618...69,702,443
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases glucuronidation
ISO
UGT1A1 protein results in increased glucuronidation of Emodin
CTD
PMID:14557274
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of Emodin
CTD
PMID:14557274 PMID:24854283
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b15
UDP glucuronosyltransferase family 2 member B15
increases metabolic processing
EXP
UGT2B15 protein results in increased metabolism of Emodin
CTD
PMID:7574722
NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
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Ugt2b7
UDP glucuronosyltransferase family 2 member B7
decreases expression
ISO EXP
Emodin results in decreased expression of UGT2B7 mRNA; Emodin results in decreased expression of UGT2B7 protein
CTD
PMID:32538071
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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Vdac1
voltage-dependent anion channel 1
decreases expression
ISO
Emodin results in decreased expression of VDAC1 mRNA
CTD
PMID:16045814
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
Emodin results in decreased expression of VEGFA mRNA; Emodin results in decreased expression of VEGFA protein
CTD
PMID:23848338
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vim
vimentin
decreases expression multiple interactions
EXP
Emodin results in decreased expression of VIM protein 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]
CTD
PMID:27989784
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Xrcc1
X-ray repair cross complementing 1
affects expression
EXP
Emodin affects the expression of XRCC1 protein
CTD
PMID:19549930
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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Zfp37
zinc finger protein 37
increases expression
ISO
Emodin results in increased expression of ZFP37 mRNA
CTD
PMID:21319176
NCBI chr 5:75,598,732...75,638,896
Ensembl chr 5:75,598,732...75,638,942
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Casp3
caspase 3
multiple interactions increases activity
ISO
pyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [ferruginol results in increased activity of CASP3 protein]
CTD
PMID:30086653
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
ferruginol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
CTD
PMID:32946155
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Il6
interleukin 6
multiple interactions
EXP
ferruginol inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein]
CTD
PMID:32946155
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases expression
ISO
pyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased expression of RELA protein]; SB 203580 inhibits the reaction [ferruginol results in increased expression of RELA protein]
CTD
PMID:30086653
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Tnf
tumor necrosis factor
multiple interactions
EXP
ferruginol inhibits the reaction [Isoproterenol results in increased secretion of TNF protein]
CTD
PMID:32946155
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnni3
troponin I3, cardiac type
multiple interactions
EXP
ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]
CTD
PMID:32946155
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Tnnt2
troponin T2, cardiac type
multiple interactions
EXP
ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]
CTD
PMID:32946155
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
9-fluorenone results in increased expression of CYP1A1 protein
CTD
PMID:10445401
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
9-fluorenone results in increased expression of CYP2B1 protein
CTD
PMID:10445401
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
EXP
9-fluorenone results in increased expression of CYP3A2 protein
CTD
PMID:10445401
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Akr1b10
aldo-keto reductase family 1 member B10
decreases activity
ISO
frangulin A results in decreased activity of AKR1B10 protein
CTD
PMID:35065925
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
G
Akr1c3
aldo-keto reductase family 1, member C3
decreases activity
ISO
frangulin A results in decreased activity of AKR1C3 protein
CTD
PMID:35065925
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Cbr1
carbonyl reductase 1
decreases activity
ISO
frangulin A results in decreased activity of CBR1 protein
CTD
PMID:35065925
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
[frangulin A co-treated with frangulin B] results in decreased activity of CYP1A2 protein
CTD
PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Akr1b10
aldo-keto reductase family 1 member B10
decreases activity
ISO
frangulin B results in decreased activity of AKR1B10 protein
CTD
PMID:35065925
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
G
Akr1c3
aldo-keto reductase family 1, member C3
decreases activity
ISO
frangulin B results in decreased activity of AKR1C3 protein
CTD
PMID:35065925
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Cbr1
carbonyl reductase 1
decreases activity
ISO
frangulin B results in decreased activity of CBR1 protein
CTD
PMID:35065925
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
[frangulin A co-treated with frangulin B] results in decreased activity of CYP1A2 protein
CTD
PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
halofantrine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
isopimaric acid results in increased expression of BAD protein
CTD
PMID:36754215
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
isopimaric acid results in increased expression of BAX protein
CTD
PMID:36754215
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
isopimaric acid results in decreased expression of BCL2L1 protein
CTD
PMID:36754215
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
G
Ccnd1
cyclin D1
decreases expression
ISO
isopimaric acid results in decreased expression of CCND1 protein
CTD
PMID:36754215
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdh1
cadherin 1
increases expression
ISO
isopimaric acid results in increased expression of CDH1 protein
CTD
PMID:36754215
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
isopimaric acid results in decreased expression of CDK2 protein
CTD
PMID:36754215
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
isopimaric acid results in decreased expression of CDK4 protein
CTD
PMID:36754215
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Ctnnb1
catenin beta 1
decreases expression
ISO
isopimaric acid results in decreased expression of CTNNB1 protein
CTD
PMID:36754215
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
isopimaric acid results in decreased expression of MKI67 protein
CTD
PMID:36754215
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Ndufb8
NADH:ubiquinone oxidoreductase subunit B8
decreases expression
ISO
isopimaric acid results in decreased expression of NDUFB8 protein
CTD
PMID:36754215
NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817
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Sdhb
succinate dehydrogenase complex iron sulfur subunit B
decreases expression
ISO
isopimaric acid results in decreased expression of SDHB protein
CTD
PMID:36754215
NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
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Vim
vimentin
decreases expression
ISO
isopimaric acid results in decreased expression of VIM protein
CTD
PMID:36754215
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Abcg2
ATP binding cassette subfamily G member 2
affects binding
ISO
ledipasvir binds to ABCG2 protein
CTD
PMID:33954893
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
G
Klrc1
killer cell lectin like receptor C1
decreases expression
ISO
ledipasvir co-treated with sofosbuvir decreases expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425
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Ncr1
natural cytotoxicity triggering receptor 1
affects expression
ISO
ledipasvir co-treated sofosbuvir with affects expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558
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Fshb
follicle stimulating hormone subunit beta
decreases secretion
EXP
Lumefantrine results in decreased secretion of FSHB protein
CTD
PMID:26811345
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Prl
prolactin
increases secretion
EXP
Lumefantrine results in increased secretion of PRL protein
CTD
PMID:26811345
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Top2a
DNA topoisomerase II alpha
decreases activity
ISO
macrosporin results in decreased activity of TOP2A protein
CTD
PMID:27682608
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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Abcb11
ATP binding cassette subfamily B member 11
increases expression
EXP
Maprotiline results in increased expression of ABCB11 mRNA
CTD
PMID:27765674
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcc2
ATP binding cassette subfamily C member 2
decreases expression
EXP
Maprotiline results in decreased expression of ABCC2 mRNA
CTD
PMID:27765674
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Becn1
beclin 1
increases expression
ISO
Maprotiline results in increased expression of BECN1 protein
CTD
PMID:20503272
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Casp3
caspase 3
multiple interactions increases activity
ISO
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Maprotiline results in increased activity of CASP3 protein]
CTD
PMID:23219590
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions
ISO
Maprotiline inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD
PMID:21158687
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Mapk1
mitogen activated protein kinase 1
multiple interactions increases phosphorylation
ISO
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Maprotiline results in increased phosphorylation of MAPK1 protein]
CTD
PMID:23219590
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions increases phosphorylation
ISO
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Maprotiline results in increased phosphorylation of MAPK3 protein]
CTD
PMID:23219590
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nos2
nitric oxide synthase 2
increases expression
EXP
Maprotiline results in increased expression of NOS2 mRNA
CTD
PMID:12429386
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Maprotiline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Oprm1
opioid receptor, mu 1
affects binding
ISO
methylnaltrexone binds to OPRM1 protein
CTD
PMID:17340127
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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Abca1
ATP binding cassette subfamily A member 1
affects response to substance
ISO
ABCA1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
ISO
Mitoxantrone results in increased expression of ABCB1 protein
CTD
PMID:15239124
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcg2
ATP binding cassette subfamily G member 2
affects export affects response to substance increases transport multiple interactions increases export increases expression decreases abundance decreases response to substance increases response to substance affects transport affects uptake
ISO
ABCG2 protein affects the export of Mitoxantrone ABCG2 protein affects the susceptibility to Mitoxantrone ABCG2 protein results in increased transport of Mitoxantrone 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] inhibits the reaction [Folic Acid deficiency results in decreased susceptibility to Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; [Folic Acid deficiency results in increased expression of ABCG2 protein] which results in decreased susceptibility to Mitoxantrone; [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of Mitoxantrone; ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; desisobutyrylciclesonide inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]; Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Protons promotes the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein affects the uptake of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone] Mitoxantrone results in increased expression of ABCG2 mRNA; Mitoxantrone results in increased expression of ABCG2 protein ABCG2 protein results in decreased abundance of Mitoxantrone ABCG2 protein results in increased susceptibility to Mitoxantrone
CTD
PMID:10606239 PMID:12869632 PMID:15239124 PMID:15640379 PMID:15695404 PMID:15703302 PMID:15875186 PMID:16442095 PMID:16636798 PMID:16954373 PMID:17032904 PMID:17093006 PMID:18623116 PMID:18829547 PMID:18834354 PMID:19428349 PMID:20019844 PMID:21712253 PMID:22892056 PMID:24994473 PMID:29079042 PMID:34717915 PMID:34896433 More...
