Symbol:
Nox1
Name:
NADPH oxidase 1
RGD ID:
620598
Description:
Enables NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to mercury ion; cellular response to platelet-derived growth factor stimulus; and positive regulation of cellular component organization. Part of NADPH oxidase complex. Used to study Parkinson's disease; pulmonary hypertension; transient cerebral ischemia; and vascular dementia. Biomarker of middle cerebral artery infarction; pulmonary hypertension; and traumatic brain injury. Orthologous to human NOX1 (NADPH oxidase 1); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (-)-ephedrine; (R)-lipoic acid; 1,2-dimethylhydrazine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
mitogenic oxidase 1; MOX-1; MOX1; NADH/NADPH mitogenic oxidase subunit p65-mox; NOH-1; NOX-1
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NOX1 (NADPH oxidase 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):
Nox1 (NADPH oxidase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Nox1 (NADPH oxidase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NOX1 (NADPH oxidase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NOX1 (NADPH oxidase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nox1 (NADPH oxidase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NOX1 (NADPH oxidase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
NOX1 (NADPH oxidase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Nox1 (NADPH oxidase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
NOX1 (NADPH oxidase 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Nox1 (NADPH oxidase 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
nox1 (NADPH oxidase 1)
Alliance
DIOPT (Hieranoid|OMA|OrthoFinder|PANTHER|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
FRE7
Alliance
DIOPT (Ensembl Compara|OrthoInspector)
Xenopus tropicalis (tropical clawed frog):
nox1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 X 101,572,338 - 101,625,571 (-) NCBI GRCr8 mRatBN7.2 X 97,279,058 - 97,332,291 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl X 97,279,056 - 97,302,236 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx X 98,953,200 - 98,976,388 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 X 102,462,968 - 102,486,155 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 X 99,966,365 - 99,989,543 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 X 104,909,328 - 104,932,508 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 104,909,326 - 104,932,508 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 104,742,161 - 104,765,479 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Celera X 98,325,197 - 98,348,363 (-) NCBI Celera Cytogenetic Map X q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Nox1 Rat (-)-ephedrine increases expression EXP 6480464 Ephedrine results in increased expression of NOX1 protein CTD PMID:32729338 Nox1 Rat (R)-lipoic acid multiple interactions EXP 6480464 acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] more ... CTD PMID:29760339 Nox1 Rat 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactions ISO NOX1 (Homo sapiens) 6480464 Quercetin inhibits the reaction [o and p'-DDT results in increased expression of NOX1 mRNA] CTD PMID:35122929 Nox1 Rat 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO NOX1 (Homo sapiens) 6480464 o and p'-DDT results in increased expression of NOX1 mRNA CTD PMID:35122929 Nox1 Rat 1,2-dichloroethane decreases expression ISO Nox1 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of NOX1 mRNA CTD PMID:28960355 Nox1 Rat 1,2-dimethylhydrazine decreases expression EXP 6480464 1 and 2-Dimethylhydrazine results in decreased expression of NOX1 mRNA CTD PMID:32387197 Nox1 Rat 1,2-dimethylhydrazine increases expression ISO Nox1 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in increased expression of NOX1 mRNA CTD PMID:22206623 Nox1 Rat 1,4-benzoquinone multiple interactions ISO Nox1 (Mus musculus) 6480464 [quinone results in increased expression of NOX1 protein] which results in increased abundance of Reactive Oxygen Species CTD PMID:25437431 Nox1 Rat 1,4-benzoquinone increases expression ISO Nox1 (Mus musculus) 6480464 quinone results in increased expression of NOX1 protein CTD PMID:25437431 Nox1 Rat 11-deoxycorticosterone multiple interactions EXP 6480464 [Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of NOX1 protein CTD PMID:22431579 Nox1 Rat 2,3,7,8-Tetrachlorodibenzofuran increases expression EXP 6480464 2 more ... CTD PMID:32109520 Nox1 Rat 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:32119087 Nox1 Rat 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid multiple interactions ISO Nox1 (Mus musculus) 6480464 pyridoxal phosphate-6-azophenyl-2' and 4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]] CTD PMID:24912985 Nox1 Rat acteoside decreases activity ISO NOX1 (Homo sapiens) 6480464 acteoside results in decreased activity of NOX1 protein CTD PMID:16393473 Nox1 Rat adenine multiple interactions EXP 6480464 camostat inhibits the reaction [Adenine results in increased expression of NOX1 mRNA] CTD PMID:25766432 Nox1 Rat adenine increases expression EXP 6480464 Adenine results in increased expression of NOX1 mRNA CTD PMID:25766432 Nox1 Rat Adiponectin multiple interactions ISO NOX1 (Homo sapiens) 6480464 Cholesterol and LDL affects the reaction [Adiponectin inhibits the reaction [Arachidonic Acid results in increased cleavage of NOX1 protein]] CTD PMID:20832062 Nox1 Rat aflatoxin B1 increases methylation ISO NOX1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of NOX1 intron CTD PMID:30157460 Nox1 Rat aldehydo-D-glucose increases expression ISO Nox1 (Mus musculus) 6480464 Glucose results in increased expression of NOX1 mRNA CTD PMID:23731528 Nox1 Rat aldehydo-D-glucose multiple interactions ISO Nox1 (Mus musculus) 6480464 Glucose results in increased expression of and results in increased activity of NOX1 protein more ... CTD PMID:23731528 Nox1 Rat amlodipine multiple interactions EXP 6480464 Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 Nox1 Rat amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of NOX1 mRNA CTD PMID:30779732 Nox1 Rat anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:16213474 Nox1 Rat apocynin multiple interactions EXP 6480464 acetovanillone inhibits the reaction [Ethanol results in increased expression of NOX1 protein] more ... CTD PMID:26522475 and PMID:29760339 Nox1 Rat apocynin multiple interactions ISO NOX1 (Homo sapiens) 6480464 acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA] CTD PMID:30797899 Nox1 Rat arachidonic acid multiple interactions ISO NOX1 (Homo sapiens) 6480464 Arachidonic Acid results in increased cleavage of and results in increased