Steap3 (STEAP3 metalloreductase) - Rat Genome Database

Name: Steap3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Steap3 (STEAP3 metalloreductase) Rattus norvegicus

Analyze

Symbol:

Steap3

Name:

STEAP3 metalloreductase

RGD ID:

708552

Description:

Predicted to enable cupric reductase activity; ferric-chelate reductase (NADPH) activity; and identical protein binding activity. Involved in positive regulation of apoptotic process. Predicted to be located in multivesicular body. Predicted to be active in endosome and plasma membrane. Orthologous to human STEAP3 (STEAP3 metalloreductase); PARTICIPATES IN iron uptake pathway; p53 signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC170824; metalloreductase STEAP3; MGC93147; pHyde; six-transmembrane epithelial antigen of prostate 3; STEAP family member 3; STEAP family member 3, metalloreductase; tumor suppressor pHyde

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	STEAP3 (STEAP3 metalloreductase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Steap3 (STEAP family member 3)	HGNC	EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Steap3 (STEAP3 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	STEAP3 (STEAP3 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	STEAP3 (STEAP3 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Steap3 (STEAP3 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	STEAP3 (STEAP3 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	STEAP3 (STEAP3 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Steap3 (STEAP3 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Steap3 (STEAP family member 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	STEAP3 (STEAP3 metalloreductase)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	steap3 (STEAP family member 3, metalloreductase)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	31,351,954 - 31,397,344 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	13	31,351,954 - 31,396,519 (-)	Ensembl
Rnor_6.0	13	36,257,220 - 36,274,144 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	36,257,112 - 36,290,531 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	41,363,988 - 41,380,912 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	13	31,233,071 - 31,251,234 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

hypochromic microcytic anemia (ISS)

Hypochromic Microcytic Anemia with Iron Overload (ISO)

Hypochromic Microcytic Anemia with Iron Overload 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2-acetamidofluorene (EXP)

2-butoxyethanol (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

4-nitrophenol (ISO)

aflatoxin B1 (EXP,ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzene-1,2,4-triol (ISO)

benzo[a]pyrene (ISO)

benzophenone (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buspirone (EXP)

cadmium dichloride (EXP)

calcitriol (ISO)

capsaicin (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

diazinon (EXP,ISO)

dieldrin (EXP)

diuron (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

formaldehyde (ISO)

genistein (ISO)

indometacin (ISO)

iron atom (ISO)

iron(0) (ISO)

levofloxacin (EXP)

methyl methanesulfonate (ISO)

nefazodone (EXP)

nickel sulfate (ISO)

nimesulide (EXP)

oxaliplatin (EXP)

ozone (ISO)

panobinostat (ISO)

paracetamol (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

SB 431542 (ISO)

sunitinib (ISO)

temozolomide (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

topotecan (EXP)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

copper ion import (IBA,ISO)

establishment of localization in cell (ISO)

exosomal secretion (ISO)

iron import into cell (ISO)

iron ion homeostasis (IEA)

iron ion import across cell outer membrane (ISO)

iron ion transport (ISO)

positive regulation of apoptotic process (IDA)

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ISO)

protein secretion (ISO,ISS)

Cellular Component

cytoplasm (ISO)

endosome (IBA,ISO)

endosome membrane (IEA)

integral component of membrane (IEA)

multivesicular body (ISO)

plasma membrane (IBA,ISO)

Molecular Function

cupric reductase activity (IBA,ISO)

ferric-chelate reductase (NADPH) activity (IBA,ISO)

ferric-chelate reductase activity (ISO)

identical protein binding (ISO)

metal ion binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

iron uptake pathway (ISO)

p53 signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.	Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde.	Steiner MS, etal., Cancer Res 2000 Aug 15;60(16):4419-25.
10.	Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.	Wan C, etal., PLoS One. 2012;7(5):e37452. doi: 10.1371/journal.pone.0037452. Epub 2012 May 18.