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Acadvl
acyl-CoA dehydrogenase, very long chain
decreases expression
ISO
Mitoxantrone results in decreased expression of ACADVL protein
CTD
PMID:34246718
NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
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Acsl3
acyl-CoA synthetase long-chain family member 3
affects response to substance
ISO
ACSL3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
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Acta1
actin, alpha 1, skeletal muscle
decreases expression
ISO
Mitoxantrone results in decreased expression of ACTA1 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
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Actg2
actin gamma 2, smooth muscle
affects response to substance
ISO
ACTG2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
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Adarb1
adenosine deaminase, RNA-specific, B1
affects response to substance
ISO
ADARB1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852
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Agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5
affects response to substance
ISO
AGPAT5 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr16:70,939,480...70,985,745
Ensembl chr16:70,943,135...70,985,560
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Ahcyl1
adenosylhomocysteinase-like 1
affects response to substance
ISO
AHCYL1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815
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Aldh2
aldehyde dehydrogenase 2 family member
affects response to substance
ISO
ALDH2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Amotl1
angiomotin-like 1
affects response to substance
ISO
AMOTL1 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573
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Ank2
ankyrin 2
decreases expression
ISO
Mitoxantrone results in decreased expression of ANK2 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
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Asns
asparagine synthetase (glutamine-hydrolyzing)
affects response to substance
ISO
ASNS protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Ass1
argininosuccinate synthase 1
affects response to substance
ISO
ASS1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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Atg5
autophagy related 5
decreases expression
ISO
Mitoxantrone results in decreased expression of ATG5 protein
CTD
PMID:36216988
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Atm
ATM serine/threonine kinase
decreases expression increases phosphorylation multiple interactions
ISO EXP
Mitoxantrone results in decreased expression of ATM mRNA Mitoxantrone results in increased phosphorylation of ATM protein [Poly(ADP-ribose) Polymerase Inhibitors co-treated with Mitoxantrone] results in increased phosphorylation of ATM protein
CTD
PMID:22832221 PMID:29913208
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Atp1a2
ATPase Na+/K+ transporting subunit alpha 2
decreases expression
ISO
Mitoxantrone results in decreased expression of ATP1A2 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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Atp5f1a
ATP synthase F1 subunit alpha
decreases expression
ISO
Mitoxantrone results in decreased expression of ATP5F1A protein
CTD
PMID:34246718
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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Atp5f1b
ATP synthase F1 subunit beta
decreases expression
ISO
Mitoxantrone results in decreased expression of ATP5F1B protein
CTD
PMID:34246718
NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
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Atp5f1c
ATP synthase F1 subunit gamma
decreases expression
ISO
Mitoxantrone results in decreased expression of ATP5F1C protein
CTD
PMID:34246718
NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367
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Atp7a
ATPase copper transporting alpha
decreases response to substance
ISO
ATP7A protein results in decreased susceptibility to Mitoxantrone
CTD
PMID:17510416
NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354
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Bace2
beta-secretase 2
affects response to substance
ISO
BACE2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Mitoxantrone results in increased expression of BAX mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bbx
BBX high mobility group box domain containing
affects response to substance
ISO
BBX protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251
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Bcam
basal cell adhesion molecule (Lutheran blood group)
affects response to substance
ISO
BCAM protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403
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Bcat1
branched chain amino acid transaminase 1
increases expression
EXP
Mitoxantrone results in increased expression of BCAT1 mRNA
CTD
PMID:23558518
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein] Mitoxantrone results in decreased expression of BCL2 mRNA
CTD
PMID:8219202 PMID:8840993 PMID:15582267
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions
ISO
BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]
CTD
PMID:8840993
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Becn1
beclin 1
decreases expression
ISO
Mitoxantrone results in decreased expression of BECN1 protein
CTD
PMID:36216988
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Birc2
baculoviral IAP repeat-containing 2
decreases expression
ISO
Mitoxantrone results in decreased expression of BIRC2 protein
CTD
PMID:15359644
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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Birc5
baculoviral IAP repeat-containing 5
affects expression increases expression
ISO
Mitoxantrone affects the expression of BIRC5 mRNA Mitoxantrone results in increased expression of BIRC5 protein
CTD
PMID:16638212
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Bmp7
bone morphogenetic protein 7
affects response to substance
ISO
BMP7 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
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Bst2
bone marrow stromal cell antigen 2
affects response to substance
ISO
BST2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979
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Btbd3
BTB domain containing 3
affects response to substance
ISO
BTBD3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038
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Cacna1g
calcium voltage-gated channel subunit alpha1 G
decreases expression
ISO
Mitoxantrone results in decreased expression of CACNA1G mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
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Cacna2d2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
decreases expression
ISO
Mitoxantrone results in decreased expression of CACNA2D2 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173
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Calr
calreticulin
affects localization
ISO
Mitoxantrone affects the localization of CALR protein
CTD
PMID:20003823
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
affects response to substance
ISO
CAMK2N1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600
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Casc3
CASC3 exon junction complex subunit
affects response to substance
ISO
CASC3 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr10:83,769,014...83,788,966
Ensembl chr10:83,769,001...83,788,966
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Casp2
caspase 2
increases expression increases splicing
ISO
Mitoxantrone results in increased expression of CASP2 mRNA alternative form Mitoxantrone results in increased splicing of CASP2 mRNA
CTD
PMID:14757846
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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Casp3
caspase 3
multiple interactions increases activity
ISO
BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein] acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]
CTD
PMID:8840993 PMID:12948851 PMID:16215684 PMID:22700542 PMID:32894303
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp6
caspase 6
increases activity
ISO
Mitoxantrone results in increased activity of CASP6 protein
CTD
PMID:12948851
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp7
caspase 7
increases activity multiple interactions
ISO
Mitoxantrone results in increased activity of CASP7 protein Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein]
CTD
PMID:12948851 PMID:22700542
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8
caspase 8
increases activity
ISO
Mitoxantrone results in increased activity of CASP8 protein
CTD
PMID:12948851 PMID:32894303
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity
ISO
Mitoxantrone results in increased activity of CASP9 protein
CTD
PMID:12948851
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
decreases activity
EXP
Mitoxantrone results in decreased activity of CAT protein
CTD
PMID:29913208
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cavin3
caveolae associated protein 3
affects response to substance
ISO
CAVIN3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
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Cavin4
caveolae associated protein 4
decreases expression
ISO
Mitoxantrone results in decreased expression of CAVIN4 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 5:62,996,906...63,007,677
Ensembl chr 5:62,996,865...63,007,678
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Cd55
CD55 molecule (Cromer blood group)
affects response to substance
ISO
CD55 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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Celf2
CUGBP, Elav-like family member 2
affects response to substance
ISO
CELF2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333
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Cep15
centrosomal protein 15
affects response to substance
ISO
CEP15 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838
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Ces2h
carboxylesterase 2H
affects response to substance
ISO
CES2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Chrdl1
chordin-like 1
affects response to substance
ISO
CHRDL1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr X:106,889,125...106,992,937
Ensembl chr X:106,889,125...106,992,921
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Cklf
chemokine-like factor
affects response to substance
ISO
CKLF protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr19:698,097...706,570
Ensembl chr19:698,033...706,570
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Ckm
creatine kinase, M-type
decreases expression
ISO
Mitoxantrone results in decreased expression of CKM mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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Clns1a
chloride nucleotide-sensitive channel 1A
affects response to substance
ISO
CLNS1A protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:152,019,369...152,039,670
Ensembl chr 1:152,019,378...152,039,661
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Clu
clusterin
affects response to substance
ISO
CLU protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Coch
cochlin
affects response to substance
ISO
COCH protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109
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Col11a1
collagen type XI alpha 1 chain
affects response to substance
ISO
COL11A1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
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Corin
corin, serine peptidase
decreases expression
ISO
Mitoxantrone results in decreased expression of CORIN mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
G
Cpvl
carboxypeptidase, vitellogenic-like
affects response to substance
ISO
CPVL protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 4:82,981,421...83,091,730
Ensembl chr 4:82,981,422...83,085,655
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Crebl2
cAMP responsive element binding protein-like 2
affects response to substance
ISO
CREBL2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 4:167,673,359...167,699,299
Ensembl chr 4:167,673,315...167,699,292
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Cs
citrate synthase
decreases activity
ISO
Mitoxantrone results in decreased activity of CS protein
CTD
PMID:34246718
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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Csrnp2
cysteine and serine rich nuclear protein 2
affects response to substance
ISO
CSRNP2 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 7:131,594,232...131,610,075
Ensembl chr 7:131,594,232...131,610,075
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Cth
cystathionine gamma-lyase
affects response to substance
ISO
CTH protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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Cxadr
CXADR, Ig-like cell adhesion molecule
affects response to substance
ISO
CXADR protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Mitoxantrone results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Mitoxantrone results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Dapk1
death associated protein kinase 1
affects response to substance
ISO
DAPK1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
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Ddit4
DNA-damage-inducible transcript 4
affects response to substance
ISO
DDIT4 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Dhrs2
dehydrogenase/reductase 2
affects response to substance
ISO
DHRS2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
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Dis3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
affects response to substance
ISO
DIS3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642
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Dmd
dystrophin
decreases expression
ISO
Mitoxantrone results in decreased expression of DMD mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207
G
Dusp4
dual specificity phosphatase 4
affects response to substance increases expression
ISO
DUSP4 protein affects the susceptibility to Mitoxantrone Mitoxantrone results in increased expression of DUSP4 mRNA
CTD
PMID:16217747 PMID:26537877 PMID:28940058
NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
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Dyrk2
dual specificity tyrosine phosphorylation regulated kinase 2
affects response to substance
ISO
DYRK2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
G
Egr1
early growth response 1
affects response to substance
ISO
EGR1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
affects response to substance
ISO
EIF2S1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
G
Eif5a
eukaryotic translation initiation factor 5A
affects response to substance
ISO
EIF5A protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
G
Elavl4
ELAV like RNA binding protein 4
affects response to substance
ISO
ELAVL4 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 5:125,056,848...125,200,543
Ensembl chr 5:125,056,848...125,200,446
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Elovl5
ELOVL fatty acid elongase 5
affects response to substance
ISO
ELOVL5 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284
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En2
engrailed homeobox 2
affects response to substance
ISO
EN2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943
G
Enc1
ectodermal-neural cortex 1
affects response to substance
ISO
ENC1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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Epb41l2
erythrocyte membrane protein band 4.1-like 2
affects response to substance
ISO
EPB41L2 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721
G
Erbb2
erb-b2 receptor tyrosine kinase 2
multiple interactions decreases response to substance
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]
CTD
PMID:21712253
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Erbb3
erb-b2 receptor tyrosine kinase 3
decreases expression
ISO
Mitoxantrone results in decreased expression of ERBB3 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
G
Etfdh
electron transfer flavoprotein dehydrogenase
