Nox1 (NADPH oxidase 1) - Rat Genome Database

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Gene: Nox1 (NADPH oxidase 1) Rattus norvegicus
Analyze
Symbol: Nox1
Name: NADPH oxidase 1
RGD ID: 620598
Description: Enables NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including positive regulation of reactive oxygen species metabolic process; positive regulation of smooth muscle cell proliferation; and superoxide anion generation. Part of NADPH oxidase complex. Orthologous to human NOX1 (NADPH oxidase 1); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mitogenic oxidase 1; MOX-1; MOX1; NADH/NADPH mitogenic oxidase subunit p65-mox; NOH-1; NOX-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X97,279,058 - 97,332,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX98,953,200 - 98,976,388 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X102,462,968 - 102,486,155 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X99,966,365 - 99,989,543 (-)NCBIRnor_WKY
Rnor_6.0X104,909,328 - 104,932,508 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX104,909,326 - 104,932,508 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X104,742,161 - 104,765,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX98,325,197 - 98,348,363 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-benzoquinone  (ISO)
11-deoxycorticosterone  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (ISO)
acteoside  (ISO)
adenine  (EXP)
Adiponectin  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amlodipine  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camostat  (EXP)
candesartan  (EXP)
carvedilol  (EXP)
celecoxib  (EXP)
CGP-42112A  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
crystal violet  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
Deoxycorticosterone acetate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diminazene diaceturate  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
glycyl-L-phenylalanine 2-naphthylamide  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP)
icosanoid  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
maneb  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
mevinphos  (EXP)
miconazole  (EXP)
mirtazapine  (ISO)
mitogen  (EXP)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
nebivolol  (EXP)
nickel dichloride  (ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
paraquat  (EXP,ISO)
PD123319  (ISO)
PhIP  (EXP,ISO)
pioglitazone  (ISO)
pirfenidone  (ISO)
quercetin  (EXP,ISO)
razoxane  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (EXP)
rotenone  (ISO)
rottlerin  (EXP)
ruxolitinib  (ISO)
Salidroside  (EXP,ISO)
SB 203580  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
superoxide  (EXP,ISO)
tacrolimus hydrate  (EXP)
testosterone  (ISO)
thioacetamide  (EXP,ISO)
titanium atom  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP)
valproic acid  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. Ambasta RK, etal., J Biol Chem. 2004 Oct 29;279(44):45935-41. Epub 2004 Aug 18.
2. l-Carnitine ameliorates the oxidative stress response to angiotensin II by modulating NADPH oxidase through a reduction in protein kinase c activity and NF-κB translocation to the nucleus. Blanca AJ, etal., Food Chem. 2017 Aug 1;228:356-366. doi: 10.1016/j.foodchem.2017.02.011. Epub 2017 Feb 6.
3. Superoxide anion is elevated in sympathetic neurons in DOCA-salt hypertension via activation of NADPH oxidase. Dai X, etal., Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1019-26. Epub 2005 Oct 7.
4. Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome. Fortuno A, etal., Diabetes. 2006 Jan;55(1):209-15.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha. Katsuyama M, etal., J Biol Chem 2002 Apr 19;277(16):13438-42.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. Pleskova M, etal., FASEB J. 2006 Jan;20(1):139-41. Epub 2005 Oct 27.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Cell transformation by the superoxide-generating oxidase Mox1. Suh YA, etal., Nature 1999 Sep 2;401(6748):79-82.