Additional References at PubMed

PMID:12477932	PMID:15319436	PMID:16227996	PMID:16609065	PMID:18495927	PMID:18617898	PMID:18955558	PMID:25468996

Genomics

Comparative Map Data

Steap3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	31,351,954 - 31,397,344 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	13	31,351,954 - 31,396,519 (-)	Ensembl
Rnor_6.0	13	36,257,220 - 36,274,144 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	36,257,112 - 36,290,531 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	41,363,988 - 41,380,912 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	13	31,233,071 - 31,251,234 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

STEAP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	119,223,834 - 119,265,652 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	119,223,831 - 119,265,652 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	119,981,410 - 120,023,228 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	119,697,854 - 119,739,698 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	2	113,307,446 - 113,349,273 (+)	NCBI
Cytogenetic Map	2	q14.2	NCBI
HuRef	2	112,313,141 - 112,348,432 (+)	NCBI		HuRef
CHM1_1	2	119,984,899 - 120,026,728 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	119,657,360 - 119,699,155 (+)	NCBI

Steap3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	120,154,137 - 120,198,810 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	1	120,118,487 - 120,200,435 (-)	Ensembl
GRCm38	1	120,226,414 - 120,271,081 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	120,190,757 - 120,272,705 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	122,122,993 - 122,167,659 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	1	122,054,752 - 122,092,804 (-)	NCBI			mm8
Celera	1	122,886,890 - 122,931,707 (-)	NCBI		Celera
Cytogenetic Map	1	E2.3	NCBI

Steap3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	10,441,752 - 10,485,269 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955459	10,441,906 - 10,485,235 (-)	NCBI	ChiLan1.0	ChiLan1.0

STEAP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2B	119,760,650 - 119,787,051 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	119,752,363 - 119,787,051 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2B	6,166,296 - 6,208,338 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

STEAP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	30,745,910 - 30,795,310 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	30,747,921 - 30,795,338 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	31,010,053 - 31,054,670 (-)	NCBI
ROS_Cfam_1.0	19	32,130,144 - 32,174,780 (-)	NCBI
ROS_Cfam_1.0 Ensembl	19	32,130,148 - 32,179,975 (-)	Ensembl
UMICH_Zoey_3.1	19	30,816,807 - 30,861,428 (-)	NCBI
UNSW_CanFamBas_1.0	19	30,982,936 - 31,027,552 (-)	NCBI
UU_Cfam_GSD_1.0	19	32,169,778 - 32,214,376 (-)	NCBI

Steap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	90,496,040 - 90,533,500 (+)	NCBI
SpeTri2.0	NW_004936469	51,084,250 - 51,121,738 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STEAP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	24,736,594 - 24,787,865 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	24,736,556 - 24,785,376 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	28,419,225 - 28,467,997 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STEAP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	11,055,446 - 11,097,131 (-)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	10	11,053,981 - 11,075,452 (-)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666061	11,590,282 - 11,632,109 (+)	NCBI	Vero_WHO_p1.0

Steap3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	25,913,736 - 25,958,582 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624732	25,913,034 - 25,958,537 (-)	NCBI	HetGla_female_1.0		hetGla2

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34266636	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	42356786	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	5994668	34535351	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	5994668	44807491	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317034	Aia9	Adjuvant induced arthritis QTL 9	4.62		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	11766535	32331607	Rat
2317044	Aia23	Adjuvant induced arthritis QTL 23	2.3		joint integrity trait (VT:0010548)	ankle joint diameter (CMO:0002148)	13	11766535	32331607	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	11929449	45417941	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	30395351	41184251	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	375
Count of miRNA genes:	219
Interacting mature miRNAs:	257
Transcripts:	ENSRNOT00000071388
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	11	39	39	4	39	4	7			12		4
Low		32	18	2	15	2	4	4	74	35	29	11	4
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF238865	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF335281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000071388 ⟹ ENSRNOP00000064137