decreases expression
ISO
Mitoxantrone results in decreased expression of ETFDH protein
CTD
PMID:34246718
NCBI chr 2:164,740,547...164,762,754
Ensembl chr 2:164,729,749...164,762,745
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Evi5
ecotropic viral integration site 5
affects response to substance
ISO
EVI5 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678
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Extl2
exostosin-like glycosyltransferase 2
affects response to substance
ISO
EXTL2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:203,922,217...203,946,940
Ensembl chr 2:203,922,187...203,943,653
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Fabp3
fatty acid binding protein 3
increases expression
EXP
Mitoxantrone results in increased expression of FABP3 protein
CTD
PMID:22878004
NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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Fam117a
family with sequence similarity 117, member A
affects response to substance
ISO
FAM117A protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr10:80,281,411...80,325,345
Ensembl chr10:80,281,408...80,325,343
G
Fas
Fas cell surface death receptor
multiple interactions increases expression
ISO
Hydrocortisone promotes the reaction [Mitoxantrone results in increased expression of FAS] Mitoxantrone results in increased expression of FAS mRNA; Mitoxantrone results in increased expression of FAS protein
CTD
PMID:9676859 PMID:26537877 PMID:28940058
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fasn
fatty acid synthase
decreases response to substance multiple interactions
ISO
FASN protein results in decreased susceptibility to Mitoxantrone orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]
CTD
PMID:18281512
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
G
Fdft1
farnesyl diphosphate farnesyl transferase 1
affects response to substance
ISO
FDFT1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
G
Fhl1
four and a half LIM domains 1
increases expression
EXP
Mitoxantrone results in increased expression of FHL1 mRNA
CTD
PMID:23558518
NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928
G
Flrt3
fibronectin leucine rich transmembrane protein 3
affects response to substance
ISO
FLRT3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841
G
Fndc3a
fibronectin type III domain containing 3a
affects response to substance
ISO
FNDC3A protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784
G
Foxf2
forkhead box F2
affects response to substance
ISO
FOXF2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176
G
Fyn
FYN proto-oncogene, Src family tyrosine kinase
affects response to substance
ISO
FYN protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
G
Fzd2
frizzled class receptor 2
affects response to substance
ISO
FZD2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
G
Gch1
GTP cyclohydrolase 1
affects response to substance
ISO
GCH1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
G
Gdf15
growth differentiation factor 15
increases expression
ISO
Mitoxantrone results in increased expression of GDF15 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
G
Glul
glutamate-ammonia ligase
affects response to substance
ISO
GLUL protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
G
Gpx1
glutathione peroxidase 1
increases expression
ISO
Mitoxantrone results in increased expression of GPX1 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Gpx3
glutathione peroxidase 3
affects response to substance
ISO
GPX3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
G
Gucy1b1
guanylate cyclase 1 soluble subunit beta 1
affects response to substance
ISO
GUCY1B1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
G
H2ax
H2A.X variant histone
increases expression increases phosphorylation multiple interactions
ISO EXP
Mitoxantrone results in increased expression of H2AX protein Mitoxantrone results in increased phosphorylation of H2AX protein Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein]
CTD
PMID:19738048 PMID:24994473 PMID:29913208
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
decreases expression
ISO
Mitoxantrone results in decreased expression of HADHB protein
CTD
PMID:34246718
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
G
Hdac4
histone deacetylase 4
affects response to substance
ISO
HDAC4 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
G
Hmg20b
high mobility group 20 B
affects response to substance
ISO
HMG20B protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 7:8,368,934...8,373,650
Ensembl chr 7:8,368,990...8,373,640
G
Hoxa5
homeo box A5
affects response to substance
ISO
HOXA5 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234
G
Hrc
histidine rich calcium binding protein
decreases expression
ISO
Mitoxantrone results in decreased expression of HRC mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984
G
Hspa2
heat shock protein family A (Hsp70) member 2
affects response to substance
ISO
HSPA2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
G
Idh3a
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
affects response to substance decreases expression
ISO
IDH3A protein affects the susceptibility to Mitoxantrone Mitoxantrone results in decreased expression of IDH3A protein
CTD
PMID:16217747 PMID:34246718
NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
G
Ifitm1
interferon induced transmembrane protein 1
affects response to substance
ISO
IFITM1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169
G
Igf1r
insulin-like growth factor 1 receptor
affects response to substance
ISO
IGF1R protein affects the susceptibility to Mitoxantrone
CTD
PMID:15499378
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
G
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
affects response to substance
ISO
IGF2BP3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
G
Igfbp3
insulin-like growth factor binding protein 3
affects response to substance
ISO
IGFBP3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
G
Igfbp7
insulin-like growth factor binding protein 7
affects response to substance
ISO
IGFBP7 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
G
Il13ra2
interleukin 13 receptor subunit alpha 2
affects response to substance
ISO
IL13RA2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
G
Immt
inner membrane mitochondrial protein
decreases expression
ISO
Mitoxantrone results in decreased expression of IMMT protein
CTD
PMID:34246718
NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109
G
Iqgap1
IQ motif containing GTPase activating protein 1
affects response to substance
ISO
IQGAP1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
G
Irf7
interferon regulatory factor 7
affects response to substance
ISO
IRF7 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
G
Irx1
iroquois homeobox 1
affects response to substance
ISO
IRX1 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 1:31,294,615...31,300,444
Ensembl chr 1:31,294,615...31,300,444
G
Irx4
iroquois homeobox 4
decreases expression
ISO
Mitoxantrone results in decreased expression of IRX4 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549
G
Isg15
ISG15 ubiquitin-like modifier
affects response to substance
ISO
ISG15 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
G
Isg20
interferon stimulated exonuclease gene 20
affects response to substance
ISO
ISG20 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
G
Jak2
Janus kinase 2
decreases expression
ISO
Mitoxantrone results in decreased expression of JAK2 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
ISO
Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in increased expression of JUN mRNA]
CTD
PMID:8219202
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Kcnab2
potassium voltage-gated channel subfamily A regulatory beta subunit 2
affects response to substance
ISO
KCNAB2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 5:162,899,511...162,988,057
Ensembl chr 5:162,901,896...162,988,243
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases expression
ISO
Mitoxantrone results in decreased expression of KCNH2 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
increases expression
ISO
Mitoxantrone results in increased expression of KCNJ2 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445
G
Kcnq1
potassium voltage-gated channel subfamily Q member 1
decreases expression
ISO
Mitoxantrone results in decreased expression of KCNQ1 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
G
Krr1
KRR1, small subunit processome component homolog
affects response to substance
ISO
KRR1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 7:47,475,557...47,486,996
Ensembl chr 7:47,475,557...47,486,985
G
Lama2
laminin subunit alpha 2
affects response to substance
ISO
LAMA2 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
G
Lamb1
laminin subunit beta 1
affects response to substance
ISO
LAMB1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
G
Lamc1
laminin subunit gamma 1
affects response to substance
ISO
LAMC1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
G
Lbh
LBH regulator of WNT signaling pathway
affects response to substance
ISO
LBH protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079
G
Ldb3
LIM domain binding 3
decreases expression
ISO
Mitoxantrone results in decreased expression of LDB3 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532
G
Lemd2
LEM domain nuclear envelope protein 2
affects response to substance
ISO
LEMD2 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626
G
Lgr4
leucine-rich repeat-containing G protein-coupled receptor 4
affects response to substance
ISO
LGR4 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899
G
Lipa
lipase A, lysosomal acid type
affects response to substance
ISO
LIPA protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
G
Lipg
lipase G, endothelial type
affects response to substance
ISO
LIPG protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
G
Lmcd1
LIM and cysteine-rich domains 1
increases expression
EXP
Mitoxantrone results in increased expression of LMCD1 mRNA
CTD
PMID:23558518
NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
G
Lmnb1
lamin B1
multiple interactions
ISO
[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein
CTD
PMID:15582267
NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
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Macrod1
mono-ADP ribosylhydrolase 1
affects response to substance
ISO
MACROD1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:204,246,238...204,387,027
Ensembl chr 1:204,246,166...204,389,716
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Maff
MAF bZIP transcription factor F
affects response to substance
ISO
MAFF mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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Maged1
MAGE family member D1
affects response to substance
ISO
MAGED1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr X:59,422,715...59,429,381
Ensembl chr X:59,422,717...59,429,364
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO
Mitoxantrone results in decreased expression of and results in increased lipidation of MAP1LC3B protein
CTD
PMID:36216988
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Mdh2
malate dehydrogenase 2
decreases expression
ISO
Mitoxantrone results in decreased expression of MDH2 protein
CTD
PMID:34246718
NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
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Mdm2
MDM2 proto-oncogene
decreases response to substance
ISO
MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone
CTD
PMID:17575151
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Mest
mesoderm specific transcript
affects response to substance
ISO
MEST protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145
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Mocos
molybdenum cofactor sulfurase
affects response to substance
ISO
MOCOS protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187
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Mpc2
mitochondrial pyruvate carrier 2
affects response to substance
ISO
MPC2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664
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Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
affects response to substance
ISO
MTHFD2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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Mxi1
MAX interactor 1, dimerization protein
affects response to substance
ISO
MXI1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression multiple interactions
ISO
Mitoxantrone results in decreased expression of MYC mRNA Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in decreased expression of MYC mRNA]
CTD
PMID:8219202
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Mycbp2
MYC binding protein 2
affects response to substance
ISO
MYCBP2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498
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Myh6
myosin heavy chain 6
decreases expression
ISO
Mitoxantrone results in decreased expression of MYH6 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
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Myh7
myosin heavy chain 7
decreases expression
ISO
Mitoxantrone results in decreased expression of MYH7 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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Myom2
myomesin 2
decreases expression
ISO
Mitoxantrone results in decreased expression of MYOM2 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772
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Nampt
nicotinamide phosphoribosyltransferase
affects response to substance
ISO
NAMPT protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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Ndufs5
NADH:ubiquinone oxidoreductase subunit S5
affects response to substance
ISO
NDUFS5 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603 Ensembl chr14:135,974,034...135,979,603 Ensembl chr 2:135,974,034...135,979,603
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Nefh
neurofilament heavy chain
affects response to substance
ISO
NEFH protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Nid2
nidogen 2
affects response to substance
ISO
NID2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
decreases activity
ISO
Mitoxantrone results in decreased activity of NR3C1 protein
CTD
PMID:19255438
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
affects response to substance
ISO
NR4A2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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Nrap
nebulin-related anchoring protein
decreases expression
ISO
Mitoxantrone results in decreased expression of NRAP mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 1:255,350,113...255,427,704
Ensembl chr 1:255,350,113...255,427,693
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Nrip1
nuclear receptor interacting protein 1
affects response to substance
ISO
NRIP1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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Oxct1
3-oxoacid CoA transferase 1
affects response to substance
ISO
OXCT1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714
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P4ha1
prolyl 4-hydroxylase subunit alpha 1
affects response to substance
ISO
P4HA1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
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Pacrgl
parkin coregulated like
affects response to substance
ISO
PACRGL mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr14:62,532,019...62,556,977
Ensembl chr14:62,532,030...62,556,993
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]
CTD
PMID:8840993 PMID:15582267
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pbx1
PBX homeobox 1
affects response to substance
ISO
PBX1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594
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Pde4d
phosphodiesterase 4D
affects response to substance
ISO
PDE4D protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
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Pde8a
phosphodiesterase 8A
affects response to substance
ISO
PDE8A protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
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Pdha1
pyruvate dehydrogenase E1 subunit alpha 1
decreases expression
ISO
Mitoxantrone results in decreased expression of PDHA1 protein
CTD
PMID:34246718
NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311