16. Production and actions of superoxide in the renal medulla. Zou AP, etal., Hypertension 2001 Feb;37(2 Part 2):547-53.
Additional References at PubMed
PMID:10615049   PMID:11331784   PMID:11805326   PMID:12473664   PMID:14670934   PMID:15123630   PMID:15710429   PMID:15777779   PMID:15826947   PMID:15922295   PMID:16085178   PMID:16129699  
PMID:16207877   PMID:16373635   PMID:16386251   PMID:16636067   PMID:16879806   PMID:16914424   PMID:17015265   PMID:17085464   PMID:17283869   PMID:17324585   PMID:17435218   PMID:17440033  
PMID:17462535   PMID:17493633   PMID:17673675   PMID:17698723   PMID:17765919   PMID:17822438   PMID:17876872   PMID:17982273   PMID:18023288   PMID:18250367   PMID:18289732   PMID:18397177  
PMID:18436224   PMID:18454179   PMID:18488907   PMID:18514509   PMID:18566342   PMID:18651560   PMID:18723759   PMID:18760347   PMID:18848961   PMID:19029489   PMID:19134410   PMID:19147679  
PMID:19471020   PMID:19660816   PMID:19661248   PMID:19716351   PMID:19755710   PMID:19804648   PMID:19875720   PMID:20018867   PMID:20414976   PMID:20448043   PMID:20525691   PMID:20715105  
PMID:20732386   PMID:20807796   PMID:20830300   PMID:20857410   PMID:20943855   PMID:20970480   PMID:21138635   PMID:21419746   PMID:21505267   PMID:21537828   PMID:21660950   PMID:21814483  
PMID:22098189   PMID:22203737   PMID:22431579   PMID:22433789   PMID:22565378   PMID:22566500   PMID:22636674   PMID:22738259   PMID:22997161   PMID:23087362   PMID:23225244   PMID:23592126  
PMID:23827392   PMID:24152438   PMID:24211271   PMID:24233492   PMID:24294978   PMID:24372242   PMID:24824652   PMID:24973900   PMID:25536219   PMID:25550204   PMID:25601753   PMID:25682169  
PMID:25700020   PMID:25820554   PMID:25880095   PMID:25997532   PMID:26310573   PMID:26585490   PMID:26658815   PMID:26824355   PMID:26872992   PMID:27276705   PMID:27665186   PMID:27816504  
PMID:27847553   PMID:27923787   PMID:28119263   PMID:28263293   PMID:28336111   PMID:28363602   PMID:28826906   PMID:28849167   PMID:29472601   PMID:30551445   PMID:30816157   PMID:31391086  
PMID:32131490   PMID:33658472   PMID:34843718   PMID:35354309  


Genomics

Comparative Map Data
Nox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X97,279,058 - 97,332,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX98,953,200 - 98,976,388 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X102,462,968 - 102,486,155 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X99,966,365 - 99,989,543 (-)NCBIRnor_WKY
Rnor_6.0X104,909,328 - 104,932,508 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX104,909,326 - 104,932,508 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X104,742,161 - 104,765,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX98,325,197 - 98,348,363 (-)NCBICelera
Cytogenetic MapXq32NCBI
NOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X100,843,324 - 100,874,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX100,843,324 - 100,874,359 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,098,313 - 100,129,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X99,984,969 - 100,015,990 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X99,904,969 - 99,935,343NCBI
CeleraX100,617,105 - 100,648,120 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX89,897,075 - 89,927,719 (-)NCBIHuRef
CHM1_1X99,991,243 - 100,022,267 (-)NCBICHM1_1
T2T-CHM13v2.0X99,285,862 - 99,317,015 (-)NCBIT2T-CHM13v2.0
Nox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X132,987,170 - 133,038,455 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX132,987,170 - 133,122,705 (-)EnsemblGRCm39 Ensembl
GRCm38X134,086,421 - 134,137,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,086,421 - 134,221,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X130,621,685 - 130,646,247 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,433,496 - 129,458,058 (-)NCBIMGSCv36mm8
CeleraX116,963,302 - 116,987,732 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX55.69NCBI
Nox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555036,974,239 - 6,997,618 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555036,973,965 - 7,020,182 (-)NCBIChiLan1.0ChiLan1.0
NOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X100,182,881 - 100,215,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,182,398 - 100,215,192 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X90,046,023 - 90,076,968 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X74,784,627 - 74,811,796 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX74,785,168 - 74,811,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,195,825 - 76,224,844 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,195,810 - 76,224,962 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X73,760,799 - 73,789,818 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,424,758 - 75,453,798 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,186,299 - 75,215,328 (-)NCBIUU_Cfam_GSD_1.0
