Steap3 (STEAP3 metalloreductase) - Rat Genome Database

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Gene: Steap3 (STEAP3 metalloreductase) Rattus norvegicus
Analyze
Symbol: Steap3
Name: STEAP3 metalloreductase
RGD ID: 708552
Description: Predicted to enable several functions, including FAD binding activity; heme binding activity; and oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor. Involved in positive regulation of apoptotic process. Predicted to be located in endosome membrane and multivesicular body. Predicted to be active in endosome and plasma membrane. Orthologous to human STEAP3 (STEAP3 metalloreductase); PARTICIPATES IN iron uptake pathway; p53 signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC170824; metalloreductase STEAP3; MGC93147; pHyde; six-transmembrane epithelial antigen of prostate 3; STEAP family member 3; STEAP family member 3, metalloreductase; tumor suppressor pHyde
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,904,710 - 33,950,100 (-)NCBIGRCr8
GRCr8 Ensembl1333,904,710 - 33,950,080 (-)EnsemblGRCr8 Ensembl
mRatBN7.21331,351,954 - 31,397,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,351,954 - 31,396,519 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1333,919,075 - 33,958,529 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,206,922 - 35,246,367 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,481,358 - 32,520,829 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,257,220 - 36,274,144 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,257,112 - 36,290,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,363,988 - 41,380,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,233,071 - 31,251,234 (-)NCBICelera
Cytogenetic Map13q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminobenzohydrazide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzophenone  (EXP)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diazinon  (EXP,ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoniazide  (ISO)
ketoconazole  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
endosome  (IBA,IEA,ISO)
endosome membrane  (IEA,ISO,ISS)
membrane  (IEA)
multivesicular body  (ISO)
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde. Steiner MS, etal., Cancer Res 2000 Aug 15;60(16):4419-25.
10. Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis. Wan C, etal., PLoS One. 2012;7(5):e37452. doi: 10.1371/journal.pone.0037452. Epub 2012 May 18.
Additional References at PubMed
PMID:12477932   PMID:15319436   PMID:16227996   PMID:16609065   PMID:18495927   PMID:18617898   PMID:18955558   PMID:25468996   PMID:37820423  