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	31,351,954 - 31,385,343 (-)	Ensembl
Rnor_6.0 Ensembl	13	36,257,112 - 36,290,531 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101486 ⟹ ENSRNOP00000095399

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	31,351,954 - 31,396,519 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104769 ⟹ ENSRNOP00000086517

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	31,352,843 - 31,391,589 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106336 ⟹ ENSRNOP00000092490

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	31,351,954 - 31,385,136 (-)	Ensembl

RefSeq Acc Id:

NM_133314 ⟹ NP_579848

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	31,351,954 - 31,391,600 (-)	NCBI
Rnor_6.0	13	36,257,220 - 36,274,144 (-)	NCBI
Rnor_5.0	13	41,363,988 - 41,380,912 (-)	NCBI
Celera	13	31,233,071 - 31,251,234 (-)	RGD

Sequence:

show sequence

GGCACGAGGCTGCCGAGGCACTGTGATGTCCGGGGAGATGGACAAACCGCTCATCAGTCGCCGC
TTGGTGGACAGTGATGGCAGTCTGGCTGAGGTCCCCAAGGAGGCTCCCAAAGTGGGCATCCTGG
GCAGCGGGGATTTTGCCCGGTCCCTGGCCACACGCCTGGTGGGCTCTGGCTTCTTTGTGGTGGT
GGGAAGCCGTAACCCCAAACGCACTGCCGGCCTCTTCCCCTCCTTAGCCCAAGTGACTTTCCAG
GAGGAGGCCGTGAGCTCTCCAGAGGTCATCTTTGTGGCCGTGTTCCGGGAGCACTACTCCTCAC
TGTGCAGTCTTGCTGACCAGTTGGCTGGCAAGATCCTAGTGGATGTAAGCAACCCCACGGAGAA
GGAGCGTCTTCAGCACCGCCAGTCGAACGCCGAGTACCTGGCCTCCCTCTTCCCTGCCTGCACT
GTGGTCAAGGCCTTCAACGTCATCTCTGCATGGGCCCTACAGGCTGGCCCAAGGGATGGGAACA
GGCAGGTGCTCATCTGCGGTGACCAGCTGGAAGCCAAGCACACCGTCTCAGAGATGGCGCGCGC
CATGGGTTTCACCCCACTGGACATGGGATCCCTGGCCTCAGCGAGGGAGGTAGAGGCCATACCC
CTGCGCCTCCTTCCATCCTGGAAGGTGCCCACCCTCCTGGCCCTGGGGCTAAGCACACAAAGCT
ATGCCTACAACTTCATCCGGGACGTTCTACAGCCGTACATCCGGAAAGATGAGAACAAGTTCTA
CAAGATGCCCCTGTCTGTGGTCAACACCACGATACCCTGTGTGGCTTACGTGCTGCTGTCCCTG
GTTTACCTGCCTGGTGTGCTGGCAGCTGCCCTTCAGCTGAGGAGGGGGACCAAGTACCAGCGCT
TCCCAGACTGGCTGGACCATTGGCTGCAGCACCGCAAGCAGATCGGGCTACTCAGCTTTTTTTT
CGCCATGCTGCACGCTCTCTACAGCTTCTGCCTGCCGCTGCGCCGCTCCCACCGCTATGATCTG
