Ugt2b15 (UDP glucuronosyltransferase family 2 member B15) - Rat Genome Database

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Gene: Ugt2b15 (UDP glucuronosyltransferase family 2 member B15) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ugt2b15
Name: UDP glucuronosyltransferase family 2 member B15
RGD ID: 628623
Description: Enables glucuronosyltransferase activity. Involved in several processes, including cellular response to ethanol; cellular response to hormone stimulus; and cellular response to testosterone stimulus. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15); INTERACTS WITH (+)-isoborneol; (S)-naringenin; 1,1,1,3,3,3-hexafluoropropan-2-ol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 17-beta-hydroxysteroid specific; 17-beta-hydroxysteroid-specific UDPGT; liver 17 beta-hydroxysteroid UDP-glucuronosyltransferase; LOC102550618; LOC102550717; LOC689702; Rlug38; similar to UDP glucuronosyltransferase 2 family, polypeptide A3; testosterone, dihydrotestosterone, and beta-estradiol specific; testosterone, dihydrotestosterone, and beta-estradiol-specific UDPGT; UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glucuronosyltransferase 2 family, polypeptide B17; UDP glucuronosyltransferase 2 family, polypeptide B5; UDP glycosyltransferase 2 family, member 3; UDP-glucuronosyltransferase 2A3-like; UDP-glucuronosyltransferase 2B17; UDP-glucuronosyltransferase 2B17-like; UDP-glucuronosyltransferase 2B3; UDP-glucuronosyltransferase 2B3 precursor, microsomal; UDP-glucuronosyltransferase 2B5; Udpgt; UDPGT 2B17; UDPGT 2B3; UDPGT 2B5; Udpgtr-3; Ugt2b17; Ugt2b3; Ugt2b5
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21420,768,015 - 20,783,599 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,768,015 - 20,783,589 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1421,106,348 - 21,121,945 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,425,277 - 22,440,874 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,956,372 - 20,971,969 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,375,428 - 22,486,291 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1422,375,955 - 22,534,720 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01422,286,423 - 22,295,392 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41422,346,334 - 22,366,860 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11422,346,333 - 22,366,860 (+)NCBI
Celera1420,276,987 - 20,292,566 (+)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats. Alkharfy KM, etal., Drug Metab Lett. 2008 Dec;2(4):248-55.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Nucleotide and deduced amino acid sequence of rat liver 17 beta-hydroxysteroid UDP-glucuronosyltransferase. Harding D, etal., Nucleic Acids Res 1987 May 11;15(9):3936.
5. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Li Y, etal., Zhonghua Gan Zang Bing Za Zhi. 2001 Jun;9(3):172-4.
6. The effect of hormones on the expression of five isoforms of UDP-glucuronosyltransferase in primary cultures of rat hepatocytes. Li YQ, etal., Pharm Res. 1999 Feb;16(2):191-7.
7. Rat liver UDP-glucuronosyltransferase. Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol. Mackenzie PI J Biol Chem 1987 Jul 15;262(20):9744-9.
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ugt2b15
139 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:97
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000002712
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat

Markers in Region
AA945116  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map14307.7UniSTS
Cytogenetic Map14p21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23
Low 1 2 28 12 17 12 3 3 9 9 8 9 3
Below cutoff 1 8 4 4 1 4 5 7 8 6 7 1 5

Sequence


RefSeq Acc Id: ENSRNOT00000034784   ⟹   ENSRNOP00000034723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,768,015 - 20,783,589 (+)Ensembl
Rnor_6.0 Ensembl1422,375,978 - 22,486,281 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000047655   ⟹   ENSRNOP00000045002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,817,285 - 20,833,917 (+)Ensembl
Rnor_6.0 Ensembl1422,517,774 - 22,534,604 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000052369   ⟹   ENSRNOP00000043239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1422,417,206 - 22,438,435 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000063915   ⟹   ENSRNOP00000063270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1422,375,955 - 22,534,720 (+)Ensembl
RefSeq Acc Id: NM_153314   ⟹   NP_695226
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21420,768,015 - 20,783,599 (+)NCBI
Rnor_6.01422,375,978 - 22,486,291 (+)NCBI
RGSC_v3.41422,346,334 - 22,366,860 (+)RGD
Celera1420,276,987 - 20,292,566 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_695226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41280 (Get FASTA)   NCBI Sequence Viewer  
  CAA68351 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034723
  ENSRNOP00000034723.7
GenBank Protein P08542 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_695226   ⟸   NM_153314
- Peptide Label: precursor
- UniProtKB: P16915 (UniProtKB/Swiss-Prot),   P08542 (UniProtKB/Swiss-Prot),   D3ZLR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000045002   ⟸   ENSRNOT00000047655
RefSeq Acc Id: ENSRNOP00000063270   ⟸   ENSRNOT00000063915
RefSeq Acc Id: ENSRNOP00000034723   ⟸   ENSRNOT00000034784
RefSeq Acc Id: ENSRNOP00000043239   ⟸   ENSRNOT00000052369