secretion of NOX1 protein more ... CTD PMID:20832062 Nox1 Rat arsane increases expression ISO Nox1 (Mus musculus) 6480464 Arsenic results in increased expression of NOX1 protein CTD PMID:22552367 Nox1 Rat arsane increases expression ISO NOX1 (Homo sapiens) 6480464 Arsenic results in increased expression of NOX1 protein CTD PMID:22552367 Nox1 Rat arsenic atom increases expression ISO NOX1 (Homo sapiens) 6480464 Arsenic results in increased expression of NOX1 protein CTD PMID:22552367 Nox1 Rat arsenic atom increases expression ISO Nox1 (Mus musculus) 6480464 Arsenic results in increased expression of NOX1 protein CTD PMID:22552367 Nox1 Rat arsenous acid multiple interactions ISO NOX1 (Homo sapiens) 6480464 [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of NOX1 mRNA CTD PMID:30012499 Nox1 Rat aspartame multiple interactions ISO Nox1 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA CTD PMID:23783067 Nox1 Rat atorvastatin calcium multiple interactions EXP 6480464 Atorvastatin inhibits the reaction [AGT protein results in increased expression of NOX1 protein] CTD PMID:19451411 Nox1 Rat benzo[a]pyrene multiple interactions ISO Nox1 (Mus musculus) 6480464 [lipopolysaccharide and E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of NOX1 mRNA CTD PMID:28987381 Nox1 Rat benzo[b]fluoranthene increases expression ISO Nox1 (Mus musculus) 6480464 benzo(b)fluoranthene results in increased expression of NOX1 mRNA CTD PMID:26377693 Nox1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NOX1 mRNA CTD PMID:25181051 Nox1 Rat bisphenol A multiple interactions ISO NOX1 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of NOX1 gene and Melatonin inhibits the reaction [bisphenol A results in increased expression of NOX1 mRNA] CTD PMID:31601247 and PMID:36633214 Nox1 Rat bisphenol A multiple interactions ISO Nox1 (Mus musculus) 6480464 Melatonin inhibits the reaction [bisphenol A results in increased expression of NOX1 mRNA] CTD PMID:36633214 Nox1 Rat bisphenol A increases expression ISO Nox1 (Mus musculus) 6480464 bisphenol A results in increased expression of NOX1 mRNA CTD PMID:36633214 Nox1 Rat bisphenol A increases expression ISO NOX1 (Homo sapiens) 6480464 bisphenol A results in increased expression of NOX1 mRNA CTD PMID:36633214 Nox1 Rat bisphenol F decreases expression ISO Nox1 (Mus musculus) 6480464 bisphenol F results in decreased expression of NOX1 mRNA CTD PMID:38685157 Nox1 Rat BQ 123 multiple interactions EXP 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Oxygen deficiency results in increased expression of NOX1 protein] CTD PMID:34478853 Nox1 Rat butanal decreases expression ISO NOX1 (Homo sapiens) 6480464 butyraldehyde results in decreased expression of NOX1 mRNA CTD PMID:26079696 Nox1 Rat cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOX1 mRNA and MIR34A mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOX1 mRNA] CTD PMID:34558789 Nox1 Rat cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of NOX1 protein CTD PMID:32738273 Nox1 Rat cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOX1 mRNA and MIR34A mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOX1 mRNA] CTD PMID:34558789 Nox1 Rat calcitriol increases expression ISO NOX1 (Homo sapiens) 6480464 Calcitriol results in increased expression of NOX1 mRNA CTD PMID:21592394 Nox1 Rat calcitriol multiple interactions ISO NOX1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of NOX1 mRNA CTD PMID:21592394 Nox1 Rat calcium atom multiple interactions ISO Nox1 (Mus musculus) 6480464 1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2 more ... CTD PMID:24912985 Nox1 Rat calcium(0) multiple interactions ISO Nox1 (Mus musculus) 6480464 1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2 more ... CTD PMID:24912985 Nox1 Rat camostat multiple interactions EXP 6480464 camostat inhibits the reaction [Adenine results in increased expression of NOX1 mRNA] CTD PMID:25766432 Nox1 Rat candesartan multiple interactions EXP 6480464 Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1] and Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 Nox1 Rat candesartan decreases expression EXP 6480464 candesartan results in decreased expression of NOX1 CTD PMID:21107329 Nox1 Rat carnosic acid decreases expression ISO Nox1 (Mus musculus) 6480464 salvin results in decreased expression of NOX1 protein CTD PMID:35926579 Nox1 Rat carvacrol multiple interactions EXP 6480464 carvacrol inhibits the reaction [Ethanol results in increased expression of NOX1 protein] CTD PMID:37499997 Nox1 Rat carvacrol affects binding ISO NOX1 (Homo sapiens) 6480464 carvacrol binds to NOX1 protein CTD PMID:37499997 Nox1 Rat carvedilol multiple interactions EXP 6480464 carvedilol inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:16213474 Nox1 Rat celecoxib multiple interactions EXP 6480464 Celecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA] and Celecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682 and PMID:25596430 Nox1 Rat CGP-42112A multiple interactions ISO Nox1 (Mus musculus) 6480464 CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA] more ... CTD PMID:25446015 Nox1 Rat chlorpyrifos multiple interactions EXP 6480464 Chlorpyrifos promotes the reaction [STAT1 protein binds to NOX1 promoter] and STAT1 protein affects the reaction [Chlorpyrifos results in increased expression of NOX1 protein] CTD PMID:29859868 Nox1 Rat chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of NOX1 protein CTD PMID:29859868 Nox1 Rat chromium(6+) increases expression ISO Nox1 (Mus musculus) 6480464 chromium hexavalent ion results in increased expression of NOX1 protein CTD PMID:22552367 Nox1 Rat chromium(6+) increases expression ISO NOX1 (Homo sapiens) 6480464 chromium hexavalent ion results in increased expression of NOX1 protein CTD PMID:21742780 and PMID:22552367 Nox1 Rat cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of NOX1 mRNA CTD PMID:23603837 Nox1 Rat cisplatin multiple interactions EXP 6480464 Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of NOX1 mRNA] CTD PMID:23603837 Nox1 Rat cobalt dichloride multiple interactions EXP 6480464 GHRL protein modified form inhibits the reaction [cobaltous chloride results in increased expression of NOX1 mRNA] CTD PMID:23000094 Nox1 Rat cobalt dichloride increases expression ISO Nox1 (Mus musculus) 6480464 cobaltous chloride results in increased expression of NOX1 mRNA and cobaltous chloride results in increased expression of NOX1 protein CTD PMID:16507596 Nox1 Rat cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of NOX1 mRNA CTD PMID:23000094 Nox1 Rat copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of NOX1 mRNA CTD PMID:26033743 Nox1 Rat copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of