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Phb2
prohibitin 2
decreases expression
ISO
Mitoxantrone results in decreased expression of PHB2 protein
CTD
PMID:34246718
NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272
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Phgdh
phosphoglycerate dehydrogenase
affects response to substance
ISO
PHGDH protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
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Plagl1
PLAG1 like zinc finger 1
affects response to substance
ISO
PLAGL1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228
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Plat
plasminogen activator, tissue type
affects response to substance
ISO
PLAT protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plcb4
phospholipase C, beta 4
affects response to substance
ISO
PLCB4 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
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Plpbp
pyridoxal phosphate binding protein
affects response to substance
ISO
PLPBP protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886
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Pml
PML nuclear body scaffold
affects mutagenesis
ISO
Mitoxantrone affects the mutagenesis of PML gene
CTD
PMID:19884644
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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Ppp1r2
protein phosphatase 1, regulatory (inhibitor) subunit 2
affects response to substance
ISO
PPP1R2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463
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Ppp1r3a
protein phosphatase 1, regulatory subunit 3A
decreases expression
ISO
Mitoxantrone results in decreased expression of PPP1R3A mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638
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Prdm16
PR/SET domain 16
decreases expression
ISO
Mitoxantrone results in decreased expression of PRDM16 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601
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Prdx2
peroxiredoxin 2
affects response to substance
ISO
PRDX2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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Prelid3b
PRELI domain containing 3B
affects response to substance
ISO
PRELID3B protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 3:163,263,059...163,271,055
Ensembl chr 3:163,262,985...163,271,181
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Prkx
protein kinase cAMP-dependent X-linked catalytic subunit
increases expression
ISO
Mitoxantrone results in increased expression of PRKX mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr X:41,823,349...41,866,844
Ensembl chr X:41,823,355...41,866,669
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Ptpre
protein tyrosine phosphatase, receptor type, E
affects response to substance
ISO
PTPRE protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534
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Pygm
glycogen phosphorylase, muscle associated
decreases expression
ISO
Mitoxantrone results in decreased expression of PYGM mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368
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Rara
retinoic acid receptor, alpha
affects mutagenesis
ISO
Mitoxantrone affects the mutagenesis of RARA gene
CTD
PMID:19884644
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rarb
retinoic acid receptor, beta
increases expression
ISO
Mitoxantrone results in increased expression of RARB mRNA alternative form
CTD
PMID:17608728
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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Rasa1
RAS p21 protein activator 1
affects response to substance
ISO
RASA1 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
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Rbbp8
RB binding protein 8, endonuclease
affects response to substance
ISO
RBBP8 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846
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Rbm17
RNA binding motif protein 17
multiple interactions decreases response to substance
ISO
LY 117018 inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]; Tamoxifen inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]
CTD
PMID:16061639
NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014
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Rcbtb1
RCC1 and BTB domain containing protein 1
affects response to substance
ISO
RCBTB1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:33,319,586...33,362,421
Ensembl chr15:33,319,586...33,365,302
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Rchy1
ring finger and CHY zinc finger domain containing 1
affects response to substance
ISO
RCHY1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr14:16,113,263...16,129,017
Ensembl chr14:16,113,224...16,129,167
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Rgs2
regulator of G-protein signaling 2
affects response to substance
ISO
RGS2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rnd1
Rho family GTPase 1
increases expression
EXP
Mitoxantrone results in increased expression of RND1 mRNA
CTD
PMID:23558518
NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
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Rragd
Ras-related GTP binding D
affects response to substance
ISO
RRAGD mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
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Runx3
RUNX family transcription factor 3
affects response to substance
ISO
RUNX3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156
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Ryr2
ryanodine receptor 2
decreases expression
ISO
Mitoxantrone results in decreased expression of RYR2 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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Sall2
spalt-like transcription factor 2
affects response to substance
ISO
SALL2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr15:25,021,345...25,038,918
Ensembl chr15:25,021,345...25,038,918
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Satb2
SATB homeobox 2
affects response to substance
ISO
SATB2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707
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Scd
stearoyl-CoA desaturase
affects response to substance
ISO
SCD protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Schip1
schwannomin interacting protein 1
affects response to substance
ISO
SCHIP1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585
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Scn2b
sodium voltage-gated channel beta subunit 2
decreases expression
ISO
Mitoxantrone results in decreased expression of SCN2B mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765
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Scn5a
sodium voltage-gated channel alpha subunit 5
decreases expression
ISO
Mitoxantrone results in decreased expression of SCN5A mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
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Sdc2
syndecan 2
affects response to substance
ISO
SDC2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081
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Sec31a
SEC31 homolog A, COPII coat complex component
affects response to substance
ISO
SEC31A protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273
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Serpine1
serpin family E member 1
increases expression
EXP
Mitoxantrone results in increased expression of SERPINE1 mRNA
CTD
PMID:23558518
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Sfn
stratifin
affects response to substance
ISO
SFN protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
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Sfrp4
secreted frizzled-related protein 4
affects response to substance
ISO
SFRP4 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736
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Slc16a6
solute carrier family 16, member 6
affects response to substance
ISO
SLC16A6 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779
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Slc25a11
solute carrier family 25 member 11
decreases expression
ISO
Mitoxantrone results in decreased expression of SLC25A11 protein
CTD
PMID:34246718
NCBI chr10:55,357,590...55,360,441
Ensembl chr10:55,357,597...55,360,410
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Slc7a5
solute carrier family 7 member 5
affects response to substance
ISO
SLC7A5 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
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Slco4a1
solute carrier organic anion transporter family, member 4a1
affects response to substance
ISO
SLCO4A1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
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Smad2
SMAD family member 2
affects response to substance
ISO
SMAD2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Sorbs1
sorbin and SH3 domain containing 1
affects response to substance
ISO
SORBS1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169
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Spon1
spondin 1
affects response to substance
ISO
SPON1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
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Spon2
spondin 2
affects response to substance
ISO
SPON2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996
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Spp1
secreted phosphoprotein 1
increases expression
EXP
Mitoxantrone results in increased expression of SPP1 mRNA
CTD
PMID:23558518
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Sqstm1
sequestosome 1
affects expression decreases expression
ISO
Mitoxantrone affects the expression of SQSTM1 protein Mitoxantrone metabolite results in decreased expression of SQSTM1 protein
CTD
PMID:36216988
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Srd5a1
steroid 5 alpha-reductase 1
affects response to substance
ISO
SRD5A1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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Sucla2
succinate-CoA ligase ADP-forming subunit beta
decreases expression
ISO
Mitoxantrone results in decreased expression of SUCLA2 protein
CTD
PMID:34246718
NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138
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Sytl2
synaptotagmin-like 2
affects response to substance
ISO
SYTL2 mRNA affects the susceptibility to Mitoxantrone
CTD
PMID:16044152
NCBI chr 1:144,272,870...144,379,310
Ensembl chr 1:144,273,360...144,379,222
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Tagln
transgelin
affects response to substance
ISO
TAGLN protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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Tap1
transporter 1, ATP binding cassette subfamily B member
affects response to substance
ISO
TAP1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:17523305
NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
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Tbc1d8
TBC1 domain family, member 8
affects response to substance
ISO
TBC1D8 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409
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Tff3
trefoil factor 3
affects response to substance
ISO
TFF3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054
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Tgfb2
transforming growth factor, beta 2
increases expression
EXP
Mitoxantrone results in increased expression of TGFB2 mRNA
CTD
PMID:23558518
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Tia1
TIA1 cytotoxic granule-associated RNA binding protein
affects response to substance
ISO
TIA1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Mitoxantrone results in increased expression of TIMP1 mRNA
CTD
PMID:23558518
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tmem47
transmembrane protein 47
affects response to substance
ISO
TMEM47 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr X:45,421,405...45,447,900
Ensembl chr X:45,421,405...45,447,900
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Tnks
tankyrase
affects response to substance
ISO
TNKS protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260
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Tnnt1
troponin T1, slow skeletal type
decreases expression
ISO
Mitoxantrone results in decreased expression of TNNT1 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
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Tp53
tumor protein p53
affects activity
ISO
Mitoxantrone affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpd52
tumor protein D52
affects response to substance
ISO
TPD52 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622
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Tpm1
tropomyosin 1
affects response to substance
ISO
TPM1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
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Trib1
tribbles pseudokinase 1
affects response to substance
ISO
TRIB1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
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Trim2
tripartite motif-containing 2
affects response to substance
ISO
TRIM2 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927
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Ubl3
ubiquitin-like 3
affects response to substance
ISO
UBL3 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr12:6,473,684...6,518,331
Ensembl chr12:6,473,460...6,518,862
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Uchl1
ubiquitin C-terminal hydrolase L1
affects response to substance
ISO
UCHL1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
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Uqcrh
ubiquinol-cytochrome c reductase hinge protein
affects response to substance
ISO
UQCRH protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
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Utrn
utrophin
affects response to substance
ISO
UTRN protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
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Vcan
versican
affects response to substance
ISO
VCAN protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
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Vdac1
voltage-dependent anion channel 1
decreases expression
ISO
Mitoxantrone results in decreased expression of VDAC1 protein
CTD
PMID:34246718
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Wars1
tryptophanyl-tRNA synthetase 1
affects response to substance
ISO
WARS1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
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Xiap
X-linked inhibitor of apoptosis
affects localization decreases expression
ISO
Mitoxantrone affects the localization of XIAP protein Mitoxantrone results in decreased expression of XIAP protein
CTD
PMID:15359644
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
increases expression
ISO
Mitoxantrone results in increased expression of YWHAE protein
CTD
PMID:32894303
NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
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Zfand1
zinc finger AN1-type containing 1
affects response to substance
ISO
ZFAND1 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 2:91,444,497...91,457,540
Ensembl chr 2:91,444,508...91,453,246
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Zmat3
zinc finger, matrin type 3
increases expression
ISO
Mitoxantrone results in increased expression of ZMAT3 mRNA
CTD
PMID:26537877 PMID:28940058
NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863
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Zscan18
zinc finger and SCAN domain containing 18
affects response to substance
ISO
ZSCAN18 protein affects the susceptibility to Mitoxantrone
CTD
PMID:16217747
NCBI chr 1:73,332,883...73,349,846
Ensembl chr 1:73,332,889...73,345,897
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[mumbaistatin analog results in decreased activity of SLC37A4 protein] which results in decreased phosphorylation of AKT1 protein
CTD
PMID:19074414
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Slc37a4
solute carrier family 37 member 4
multiple interactions decreases activity
ISO
[mumbaistatin analog results in decreased activity of SLC37A4 protein] which results in decreased phosphorylation of AKT1 protein
CTD
PMID:19074414
NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
