Gene: Isl1 (ISL LIM homeobox 1) Rattus norvegicus
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Symbol: Isl1
Name: ISL LIM homeobox 1
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen receptor binding; nuclear receptor binding; INVOLVED IN axon regeneration; cellular response to glucocorticoid stimulus; negative regulation of epithelial cell proliferation; ASSOCIATED WITH bladder exstrophy (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); congenital heart disease (ortholog); FOUND IN nucleus; nucleoplasm (ortholog); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; all-trans-retinoic acid; ammonium chloride
AGR Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II proximal promoter sequence-specific DNA binding activity, and estrogen receptor binding activity; involved in several processes, including axon regeneration, cellular response to glucocorticoid stimulus, and negative regulation of epithelial cell proliferation; localizes to the nucleus; orthologous to human ISL1 (ISL LIM homeobox 1).
Merged Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II proximal promoter sequence-specific DNA binding activity, and estrogen receptor binding activity; involved in several processes, including axon regeneration, cellular response to glucocorticoid stimulus, and negative regulation of epithelial cell proliferation; localizes to the nucleus; orthologous to human ISL1 (ISL LIM homeobox 1); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; all-trans-retinoic acid; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ISL1 transcription factor, LIM/homeodomain, (islet-1) ; insulin gene enhancer protein ISL-1; Isl-1; isl-1 homeobox; isl-1=homeobox; ISL1 transcription factor LIM/homeodomain; ISL1 transcription factor LIM/homeodomain (islet-1); ISL1 transcription factor, LIM/homeodomain; ISL1 transcription factor, LIM/homeodomain 1; islet-1
Orthologs:
Homo sapiens (human) : ISL1 (ISL LIM homeobox 1)  HGNC  Alliance
Mus musculus (house mouse) : Isl1 (ISL1 transcription factor, LIM/homeodomain)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Isl1 (ISL LIM homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ISL1 (ISL LIM homeobox 1)
Canis lupus familiaris (dog) : ISL1 (ISL LIM homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Isl1 (ISL LIM homeobox 1)
Sus scrofa (pig) : ISL1 (ISL LIM homeobox 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0248,488,911 - 48,501,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0266,871,790 - 66,883,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4248,050,124 - 48,060,394 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1247,978,356 - 47,988,627 (-)NCBI
Celera243,808,350 - 43,818,250 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

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QTLs in Region (Rnor_6.0)
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Sequence

Nucleotide Sequences
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Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
RGD Curation Notes
  
More on Isl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61957
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.