NOX1 mRNA CTD PMID:26033743 Nox1 Rat crystal violet multiple interactions ISO NOX1 (Homo sapiens) 6480464 Gentian Violet inhibits the reaction [NOX1 protein results in decreased activity of TP53 protein] CTD PMID:24535435 Nox1 Rat D-glucose multiple interactions ISO Nox1 (Mus musculus) 6480464 Glucose results in increased expression of and results in increased activity of NOX1 protein more ... CTD PMID:23731528 Nox1 Rat D-glucose increases expression ISO Nox1 (Mus musculus) 6480464 Glucose results in increased expression of NOX1 mRNA CTD PMID:23731528 Nox1 Rat DDE increases expression ISO NOX1 (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of NOX1 mRNA CTD PMID:25386960 Nox1 Rat decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of NOX1 mRNA CTD PMID:23640034 Nox1 Rat Deoxycorticosterone acetate multiple interactions ISO Nox1 (Mus musculus) 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA and CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA] CTD PMID:27678262 Nox1 Rat diarsenic trioxide multiple interactions ISO NOX1 (Homo sapiens) 6480464 [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of NOX1 mRNA CTD PMID:30012499 Nox1 Rat dibenziodolium multiple interactions ISO Nox1 (Mus musculus) 6480464 diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:24912985 Nox1 Rat dibenziodolium decreases activity ISO NOX1 (Homo sapiens) 6480464 diphenyleneiodonium results in decreased activity of NOX1 protein CTD PMID:16393473 Nox1 Rat dibenziodolium multiple interactions ISO NOX1 (Homo sapiens) 6480464 [diphenyleneiodonium results in decreased activity of NOX1 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:22307971 and PMID:30797899 Nox1 Rat diclofenac decreases expression ISO Nox1 (Mus musculus) 6480464 Diclofenac results in decreased expression of NOX1 mRNA CTD PMID:35537566 Nox1 Rat dieldrin multiple interactions EXP 6480464 [Hexachlorocyclohexane co-treated with Dieldrin] results in decreased expression of NOX1 protein CTD PMID:30240590 Nox1 Rat diminazene diaceturate decreases expression ISO NOX1 (Homo sapiens) 6480464 diminazene aceturate results in decreased expression of NOX1 protein CTD PMID:29977014 Nox1 Rat dioxygen multiple interactions EXP 6480464 BQ 788 inhibits the reaction [Oxygen deficiency results in increased expression of NOX1 mRNA] more ... CTD PMID:34478853 Nox1 Rat dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of NOX1 mRNA and Oxygen deficiency results in increased expression of NOX1 protein CTD PMID:34478853 Nox1 Rat doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of NOX1 mRNA and Doxorubicin results in increased expression of NOX1 protein CTD PMID:16213474 more ... Nox1 Rat doxorubicin increases expression ISO Nox1 (Mus musculus) 6480464 Doxorubicin results in increased expression of NOX1 mRNA and Doxorubicin results in increased expression of NOX1 protein CTD PMID:24072175 and PMID:31158416 Nox1 Rat doxorubicin multiple interactions ISO Nox1 (Mus musculus) 6480464 rhodioloside inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:24072175 Nox1 Rat doxorubicin multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of NOX1 mRNA] more ... CTD PMID:16213474 more ... Nox1 Rat endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of NOX1 mRNA CTD PMID:29391264 Nox1 Rat epoxiconazole increases expression ISO Nox1 (Mus musculus) 6480464 epoxiconazole results in increased expression of NOX1 mRNA CTD PMID:35436446 Nox1 Rat ethanol multiple interactions EXP 6480464 acetovanillone inhibits the reaction [Ethanol results in increased expression of NOX1 protein] and carvacrol inhibits the reaction [Ethanol results in increased expression of NOX1 protein] CTD PMID:26522475 and PMID:37499997 Nox1 Rat ethanol increases expression ISO Nox1 (Mus musculus) 6480464 Ethanol results in increased expression of NOX1 mRNA and Ethanol results in increased expression of NOX1 protein CTD PMID:35639301 Nox1 Rat ethanol multiple interactions ISO Nox1 (Mus musculus) 6480464 sodium propionate inhibits the reaction [Ethanol results in increased expression of NOX1 mRNA] CTD PMID:35639301 Nox1 Rat ethanol increases expression EXP 6480464 Ethanol results in increased expression of NOX1 protein CTD PMID:26522475 and PMID:37499997 Nox1 Rat fulvestrant multiple interactions ISO NOX1 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of NOX1 gene CTD PMID:31601247 Nox1 Rat fulvestrant multiple interactions EXP 6480464 Fulvestrant inhibits the reaction [Glyphosate results in increased expression of NOX1 protein] CTD PMID:34906888 Nox1 Rat furan increases expression EXP 6480464 furan results in increased expression of NOX1 mRNA CTD PMID:27387713 Nox1 Rat galangin multiple interactions EXP 6480464 galangin inhibits the reaction [Doxorubicin results in increased expression of NOX1 protein] CTD PMID:35843304 Nox1 Rat gamma-hexachlorocyclohexane multiple interactions EXP 6480464 [Hexachlorocyclohexane co-treated with Dieldrin] results in decreased expression of NOX1 protein CTD PMID:30240590 Nox1 Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of NOX1 mRNA CTD PMID:33387578 Nox1 Rat geraniol multiple interactions ISO NOX1 (Homo sapiens) 6480464 geraniol inhibits the reaction [Palmitic Acid results in increased expression of NOX1 protein] CTD PMID:27107694 Nox1 Rat glucose increases expression ISO Nox1 (Mus musculus) 6480464 Glucose results in increased expression of NOX1 mRNA CTD PMID:23731528 Nox1 Rat glucose multiple interactions ISO Nox1 (Mus musculus) 6480464 Glucose results in increased expression of and results in increased activity of NOX1 protein more ... CTD PMID:23731528 Nox1 Rat glycyl-L-phenylalanine 2-naphthylamide multiple interactions ISO Nox1 (Mus musculus) 6480464 1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2 more ... CTD PMID:24912985 Nox1 Rat glyphosate multiple interactions EXP 6480464 Fulvestrant inhibits the reaction [Glyphosate results in increased expression of NOX1 protein] more ... CTD PMID:34906888 Nox1 Rat glyphosate increases expression EXP 6480464 Glyphosate results in increased expression of NOX1 mRNA and Glyphosate results in increased expression of NOX1 protein CTD PMID:34906888 Nox1 Rat hexadecanoic acid increases expression EXP 6480464 Palmitic Acid results in increased expression of NOX1 mRNA CTD PMID:24080574 Nox1 Rat hexadecanoic acid multiple interactions ISO NOX1 (Homo sapiens) 6480464 geraniol inhibits the reaction [Palmitic Acid results in increased expression of NOX1 protein] CTD PMID:27107694 Nox1 Rat hexadecanoic acid increases expression ISO NOX1 (Homo sapiens) 6480464 Palmitic Acid results in increased expression of NOX1 protein CTD PMID:27107694 Nox1 Rat hydrochlorothiazide multiple interactions