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Tp53
tumor protein p53
multiple interactions
EXP
[Acetoxyacetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TP53 protein
CTD
PMID:10741303
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Abcb1b
ATP-binding cassette, sub-family B member 1B
increases expression
EXP
Hydroxyacetylaminofluorene results in increased expression of ABCB1B mRNA; Hydroxyacetylaminofluorene results in increased expression of ABCB1B protein
CTD
PMID:22084566
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Nat1
N-acetyltransferase 1
decreases activity
ISO
Hydroxyacetylaminofluorene results in decreased activity of NAT1 protein
CTD
PMID:19842618
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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Nat2
N-acetyltransferase 2
decreases activity
ISO
Hydroxyacetylaminofluorene results in decreased activity of NAT2 protein
CTD
PMID:19842618
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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Sult2a1
sulfotransferase family 2A member 1
increases sulfation
ISO
SULT2A1 protein results in increased sulfation of Hydroxyacetylaminofluorene
CTD
PMID:10752640
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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Tp53
tumor protein p53
increases expression
EXP
Hydroxyacetylaminofluorene results in increased expression of TP53 protein
CTD
PMID:9163691
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
norbuprenorphine results in decreased activity of CYP2D6 protein
CTD
PMID:12756210
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects chemical synthesis decreases activity
ISO
CYP3A4 protein affects the chemical synthesis of norbuprenorphine norbuprenorphine results in decreased activity of CYP3A4 protein
CTD
PMID:12756210 PMID:15966752
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
telithromycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of noroxycodone]
CTD
PMID:19755414
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Abcb1a
ATP binding cassette subfamily B member 1A
increases transport affects response to substance
ISO
ABCB1A protein results in increased transport of Nortriptyline; ABCB1A protein results in increased transport of Nortriptyline metabolite ABCB1 exon SNP affects the susceptibility to Nortriptyline
CTD
PMID:10700657 PMID:12082591
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb4
ATP binding cassette subfamily B member 4
decreases activity
ISO
Nortriptyline results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Casp3
caspase 3
decreases activity increases activity multiple interactions
ISO
Nortriptyline results in decreased activity of CASP3 protein Nortriptyline results in increased activity of CASP3 protein Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP3 protein]
CTD
PMID:17686041 PMID:18174477 PMID:22700542
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
multiple interactions increases activity
ISO
Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP7 protein]
CTD
PMID:22700542
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Cycs
cytochrome c, somatic
decreases secretion
ISO
Nortriptyline results in decreased secretion of CYCS protein
CTD
PMID:17686041
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases metabolic processing
ISO
Nortriptyline results in increased metabolism of CYP1A2 protein
CTD
PMID:18359012
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
decreases activity multiple interactions
ISO
Nortriptyline results in decreased activity of CYP2C8 protein torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]
CTD
PMID:15304522
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases response to substance multiple interactions increases metabolic processing increases hydroxylation
ISO
CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline] Nortriptyline results in increased metabolism of CYP2D6 protein CYP2D6 protein results in increased hydroxylation of Nortriptyline
CTD
PMID:11673748 PMID:17470523 PMID:18359012
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases metabolic processing
ISO
Nortriptyline results in increased metabolism of CYP3A4 protein
CTD
PMID:18359012
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases metabolic processing
ISO
Nortriptyline results in increased metabolism of CYP3A5 protein
CTD
PMID:18359012
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Gnb3
G protein subunit beta 3
decreases response to substance increases response to substance
ISO
GNB3 gene polymorphism results in decreased susceptibility to Nortriptyline GNB3 protein results in increased susceptibility to Nortriptyline
CTD
PMID:14604448
NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
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Htr2c
5-hydroxytryptamine receptor 2C
decreases expression
ISO
Nortriptyline results in decreased expression of HTR2C protein
CTD
PMID:8131152
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Il1a
interleukin 1 alpha
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline
CTD
PMID:19362101
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il6
interleukin 6
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline
CTD
PMID:19362101
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions
ISO
Nortriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD
PMID:21158687
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Pf4
platelet factor 4
affects expression
ISO
Nortriptyline affects the expression of PF4 protein
CTD
PMID:10770450
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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Ppbp
pro-platelet basic protein
affects expression
ISO
Nortriptyline affects the expression of PPBP protein
CTD
PMID:10770450
NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Nortriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc6a2
solute carrier family 6 member 2
affects response to substance
ISO
SLC6A2 gene polymorphism affects the susceptibility to Nortriptyline
CTD
PMID:17018806
NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
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Slc6a4
solute carrier family 6 member 4
affects response to substance increases response to substance decreases response to substance
ISO
SLC6A4 polymorphism affects the susceptibility to Nortriptyline; SLC6A4 promoter polymorphism affects the susceptibility to Nortriptyline SLC6A4 protein results in increased susceptibility to Nortriptyline SLC6A4 gene polymorphism results in decreased susceptibility to Nortriptyline
CTD
PMID:14604448 PMID:17018806 PMID:21658141
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Tnf
tumor necrosis factor
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline
CTD
PMID:19362101
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Slc22a6
solute carrier family 22 member 6
decreases activity
ISO
obtusifolin results in decreased activity of SLC22A6 protein
CTD
PMID:29045746
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
decreases activity
ISO
obtusifolin results in decreased activity of SLC22A8 protein
CTD
PMID:29045746
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation decreases response to substance
ISO
OSU 03012 results in decreased phosphorylation of AKT1 protein AKT1 protein modified form results in decreased susceptibility to OSU 03012
CTD
PMID:15205346
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Pdpk1
3-phosphoinositide dependent protein kinase-1
multiple interactions decreases response to substance
ISO
OSU 03012 binds to and results in decreased activity of PDPK1 protein PDPK1 protein modified form results in decreased susceptibility to OSU 03012
CTD
PMID:15205346
NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
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Cat
catalase
multiple interactions
EXP
patchouli alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein]
CTD
PMID:25168850
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Il10
interleukin 10
multiple interactions
EXP
patchouli alcohol inhibits the reaction [Ethanol results in decreased expression of IL10 protein]
CTD
PMID:25168850
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il6
interleukin 6
multiple interactions
ISO EXP
patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] patchouli alcohol inhibits the reaction [Ethanol results in increased expression of IL6 protein] patchouli alcohol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of IL6 protein]
CTD
PMID:23348408 PMID:25168850
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of MAPK1 protein modified form]
CTD
PMID:23348408
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of MAPK3 protein modified form]
CTD
PMID:23348408
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] patchouli alcohol inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]
CTD
PMID:23348408
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
patchouli alcohol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of NOS2 protein] patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; patchouli alcohol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:23348408
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ptgs1
prostaglandin-endoperoxide synthase 1
multiple interactions
EXP
patchouli alcohol inhibits the reaction [Indomethacin results in decreased expression of PTGS1 mRNA]
CTD
PMID:25168850
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
patchouli alcohol inhibits the reaction [Indomethacin results in decreased expression of PTGS2 mRNA]
CTD
PMID:25168850
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
patchouli alcohol inhibits the reaction [TNF protein affects the localization of RELA protein] patchouli alcohol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD
PMID:23348408
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Tnf
tumor necrosis factor
multiple interactions
ISO EXP
patchouli alcohol inhibits the reaction [TNF protein affects the localization of RELA protein]; patchouli alcohol inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of IL6 protein]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of NOS2 protein] patchouli alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein] patchouli alcohol inhibits the reaction [TNF protein results in increased expression of MAPK1 protein modified form]; patchouli alcohol inhibits the reaction [TNF protein results in increased expression of MAPK3 protein modified form]
CTD
PMID:23348408 PMID:25168850
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Acp2
acid phosphatase 2, lysosomal
multiple interactions affects expression
ISO
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of ACP2 protein phenanthrene affects the expression of ACP2 protein
CTD
PMID:28803881
NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680
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Ahr
aryl hydrocarbon receptor
multiple interactions affects binding increases activity
EXP ISO
phenanthrene binds to and results in increased activity of AHR protein phenanthrene binds to AHR protein [acenaphthene co-treated with anthracene co-treated with 1,12-benzoperylene co-treated with 1,2,5,6-dibenzanthracene co-treated with fluorene co-treated with naphthalene co-treated with phenanthrene] results in increased activity of AHR protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein; [phenanthrene co-treated with naphthalene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [pyrene co-treated with phenanthrene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; phenanthrene inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein] phenanthrene results in increased activity of AHR protein
CTD
PMID:3024361 PMID:12850102 PMID:17665671 PMID:28710019 PMID:29502740 PMID:30980910 More...
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ahrr
aryl-hydrocarbon receptor repressor
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHRR protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]
CTD
PMID:28710019 PMID:30980910
NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
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Akt1
AKT serine/threonine kinase 1
increases phosphorylation
ISO
phenanthrene results in increased phosphorylation of AKT1 protein
CTD
PMID:34453960
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aldh3a1
aldehyde dehydrogenase 3 family, member A1
increases expression
ISO
phenanthrene results in increased expression of ALDH3A1 mRNA
CTD
PMID:32890658
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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Ar
androgen receptor
affects binding multiple interactions
EXP ISO
phenanthrene analog binds to AR protein [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; phenanthrene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; phenanthrene inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] phenanthrene analog inhibits the reaction [Androgens binds to AR protein]; phenanthrene analog inhibits the reaction [Metribolone binds to AR protein]; phenanthrene inhibits the reaction [Metribolone binds to AR protein]
CTD
PMID:3695475 PMID:6323860 PMID:26022396 PMID:30980910 PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arnt
aryl hydrocarbon receptor nuclear translocator
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA
CTD
PMID:28710019
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions affects expression
ISO
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of BAX protein phenanthrene affects the expression of BAX protein
CTD
PMID:28803881
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Becn1
beclin 1
multiple interactions decreases expression
ISO
Sirolimus inhibits the reaction [phenanthrene results in decreased expression of BECN1 mRNA]
CTD
PMID:34453960
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Casp3
caspase 3
multiple interactions increases expression
ISO
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CASP3 protein phenanthrene results in increased expression of CASP3 protein
CTD
PMID:28803881
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
increases expression multiple interactions increases activity
ISO
phenanthrene results in increased expression of CAT protein [phenanthrene co-treated with fluorene] results in increased activity of CAT protein phenanthrene results in increased activity of CAT protein
CTD
PMID:20238386 PMID:32856796
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccna2
cyclin A2
decreases expression multiple interactions
ISO
phenanthrene results in decreased expression of CCNA2 protein [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in decreased expression of CCNA2 protein
CTD
PMID:28803881
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnd1
cyclin D1
multiple interactions increases expression
ISO
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CCND1 protein phenanthrene results in increased expression of CCND1 protein
CTD
PMID:28803881
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdk2
cyclin dependent kinase 2
multiple interactions increases expression
ISO
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CDK2 protein phenanthrene results in increased expression of CDK2 protein
CTD
PMID:28803881
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Comt
catechol-O-methyltransferase
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein
CTD
PMID:28710019
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions increases expression
ISO
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of CYP19A1 protein phenanthrene results in increased expression of CYP19A1 protein
CTD
PMID:28803881
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases expression increases oxidation increases metabolic processing increases activity
ISO EXP
[CYP1A1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]; CYP1A1 protein results in increased metabolism of and results in increased activity of phenanthrene; GSTM1 gene polymorphism promotes the reaction [CYP1A1 gene polymorphism results in increased metabolism of phenanthrene] phenanthrene results in increased expression of CYP1A1 mRNA phenanthrene results in increased expression of CYP1A1 mRNA; phenanthrene results in increased expression of CYP1A1 protein phenanthrene results in increased activity of CYP1A1 protein
CTD
PMID:15566942 PMID:16906435 PMID:17035385 PMID:19766613 PMID:27137136 PMID:28710019 PMID:30980910 PMID:31181217 PMID:32890658 More...