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08542-F1-model_v2 AlphaFold P08542 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699256
Promoter ID:EPDNEW_R9777
Type:multiple initiation site
Name:Ugt2b_2
Description:UDP glycosyltransferase 2 family, polypeptide B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9778  EPDNEW_R9779  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01422,375,974 - 22,376,034EPDNEW
RGD ID:13699254
Promoter ID:EPDNEW_R9778
Type:multiple initiation site
Name:Ugt2b_1
Description:UDP glycosyltransferase 2 family, polypeptide B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9779  EPDNEW_R9777  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01422,417,548 - 22,417,608EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628623 AgrOrtholog
BioCyc Gene G2FUF-16103 BioCyc
Ensembl Genes ENSRNOG00000046540 Ensembl
  ENSRNOG00000064466 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034784 ENTREZGENE
  ENSRNOT00000034784.7 UniProtKB/TrEMBL
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro UDP_glucos_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266685 UniProtKB/Swiss-Prot
NCBI Gene 266685 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B38-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UGT2B17 RGD
PhenoGen Ugt2b15 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046540 RatGTEx
  ENSRNOG00000064466 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3ZLR6 ENTREZGENE, UniProtKB/TrEMBL
  P08542 ENTREZGENE
  P16915 ENTREZGENE
  UDB17_RAT UniProtKB/Swiss-Prot
UniProt Secondary P16915 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ugt2b15  UDP glucuronosyltransferase family 2 member B15  Ugt2b15  UDP glucuronosyltransferase 2 family, polypeptide B15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Ugt2b15  UDP glucuronosyltransferase 2 family, polypeptide B15  LOC102550717  UDP-glucuronosyltransferase 2B17-like  Data merged from RGD:7617559 737654 PROVISIONAL
2015-07-29 Ugt2b15  UDP glucuronosyltransferase 2 family, polypeptide B15  LOC102550618  UDP-glucuronosyltransferase 2A3-like  Data merged from RGD:7693358 737654 PROVISIONAL
2015-07-29 Ugt2b15  UDP glucuronosyltransferase 2 family, polypeptide B15  LOC689702  similar to UDP glucuronosyltransferase 2 family, polypeptide A3  Data merged from RGD:1588786 737654 PROVISIONAL
2013-12-18 LOC102550717  UDP-glucuronosyltransferase 2B17-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-12-18 LOC102550618  UDP-glucuronosyltransferase 2A3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-01-23 Ugt2b15  UDP glucuronosyltransferase 2 family, polypeptide B15  Ugt2b17  UDP glucuronosyltransferase 2 family, polypeptide B17  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Ugt2b17  UDP glucuronosyltransferase 2 family, polypeptide B17  Ugt2b5  UDP glucuronosyltransferase 2 family, polypeptide B5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Ugt2b5  UDP glucuronosyltransferase 2 family, polypeptide B5  Ugt2b3  UDP glycosyltransferase 2 family, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC689702  similar to UDP glucuronosyltransferase 2 family, polypeptide A3      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-07-08 Ugt2b3  UDP glycosyltransferase 2 family, member 3  Udpgt  UDP-glucuronosyltransferase 2B3 precursor, microsomal  Symbol and Name updated 1299863 APPROVED
2003-02-27 Udpgt  UDP-glucuronosyltransferase 2B3 precursor, microsomal      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a signal peptide and a carboxyl-terminal transmembrane anchoring region 634452
gene_expression expressed in liver and were barely detectable in kidney, lung, testis, and small intestinal mucosa 634452