Nox1 (NADPH oxidase 1) - Rat Genome Database

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Gene: Nox1 (NADPH oxidase 1) Rattus norvegicus
Analyze
Symbol: Nox1
Name: NADPH oxidase 1
RGD ID: 620598
Description: Enables NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to mercury ion; cellular response to platelet-derived growth factor stimulus; and positive regulation of cellular component organization. Part of NADPH oxidase complex. Used to study Parkinson's disease; pulmonary hypertension; transient cerebral ischemia; and vascular dementia. Biomarker of middle cerebral artery infarction; pulmonary hypertension; and traumatic brain injury. Orthologous to human NOX1 (NADPH oxidase 1); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mitogenic oxidase 1; MOX-1; MOX1; NADH/NADPH mitogenic oxidase subunit p65-mox; NOH-1; NOX-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X101,572,338 - 101,625,571 (-)NCBIGRCr8
mRatBN7.2X97,279,058 - 97,332,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX98,953,200 - 98,976,388 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,462,968 - 102,486,155 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X99,966,365 - 99,989,543 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X104,909,328 - 104,932,508 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX104,909,326 - 104,932,508 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X104,742,161 - 104,765,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX98,325,197 - 98,348,363 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-benzoquinone  (ISO)
11-deoxycorticosterone  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (ISO)
acteoside  (ISO)
adenine  (EXP)
Adiponectin  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amlodipine  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camostat  (EXP)
candesartan  (EXP)
carnosic acid  (ISO)
carvacrol  (EXP,ISO)
carvedilol  (EXP)
celecoxib  (EXP)
CGP-42112A  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
crystal violet  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
Deoxycorticosterone acetate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diminazene diaceturate  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
galangin  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
glycyl-L-phenylalanine 2-naphthylamide  (ISO)
glyphosate  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP)
icosanoid  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (EXP)
levetiracetam  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
maneb  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
mevinphos  (EXP)
miconazole  (EXP)
mirtazapine  (ISO)
mitogen  (EXP)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
nebivolol  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
paraquat  (EXP,ISO)
PD123319  (ISO)
PhIP  (EXP,ISO)
pioglitazone  (ISO)
pirfenidone  (ISO)
quercetin  (EXP,ISO)
razoxane  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (EXP)
rotenone  (ISO)
rottlerin  (EXP)
ruxolitinib  (ISO)
Salidroside  (EXP,ISO)
SB 203580  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
sodium propionate  (ISO)
superoxide  (EXP,ISO)
tacrolimus hydrate  (EXP)
testosterone  (ISO)
thioacetamide  (EXP,ISO)
titanium atom  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP)
valproic acid  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
cell chemotaxis  (IMP)
cell migration  (IEA,ISO)
cellular response to angiotensin  (IEP)
cellular response to hyperoxia  (IEA,ISO)
cellular response to interleukin-1  (IEP)
cellular response to mercury ion  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular stress response to acidic pH  (IEA)
defense response  (IBA)
extracellular matrix organization  (IEA,ISO)
glutathione metabolic process  (IMP)
hydrogen peroxide metabolic process  (IEA,ISO)
intracellular pH elevation  (IEA)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
JNK cascade  (IEA,ISO)
MAPK cascade  (ISO)
negative regulation of neuron maturation  (IMP)
oxygen metabolic process  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of inclusion body assembly  (IMP)
positive regulation of integrin biosynthetic process  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron projection development  (IMP)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of superoxide anion generation  (IMP)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
positive regulation of vascular endothelial growth factor production  (IEA,ISO)
regulation of systemic arterial blood pressure by renin-angiotensin  (IEA,ISO)
response to reactive oxygen species  (IDA)
superoxide anion generation  (IBA,IEA,IMP,ISO)

Cellular Component
anchoring junction  (IEA)
cell projection  (IEA)
cytoplasm  (ISO)
early endosome  (IEA,ISO)
endosome  (ISO)
NADPH oxidase complex  (IBA,IDA,IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration. Abdul-Muneer PM, etal., Brain Behav Immun. 2017 Jan;59:190-199. doi: 10.1016/j.bbi.2016.09.002. Epub 2016 Sep 7.
2. Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells. Aguado A, etal., J Hypertens. 2016 Feb;34(2):253-65. doi: 10.1097/HJH.0000000000000801.
3. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. Ambasta RK, etal., J Biol Chem. 2004 Oct 29;279(44):45935-41. Epub 2004 Aug 18.
4. Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion. Arroja MMC, etal., Sci Rep. 2019 Feb 28;9(1):3154. doi: 10.1038/s41598-019-39102-8.
5. l-Carnitine ameliorates the oxidative stress response to angiotensin II by modulating NADPH oxidase through a reduction in protein kinase c activity and NF-κB translocation to the nucleus. Blanca AJ, etal., Food Chem. 2017 Aug 1;228:356-366. doi: 10.1016/j.foodchem.2017.02.011. Epub 2017 Feb 6.
6. NADPH oxidase 1, a novel molecular source of ROS in hippocampal neuronal death in vascular dementia. Choi DH, etal., Antioxid Redox Signal. 2014 Aug 1;21(4):533-50. doi: 10.1089/ars.2012.5129. Epub 2014 Feb 6.
7. Role of neuronal NADPH oxidase 1 in the peri-infarct regions after stroke. Choi DH, etal., PLoS One. 2015 Jan 24;10(1):e0116814. doi: 10.1371/journal.pone.0116814. eCollection 2015.
8. NADPH oxidase 1 mediates α-synucleinopathy in Parkinson's disease. Cristóvão AC, etal., J Neurosci. 2012 Oct 17;32(42):14465-77. doi: 10.1523/JNEUROSCI.2246-12.2012.
9. Superoxide anion is elevated in sympathetic neurons in DOCA-salt hypertension via activation of NADPH oxidase. Dai X, etal., Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1019-26. Epub 2005 Oct 7.
10. Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome. Fortuno A, etal., Diabetes. 2006 Jan;55(1):209-15.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. NOX1 deficiency protects from aortic dissection in response to angiotensin II. Gavazzi G, etal., Hypertension. 2007 Jul;50(1):189-96. doi: 10.1161/HYPERTENSIONAHA.107.089706. Epub 2007 May 14.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Deficiency of NOX1/nicotinamide adenine dinucleotide phosphate, reduced form oxidase leads to pulmonary vascular remodeling. Iwata K, etal., Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):110-9. doi: 10.1161/ATVBAHA.113.302107. Epub 2013 Nov 14.
15. NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha. Katsuyama M, etal., J Biol Chem 2002 Apr 19;277(16):13438-42.
16. Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma. Kohsari M, etal., Asian Pac J Cancer Prev. 2020 Aug 1;21(8):2237-2242. doi: 10.31557/APJCP.2020.21.8.2237.
17. Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice. Matsuno K, etal., Circulation. 2005 Oct 25;112(17):2677-85. doi: 10.1161/CIRCULATIONAHA.105.573709.
18. NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis. Matsuno K, etal., Free Radic Biol Med. 2012 Nov 1;53(9):1718-28. doi: 10.1016/j.freeradbiomed.2012.08.590. Epub 2012 Sep 4.
19. Beneficial effects of aqueous extract of stem bark of Terminalia arjuna (Roxb.), An ayurvedic drug in experimental pulmonary hypertension. Meghwani H, etal., J Ethnopharmacol. 2017 Feb 2;197:184-194. doi: 10.1016/j.jep.2016.07.029. Epub 2016 Jul 9.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Mercury exposure induces proinflammatory enzymes in vascular fibroblasts. Millán Longo A, etal., Clin Investig Arterioscler. 2017 Nov-Dec;29(6):231-238. doi: 10.1016/j.arteri.2017.07.002. Epub 2017 Sep 19.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Endothelium-restricted endothelin-1 overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1. Ouerd S, etal., Cardiovasc Res. 2021 Mar 21;117(4):1144-1153. doi: 10.1093/cvr/cvaa168.