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases activity increases expression increases oxidation multiple interactions
ISO
phenanthrene results in increased activity of CYP1A2 protein phenanthrene results in increased expression of CYP1A2 mRNA; phenanthrene results in increased expression of CYP1A2 protein CYP1A2 protein results in increased oxidation of phenanthrene [acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA; CYP1A2 protein results in increased metabolism of and results in increased activity of phenanthrene [CYP1A2 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol; CYP1A2 protein results in increased metabolism of and results in increased activity of phenanthrene
CTD
PMID:7750161 PMID:8001243 PMID:19766613 PMID:27137136 PMID:31181217
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions increases expression increases oxidation decreases metabolic processing
ISO
[CYP1B1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; CYP1B1 protein results in increased metabolism of and results in increased activity of phenanthrene; phenanthrene binds to and results in decreased activity of CYP1B1 protein phenanthrene results in increased expression of CYP1B1 mRNA CYP1B1 gene polymorphism results in decreased metabolism of phenanthrene
CTD
PMID:15566942 PMID:17035385 PMID:19563207 PMID:19766613 PMID:27137136 PMID:32890658 More...
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
increases oxidation affects binding multiple interactions
ISO
CYP2A13 protein results in increased oxidation of phenanthrene phenanthrene binds to CYP2A13 protein [CYP2A13 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CTD
PMID:27137136
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression multiple interactions
ISO
phenanthrene results in increased expression of CYP2B6 mRNA phenanthrene results in increased expression of CYP2B10 mRNA; phenanthrene results in increased expression of CYP2B10 protein NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP2B10 protein]
CTD
PMID:31181217
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
increases metabolic processing
ISO
CYP2D6 protein results in increased metabolism of phenanthrene
CTD
PMID:9429232
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
CYP2E1 protein results in increased metabolism of and results in increased activity of phenanthrene
CTD
PMID:19766613
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Egr1
early growth response 1
increases expression
ISO
phenanthrene results in increased expression of EGR1 protein
CTD
PMID:15342960
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Eif4e
eukaryotic translation initiation factor 4E
increases expression
ISO
phenanthrene results in increased expression of EIF4E mRNA
CTD
PMID:34453960
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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Esr1
estrogen receptor 1
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; phenanthrene analog binds to and results in decreased activity of ESR1 protein; phenanthrene binds to and results in increased activity of ESR1 protein
CTD
PMID:12672240 PMID:30980910 PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
affects binding
ISO
phenanthrene analog binds to ESR2 protein
CTD
PMID:12672240
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Foxp3
forkhead box P3
decreases expression
EXP
phenanthrene results in decreased expression of FOXP3 mRNA; phenanthrene results in decreased expression of FOXP3 protein
CTD
PMID:31456356
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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Gjb1
gap junction protein, beta 1
decreases expression
EXP
phenanthrene results in decreased expression of GJB1 protein
CTD
PMID:25268939
NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925
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Gsr
glutathione-disulfide reductase
increases expression
ISO
phenanthrene results in increased expression of GSR protein
CTD
PMID:20238386
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Gsta1
glutathione S-transferase alpha 1
increases expression
ISO
phenanthrene results in increased expression of GSTA1 mRNA
CTD
PMID:32890658
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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Gstm1
glutathione S-transferase mu 1
multiple interactions affects metabolic processing
ISO
GSTM1 gene polymorphism promotes the reaction [CYP1A1 gene polymorphism results in increased metabolism of phenanthrene] GSTM1 protein affects the metabolism of phenanthrene
CTD
PMID:17035385 PMID:22674470
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Gstm5
glutathione S-transferase, mu 5
multiple interactions increases expression
ISO
NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of GSTM3 mRNA]
CTD
PMID:31181217
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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Icam1
intercellular adhesion molecule 1
increases expression
ISO
phenanthrene results in increased expression of ICAM1 protein
CTD
PMID:22313677
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ier3
immediate early response 3
increases expression
ISO
phenanthrene results in increased expression of IER3 mRNA
CTD
PMID:22579512
NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
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Ighe
immunoglobulin heavy constant epsilon
affects expression increases expression
ISO
phenanthrene affects the expression of IGHE mRNA alternative form phenanthrene results in increased expression of IGHE mRNA; phenanthrene results in increased expression of IGHE protein
CTD
PMID:9070347
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Il10
interleukin 10
decreases expression
EXP
phenanthrene results in decreased expression of IL10 mRNA; phenanthrene results in decreased expression of IL10 protein
CTD
PMID:31456356
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il6
interleukin 6
increases expression multiple interactions
EXP ISO
phenanthrene results in increased expression of IL6 mRNA; phenanthrene results in increased expression of IL6 protein [fluorene co-treated with phenanthrene] results in increased expression of IL6 mRNA; [fluorene co-treated with phenanthrene] results in increased expression of IL6 protein
CTD
PMID:31456356 PMID:32856796
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Lgals1
galectin 1
increases expression
ISO
phenanthrene results in increased expression of LGALS1 mRNA
CTD
PMID:22579512
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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Ndc80
NDC80 kinetochore complex component
decreases expression
ISO
phenanthrene results in decreased expression of NDC80 mRNA
CTD
PMID:22579512
NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
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Nfkb2
nuclear factor kappa B subunit 2
multiple interactions
ISO
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of NFKB2 protein
CTD
PMID:30980910
NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
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Nlgn1
neuroligin 1
decreases expression
ISO
phenanthrene results in decreased expression of NLGN1 mRNA
CTD
PMID:34453960
NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases activity increases expression
EXP ISO
phenanthrene results in increased activity of NQO1 protein phenanthrene results in increased expression of NQO1 mRNA
CTD
PMID:16906435 PMID:31181217
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
phenanthrene binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity multiple interactions
ISO
phenanthrene results in increased activity of NR1I3 protein NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP2B10 protein]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP3A11 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of GSTM3 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of SULT2A1 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of UGT1A1 mRNA]
CTD
PMID:28927721 PMID:31181217
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Pah
phenylalanine hydroxylase
decreases expression
ISO
phenanthrene results in decreased expression of PAH mRNA
CTD
PMID:22579512
NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
phenanthrene results in increased cleavage of PARP1 protein
CTD
PMID:21132278
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pgr
progesterone receptor
multiple interactions
ISO
phenanthrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]
CTD
PMID:26022396
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Pou5f1
POU class 5 homeobox 1
multiple interactions decreases expression
ISO
phenanthrene affects the reaction [Tretinoin results in decreased expression of POU5F1 protein] phenanthrene results in decreased expression of POU5F1 protein
CTD
PMID:21111795
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Rhoc
ras homolog family member C
increases expression
ISO
phenanthrene results in increased expression of RHOC mRNA
CTD
PMID:22579512
NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306
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Shank3
SH3 and multiple ankyrin repeat domains 3
multiple interactions decreases expression
ISO
Sirolimus inhibits the reaction [phenanthrene results in decreased expression of SHANK3 mRNA]
CTD
PMID:34453960
NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374
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Sod2
superoxide dismutase 2
increases expression
ISO
phenanthrene results in increased expression of SOD2 protein
CTD
PMID:20238386
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sult2a1
sulfotransferase family 2A member 1
increases expression multiple interactions
ISO
phenanthrene results in increased expression of SULT2A1 mRNA NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of SULT2A1 mRNA]
CTD
PMID:31181217
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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Tgfb1
transforming growth factor, beta 1
decreases expression
EXP
phenanthrene results in decreased expression of TGFB1 mRNA; phenanthrene results in decreased expression of TGFB1 protein
CTD
PMID:31456356
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
ISO
phenanthrene results in increased expression of TIMP1 mRNA
CTD
PMID:22579512
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tnf
tumor necrosis factor
multiple interactions increases expression
ISO EXP
[fluorene co-treated with phenanthrene] results in increased expression of TNF mRNA; [fluorene co-treated with phenanthrene] results in increased expression of TNF protein; TNF protein promotes the reaction [phenanthrene results in increased expression of CXCL8 mRNA] phenanthrene results in increased expression of TNF protein phenanthrene results in increased expression of TNF mRNA; phenanthrene results in increased expression of TNF protein
CTD
PMID:18434080 PMID:31456356 PMID:32856796 PMID:34453960
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression multiple interactions
ISO
phenanthrene results in increased expression of UGT1A1 mRNA NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of UGT1A1 mRNA]
CTD
PMID:31181217
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
multiple interactions
ISO
[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA
CTD
PMID:15566942
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
Phenanthrenes analog results in increased expression of CYP1A1 protein
CTD
PMID:19365803
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
Phenanthrenes analog results in increased expression of CYP1B1 protein
CTD
PMID:19365803
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
affects binding multiple interactions
ISO
Phenanthrenes analog binds to CYP2A13 protein [NADP co-treated with CYP2A13 protein] results in increased oxidation of Phenanthrenes analog
CTD
PMID:27137136
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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Grin2d
