Fgfr2 (fibroblast growth factor receptor 2) - Rat Genome Database

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Gene: Fgfr2 (fibroblast growth factor receptor 2) Rattus norvegicus
Analyze
Symbol: Fgfr2
Name: fibroblast growth factor receptor 2
RGD ID: 2611
Description: Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Involved in several processes, including cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; and positive regulation of vascular associated smooth muscle cell proliferation. Located in cell surface. Used to study prostate cancer and retinitis pigmentosa. Biomarker of essential hypertension; hypospadias; portal hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2); PARTICIPATES IN fibroblast growth factor signaling pathway; endocytosis pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KGFR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21184,745,418 - 184,850,655 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,745,420 - 184,850,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,095,683 - 193,200,892 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01200,270,134 - 200,375,502 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01192,941,908 - 193,047,272 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01200,590,951 - 200,696,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1200,590,953 - 200,696,928 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01207,626,732 - 207,731,841 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41189,482,975 - 189,589,279 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11189,667,865 - 189,734,790 (-)NCBI
Celera1182,362,666 - 182,467,651 (-)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acneiform Eruptions  (ISO)
acrocephalosyndactylia  (ISO,ISS)
adenoid cystic carcinoma  (ISO)
ankylosis  (ISO)
Anorectal Malformations  (IEP)
Antley-Bixler syndrome  (ISO)
Antley-Bixler syndrome with disordered steroidogenesis  (ISO)
Antley-Bixler syndrome without disordered steroidogenesis  (ISO)
atherosclerosis  (ISO)
Beare-Stevenson cutis gyrata syndrome  (ISO,ISS)
Bent Bone Dysplasia Syndrome 1  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Chemical Burns  (ISO)
cholangiocarcinoma  (ISO)
classic citrullinemia  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Congenital Aural Atresia  (ISO)
Congenital Limb Deformities  (ISO)
Craniofacial Abnormalities  (ISO)
craniosynostosis  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Crouzon syndrome  (ISO,ISS)
developmental coordination disorder  (ISO)
disorder of sexual development  (ISO)
duodenal atresia  (ISO)
dysgerminoma  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
Epstein-Barr Virus Infections  (ISO)
esophageal carcinoma  (ISO)
essential hypertension  (IEP)
female breast carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
head and neck cancer  (ISO)
hepatocellular carcinoma  (ISO)
Hypertelorism  (ISO)
hypospadias  (IEP)
idiopathic pulmonary fibrosis  (ISO)
intellectual disability  (ISO)
intestinal atresia  (ISS)
Jackson-Weiss syndrome  (ISO)
Kaposi's sarcoma  (ISO)
Kidney Reperfusion Injury  (IMP,ISO)
lacrimoauriculodentodigital syndrome 1  (ISO)
LADD syndrome  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leg Ulcer  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Multiple Abnormalities  (ISO)
myocardial infarction  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Ovarian Neoplasms  (ISO)
Pfeiffer syndrome  (ISO,ISS)
Plagiocephaly, Nonsynostotic  (ISO)
Plaque, Atherosclerotic  (ISO)
portal hypertension  (IEP)
primary pulmonary hypertension  (ISO)
prostate cancer  (IDA,ISO)
prostate carcinoma in situ  (ISO)
PTEN hamartoma tumor syndrome  (ISO)
retinitis pigmentosa  (IDA)
Saethre-Chotzen syndrome  (ISO)
Scaphocephaly, Maxillary Retrusion, and Impaired Intellectual Development  (ISO)
sensorineural hearing loss  (ISO)
Skin Abnormalities  (ISO)
skin disease  (ISO)
spina bifida  (ISO)
Spinal Cord Compression  (IEP)
split hand-foot malformation  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Tooth Abnormalities  (ISO)
Tracheoesophageal Fistula  (IEP)
transient cerebral ischemia  (IEP)
transitional cell carcinoma  (ISO)
umbilical hernia  (ISO)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
ventricular septal defect  (ISO)
viral pneumonia  (ISO)
Volvulus Of Midgut  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetone  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
ANTU  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
cadmium atom  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dibutyl phthalate  (EXP)
diethyl malate  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enzacamene  (EXP)
ethanol  (EXP,ISO)
flavonoids  (EXP)
fluprostenol  (EXP)
fluvalinate  (ISO)
genistein  (ISO)
gentamycin  (EXP)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
lenalidomide  (ISO)
linuron  (EXP)
manganese(II) chloride  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-(1-naphthyl)ethylenediamine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
Neferine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