EXP 6480464 Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 Nox1 Rat hydrogen chloride affects response to substance ISO Nox1 (Mus musculus) 6480464 NOX1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:21339339 Nox1 Rat hydrogen peroxide multiple interactions EXP 6480464 NOX1 protein affects the reaction [Hydrogen Peroxide results in increased expression of ARPC2 protein] CTD PMID:24152438 Nox1 Rat icosanoid multiple interactions EXP 6480464 Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of NOX1 mRNA] CTD PMID:23603837 Nox1 Rat L-ascorbic acid increases expression ISO Nox1 (Mus musculus) 6480464 Ascorbic Acid results in increased expression of NOX1 protein CTD PMID:21570463 Nox1 Rat lead diacetate multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of NOX1 mRNA CTD PMID:39276841 Nox1 Rat lead(0) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of NOX1 mRNA more ... CTD PMID:25596430 and PMID:39276841 Nox1 Rat lead(0) increases expression EXP 6480464 Lead results in increased expression of NOX1 mRNA CTD PMID:25596430 Nox1 Rat levetiracetam multiple interactions EXP 6480464 Quercetin inhibits the reaction [Levetiracetam results in decreased expression of NOX1 protein] CTD PMID:37098359 Nox1 Rat levetiracetam decreases expression EXP 6480464 Levetiracetam results in decreased expression of NOX1 protein CTD PMID:37098359 Nox1 Rat lipoic acid multiple interactions EXP 6480464 acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] more ... CTD PMID:29760339 Nox1 Rat lipopolysaccharide multiple interactions ISO NOX1 (Homo sapiens) 6480464 alisol B 23-acetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 protein] more ... CTD PMID:20715105 more ... Nox1 Rat lipopolysaccharide multiple interactions EXP 6480464 Sialic Acids inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 protein] CTD PMID:24973090 Nox1 Rat lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of NOX1 protein CTD PMID:24973090 Nox1 Rat lipopolysaccharide increases expression ISO Nox1 (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of NOX1 mRNA and Lipopolysaccharides results in increased expression of NOX1 protein CTD PMID:19293636 and PMID:24835767 Nox1 Rat lipopolysaccharide increases activity ISO Nox1 (Mus musculus) 6480464 Lipopolysaccharides results in increased activity of NOX1 protein CTD PMID:19005069 Nox1 Rat lipopolysaccharide multiple interactions ISO Nox1 (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA] and resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA] CTD PMID:19293636 Nox1 Rat lipopolysaccharide increases expression ISO NOX1 (Homo sapiens) 6480464 Lipopolysaccharides results in increased expression of NOX1 mRNA and Lipopolysaccharides results in increased expression of NOX1 protein CTD PMID:24835767 more ... Nox1 Rat LY294002 multiple interactions ISO Nox1 (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA] CTD PMID:19293636 Nox1 Rat maneb multiple interactions ISO NOX1 (Homo sapiens) 6480464 [Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA more ... CTD PMID:30797899 Nox1 Rat melatonin multiple interactions ISO NOX1 (Homo sapiens) 6480464 Melatonin inhibits the reaction [bisphenol A results in increased expression of NOX1 mRNA] CTD PMID:36633214 Nox1 Rat melatonin multiple interactions ISO Nox1 (Mus musculus) 6480464 Melatonin inhibits the reaction [bisphenol A results in increased expression of NOX1 mRNA] CTD PMID:36633214 Nox1 Rat menadione increases expression ISO Nox1 (Mus musculus) 6480464 Vitamin K 3 results in increased expression of NOX1 mRNA and Vitamin K 3 results in increased expression of NOX1 protein CTD PMID:16507596 Nox1 Rat mercury dichloride multiple interactions EXP 6480464 celecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] more ... CTD PMID:23415682 Nox1 Rat mercury dichloride decreases expression EXP 6480464 Mercuric Chloride results in decreased expression of NOX1 protein CTD PMID:28987480 Nox1 Rat mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of NOX1 mRNA CTD PMID:21232032 and PMID:23415682 Nox1 Rat mevinphos multiple interactions EXP 6480464 [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:23824088 Nox1 Rat miconazole decreases expression EXP 6480464 Miconazole results in decreased expression of NOX1 mRNA CTD PMID:22262564 Nox1 Rat mirtazapine multiple interactions ISO Nox1 (Mus musculus) 6480464 mirtazapine inhibits the reaction [Thioacetamide results in increased expression of NOX1 protein] CTD PMID:28623179 Nox1 Rat mitogen multiple interactions EXP 6480464 acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA] more ... CTD PMID:29760339 Nox1 Rat mitogen increases expression EXP 6480464 Mitogens results in increased expression of NOX1 mRNA CTD PMID:29760339 Nox1 Rat monocrotaline increases expression EXP 6480464 Monocrotaline results in increased expression of NOX1 mRNA CTD PMID:24947524 Nox1 Rat monosodium L-glutamate multiple interactions ISO Nox1 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA CTD PMID:23783067 Nox1 Rat N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:16213474 Nox1 Rat nebivolol multiple interactions EXP 6480464 Nebivolol inhibits the reaction [AGT protein results in increased expression of NOX1 protein] CTD PMID:16940222 Nox1 Rat nickel dichloride increases expression ISO NOX1 (Homo sapiens) 6480464 nickel chloride results in increased expression of NOX1 protein CTD PMID:22648416 Nox1 Rat niclosamide decreases expression ISO NOX1 (Homo sapiens) 6480464 Niclosamide results in decreased expression of NOX1 mRNA CTD PMID:36318118 Nox1 Rat nicotinic acid-adenine dinucleotide phosphate multiple interactions ISO Nox1 (Mus musculus) 6480464 NOX1 mutant form inhibits the reaction [EDN1 protein results in increased metabolism of NAADP] CTD PMID:23940720 Nox1 Rat nitrofen increases expression EXP 6480464 nitrofen results in increased expression of NOX1 mRNA CTD PMID:26534761 Nox1 Rat nitroglycerin decreases expression EXP 6480464 Nitroglycerin results in decreased expression of NOX1 mRNA CTD PMID:17493633 Nox1 Rat paraquat increases expression EXP 6480464 Paraquat results in increased expression of NOX1 mRNA and Paraquat results in increased expression of NOX1 protein CTD PMID:23827392 Nox1 Rat paraquat multiple interactions ISO NOX1 (Homo sapiens) 6480464 [Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA more ... CTD PMID:30797899 Nox1 Rat paraquat increases expression ISO Nox1 (Mus musculus) 6480464 Paraquat results in increased expression of NOX1 mRNA CTD PMID:29273418 Nox1 Rat paraquat multiple interactions ISO Nox1 (Mus musculus) 6480464 [MTHFR gene polymorphism affects the susceptibility to Paraquat] which results in increased expression of NOX1 protein and