Nox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X63,512,975 - 63,529,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365846,024,008 - 6,039,866 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365846,023,960 - 6,040,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX82,540,667 - 82,586,532 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X82,540,664 - 82,575,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X90,483,590 - 90,496,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,182,636 - 89,210,176 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX89,183,264 - 89,209,298 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606514,108,862 - 14,147,312 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,736,704 - 1,755,504 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,741,921 - 1,754,932 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nox1
104 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:115
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000075325
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 2 13 2 5
Below cutoff 2 22 17 7 6 7 6 9 42 9 23 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075325   ⟹   ENSRNOP00000065995
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)Ensembl
Rnor_6.0 EnsemblX104,909,326 - 104,932,508 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097078   ⟹   ENSRNOP00000084058
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101509   ⟹   ENSRNOP00000081363
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103999   ⟹   ENSRNOP00000082975
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,279,056 - 97,298,116 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116559   ⟹   ENSRNOP00000091510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,279,148 - 97,293,445 (-)Ensembl
RefSeq Acc Id: NM_053683   ⟹   NP_446135
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X97,279,058 - 97,302,236 (-)NCBI
Rnor_6.0X104,909,328 - 104,932,508 (-)NCBI
Rnor_5.0X104,742,161 - 104,765,479 (-)NCBI
CeleraX98,325,197 - 98,348,363 (-)RGD
Sequence:
RefSeq Acc Id: XM_039099397   ⟹   XP_038955325
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X97,279,059 - 97,332,291 (-)NCBI
RefSeq Acc Id: XM_039099398   ⟹   XP_038955326
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X97,279,059 - 97,332,291 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446135   ⟸   NM_053683
- UniProtKB: M0R934 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065995   ⟸   ENSRNOT00000075325
RefSeq Acc Id: XP_038955326   ⟸   XM_039099398
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038955325   ⟸   XM_039099397
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000081363   ⟸   ENSRNOT00000101509
RefSeq Acc Id: ENSRNOP00000084058   ⟸   ENSRNOT00000097078
RefSeq Acc Id: ENSRNOP00000091510   ⟸   ENSRNOT00000116559
RefSeq Acc Id: ENSRNOP00000082975   ⟸   ENSRNOT00000103999
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WV87-F1-model_v2 AlphaFold Q9WV87 1-563 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701930
Promoter ID:EPDNEW_R12454
Type:single initiation site
Name:Nox1_1
Description:NADPH oxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X104,932,536 - 104,932,596EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620598 AgrOrtholog
BioCyc Gene G2FUF-1695 BioCyc
Ensembl Genes ENSRNOG00000048706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000065995 ENTREZGENE
  ENSRNOP00000065995.1 UniProtKB/TrEMBL
  ENSRNOP00000081363.1 UniProtKB/TrEMBL
  ENSRNOP00000082975.1 UniProtKB/TrEMBL
  ENSRNOP00000084058.1 UniProtKB/TrEMBL
  ENSRNOP00000091510 ENTREZGENE
  ENSRNOP00000091510.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075325 ENTREZGENE
  ENSRNOT00000075325.2 UniProtKB/TrEMBL
  ENSRNOT00000097078.1 UniProtKB/TrEMBL
  ENSRNOT00000101509.1 UniProtKB/TrEMBL
  ENSRNOT00000103999.1 UniProtKB/TrEMBL
  ENSRNOT00000116559 ENTREZGENE
  ENSRNOT00000116559.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_b245_heavy_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fe3_Rdtase_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fe_red_NAD-bd_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114243 UniProtKB/Swiss-Prot
NCBI Gene 114243 ENTREZGENE
PANTHER PTHR11972:SF71 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAD_binding_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nox1 PhenoGen
PRINTS GP91PHOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZRV5_RAT UniProtKB/TrEMBL
  A0A8I5ZW90_RAT UniProtKB/TrEMBL
  A0A8I6AG93_RAT UniProtKB/TrEMBL
  A0A8I6GBE7_RAT UniProtKB/TrEMBL
  M0R934 ENTREZGENE, UniProtKB/TrEMBL
  NOX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nox1  NADPH oxidase 1    NADH/NADPH mitogenic oxidase subunit p65-mox  Name updated 1299863 APPROVED
2002-08-07 Nox1  NADH/NADPH mitogenic oxidase subunit p65-mox      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may regulate renal medullary blood flow (MBF) and water/sodium excretion 628559
gene_process major superoxide-producing enzyme in the renal outer medulla (OM) of kidney 628559
gene_regulation expression is induced by PGF(2alpha) 625378