24. Y-27632 Induces Neurite Outgrowth by Activating the NOX1-Mediated AKT and PAK1 Phosphorylation Cascades in PC12 Cells. Park SY, etal., Int J Mol Sci. 2020 Oct 16;21(20):7679. doi: 10.3390/ijms21207679.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. Pleskova M, etal., FASEB J. 2006 Jan;20(1):139-41. Epub 2005 Oct 27.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration. Shinohara M, etal., J Biol Chem. 2010 Feb 12;285(7):4481-8. doi: 10.1074/jbc.M109.071779. Epub 2009 Dec 17.
31. CCR5 antagonist treatment inhibits vascular injury by regulating NADPH oxidase 1. Singh S, etal., Biochem Pharmacol. 2022 Jan;195:114859. doi: 10.1016/j.bcp.2021.114859. Epub 2021 Nov 26.
32. Phosphorylation of Nox1 regulates association with NoxA1 activation domain. Streeter J, etal., Circ Res. 2014 Nov 7;115(11):911-8. doi: 10.1161/CIRCRESAHA.115.304267. Epub 2014 Sep 16.
33. Cell transformation by the superoxide-generating oxidase Mox1. Suh YA, etal., Nature 1999 Sep 2;401(6748):79-82.
34. miR-145-5p attenuates inflammatory response and apoptosis in myocardial ischemia-reperfusion injury by inhibiting (NADPH) oxidase homolog 1. Tan L, etal., Exp Anim. 2021 Aug 6;70(3):311-321. doi: 10.1538/expanim.20-0160. Epub 2021 Mar 4.
35. Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling. Veit F, etal., Antioxid Redox Signal. 2013 Dec 20;19(18):2213-31. doi: 10.1089/ars.2012.4904. Epub 2013 Jul 20.
36. NOX1/NADPH oxidase regulates the expression of multidrug resistance-associated protein 1 and maintains intracellular glutathione levels. Wen X, etal., FEBS J. 2019 Feb;286(4):678-687. doi: 10.1111/febs.14753. Epub 2019 Feb 6.
37. Alamandine protects against renal ischaemia-reperfusion injury in rats via inhibiting oxidative stress. Zhu J, etal., J Pharm Pharmacol. 2021 Oct 7;73(11):1491-1502. doi: 10.1093/jpp/rgab091.
38. Production and actions of superoxide in the renal medulla. Zou AP, etal., Hypertension 2001 Feb;37(2 Part 2):547-53.
Additional References at PubMed
PMID:10615049   PMID:11331784   PMID:11805326   PMID:12473664   PMID:14670934   PMID:15123630   PMID:15710429   PMID:15777779   PMID:15826947   PMID:15922295   PMID:16085178   PMID:16129699  
PMID:16207877   PMID:16373635   PMID:16386251   PMID:16636067   PMID:16879806   PMID:16914424   PMID:17015265   PMID:17085464   PMID:17283869   PMID:17324585   PMID:17435218   PMID:17440033  
PMID:17462535   PMID:17493633   PMID:17673675   PMID:17698723   PMID:17765919   PMID:17822438   PMID:17876872   PMID:17982273   PMID:18023288   PMID:18250367   PMID:18289732   PMID:18397177  
PMID:18436224   PMID:18454179   PMID:18488907   PMID:18514509   PMID:18566342   PMID:18651560   PMID:18723759   PMID:18760347   PMID:18848961   PMID:19029489   PMID:19134410   PMID:19147679  
PMID:19471020   PMID:19660816   PMID:19661248   PMID:19716351   PMID:19755710   PMID:19804648   PMID:19875720   PMID:20414976   PMID:20448043   PMID:20525691   PMID:20715105   PMID:20732386  
PMID:20807796   PMID:20830300   PMID:20857410   PMID:20943855   PMID:20970480   PMID:21138635   PMID:21419746   PMID:21505267   PMID:21537828   PMID:21660950   PMID:21814483   PMID:22098189  
PMID:22203737   PMID:22431579   PMID:22433789   PMID:22565378   PMID:22566500   PMID:22636674   PMID:22738259   PMID:22997161   PMID:23087362   PMID:23225244   PMID:23592126   PMID:23827392  
PMID:24152438   PMID:24211271   PMID:24372242   PMID:24824652   PMID:24973900   PMID:25536219   PMID:25550204   PMID:25601753   PMID:25682169   PMID:25700020   PMID:25820554   PMID:25880095  
PMID:25997532   PMID:26310573   PMID:26585490   PMID:26658815   PMID:26824355   PMID:26872992   PMID:27276705   PMID:27665186   PMID:27816504   PMID:27847553   PMID:27923787   PMID:28119263  
PMID:28263293   PMID:28336111   PMID:28363602   PMID:28826906   PMID:28849167   PMID:29472601   PMID:30551445   PMID:31391086   PMID:32131490   PMID:35354309   PMID:37985248  


Genomics

Comparative Map Data
Nox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X101,572,338 - 101,625,571 (-)NCBIGRCr8