pirfenidone inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA] CTD PMID:29273418 and PMID:30726997 Nox1 Rat paraquat multiple interactions EXP 6480464 PRKCD mutant form inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA] more ... CTD PMID:23827392 Nox1 Rat PD123319 multiple interactions ISO Nox1 (Mus musculus) 6480464 PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]] and PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]] CTD PMID:25446015 Nox1 Rat PhIP multiple interactions ISO NOX1 (Homo sapiens) 6480464 [diphenyleneiodonium results in decreased activity of NOX1 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:22307971 Nox1 Rat PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of NOX1 CTD PMID:20715105 Nox1 Rat PhIP affects response to substance ISO NOX1 (Homo sapiens) 6480464 NOX1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine CTD PMID:22307971 Nox1 Rat PhIP increases expression ISO NOX1 (Homo sapiens) 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of NOX1 protein CTD PMID:22307971 Nox1 Rat pioglitazone affects activity ISO Nox1 (Mus musculus) 6480464 pioglitazone affects the activity of NOX1 protein CTD PMID:21962020 Nox1 Rat pirfenidone multiple interactions ISO Nox1 (Mus musculus) 6480464 pirfenidone inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA] CTD PMID:29273418 Nox1 Rat quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] and Quercetin inhibits the reaction [Levetiracetam results in decreased expression of NOX1 protein] CTD PMID:24902966 and PMID:37098359 Nox1 Rat quercetin multiple interactions ISO NOX1 (Homo sapiens) 6480464 Quercetin inhibits the reaction [o and p'-DDT results in increased expression of NOX1 mRNA] CTD PMID:35122929 Nox1 Rat razoxane multiple interactions EXP 6480464 Razoxane inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:16213474 Nox1 Rat reactive oxygen species multiple interactions ISO NOX1 (Homo sapiens) 6480464 [diphenyleneiodonium results in decreased activity of NOX1 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:22307971 Nox1 Rat reactive oxygen species multiple interactions ISO Nox1 (Mus musculus) 6480464 [quinone results in increased expression of NOX1 protein] which results in increased abundance of Reactive Oxygen Species CTD PMID:25437431 Nox1 Rat reactive oxygen species affects abundance ISO NOX1 (Homo sapiens) 6480464 NOX1 protein affects the abundance of Reactive Oxygen Species CTD PMID:22307971 Nox1 Rat resveratrol multiple interactions ISO Nox1 (Mus musculus) 6480464 Resveratrol inhibits the reaction [Glucose results in increased expression of and results in increased activity of NOX1 protein] more ... CTD PMID:19293636 more ... Nox1 Rat resveratrol decreases expression ISO Nox1 (Mus musculus) 6480464 resveratrol results in decreased expression of NOX1 mRNA CTD PMID:24322615 Nox1 Rat resveratrol multiple interactions ISO NOX1 (Homo sapiens) 6480464 resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA] CTD PMID:26667767 Nox1 Rat resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of NOX1 mRNA CTD PMID:20081535 Nox1 Rat rofecoxib multiple interactions EXP 6480464 rofecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA] and rofecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682 and PMID:25596430 Nox1 Rat rotenone increases expression ISO Nox1 (Mus musculus) 6480464 Rotenone results in increased expression of NOX1 mRNA and Rotenone results in increased expression of NOX1 protein CTD PMID:25446015 and PMID:29665408 Nox1 Rat rotenone multiple interactions ISO Nox1 (Mus musculus) 6480464 7-Ala-angiotensin (1-7) inhibits the reaction [angiotensin I (1-7) inhibits the reaction [Rotenone results in increased expression of NOX1 mRNA]] more ... CTD PMID:25446015 and PMID:29665408 Nox1 Rat rottlerin multiple interactions EXP 6480464 rottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA] and rottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 protein] CTD PMID:23827392 Nox1 Rat ruxolitinib multiple interactions ISO NOX1 (Homo sapiens) 6480464 [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of NOX1 mRNA CTD PMID:30012499 Nox1 Rat Salidroside multiple interactions EXP 6480464 rhodioloside inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:24072175 Nox1 Rat Salidroside multiple interactions ISO Nox1 (Mus musculus) 6480464 rhodioloside inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:24072175 Nox1 Rat SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Lead results in increased expression of NOX1 mRNA] and SB 203580 inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682 and PMID:25596430 Nox1 Rat sevoflurane increases expression EXP 6480464 Sevoflurane results in increased expression of NOX1 protein CTD PMID:35110470 Nox1 Rat silicon dioxide decreases expression ISO NOX1 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of NOX1 mRNA CTD PMID:25895662 Nox1 Rat silicon dioxide increases expression ISO Nox1 (Mus musculus) 6480464 Silicon Dioxide results in increased expression of NOX1 protein CTD PMID:37075931 Nox1 Rat silver atom increases expression ISO Nox1 (Mus musculus) 6480464 Silver results in increased expression of NOX1 mRNA CTD PMID:19429238 Nox1 Rat silver(0) increases expression ISO Nox1 (Mus musculus) 6480464 Silver results in increased expression of NOX1 mRNA CTD PMID:19429238 Nox1 Rat sodium arsenite affects expression ISO NOX1 (Homo sapiens) 6480464 sodium arsenite affects the expression of NOX1 mRNA CTD PMID:29301061 Nox1 Rat sodium chloride multiple interactions ISO Nox1 (Mus musculus) 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA and CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA] CTD PMID:27678262 Nox1 Rat sodium chloride multiple interactions EXP 6480464 [Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of NOX1 protein CTD PMID:22431579 Nox1 Rat sodium propionate multiple interactions ISO Nox1 (Mus musculus) 6480464 sodium propionate inhibits the reaction [Ethanol results in increased expression of NOX1 mRNA] and sodium propionate inhibits the reaction [TNF protein affects the acetylation of NOX1 promoter] CTD PMID:35639301 Nox1 Rat superoxide multiple interactions ISO Nox1 (Mus musculus) 6480464 diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides] and NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides] CTD PMID:23940720 and PMID:24912985 Nox1 Rat superoxide multiple interactions EXP 6480464 [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] and NOX1 mRNA promotes the reaction [Tobacco Smoke Pollution results in increased chemical synthesis of Superoxides] CTD PMID:23824088 and PMID:27816504 Nox1 Rat superoxide increases abundance ISO Nox1 (Mus musculus) 6480464 NOX1 protein results