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Gene: NOX1 (NADPH oxidase 1) Homo sapiens
Symbol: NOX1
Name: NADPH oxidase 1
Description: Exhibits Rac GTPase binding activity and superoxide-generating NADPH oxidase activity. Involved in several processes, including cellular stress response to acidic pH; positive regulation of vascular endothelial growth factor production; and superoxide anion generation. Localizes to the NADPH oxidase complex; early endosome; and invadopodium membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GP91-2; mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); mitogenic oxidase 1; MOX-1; MOX1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase 1 variant NOH-1L; NADPH oxidase homolog-1; NOH-1; NOH1; NOX-1
Mus musculus (house mouse) : Nox1 (NADPH oxidase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nox1 (NADPH oxidase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nox1 (NADPH oxidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NOX1 (NADPH oxidase 1)
Canis lupus familiaris (dog) : NOX1 (NADPH oxidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nox1 (NADPH oxidase 1)
Sus scrofa (pig) : NOX1 (NADPH oxidase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X100,843,324 - 100,874,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X100,098,313 - 100,129,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X99,984,969 - 100,015,990 (-)NCBINCBI36hg18NCBI36
Build 34X99,904,969 - 99,935,343NCBI
CeleraX100,617,105 - 100,648,120 (-)NCBI
Cytogenetic MapXq22.1NCBI
HuRefX89,897,075 - 89,927,719 (-)NCBIHuRef
CHM1_1X99,991,243 - 100,022,267 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NOX1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732308
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.