Genomics

Comparative Map Data
Steap3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,904,710 - 33,950,100 (-)NCBIGRCr8
GRCr8 Ensembl1333,904,710 - 33,950,080 (-)EnsemblGRCr8 Ensembl
mRatBN7.21331,351,954 - 31,397,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,351,954 - 31,396,519 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1333,919,075 - 33,958,529 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,206,922 - 35,246,367 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,481,358 - 32,520,829 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,257,220 - 36,274,144 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,257,112 - 36,290,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,363,988 - 41,380,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,233,071 - 31,251,234 (-)NCBICelera
Cytogenetic Map13q11NCBI
STEAP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382119,223,834 - 119,265,652 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2119,223,831 - 119,265,652 (+)EnsemblGRCh38hg38GRCh38
GRCh372119,981,410 - 120,023,228 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,697,854 - 119,739,698 (+)NCBINCBI36Build 36hg18NCBI36
Celera2113,307,446 - 113,349,273 (+)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2112,313,141 - 112,348,432 (+)NCBIHuRef
CHM1_12119,984,899 - 120,026,728 (+)NCBICHM1_1
T2T-CHM13v2.02119,657,360 - 119,699,155 (+)NCBIT2T-CHM13v2.0
Steap3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,154,137 - 120,198,810 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,118,487 - 120,200,435 (-)EnsemblGRCm39 Ensembl
GRCm381120,226,414 - 120,271,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,190,757 - 120,272,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371122,122,993 - 122,167,659 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,054,752 - 122,092,804 (-)NCBIMGSCv36mm8
Celera1122,886,890 - 122,931,707 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.66NCBI
Steap3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545910,441,752 - 10,485,269 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545910,441,906 - 10,485,235 (-)NCBIChiLan1.0ChiLan1.0
STEAP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21321,232,416 - 21,274,503 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B21,269,221 - 21,289,476 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B6,166,296 - 6,208,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B119,760,650 - 119,787,051 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B119,752,363 - 119,787,051 (+)Ensemblpanpan1.1panPan2
STEAP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11930,745,910 - 30,795,310 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1930,747,921 - 30,795,338 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1931,010,053 - 31,054,670 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01932,130,144 - 32,174,780 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1932,130,148 - 32,179,975 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11930,816,807 - 30,861,428 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01930,982,936 - 31,027,552 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01932,169,778 - 32,214,376 (-)NCBIUU_Cfam_GSD_1.0
Steap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,496,040 - 90,533,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646951,054,517 - 51,126,664 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646951,084,250 - 51,121,738 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STEAP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1524,736,594 - 24,787,865 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11524,736,556 - 24,785,376 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,419,225 - 28,467,997 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STEAP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11011,055,446 - 11,097,131 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1011,053,981 - 11,075,452 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606111,590,282 - 11,632,109 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Steap3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473225,913,736 - 25,958,582 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473225,913,034 - 25,958,537 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Steap3
367 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:375
Count of miRNA genes:219
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000071388
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071388   ⟹   ENSRNOP00000064137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1333,904,710 - 33,944,361 (-)Ensembl
mRatBN7.2 Ensembl1331,351,954 - 31,385,343 (-)Ensembl
Rnor_6.0 Ensembl1336,257,112 - 36,290,531 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101486   ⟹   ENSRNOP00000095399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1333,904,710 - 33,944,356 (-)Ensembl
mRatBN7.2 Ensembl1331,351,954 - 31,396,519 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104769   ⟹   ENSRNOP00000086517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1333,904,710 - 33,922,689 (-)Ensembl
mRatBN7.2 Ensembl1331,352,843 - 31,391,589 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106336   ⟹   ENSRNOP00000092490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1333,904,710 - 33,938,023 (-)Ensembl
mRatBN7.2 Ensembl1331,351,954 - 31,385,136 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123261   ⟹   ENSRNOP00000105584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1333,904,710 - 33,950,080 (-)Ensembl
RefSeq Acc Id: NM_133314   ⟹   NP_579848
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,904,710 - 33,944,356 (-)NCBI
mRatBN7.21331,351,954 - 31,391,600 (-)NCBI
Rnor_6.01336,257,220 - 36,274,144 (-)NCBI
Rnor_5.01341,363,988 - 41,380,912 (-)NCBI
Celera1331,233,071 - 31,251,234 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090294   ⟹   XP_038946222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,904,710 - 33,950,100 (-)NCBI
mRatBN7.21331,351,954 - 31,397,344 (-)NCBI
RefSeq Acc Id: XM_039090295   ⟹   XP_038946223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,904,710 - 33,938,305 (-)NCBI
mRatBN7.21331,351,954 - 31,385,551 (-)NCBI
RefSeq Acc Id: XM_039090296   ⟹   XP_038946224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,904,710 - 33,950,100 (-)NCBI
mRatBN7.21331,351,954 - 31,397,344 (-)NCBI
RefSeq Acc Id: XM_063271984   ⟹   XP_063128054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,904,710 - 33,930,371 (-)NCBI
RefSeq Acc Id: XM_063271985   ⟹   XP_063128055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,904,710 - 33,949,974 (-)NCBI
RefSeq Acc Id: XM_063271986   ⟹   XP_063128056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,904,710 - 33,930,408 (-)NCBI
RefSeq Acc Id: XM_063271987   ⟹   XP_063128057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,904,710 - 33,944,445 (-)NCBI
RefSeq Acc Id: NP_579848   ⟸   NM_133314
- UniProtKB: Q5RKL5 (UniProtKB/Swiss-Prot),   Q99P41 (UniProtKB/Swiss-Prot),   A6K7Z6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064137   ⟸   ENSRNOT00000071388
RefSeq Acc Id: XP_038946224   ⟸   XM_039090296
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038946222   ⟸   XM_039090294
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AMK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946223   ⟸   XM_039090295
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AGN2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095399   ⟸   ENSRNOT00000101486
Ensembl Acc Id: ENSRNOP00000086517   ⟸   ENSRNOT00000104769
Ensembl Acc Id: ENSRNOP00000092490   ⟸   ENSRNOT00000106336
RefSeq Acc Id: XP_063128055   ⟸   XM_063271985
- Peptide Label: isoform X4
- UniProtKB: Q99P41 (UniProtKB/Swiss-Prot),   Q5RKL5 (UniProtKB/Swiss-Prot),   A6K7Z6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128057   ⟸   XM_063271987
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063128056   ⟸   XM_063271986
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063128054   ⟸   XM_063271984
- Peptide Label: isoform X3
- UniProtKB: A0A0H2UI26 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105584   ⟸   ENSRNOT00000123261
Protein Domains
Ferric oxidoreductase   Pyrroline-5-carboxylate reductase catalytic N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RKL5-F1-model_v2 AlphaFold Q5RKL5 1-488 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708552 AgrOrtholog
BioCyc Gene G2FUF-18506 BioCyc
Ensembl Genes ENSRNOG00000049471 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071388 ENTREZGENE
  ENSRNOT00000101486 ENTREZGENE
  ENSRNOT00000104769 ENTREZGENE
  ENSRNOT00000104769.1 UniProtKB/Swiss-Prot
  ENSRNOT00000106336 ENTREZGENE
  ENSRNOT00000123261 ENTREZGENE
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190374 IMAGE-MGC_LOAD
InterPro Fe3_Rdtase_TM_dom UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  P5C_Rdtase_cat_N UniProtKB/Swiss-Prot
  STEAP_metalloreductase UniProtKB/Swiss-Prot
KEGG Report rno:170824 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93147 IMAGE-MGC_LOAD
NCBI Gene 170824 ENTREZGENE
PANTHER DUDULIN-RELATED UniProtKB/Swiss-Prot
  METALLOREDUCTASE STEAP3 UniProtKB/Swiss-Prot
Pfam F420_oxidored UniProtKB/Swiss-Prot
  Ferric_reduct UniProtKB/Swiss-Prot
PhenoGen Steap3 PhenoGen
RatGTEx ENSRNOG00000049471 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A0A0H2UI26 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMK0 ENTREZGENE, UniProtKB/TrEMBL
  A6K7Z6 ENTREZGENE, UniProtKB/TrEMBL
  Q5RKL5 ENTREZGENE
  Q99P41 ENTREZGENE
  STEA3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q99P41 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Steap3  STEAP3 metalloreductase  Steap3  STEAP family member 3, metalloreductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-18 Steap3  STEAP family member 3, metalloreductase  Steap3  STEAP family member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Steap3  STEAP family member 3  LOC170824  tumor suppressor pHyde  Symbol and Name updated 1299863 APPROVED
2005-09-30 LOC170824        Symbol and Name status set to provisional 70820 PROVISIONAL