in increased abundance of Superoxides CTD PMID:24912985 Nox1 Rat tacrolimus hydrate increases expression EXP 6480464 Tacrolimus results in increased expression of NOX1 mRNA CTD PMID:17085464 Nox1 Rat testosterone increases expression ISO NOX1 (Homo sapiens) 6480464 Testosterone results in increased expression of NOX1 mRNA CTD PMID:21592394 Nox1 Rat testosterone multiple interactions ISO NOX1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of NOX1 mRNA CTD PMID:21592394 Nox1 Rat thioacetamide multiple interactions ISO Nox1 (Mus musculus) 6480464 mirtazapine inhibits the reaction [Thioacetamide results in increased expression of NOX1 protein] CTD PMID:28623179 Nox1 Rat thioacetamide multiple interactions EXP 6480464 S100B protein promotes the reaction [Thioacetamide results in increased expression of NOX1 protein] more ... CTD PMID:34792689 Nox1 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of NOX1 protein CTD PMID:34792689 Nox1 Rat thioacetamide increases expression ISO Nox1 (Mus musculus) 6480464 Thioacetamide results in increased expression of NOX1 protein CTD PMID:28623179 Nox1 Rat titanium atom multiple interactions ISO Nox1 (Mus musculus) 6480464 resveratrol inhibits the reaction [Titanium results in increased expression of NOX1 mRNA] CTD PMID:26878849 Nox1 Rat titanium atom increases expression ISO Nox1 (Mus musculus) 6480464 Titanium results in increased expression of NOX1 mRNA CTD PMID:26878849 Nox1 Rat torcetrapib increases expression ISO NOX1 (Homo sapiens) 6480464 torcetrapib results in increased expression of NOX1 mRNA and torcetrapib results in increased expression of NOX1 protein CTD PMID:25617244 Nox1 Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of NOX1 mRNA CTD PMID:33387578 Nox1 Rat valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of NOX1 mRNA CTD PMID:35594946 Nox1 Rat zinc atom decreases expression ISO NOX1 (Homo sapiens) 6480464 Zinc deficiency results in decreased expression of NOX1 mRNA CTD PMID:18356318 Nox1 Rat zinc(0) decreases expression ISO NOX1 (Homo sapiens) 6480464 Zinc deficiency results in decreased expression of NOX1 mRNA CTD PMID:18356318
Imported Annotations - KEGG (archival)
(-)-ephedrine (EXP) (R)-lipoic acid (EXP) 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO) 1,2-dichloroethane (ISO) 1,2-dimethylhydrazine (EXP,ISO) 1,4-benzoquinone (ISO) 11-deoxycorticosterone (EXP) 2,3,7,8-Tetrachlorodibenzofuran (EXP) 3,3',4,4',5-pentachlorobiphenyl (EXP) 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid (ISO) acteoside (ISO) adenine (EXP) Adiponectin (ISO) aflatoxin B1 (ISO) aldehydo-D-glucose (ISO) amlodipine (EXP) amphetamine (EXP) anthra[1,9-cd]pyrazol-6(2H)-one (EXP) apocynin (EXP,ISO) arachidonic acid (ISO) arsane (ISO) arsenic atom (ISO) arsenous acid (ISO) aspartame (ISO) atorvastatin calcium (EXP) benzo[a]pyrene (ISO) benzo[b]fluoranthene (ISO) bisphenol A (EXP,ISO) bisphenol F (ISO) BQ 123 (EXP) butanal (ISO) cadmium atom (EXP) cadmium dichloride (EXP) calcitriol (ISO) calcium atom (ISO) calcium(0) (ISO) camostat (EXP) candesartan (EXP) carnosic acid (ISO) carvacrol (EXP,ISO) carvedilol (EXP) celecoxib (EXP) CGP-42112A (ISO) chlorpyrifos (EXP) chromium(6+) (ISO) cisplatin (EXP) cobalt dichloride (EXP,ISO) copper atom (EXP) copper(0) (EXP) crystal violet (ISO) D-glucose (ISO) DDE (ISO) decabromodiphenyl ether (EXP) Deoxycorticosterone acetate (ISO) diarsenic trioxide (ISO) dibenziodolium (ISO) diclofenac (ISO) dieldrin (EXP) diminazene diaceturate (ISO) dioxygen (EXP) doxorubicin (EXP,ISO) endosulfan (EXP) epoxiconazole (ISO) ethanol (EXP,ISO) fulvestrant (EXP,ISO) furan (EXP) galangin (EXP) gamma-hexachlorocyclohexane (EXP) gentamycin (EXP) geraniol (ISO) glucose (ISO) glycyl-L-phenylalanine 2-naphthylamide (ISO) glyphosate (EXP) hexadecanoic acid (EXP,ISO) hydrochlorothiazide (EXP) hydrogen chloride (ISO) hydrogen peroxide (EXP) icosanoid (EXP) L-ascorbic acid (ISO) lead diacetate (EXP) lead(0) (EXP) levetiracetam (EXP) lipoic acid (EXP) lipopolysaccharide (EXP,ISO) LY294002 (ISO) maneb (ISO) melatonin (ISO) menadione (ISO) mercury dichloride (EXP) mevinphos (EXP) miconazole (EXP) mirtazapine (ISO) mitogen (EXP) monocrotaline (EXP) monosodium L-glutamate (ISO) N-acetyl-L-cysteine (EXP) nebivolol (EXP) nickel dichloride (ISO) niclosamide (ISO) nicotinic acid-adenine dinucleotide phosphate (ISO) nitrofen (EXP) nitroglycerin (EXP) paraquat (EXP,ISO) PD123319 (ISO) PhIP (EXP,ISO) pioglitazone (ISO) pirfenidone (ISO) quercetin (EXP,ISO) razoxane (EXP) reactive oxygen species (ISO) resveratrol (EXP,ISO) rofecoxib (EXP) rotenone (ISO) rottlerin (EXP) ruxolitinib (ISO) Salidroside (EXP,ISO) SB 203580 (EXP) sevoflurane (EXP) silicon dioxide (ISO) silver atom (ISO) silver(0) (ISO) sodium arsenite (ISO) sodium chloride (EXP,ISO) sodium propionate (ISO) superoxide (EXP,ISO) tacrolimus hydrate (EXP) testosterone (ISO) thioacetamide (EXP,ISO) titanium atom (ISO) torcetrapib (ISO) trichloroethene (EXP) valproic acid (EXP) zinc atom (ISO) zinc(0) (ISO)
Biological Process
angiogenesis (IEA,ISO) cell chemotaxis (IMP) cell migration (IEA,ISO) cellular response to angiotensin (IEP) cellular response to hyperoxia (IEA,ISO) cellular response to interleukin-1 (IEP) cellular response to mercury ion (IEP) cellular response to platelet-derived growth factor stimulus (IEP) defense response (IBA) extracellular matrix organization (IEA,ISO) glutathione metabolic process (IMP) hydrogen peroxide metabolic process (IEA,ISO) intrinsic apoptotic signaling pathway in response to oxidative stress (IEA,ISO) JNK cascade (IEA,ISO) MAPK cascade (IEA,ISO) negative regulation of neuron maturation (IMP) oxygen metabolic process (IEA,ISO) positive regulation of cell population proliferation (IEA,ISO) positive regulation of inclusion body assembly (IMP) positive regulation of integrin biosynthetic process (IEA,ISO) positive regulation of JNK cascade (IEA,ISO) positive regulation of MAPK cascade (IEA,ISO) positive regulation of neuron apoptotic process (IMP) positive regulation of neuron projection development (IMP) positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (IEA,ISO) positive regulation of reactive oxygen species metabolic process (IMP) positive regulation of smooth muscle cell proliferation (IMP) positive regulation of superoxide anion generation (IMP) positive regulation of vascular associated smooth muscle cell migration (IMP) positive regulation of vascular associated smooth muscle cell proliferation (IMP) positive regulation of vascular endothelial growth factor production (IEA,ISO) regulation of systemic arterial blood pressure by renin-angiotensin (IEA,ISO) response to reactive oxygen species (IDA) superoxide anion generation (IBA,IEA,IMP,ISO)
1.
Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration.
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Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells.
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Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion.
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l-Carnitine ameliorates the oxidative stress response to angiotensin II by modulating NADPH oxidase through a reduction in protein kinase c activity and NF-κB translocation to the nucleus.
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NADPH oxidase 1, a novel molecular source of ROS in hippocampal neuronal death in vascular dementia.
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Role of neuronal NADPH oxidase 1 in the peri-infarct regions after stroke.
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NADPH oxidase 1 mediates α-synucleinopathy in Parkinson's disease.
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9.
Superoxide anion is elevated in sympathetic neurons in DOCA-salt hypertension via activation of NADPH oxidase.
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Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome.
Fortuno A, etal., Diabetes. 2006 Jan;55(1):209-15.
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Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
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NOX1 deficiency protects from aortic dissection in response to angiotensin II.
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Rat ISS GO annotations from GOA human gene data--August 2006
GOA data from the GO Consortium
14.
Deficiency of NOX1/nicotinamide adenine dinucleotide phosphate, reduced form oxidase leads to pulmonary vascular remodeling.
Iwata K, etal., Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):110-9. doi: 10.1161/ATVBAHA.113.302107. Epub 2013 Nov 14.
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NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha.
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16.
Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma.
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Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice.
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18.
NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis.
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Beneficial effects of aqueous extract of stem bark of Terminalia arjuna (Roxb.), An ayurvedic drug in experimental pulmonary hypertension.
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20.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
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Mercury exposure induces proinflammatory enzymes in vascular fibroblasts.
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22.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
23.
Endothelium-restricted endothelin-1 overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1.
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Y-27632 Induces Neurite Outgrowth by Activating the NOX1-Mediated AKT and PAK1 Phosphorylation Cascades in PC12 Cells.
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25.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
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Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells.
Pleskova M, etal., FASEB J. 2006 Jan;20(1):139-41. Epub 2005 Oct 27.
27.
GOA pipeline
RGD automated data pipeline
28.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
30.
Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration.
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CCR5 antagonist treatment inhibits vascular injury by regulating NADPH oxidase 1.
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Cell transformation by the superoxide-generating oxidase Mox1.
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miR-145-5p attenuates inflammatory response and apoptosis in myocardial ischemia-reperfusion injury by inhibiting (NADPH) oxidase homolog 1.
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Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling.
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NOX1/NADPH oxidase regulates the expression of multidrug resistance-associated protein 1 and maintains intracellular glutathione levels.
Wen X, etal., FEBS J. 2019 Feb;286(4):678-687. doi: 10.1111/febs.14753. Epub 2019 Feb 6.
37.
Alamandine protects against renal ischaemia-reperfusion injury in rats via inhibiting oxidative stress.
Zhu J, etal., J Pharm Pharmacol. 2021 Oct 7;73(11):1491-1502. doi: 10.1093/jpp/rgab091.
38.
Production and actions of superoxide in the renal medulla.
Zou AP, etal., Hypertension 2001 Feb;37(2 Part 2):547-53.
Nox1 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 X 101,572,338 - 101,625,571 (-) NCBI GRCr8 mRatBN7.2 X 97,279,058 - 97,332,291 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl X 97,279,056 - 97,302,236 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx X 98,953,200 - 98,976,388 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 X 102,462,968 - 102,486,155 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 X 99,966,365 - 99,989,543 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 X 104,909,328 - 104,932,508 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 104,909,326 - 104,932,508 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 104,742,161 - 104,765,479 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Celera X 98,325,197 - 98,348,363 (-) NCBI Celera Cytogenetic Map X q32 NCBI
NOX1 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 X 100,843,324 - 100,874,359 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl X 100,843,324 - 100,874,359 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 X 100,098,313 - 100,129,348 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 X 99,984,969 - 100,015,990 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 X 99,904,969 - 99,935,343 NCBI Celera X 100,617,105 - 100,648,120 (-) NCBI Celera Cytogenetic Map X q22.1 NCBI HuRef X 89,897,075 - 89,927,719 (-) NCBI HuRef CHM1_1 X 99,991,243 - 100,022,267 (-) NCBI CHM1_1 T2T-CHM13v2.0 X 99,285,862 - 99,317,015 (-) NCBI T2T-CHM13v2.0
Nox1 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 X 132,987,170 - 133,038,455 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl X 132,987,170 - 133,122,705 (-) Ensembl GRCm39 Ensembl GRCm38 X 134,086,421 - 134,137,711 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl X 134,086,421 - 134,221,956 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 X 130,621,685 - 130,646,247 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 X 129,433,496 - 129,458,058 (-) NCBI MGSCv36 mm8 Celera X 116,963,302 - 116,987,732 (-) NCBI Celera Cytogenetic Map X E3 NCBI cM Map X 55.69 NCBI
Nox1 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955503 6,974,239 - 6,997,618 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955503 6,973,965 - 7,020,182 (-) NCBI ChiLan1.0 ChiLan1.0
NOX1 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 X 100,442,780 - 100,481,957 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 X 100,446,385 - 100,477,340 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 X 90,046,023 - 90,076,968 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 X 100,182,881 - 100,215,192 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl X 100,182,398 - 100,215,192 (-) Ensembl panpan1.1 panPan2
NOX1 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 X 74,784,627 - 74,811,796 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl X 74,785,168 - 74,811,698 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 ROS_Cfam_1.0 X 76,195,825 - 76,224,844 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl X 76,195,810 - 76,224,962 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 X 73,760,799 - 73,789,818 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 X 75,424,758 - 75,453,798 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 X 75,186,299 - 75,215,328 (-) NCBI UU_Cfam_GSD_1.0
Nox1 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 X 63,512,975 - 63,529,017 (-) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936584 6,024,008 - 6,039,866 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936584 6,023,960 - 6,040,041 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
NOX1 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl X 82,540,667 - 82,586,532 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 X 82,540,664 - 82,575,811 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 X 90,483,590 - 90,496,590 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
NOX1 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 X 89,182,636 - 89,210,176 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl X 89,183,264 - 89,209,298 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666065 14,108,862 - 14,147,312 (-) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Nox1
.