mRatBN7.2X97,279,058 - 97,332,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX98,953,200 - 98,976,388 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,462,968 - 102,486,155 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X99,966,365 - 99,989,543 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X104,909,328 - 104,932,508 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX104,909,326 - 104,932,508 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X104,742,161 - 104,765,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX98,325,197 - 98,348,363 (-)NCBICelera
Cytogenetic MapXq32NCBI
NOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X100,843,324 - 100,874,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX100,843,324 - 100,874,359 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,098,313 - 100,129,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X99,984,969 - 100,015,990 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X99,904,969 - 99,935,343NCBI
CeleraX100,617,105 - 100,648,120 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX89,897,075 - 89,927,719 (-)NCBIHuRef
CHM1_1X99,991,243 - 100,022,267 (-)NCBICHM1_1
T2T-CHM13v2.0X99,285,862 - 99,317,015 (-)NCBIT2T-CHM13v2.0
Nox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X132,987,170 - 133,038,455 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX132,987,170 - 133,122,705 (-)EnsemblGRCm39 Ensembl
GRCm38X134,086,421 - 134,137,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,086,421 - 134,221,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X130,621,685 - 130,646,247 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,433,496 - 129,458,058 (-)NCBIMGSCv36mm8
CeleraX116,963,302 - 116,987,732 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX55.69NCBI
Nox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555036,974,239 - 6,997,618 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555036,973,965 - 7,020,182 (-)NCBIChiLan1.0ChiLan1.0
NOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X100,442,780 - 100,481,957 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X100,446,385 - 100,477,340 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X90,046,023 - 90,076,968 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X100,182,881 - 100,215,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,182,398 - 100,215,192 (-)Ensemblpanpan1.1panPan2
NOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X74,784,627 - 74,811,796 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX74,785,168 - 74,811,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,195,825 - 76,224,844 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,195,810 - 76,224,962 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X73,760,799 - 73,789,818 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,424,758 - 75,453,798 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,186,299 - 75,215,328 (-)NCBIUU_Cfam_GSD_1.0
Nox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X63,512,975 - 63,529,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365846,024,008 - 6,039,866 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365846,023,960 - 6,040,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX82,540,667 - 82,586,532 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X82,540,664 - 82,575,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X90,483,590 - 90,496,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,182,636 - 89,210,176 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX89,183,264 - 89,209,298 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606514,108,862 - 14,147,312 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,736,704 - 1,755,504 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,741,921 - 1,754,932 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nox1
118 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:115
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000075325
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 2 13 2 5
Below cutoff 2 22 17 7 6 7 6 9 42 9 23 10 6

Sequence


Ensembl Acc Id: ENSRNOT00000075325   ⟹   ENSRNOP00000065995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)Ensembl