glutamate ionotropic receptor NMDA type subunit 2D
affects response to substance
ISO
GRIN2D protein affects the susceptibility to Phenanthrenes
CTD
PMID:19911010
NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
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Abcb11
ATP binding cassette subfamily B member 11
increases expression
EXP
physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein
CTD
PMID:28161596
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
G
Abcb4
ATP binding cassette subfamily B member 4
decreases expression
EXP
physcione results in decreased expression of ABCB4 mRNA
CTD
PMID:28161596
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc2
ATP binding cassette subfamily C member 2
decreases expression
EXP
physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein
CTD
PMID:28161596
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
decreases expression
EXP
physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein
CTD
PMID:28161596
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
G
Bax
BCL2 associated X, apoptosis regulator
increases expression decreases expression
ISO
physcione results in increased expression of BAX protein physcione results in decreased expression of BAX protein
CTD
PMID:22285236
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
physcione results in decreased activity of CYP1A2 protein
CTD
PMID:27633141 PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
EXP
physcione results in decreased expression of CYP27A1 mRNA
CTD
PMID:28161596
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases hydroxylation
ISO
CYP2B6 protein results in increased hydroxylation of physcione
CTD
PMID:29667811
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases hydroxylation
ISO
CYP2C19 protein results in increased hydroxylation of physcione
CTD
PMID:29667811
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases hydroxylation
ISO
CYP3A4 protein results in increased hydroxylation of physcione
CTD
PMID:29667811
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
EXP
physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein
CTD
PMID:28161596
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
G
Slc10a1
solute carrier family 10 member 1
decreases expression
EXP
physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein
CTD
PMID:28161596
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
G
Sult1a1
sulfotransferase family 1A member 1
decreases activity
ISO
physcione results in decreased activity of SULT1A1 protein
CTD
PMID:27633141
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
G
Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of physcione
CTD
PMID:24854283
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Abcb4
ATP binding cassette subfamily B member 4
decreases activity
ISO
Protriptyline results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
G
Bmp6
bone morphogenetic protein 6
increases expression
ISO
Protriptyline results in increased expression of BMP6 mRNA
CTD
PMID:32816093
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
G
Ereg
epiregulin
increases expression
ISO
Protriptyline results in increased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
G
Il24
interleukin 24
increases expression
ISO
Protriptyline results in increased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
G
Met
MET proto-oncogene, receptor tyrosine kinase
increases expression
ISO
Protriptyline results in increased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
G
Pid1
phosphotyrosine interaction domain containing 1
increases expression
ISO
Protriptyline results in increased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
G
Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
Protriptyline results in increased expression of PTGS2 mRNA
CTD
PMID:32816093
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Slc6a2
solute carrier family 6 member 2
decreases expression
ISO
Protriptyline results in decreased expression of SLC6A2 protein
CTD
PMID:18923402
NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
G
Slc7a11
solute carrier family 7 member 11
decreases expression
ISO
Protriptyline results in decreased expression of SLC7A11 mRNA
CTD
PMID:32816093
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
G
Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Protriptyline results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
1,4-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:19269596
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Alb
albumin
affects binding
ISO
1,4-dihydroxyanthraquinone binds to ALB protein
CTD
PMID:16404478
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
1,4-dihydroxyanthraquinone results in decreased activity of CYP1A2 protein
CTD
PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Esr1
estrogen receptor 1
multiple interactions
ISO
1,4-dihydroxyanthraquinone binds to and results in increased activity of ESR1 protein
CTD
PMID:20707409
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases glucuronidation
ISO
UGT1A1 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone
CTD
PMID:14557274
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone
CTD
PMID:14557274
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Gsta3
glutathione S-transferase alpha 3
decreases activity
EXP
Cibacron Blue F 3GA results in decreased activity of GSTA3 protein
CTD
PMID:8968379
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
G
Gstm2
glutathione S-transferase mu 2
decreases activity
EXP
Cibacron Blue F 3GA results in decreased activity of GSTM2 protein
CTD
PMID:8968379
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
P2rx1
purinergic receptor P2X 1
affects binding
EXP
Reactive blue 2 binds to P2rx1 protein
RGD
PMID:12237343
RGD:727431
NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
G
P2rx5
purinergic receptor P2X 5
affects transport
EXP
Reactive blue 2 affects transport ion flux of P2rx5 receptor
RGD
PMID:12237343
RGD:727431
NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
Cibacron Blue F 3GA inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]
CTD
PMID:22253048
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Tp53
tumor protein p53
increases degradation
ISO
Cibacron Blue F 3GA results in increased degradation of TP53 protein
CTD
PMID:14634213
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Abcb11
ATP binding cassette subfamily B member 11
multiple interactions
ISO
Enzymes and Coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]
CTD
PMID:35101544
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD
PMID:12546737
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
G
Adgre1
adhesion G protein-coupled receptor E1
multiple interactions
ISO
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]
CTD
PMID:37023836
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
rhein inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:19269596
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Alkbh2
alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
decreases activity
ISO
rhein results in decreased activity of ALKBH2 protein
CTD
PMID:31088072
NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
rhein results in increased expression of BAX protein
CTD
PMID:31436023
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Becn1
beclin 1
decreases expression
ISO
rhein results in decreased expression of BECN1 protein
CTD
PMID:31436023
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
G
Casp1
caspase 1
multiple interactions
ISO
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]
CTD
PMID:37023836
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Casp3
caspase 3
decreases expression
ISO
rhein results in decreased expression of CASP3 protein
CTD
PMID:31436023
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
increases cleavage
ISO
rhein results in increased cleavage of CASP8 protein
CTD
PMID:31436023
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
decreases expression
ISO
rhein results in decreased expression of CASP9 protein
CTD
PMID:31436023
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
rhein results in decreased activity of CYP1A1 protein
CTD
PMID:27633141
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
rhein results in decreased activity of CYP1A2 protein
CTD
PMID:27633141 PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
rhein results in decreased activity of CYP2C19 protein
CTD
PMID:33438235
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
rhein results in decreased activity of CYP2D6 protein
CTD
PMID:33438235
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Egf
epidermal growth factor
decreases expression
ISO
rhein results in decreased expression of EGF protein
CTD
PMID:21457705
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
G
Erbb2
erb-b2 receptor tyrosine kinase 2
decreases expression
ISO
rhein results in decreased expression of ERBB2 protein
CTD
PMID:21457705
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]
CTD
PMID:37023836
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Hif1a
hypoxia inducible factor 1 subunit alpha
decreases expression multiple interactions
ISO
rhein results in decreased expression of HIF1A protein rhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]
CTD
PMID:21457705
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Ifng
interferon gamma
increases expression multiple interactions
ISO
rhein results in increased expression of IFNG protein rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]
CTD
PMID:26784856
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il10
interleukin 10
multiple interactions
ISO
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
CTD
PMID:26784856
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il17a
interleukin 17A
increases expression
ISO
rhein results in increased expression of IL17A protein
CTD
PMID:26784856
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
G
Il18
interleukin 18
multiple interactions
ISO
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]
CTD
PMID:37023836
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
multiple interactions
ISO
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]
CTD
PMID:37023836
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
increases expression
ISO
rhein results in increased expression of IL2 protein
CTD
PMID:26784856
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il6
interleukin 6
multiple interactions
ISO
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD
PMID:26784856 PMID:37023836
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Itga4
integrin subunit alpha 4
multiple interactions
EXP
rhein inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]; rhein inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]; rhein inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]
CTD
PMID:36731809
NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
G
Kdr
kinase insert domain receptor
multiple interactions
EXP
rhein inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]
CTD
PMID:36731809
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
G
Mdk
midkine
multiple interactions
EXP
rhein inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein]
CTD
PMID:36731809
NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130
G
Nfkb1
nuclear factor kappa B subunit 1
affects localization decreases activity multiple interactions
ISO
rhein affects the localization of NFKB1 protein rhein results in decreased activity of NFKB1 protein rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]
CTD
PMID:21457705 PMID:37023836
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]
CTD
PMID:37023836
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
rhein results in decreased expression of PTGS2 protein
CTD
PMID:21457705
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
decreases activity multiple interactions affects localization
ISO EXP