Predicted Target Of
Count of predictions: 147 Count of miRNA genes: 115 Interacting mature miRNAs: 130 Transcripts: ENSRNOT00000075325 Prediction methods: Miranda, Pita, Rnahybrid, Targetscan Result types: miRGate_prediction
1598872 Memor14 Memory QTL 14 4.5 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) X 93956491 138956491 Rat 61430 Cia18 Collagen induced arthritis QTL 18 3.1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) X 14843113 120568734 Rat 61431 Cia19 Collagen induced arthritis QTL 19 4.4 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) X 65612192 120568734 Rat 738035 Stresp1 Stress response QTL 1 4.96 0.000011 stress-related behavior trait (VT:0010451) defensive burying - coping X 41304447 112935181 Rat 724551 Glom1 Glomerulus QTL 1 2.8 0.0004 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) X 75294106 120294106 Rat 1598837 Memor13 Memory QTL 13 3.2 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) X 41052407 146860749 Rat
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
9
28
77
45
47
19
25
19
6
120
69
61
17
44
28
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000075325 ⟹ ENSRNOP00000065995
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl X 97,279,056 - 97,302,236 (-) Ensembl Rnor_6.0 Ensembl X 104,909,326 - 104,932,508 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000097078 ⟹ ENSRNOP00000084058
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl X 97,279,056 - 97,302,236 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000101509 ⟹ ENSRNOP00000081363
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl X 97,279,056 - 97,302,236 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000103999 ⟹ ENSRNOP00000082975
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl X 97,279,056 - 97,298,116 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000116559 ⟹ ENSRNOP00000091510
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl X 97,279,148 - 97,293,445 (-) Ensembl
RefSeq Acc Id:
NM_053683 ⟹ NP_446135
RefSeq Status:
PROVISIONAL
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 101,572,342 - 101,595,520 (-) NCBI mRatBN7.2 X 97,279,058 - 97,302,236 (-) NCBI Rnor_6.0 X 104,909,328 - 104,932,508 (-) NCBI Rnor_5.0 X 104,742,161 - 104,765,479 (-) NCBI Celera X 98,325,197 - 98,348,363 (-) RGD
Sequence:
TTCTGAGTAGGTGTGCATTTGAGTGTCATAAAGACATATATCTTGAGCTAGACAGAAGTTCCTATCCTGAAGGATCCCATCAGAGAAACCAGATTGCTCCTAAGAGGCTCCAGACCTCCATTTGACAA
hide sequence
RefSeq Acc Id:
XM_039099397 ⟹ XP_038955325
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 101,572,338 - 101,625,571 (-) NCBI mRatBN7.2 X 97,279,059 - 97,332,291 (-) NCBI
RefSeq Acc Id:
XM_039099398 ⟹ XP_038955326
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 101,572,338 - 101,625,571 (-) NCBI mRatBN7.2 X 97,279,059 - 97,332,291 (-) NCBI
RefSeq Acc Id:
NP_446135 ⟸ NM_053683
- UniProtKB:
Q9WV87 (UniProtKB/Swiss-Prot), M0R934 (UniProtKB/TrEMBL), A6IVE4 (UniProtKB/TrEMBL)
- Sequence:
MGNWLVNHWLSVLFLVSWLGLNIFLFVYVFLNYEKSDKYYYTREILGTALALARASALCLNFNSMVILIPVCRNLLSFLRGTCSFCNHTLRKPLDHNLTFHKLVAYMICIFTAIHIIAHLFNFERYSR
hide sequence
Ensembl Acc Id:
ENSRNOP00000065995 ⟸ ENSRNOT00000075325
RefSeq Acc Id:
XP_038955326 ⟸ XM_039099398
- Peptide Label:
isoform X1
- UniProtKB:
A0A8I6AG93 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038955325 ⟸ XM_039099397
- Peptide Label:
isoform X1
- UniProtKB:
A0A8I6AG93 (UniProtKB/TrEMBL)
Ensembl Acc Id:
ENSRNOP00000081363 ⟸ ENSRNOT00000101509
Ensembl Acc Id:
ENSRNOP00000084058 ⟸ ENSRNOT00000097078
Ensembl Acc Id:
ENSRNOP00000091510 ⟸ ENSRNOT00000116559
Ensembl Acc Id:
ENSRNOP00000082975 ⟸ ENSRNOT00000103999
RGD ID: 13701930 Promoter ID: EPDNEW_R12454 Type: single initiation site Name: Nox1_1 Description: NADPH oxidase 1 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 X 104,932,536 - 104,932,596 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2004-09-10
Nox1
NADPH oxidase 1
NADH/NADPH mitogenic oxidase subunit p65-mox
Name updated
1299863 APPROVED
2002-08-07
Nox1
NADH/NADPH mitogenic oxidase subunit p65-mox
Symbol and Name status set to provisional
70820 PROVISIONAL
Note Type
Note
Reference
gene_process
may regulate renal medullary blood flow (MBF) and water/sodium excretion
628559
gene_process
major superoxide-producing enzyme in the renal outer medulla (OM) of kidney
628559
gene_regulation
expression is induced by PGF(2alpha)
625378