Rnor_6.0 EnsemblX104,909,326 - 104,932,508 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097078   ⟹   ENSRNOP00000084058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101509   ⟹   ENSRNOP00000081363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103999   ⟹   ENSRNOP00000082975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,279,056 - 97,298,116 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116559   ⟹   ENSRNOP00000091510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,279,148 - 97,293,445 (-)Ensembl
RefSeq Acc Id: NM_053683   ⟹   NP_446135
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X101,572,342 - 101,595,520 (-)NCBI
mRatBN7.2X97,279,058 - 97,302,236 (-)NCBI
Rnor_6.0X104,909,328 - 104,932,508 (-)NCBI
Rnor_5.0X104,742,161 - 104,765,479 (-)NCBI
CeleraX98,325,197 - 98,348,363 (-)RGD
Sequence:
RefSeq Acc Id: XM_039099397   ⟹   XP_038955325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X101,572,338 - 101,625,571 (-)NCBI
mRatBN7.2X97,279,059 - 97,332,291 (-)NCBI
RefSeq Acc Id: XM_039099398   ⟹   XP_038955326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X101,572,338 - 101,625,571 (-)NCBI
mRatBN7.2X97,279,059 - 97,332,291 (-)NCBI
RefSeq Acc Id: NP_446135   ⟸   NM_053683
- UniProtKB: Q9WV87 (UniProtKB/Swiss-Prot),   M0R934 (UniProtKB/TrEMBL),   A6IVE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065995   ⟸   ENSRNOT00000075325
RefSeq Acc Id: XP_038955326   ⟸   XM_039099398
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AG93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955325   ⟸   XM_039099397
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AG93 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081363   ⟸   ENSRNOT00000101509
Ensembl Acc Id: ENSRNOP00000084058   ⟸   ENSRNOT00000097078
Ensembl Acc Id: ENSRNOP00000091510   ⟸   ENSRNOT00000116559
Ensembl Acc Id: ENSRNOP00000082975   ⟸   ENSRNOT00000103999
Protein Domains
FAD-binding FR-type   Ferric oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WV87-F1-model_v2 AlphaFold Q9WV87 1-563 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701930
Promoter ID:EPDNEW_R12454
Type:single initiation site
Name:Nox1_1
Description:NADPH oxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X104,932,536 - 104,932,596EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620598 AgrOrtholog
BioCyc Gene G2FUF-1695 BioCyc
Ensembl Genes ENSRNOG00000048706 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075325.2 UniProtKB/TrEMBL
  ENSRNOT00000097078.1 UniProtKB/TrEMBL
  ENSRNOT00000101509.1 UniProtKB/TrEMBL
  ENSRNOT00000103999.1 UniProtKB/TrEMBL
  ENSRNOT00000116559.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translation factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_b245_heavy_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fe3_Rdtase_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fe_red_NAD-bd_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114243 UniProtKB/Swiss-Prot
NCBI Gene 114243 ENTREZGENE
PANTHER NADPH OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11972:SF71 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAD_binding_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nox1 PhenoGen
PRINTS GP91PHOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048706 RatGTEx
Superfamily-SCOP SSF52343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZRV5_RAT UniProtKB/TrEMBL
  A0A8I5ZW90_RAT UniProtKB/TrEMBL
  A0A8I6AG93 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GBE7_RAT UniProtKB/TrEMBL
  A6IVE3_RAT UniProtKB/TrEMBL
  A6IVE4 ENTREZGENE, UniProtKB/TrEMBL
  M0R934 ENTREZGENE, UniProtKB/TrEMBL
  NOX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nox1  NADPH oxidase 1    NADH/NADPH mitogenic oxidase subunit p65-mox  Name updated 1299863 APPROVED
2002-08-07 Nox1  NADH/NADPH mitogenic oxidase subunit p65-mox      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may regulate renal medullary blood flow (MBF) and water/sodium excretion 628559
gene_process major superoxide-producing enzyme in the renal outer medulla (OM) of kidney 628559
gene_regulation expression is induced by PGF(2alpha) 625378