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Gene: Isl1 (ISL LIM homeobox 1) Rattus norvegicus
Symbol: Isl1
Name: ISL LIM homeobox 1
RGD ID: 61957
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and estrogen receptor binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; negative regulation of intracellular estrogen receptor signaling pathway; and positive regulation of insulin secretion. Localizes to nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; all-trans-retinoic acid; ammonium chloride.
Type: protein-coding
Also known as: ISL1 transcription factor, LIM/homeodomain, (islet-1) ; insulin gene enhancer protein ISL-1; Isl-1; isl-1 homeobox; isl-1=homeobox; ISL1 transcription factor LIM/homeodomain; ISL1 transcription factor LIM/homeodomain (islet-1); ISL1 transcription factor, LIM/homeodomain; ISL1 transcription factor, LIM/homeodomain 1; islet-1
Homo sapiens (human) : ISL1 (ISL LIM homeobox 1)  HGNC  Alliance
Mus musculus (house mouse) : Isl1 (ISL1 transcription factor, LIM/homeodomain)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Isl1 (ISL LIM homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ISL1 (ISL LIM homeobox 1)
Canis lupus familiaris (dog) : ISL1 (ISL LIM homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Isl1 (ISL LIM homeobox 1)
Sus scrofa (pig) : ISL1 (ISL LIM homeobox 1)
Chlorocebus sabaeus (African green monkey) : ISL1 (ISL LIM homeobox 1)
Heterocephalus glaber (naked mole-rat) : Isl1 (ISL LIM homeobox 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0248,488,911 - 48,501,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl248,487,736 - 48,501,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0266,871,790 - 66,883,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4248,050,124 - 48,060,394 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1247,978,356 - 47,988,627 (-)NCBI
Celera243,808,350 - 43,818,250 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Isl1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61957
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.