prostaglandin F2alpha  (EXP)
raloxifene  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
sucrose octasulfate  (ISO)
suramin  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
tipifarnib  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vanillin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ morphogenesis  (ISO)
axonogenesis  (ISO)
bone development  (ISO)
bone mineralization  (ISO)
bone morphogenesis  (ISO)
branch elongation involved in salivary gland morphogenesis  (ISO)
branching involved in labyrinthine layer morphogenesis  (ISO)
branching involved in prostate gland morphogenesis  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
branching morphogenesis of a nerve  (ISO)
bud elongation involved in lung branching  (ISO)
canonical Wnt signaling pathway  (ISO)
cardiac muscle cell proliferation  (ISO)
cell division  (ISO)
cell fate commitment  (ISO)
cell population proliferation  (ISO)
cell-cell signaling  (ISO)
cellular response to fibroblast growth factor stimulus  (IEP,IMP)
cellular response to hypoxia  (IEP)
cellular response to retinoic acid  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
coronal suture morphogenesis  (ISO)
digestive tract development  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic organ development  (ISO)
embryonic organ morphogenesis  (ISO)
embryonic pattern specification  (ISO)
endochondral bone growth  (IEP)
endodermal digestive tract morphogenesis  (ISO)
epidermis morphogenesis  (ISO)
epithelial cell differentiation  (ISO)
epithelial cell proliferation  (ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (ISO)
epithelial to mesenchymal transition  (IDA)
epithelial tube branching involved in lung morphogenesis  (ISO)
ERK1 and ERK2 cascade  (ISO)
fibroblast growth factor receptor apoptotic signaling pathway  (ISO)
fibroblast growth factor receptor signaling pathway  (IDA,IMP,ISO)
fibroblast growth factor receptor signaling pathway involved in hemopoiesis  (ISO)
fibroblast growth factor receptor signaling pathway involved in mammary gland specification  (ISO)
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell  (ISO)
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development  (ISO)
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow  (ISO)
gland morphogenesis  (ISO)
hair follicle morphogenesis  (ISO)
in utero embryonic development  (ISO)
inner ear morphogenesis  (ISO)
lacrimal gland development  (ISO)
lateral sprouting from an epithelium  (ISO)
lens fiber cell development  (ISO)
limb bud formation  (ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung lobe morphogenesis  (ISO)
lung-associated mesenchyme development  (ISO)
mammary gland bud formation  (ISO)
membranous septum morphogenesis  (ISO)
mesenchymal cell differentiation  (ISO)
mesenchymal cell differentiation involved in lung development  (ISO)
mesenchymal cell proliferation  (ISO)
mesenchymal cell proliferation involved in lung development  (ISO)
mesodermal cell differentiation  (IEP)
midbrain development  (ISO)
mitotic nuclear division  (ISO)
morphogenesis of embryonic epithelium  (ISO)
negative regulation of epithelial cell proliferation  (IDA,ISO)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of mitotic nuclear division  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuromuscular junction development  (ISO)
odontogenesis  (ISO)
orbitofrontal cortex development  (ISO)
organ growth  (ISO)
otic vesicle formation  (ISO)
outflow tract septum morphogenesis  (ISO)
phosphorylation  (IEA)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of somatic stem cell division  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of urothelial cell proliferation  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
positive regulation of Wnt signaling pathway  (ISO)
post-embryonic development  (ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (ISO)
prostate epithelial cord elongation  (ISO)
prostate gland morphogenesis  (ISO)
pyramidal neuron development  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of morphogenesis of a branching structure  (ISO)
regulation of osteoblast proliferation  (ISO)
regulation of smooth muscle cell differentiation  (ISO)
regulation of smoothened signaling pathway  (ISO)
reproductive structure development  (ISO)
response to ethanol  (IEP)
response to lipopolysaccharide  (IEP)
somatic stem cell division  (ISO)
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development  (ISO)
stem cell differentiation  (ISO)
stem cell proliferation  (ISO)
synaptic vesicle transport  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
ureteric bud development  (ISO)
urothelial cell proliferation  (ISO)
ventricular cardiac muscle tissue morphogenesis  (ISO)
ventricular zone neuroblast division  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proliferation of neointimal smooth muscle cells after arterial injury. Dependence on interactions between fibroblast growth factor receptor-2 and fibroblast growth factor-9. Agrotis A, etal., J Biol Chem. 2004 Oct 1;279(40):42221-9. Epub 2004 Jul 30.