GTCAACCTGGCTGTGAAGCAGGTCCTGGCCAACAAGAGCCGCCTCTGGGTTGAGGAAGAAGTCT
GGCGGATGGAGATATACCTGTCCCTGGGTGTGCTGGCTCTGGGCATGCTGTCACTGCTGGCGGT
TACCTCGATCCCTTCCATTGCAAACTCACTCAACTGGAAGGAGTTCAGCTTTGTGCAGTCCACG
CTGGGCTTCGTGGCCCTGATGCTGAGCACAATGCACACCCTCACCTACGGCTGGACCCGTGCTT
TTGAGGAAAACCACTACAAGTTCTACCTGCCACCCACATTCACGCTCACGCTGCTCCTGCCCTG
TGTCATCATCCTGGCCAAGGGCCTCTTCCTCCTGCCCTGCCTCAGCCACAGACTCACCAAGATC
CGCAGGGGCTGGGAGAGGGATGGTGCCGTCAAGTTCATGCTGCCCGCTGGCCACACACAGGGGG
AGAAAACAAGCCACGTGTGAGGCCCTGGAAATGGAGACAGGCACAGCTTGTGGGGGCCCTGGGC
TGGGTTCGGGTCTCTTTTCTGGGATGGTATATGCGTGGGTGGCCGAGGTCTGAATTTCTGGGAT
GCAGGTGTATGCCGAGATACTCAGAATGGCGTACCACACATGCGATAAGTACTCACATATATTT
CATATATAATAGGATTTACTATTATTCTTAGTTAAAAAAAAATAGTGGGTCCTTATATTTCAAC
TTATGCAGGGTCCCTATATTTCAACTTGAGCATTTCAGAGCAAATGCCACACATTAAACAGCAG
ATCCCACCCTTGTGGTAGCTGCAGAGACAGACAGAAACTTCTGGTTATGAGAGAGACTGTATTT
TGTTGGATTCTACCTTTAATCCCCGTTCTCTACGTTCCCCTGTTAGCCACATCTTAACGTTGGT
GCAGAGCTGGGACAAGAGCTGGCTCTGGTGCAGCCTCCCCCATCCCAGGGCTAGGAAACAAGCC
TCTGATGAACAGAGGGACCAGGTCTGGACCCTCCTGCTCCCGCTTCCCTGGGCTCGAGTGGGGA
GGCTCAGCGGGATCCCCCGCAATCTGTGCAGGAGTTTTCACAGGTCTGTCCTTTCTTCCGGGAG
CGGTCTGAAGCGGCCCCATCTGATCCTAGCTGAGCCGAGATTGTTCCCCACTCCCTGAAAGTCC
AGAGTCACCGTGGAGCCTGCAAATTGCTCCTTCTGCGAAGGTGTGAAGTCACCGTCTCACCAGA
GCCATTAACGAACCTGATCTTCAGAAGAAGCATAATTGTTTCCCCTCCATTAAGTTGGTGGTGA
CCCTCTTTAAACCACTGTGCCTTCTCGCCTTTCCCATCACTAATTTGGGCATCTCCATGGAGTG
GACTCTTGTCGGGGCAGTTCAGGGGGGAGGGAAGCATTAGAGATTGCGGAGAATAACCATCGAA
GCCTCCCTTGGATGTTCCCAGGCGTGCCTTCATTAAATTGGTCCCTAATGAGAATGACAGGGGA
CCCCTGTTGCCTGTATGCAGAGAACCAGCCTTCTGAGCACCCAGGAAACACAGTGGCCCCACGC
CCTTCAGGGGGGTCCCACGTCCCCTTTCCCATGCTTTTGCCTCCCTCCCTCCCGGTTACAATCA
ACCATAAAAGTCTGCAAATATTGTTTTTTGAATTCTTAAAGAGACCACATCCTTTGTTATTACC
AAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039090294 ⟹ XP_038946222

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	31,351,954 - 31,397,344 (-)	NCBI

RefSeq Acc Id:

XM_039090295 ⟹ XP_038946223

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	31,351,954 - 31,385,551 (-)	NCBI

RefSeq Acc Id:

XM_039090296 ⟹ XP_038946224

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	31,351,954 - 31,397,344 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_579848	(Get FASTA)	NCBI Sequence Viewer
	XP_038946222	(Get FASTA)	NCBI Sequence Viewer
	XP_038946223	(Get FASTA)	NCBI Sequence Viewer
	XP_038946224	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85696	(Get FASTA)	NCBI Sequence Viewer
	AAK00361	(Get FASTA)	NCBI Sequence Viewer
	AAL78207	(Get FASTA)	NCBI Sequence Viewer
	EDL87941	(Get FASTA)	NCBI Sequence Viewer
	Q5RKL5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_579848 ⟸ NM_133314

- UniProtKB:

Q99P41 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSGEMDKPLISRRLVDSDGSLAEVPKEAPKVGILGSGDFARSLATRLVGSGFFVVVGSRNPKRT
AGLFPSLAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLADQLAGKILVDVSNPTEKERLQHRQS
NAEYLASLFPACTVVKAFNVISAWALQAGPRDGNRQVLICGDQLEAKHTVSEMARAMGFTPLDM
GSLASAREVEAIPLRLLPSWKVPTLLALGLSTQSYAYNFIRDVLQPYIRKDENKFYKMPLSVVN
TTIPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFFAMLHALYS
FCLPLRRSHRYDLVNLAVKQVLANKSRLWVEEEVWRMEIYLSLGVLALGMLSLLAVTSIPSIAN
SLNWKEFSFVQSTLGFVALMLSTMHTLTYGWTRAFEENHYKFYLPPTFTLTLLLPCVIILAKGL
FLLPCLSHRLTKIRRGWERDGAVKFMLPAGHTQGEKTSHV

hide sequence

RefSeq Acc Id:

ENSRNOP00000064137 ⟸ ENSRNOT00000071388

RefSeq Acc Id:	XP_038946224 ⟸ XM_039090296
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038946222 ⟸ XM_039090294
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038946223 ⟸ XM_039090295
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000095399 ⟸ ENSRNOT00000101486

RefSeq Acc Id:

ENSRNOP00000086517 ⟸ ENSRNOT00000104769

RefSeq Acc Id:

ENSRNOP00000092490 ⟸ ENSRNOT00000106336

Protein Domains

F420_oxidored Ferric oxidoreductase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5RKL5-F1-model_v2	AlphaFold	Q5RKL5	1-488	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (mRatBN7.2)

ACI/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708552	AgrOrtholog
BioCyc Gene	G2FUF-18506	BioCyc
Ensembl Genes	ENSRNOG00000049471	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000064137.3	UniProtKB/TrEMBL
	ENSRNOP00000086517	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000092490	ENTREZGENE
	ENSRNOP00000092490.1	UniProtKB/TrEMBL
	ENSRNOP00000095399	ENTREZGENE
	ENSRNOP00000095399.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000071388.3	UniProtKB/TrEMBL
	ENSRNOT00000101486	ENTREZGENE
	ENSRNOT00000101486.1	UniProtKB/TrEMBL
	ENSRNOT00000104769	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000106336	ENTREZGENE
	ENSRNOT00000106336.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7190374	IMAGE-MGC_LOAD
InterPro	Fe3_Rdtase_TM_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P5C_Rdtase_cat_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:170824	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93147	IMAGE-MGC_LOAD
NCBI Gene	170824	ENTREZGENE
Pfam	F420_oxidored	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ferric_reduct	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Steap3	PhenoGen
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0H2UI26_RAT	UniProtKB/TrEMBL
	A0A8I6AGN2_RAT	UniProtKB/TrEMBL
	A0A8I6AMK0_RAT	UniProtKB/TrEMBL
	Q5RKL5	ENTREZGENE
	Q99P41	ENTREZGENE
	STEA3_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q99P41	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-25	Steap3	STEAP3 metalloreductase	Steap3	STEAP family member 3, metalloreductase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-10-18	Steap3	STEAP family member 3, metalloreductase	Steap3	STEAP family member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Steap3	STEAP family member 3	LOC170824	tumor suppressor pHyde	Symbol and Name updated	1299863	APPROVED
2005-09-30	LOC170824				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)