rhein results in decreased activity of RELA protein cobaltous chloride promotes the reaction [rhein affects the localization of RELA protein] rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein] rhein inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein]
CTD
PMID:21457705 PMID:36731809 PMID:37023836
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Slc22a6
solute carrier family 22 member 6
multiple interactions
ISO
rhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD
PMID:28890383
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
G
Slc22a8
solute carrier family 22 member 8
multiple interactions
ISO
rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]
CTD
PMID:28890383
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
G
Sqstm1
sequestosome 1
increases expression
ISO
rhein results in increased expression of SQSTM1 protein
CTD
PMID:31436023
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
G
Sult1a1
sulfotransferase family 1A member 1
decreases activity
ISO
rhein results in decreased activity of SULT1A1 protein
CTD
PMID:27633141
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
G
Tek
TEK receptor tyrosine kinase
multiple interactions
EXP
rhein inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]
CTD
PMID:36731809
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
CTD
PMID:12546737
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tnf
tumor necrosis factor
increases expression multiple interactions
ISO
rhein results in increased expression of TNF protein rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:26784856 PMID:31436023 PMID:37023836
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tradd
TNFRSF1A-associated via death domain
increases expression
ISO
rhein results in increased expression of TRADD protein
CTD
PMID:31436023
NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
G
Traf1
TNF receptor-associated factor 1
increases expression
ISO
rhein results in increased expression of TRAF1 protein
CTD
PMID:31436023
NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
G
Vegfa
vascular endothelial growth factor A
decreases expression decreases response to substance multiple interactions
ISO EXP
rhein results in decreased expression of VEGFA protein rhein results in decreased susceptibility to VEGFA protein rhein inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]
CTD
PMID:21457705 PMID:36731809
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Calcr
calcitonin receptor
decreases expression
EXP
rubiadin results in decreased expression of CALCR mRNA
CTD
PMID:21945525
NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
G
Car2
carbonic anhydrase 2
decreases expression
EXP
rubiadin results in decreased expression of CA2 mRNA
CTD
PMID:21945525
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Ctsk
cathepsin K
increases activity
EXP
rubiadin results in increased activity of CTSK protein
CTD
PMID:21945525
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
rubiadin results in decreased activity of CYP1A2 protein
CTD
PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
rubiadin results in decreased activity of CYP2C19 protein
CTD
PMID:33438235
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
rubiadin results in decreased activity of CYP2D6 protein
CTD
PMID:33438235
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
EXP
rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]
CTD
PMID:21945525
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Tnfrsf11b
TNF receptor superfamily member 11B
increases expression
EXP
rubiadin results in increased expression of TNFRSF11B mRNA; rubiadin results in increased expression of TNFRSF11B protein
CTD
PMID:21945525
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
G
Tnfsf11
TNF superfamily member 11
decreases expression multiple interactions
EXP
rubiadin results in decreased expression of TNFSF11 mRNA; rubiadin results in decreased expression of TNFSF11 protein rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]
CTD
PMID:21945525
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
G
Il4
interleukin 4
multiple interactions
ISO
spathulenol inhibits the reaction [Ovalbumin results in increased expression of IL4 protein]
CTD
PMID:28344896
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
tiamulin results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Ache
acetylcholinesterase
decreases activity
ISO
Tilorone results in decreased activity of ACHE protein
CTD
PMID:33400519 PMID:33844597
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Id1
inhibitor of DNA binding 1
increases expression multiple interactions
ISO EXP
treprostinil results in increased expression of ID1 protein treprostinil inhibits the reaction [Monocrotaline results in decreased expression of ID1 mRNA]
CTD
PMID:20522807
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
G
Ahr
aryl hydrocarbon receptor
affects binding
EXP
triptycene binds to AHR protein
CTD
PMID:3024361
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
valnemulin results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19844
chemical entity
19842
molecular entity
19842
polyatomic entity
19799
molecule
19702
organic molecule
19687
organic cyclic compound
19498
carbocyclic compound
18584
carbopolycyclic compound
17184
carbotricyclic compound
1511
(+)-4-epi-cubebol
0
(+)-alpha-barbatene
0
(+)-alpha-gurjunene
0
(+)-beta-barbatene
0
(+)-caryolan-1-ol
0
(+)-isoafricanol
0
(+)-makassaric acid
0
(+)-thalianatriene
0
(-)-10-epi-cubebol
0
(-)-alpha-gurjunene +
0
(-)-alpha-isocomene
0
(-)-beta-barbatene
0
(-)-cubebol
0
(2S,3R,6S,9S)-(-)-protoillud-7-ene
0
(7S)-7-acetamido-1,2,3-trimethoxy-6,7-dihydro-5H-dibenzo[5,3-b:1',2'-e][7]annulene-9-carboxylic acid
0
1-deoxy-11-oxopentalenic acid
0
1-deoxy-11beta-hydroxypentalenic acid
0
1-deoxypentalenic acid
0
11,20-dihydroxyferruginol +
0
11,20-dihydroxysugiol
0
11-O-acetylcyathatriol
0
11-O-acetylcyathin A3
0
11-hydroxyferruginol
0
11-hydroxysugiol +
0
11-oxomiltiradiene
0
13-methyl-4,4-bisnorpodocarpa-8,11,13-trien-3-one
0
14-acetyl-mutilin
0
2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one
0
2alpha,7beta-dihydroxytaxusin
0
2alpha-hydroxytaxusin
0
3beta,12-dihydroxy-13-methyl-5,8,11,13-podocarpatetraene-7-one
0
4,5,9,10-dehydroisolongifolene
0
5-hydroxy-alpha-gurjunene
0
6'-bromomelleolide F
0
6'-chloromelleolide F(1-)
0
6beta-hydroxyferruginol
0
7beta-hydroxytaxusin
0
Azamulin
1
Colchicoside
0
Deacetylcolchicine
0
Delta(6)-protoilludene
0
Dihydropleuromutilin
0
LSM-4236
0
N-Formyldemecolcine
0
Pleuromutilin +
1
Retapamulin
0
SW219106-1
0
Tiamulin fumarate
0
Valnemulin
1
Valnemulin hydrochloride
0
[(1S,2R,3S,4S,6R,7R,8R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[2-(diethylamino)ethylsulfanyl]acetate
0
acenaphthylenes +
15
african-1-ene
0
albaflavenone
0
alpha-cubebene
0
alpha-neoclovene
0
amineptine +
0
amitriptyline +
189
an alpha-neoclovene +
0
anisotanol A
0
anisotanol B
0
anisotanol C
0
anisotanol D
0
anthracenes +
586
avermitilol
0
berkeleyone C
0
beta-cubebene
0
beta-gurjunene
0
beta-maaliene
0
betaenone A +
0
betaestacin I
0
bonnadiene
0
brasilicardin A
0
caribenol B
0
carnosate
0
carnosic acid
248
cedr-8-ene
0
cedrane sesquiterpenoid +
2
colchicine +
255
collinodiene
0
culmorin
0
cyathadiol
0
cyathatriol +
0
cyclobenzaprine +
1
cyclooctat-9-en-5,7-diol
0
cyclooctatin +
0
dehydroabietadienal
0
dehydroabietadienol
0
dehydroabietic acid
0
dolabradiene +
0
durhamycin A
0
durhamycin B
0
ent-bonnadiene
0
erinacine Q
0
erinacine Q2
0
erinacol
0
ferroptocide
0
ferruginol +
7
fluorenes +
430
indacenes +
0
isopimara-7,15-dienal
0
isopimara-7,15-dienol
0
isopimarane +
12
isopimaric acid
12
julichrome Q6 +
0
koraiol
0
lanigerol
0
levopimaradienal
0
levopimaradienol
0
lobophytumin E
0
lobophytumin F
0
lycosantalene
0
lydicene
0
melleolide F
0
miltiradien-20-al
0
miltiradiene +
0
neosartoricin
0
nezukol
0
oleoyl neocryptotanshinone
0
ophiobolin C
0
ophiobolin F
0
patchouli alcohol
11
pentalenic acid
0
phenanthrenes +
256
piroheptine
0
pleosporone
0
prespatane
0
protriptyline +
10
rhizathalene A
0
salviol
0
spathulenol
1
spiroalbatene
0
stellata-2,6,19-triene
0
stellatic acid
0
stemphyloxin II
0
sugiol +
0
syn-isopimara-7,15-diene
0
talarodiene
0
tasumatrol E
0
taxine B
0
taxusin +
0
thujopsene +
0
tiamulin
1
treprostinil +
1
tricycloalkane +
0
triptobenzene D
0
triptobenzene H
0
triptonoterpene
0
triptonoterpene methyl ether
0
triptoquinone A
0
triptoquinone B
0
triptoquinone H
0
tsukubadiene
0
variediene
0
viridiflorene
0
viridiflorol
0
Path 2
CHEBI ontology
19844
subatomic particle
19842
composite particle
19842
hadron
19842
baryon
19842
nucleon
19809
atomic nucleus
19842
atom
19842
main group element atom
19792
p-block element atom
19792
carbon group element atom
19738
carbon atom
19734
organic molecular entity
19734
organic molecule
19687
organic cyclic compound
19498
carbocyclic compound
18584
carbopolycyclic compound
17184
carbotricyclic compound
1511
(+)-4-epi-cubebol
0
(+)-alpha-barbatene
0
(+)-alpha-gurjunene
0
(+)-beta-barbatene
0
(+)-caryolan-1-ol
0
(+)-isoafricanol
0
(+)-makassaric acid
0
(+)-thalianatriene
0
(-)-10-epi-cubebol
0
(-)-alpha-gurjunene +
0
(-)-alpha-isocomene
0
(-)-beta-barbatene
0
(-)-cubebol
0
(2S,3R,6S,9S)-(-)-protoillud-7-ene
0
(7S)-7-acetamido-1,2,3-trimethoxy-6,7-dihydro-5H-dibenzo[5,3-b:1',2'-e][7]annulene-9-carboxylic acid
0
1-deoxy-11-oxopentalenic acid
0
1-deoxy-11beta-hydroxypentalenic acid
0
1-deoxypentalenic acid
0
11,20-dihydroxyferruginol +
0
11,20-dihydroxysugiol
0
11-O-acetylcyathatriol
0
11-O-acetylcyathin A3
0
11-hydroxyferruginol
0
11-hydroxysugiol +
0
11-oxomiltiradiene
0
13-methyl-4,4-bisnorpodocarpa-8,11,13-trien-3-one
0
14-acetyl-mutilin
0
2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one
0
2alpha,7beta-dihydroxytaxusin
0
2alpha-hydroxytaxusin
0
3beta,12-dihydroxy-13-methyl-5,8,11,13-podocarpatetraene-7-one
0
4,5,9,10-dehydroisolongifolene
0
5-hydroxy-alpha-gurjunene
0
6'-bromomelleolide F
0
6'-chloromelleolide F(1-)
0
6beta-hydroxyferruginol
0
7beta-hydroxytaxusin
0
Azamulin
1
Colchicoside
0
Deacetylcolchicine
0
Delta(6)-protoilludene
0
Dihydropleuromutilin
0
LSM-4236
0
N-Formyldemecolcine
0
Pleuromutilin +
1
Retapamulin
0
SW219106-1
0
Tiamulin fumarate
0
Valnemulin
1
Valnemulin hydrochloride
0
[(1S,2R,3S,4S,6R,7R,8R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[2-(diethylamino)ethylsulfanyl]acetate
0
acenaphthylenes +
15
african-1-ene
0
albaflavenone
0
alpha-cubebene
0
alpha-neoclovene
0
amineptine +
0
amitriptyline +
189
an alpha-neoclovene +
0
anisotanol A
0
anisotanol B
0
anisotanol C
0
anisotanol D
0
anthracenes +
586
avermitilol
0
berkeleyone C
0
beta-cubebene
0
beta-gurjunene
0
beta-maaliene
0
betaenone A +
0
betaestacin I
0
bonnadiene
0
brasilicardin A
0
caribenol B
0
carnosate
0
carnosic acid
248
cedr-8-ene
0
cedrane sesquiterpenoid +
2
colchicine +
255
collinodiene
0
culmorin
0
cyathadiol
0
cyathatriol +
0
cyclobenzaprine +
1
cyclooctat-9-en-5,7-diol
0
cyclooctatin +
0
dehydroabietadienal
0
dehydroabietadienol
0
dehydroabietic acid
0
dolabradiene +
0
durhamycin A
0
durhamycin B
0
ent-bonnadiene
0
erinacine Q
0
erinacine Q2
0
erinacol
0
ferroptocide
0
ferruginol +
7
fluorenes +
430
indacenes +
0
isopimara-7,15-dienal
0
isopimara-7,15-dienol
0
isopimarane +
12
isopimaric acid
12
julichrome Q6 +
0
koraiol
0
lanigerol
0
levopimaradienal
0
levopimaradienol
0
lobophytumin E
0
lobophytumin F
0
lycosantalene
0
lydicene
0
melleolide F
0
miltiradien-20-al
0
miltiradiene +
0
neosartoricin
0
nezukol
0
oleoyl neocryptotanshinone
0
ophiobolin C
0
ophiobolin F
0
patchouli alcohol
11
pentalenic acid
0
phenanthrenes +
256
piroheptine
0
pleosporone
0
prespatane
0
protriptyline +
10
rhizathalene A
0
salviol
0
spathulenol
1
spiroalbatene
0
stellata-2,6,19-triene
0
stellatic acid
0
stemphyloxin II
0
sugiol +
0
syn-isopimara-7,15-diene
0
talarodiene
0
tasumatrol E
0
taxine B
0
taxusin +
0
thujopsene +
0
tiamulin
1
treprostinil +
1
tricycloalkane +
0
triptobenzene D
0
triptobenzene H
0
triptonoterpene
0
triptonoterpene methyl ether
0
triptoquinone A
0
triptoquinone B
0
triptoquinone H
0
tsukubadiene
0
variediene
0
viridiflorene
0
viridiflorol
0