2. Early-onset low-grade papillary carcinoma of the bladder associated with Apert syndrome and a germline FGFR2 mutation (Pro253Arg). Andreou A, etal., Am J Med Genet A. 2006 Oct 15;140(20):2245-7.
3. FGF-2 converts mature oligodendrocytes to a novel phenotype. Bansal R and Pfeiffer SE, J Neurosci Res. 1997 Oct 15;50(2):215-28.
4. Beare-Stevenson syndrome: two Dutch patients with cerebral abnormalities. Barge-Schaapveld DQ, etal., Pediatr Neurol. 2011 Apr;44(4):303-7.
5. Targets of fibroblast growth factor 1 (FGF-1) and FGF-2 signaling involved in the invasive and tumorigenic behavior of carcinoma cells. Billottet C, etal., Mol Biol Cell. 2004 Oct;15(10):4725-34. Epub 2004 Jul 28.
6. Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury. Chen J, etal., Cell Death Dis. 2017 Oct 5;8(10):e3090. doi: 10.1038/cddis.2017.490.
7. A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis. Chen L, etal., Bone. 2003 Aug;33(2):169-78.
8. FGF-21 ameliorates essential hypertension of SHR via baroreflex afferent function. Chen P, etal., Brain Res Bull. 2020 Jan;154:9-20. doi: 10.1016/j.brainresbull.2019.10.003. Epub 2019 Oct 15.
9. Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China. Chen XH, etal., Breast Cancer Res Treat. 2011 Jan;125(2):575-82. doi: 10.1007/s10549-010-1032-7. Epub 2010 Jul 17.
10. Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina. Cinaroglu A, etal., J Neurosci Res. 2005 Feb 1;79(3):329-39.
11. Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein. Claus P, etal., J Biol Chem 2003 Jan 3;278(1):479-85.
12. Overexpression of the fibroblast growth factor receptor 2-IIIc in Kaposi's sarcoma. Cottoni F, etal., J Dermatol Sci. 2009 Jan;53(1):65-8. doi: 10.1016/j.jdermsci.2008.07.012. Epub 2008 Sep 19.
13. Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas. Diez de Medina SG, etal., Oncogene. 1997 Jan 23;14(3):323-30.
14. A new synthetic FGF receptor antagonist inhibits arteriosclerosis in a mouse vein graft model and atherosclerosis in apolipoprotein E-deficient mice. Dol-Gleizes F, etal., PLoS One. 2013 Nov 4;8(11):e80027. doi: 10.1371/journal.pone.0080027. eCollection 2013.
15. Fibroblast growth factor-9, a local regulator of ovarian function. Drummond AE, etal., Endocrinology. 2007 Aug;148(8):3711-21. Epub 2007 May 10.
16. Drug-sensitive FGFR2 mutations in endometrial carcinoma. Dutt A, etal., Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8713-7. Epub 2008 Jun 13.
17. Genome-wide association study identifies novel breast cancer susceptibility loci. Easton DF, etal., Nature. 2007 Jun 28;447(7148):1087-93.
18. Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling? El Agha E, etal., Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L248-L252. doi: 10.1152/ajplung.00140.2018. Epub 2018 May 3.
19. Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia. Fairbanks TJ, etal., J Pediatr Surg. 2004 Jun;39(6):872-4.
20. Second case of Beare-Stevenson syndrome with an FGFR2 Ser372Cys mutation. Fonseca R, etal., Am J Med Genet A. 2008 Mar 1;146A(5):658-60.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Ethanol inhibits fibroblast growth factor-induced proliferation of aortic smooth muscle cells. Ghiselli G, etal., Arterioscler Thromb Vasc Biol. 2003 Oct 1;23(10):1808-13. doi: 10.1161/01.ATV.0000090140.20291.CE. Epub 2003 Aug 7.
23. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
24. Two animal models of retinal degeneration are rescued by recombinant adeno-associated virus-mediated production of FGF-5 and FGF-18. Green ES, etal., Mol Ther. 2001 Apr;3(4):507-15.
25. Immunohistochemical detection of K-sam protein in stomach cancer. Hattori Y, etal., Clin Cancer Res. 1996 Aug;2(8):1373-81.
26. FGFR-associated craniosynostosis syndromes and gastrointestinal defects. Hibberd CE, etal., Am J Med Genet A. 2016 Dec;170(12):3215-3221. doi: 10.1002/ajmg.a.37862. Epub 2016 Aug 2.
27. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Hunter DJ, etal., Nat Genet. 2007 Jul;39(7):870-4. Epub 2007 May 27.
28. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Jabs EW, etal., Nat Genet. 1994 Nov;8(3):275-9.
29. Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Jang JH, etal., Cancer Res. 2001 May 1;61(9):3541-3.
30. The fibroblast growth factor receptor 2 p.Ala172Phe mutation in Pfeiffer syndrome--history repeating itself. Jay S, etal., Am J Med Genet A. 2013 May;161A(5):1158-63. doi: 10.1002/ajmg.a.35842. Epub 2013 Mar 26.
31. Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): A study on the local and systemic toxicology of DBP. Jiang JT, etal., Toxicology. 2015 Dec 2;338:77-85. doi: 10.1016/j.tox.2015.10.006. Epub 2015 Oct 26.
32. Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate. Jin C, etal., Cancer Res. 2003 Dec 15;63(24):8784-90.
33. The nonsense-mediated decay pathway and mutually exclusive expression of alternatively spliced FGFR2IIIb and -IIIc mRNAs. Jones RB, etal., J Biol Chem. 2001 Feb 9;276(6):4158-67. Epub 2000 Oct 20.
34. Evidence for fibroblast growth factor receptors in myofibroblasts during palatal mucoperiosteal repair. Kanda T, etal., Arch Oral Biol. 2003 Mar;48(3):213-21.
35. Upregulation of ANGPTL4 messenger RNA and protein in severely calcified carotid plaques. Katano H and Yamada K, J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):933-47. doi: 10.1016/j.jstrokecerebrovasdis.2013.07.046. Epub 2013 Sep 26.
36. Feeding, Communication, Hydrocephalus, and Intracranial Hypertension in Patients With Severe FGFR2-Associated Pfeiffer Syndrome. Kilcoyne S, etal., J Craniofac Surg. 2021 Jan-Feb 01;32(1):134-140. doi: 10.1097/SCS.0000000000007153.
37. Effect of Fibroblast Growth Factor-2 and its Receptor Gene Polymorphisms on the Survival of Patients With Hepatitis B Virus-associated Hepatocellular Carcinoma. Kim SS, etal., Anticancer Res. 2019 Apr;39(4):2217-2226. doi: 10.21873/anticanres.13337.
38. Fibroblast growth factor expression in the postnatal growth plate. Lazarus JE, etal., Bone. 2007 Mar;40(3):577-86. Epub 2006 Dec 13.
39. Keratinocyte growth factor expression in hormone insensitive prostate cancer. Leung HY, etal., Oncogene. 1997 Aug 28;15(9):1115-20.
40. Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma. Manavi M, etal., Gynecol Oncol. 2007 May;105(2):418-26. Epub 2007 Feb 15.
41. Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. Marguerie A, etal., Cardiovasc Res. 2006 Jul 1;71(1):50-60. doi: 10.1016/j.cardiores.2006.03.021. Epub 2006 Apr 4.
42. Inhibition of growth of malignant rat prostate tumor cells by restoration of fibroblast growth factor receptor 2. Matsubara A, etal., Cancer Res. 1998 Apr 1;58(7):1509-14.
43. Endothelium-targeted overexpression of constitutively active FGF receptor induces cardioprotection in mice myocardial infarction. Matsunaga S, etal., J Mol Cell Cardiol. 2009 May;46(5):663-73. doi: 10.1016/j.yjmcc.2009.01.015.
44. Novel phenotype of craniosynostosis and ocular anterior chamber dysgenesis with a fibroblast growth factor receptor 2 mutation. McCann E, etal., Am J Med Genet A. 2005 Oct 15;138A(3):278-81.
45. Novel breast cancer risk alleles and endometrial cancer risk. McGrath M, etal., Int J Cancer. 2008 Sep 10.
46. Fibroblast growth factor receptor-2 mutation analysis in human prostate cancer. Mehta P, etal., BJU Int. 2000 Oct;86(6):681-5.
47. Unilateral segmental acneiform naevus: a model disorder towards understanding fibroblast growth factor receptor 2 function in acne? Melnik BC, etal., Br J Dermatol. 2008 Jun;158(6):1397-9. doi: 10.1111/j.1365-2133.2008.08559.x. Epub 2008 Apr 10.
48. Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. Merrill AE, etal., Am J Hum Genet. 2012 Mar 9;90(3):550-7. doi: 10.1016/j.ajhg.2012.02.005. Epub 2012 Mar 1.
49. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
50. Endotoxin alters early fetal lung morphogenesis. Muratore CS, etal., J Surg Res. 2009 Aug;155(2):225-30. Epub 2008 Aug 9.
51. Single nucleotide polymorphisms of the fibroblast growth factor receptor 2 gene in patients with chronic venous insufficiency with leg ulcer. Nagy N, etal., J Invest Dermatol. 2005 May;124(5):1085-8. doi: 10.1111/j.0022-202X.2005.23689.x.
52. Down-regulation of (IIIb) and (IIIc) isoforms of fibroblast growth factor receptor 2 (FGFR2) is associated with malignant progression in human prostate. Naimi B, etal., Prostate. 2002 Aug 1;52(3):245-52.
53. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
54. Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation. Nichol PF, etal., J Pediatr Surg. 2011 Jan;46(1):90-6. doi: 10.1016/j.jpedsurg.2010.09.066.
55. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
56. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
57. Analysis of phenotypic features and FGFR2 mutations in Apert syndrome. Park WJ, etal., Am J Hum Genet. 1995 Aug;57(2):321-8.
58. Description of a new mutation and characterization of FGFR1, FGFR2, and FGFR3 mutations among Brazilian patients with syndromic craniosynostoses. Passos-Bueno MR, etal., Am J Med Genet. 1998 Jul 7;78(3):237-41.
59. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
60. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
61. Link between reduced nephron number and hypertension: studies in a mutant mouse model. Poladia DP, etal., Pediatr Res. 2006 Apr;59(4 Pt 1):489-93. doi: 10.1203/01.pdr.0000202764.02295.45.
62. Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Pollock PM, etal., Oncogene. 2007 Nov 1;26(50):7158-62. Epub 2007 May 21.
63. Spectrum of craniosynostosis phenotypes associated with novel mutations at the fibroblast growth factor receptor 2 locus. Pulleyn LJ, etal., Eur J Hum Genet. 1996;4(5):283-91.
64. Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes. Purushothaman R, etal., Birth Defects Res A Clin Mol Teratol. 2011 Jul;91(7):603-9. doi: 10.1002/bdra.20811. Epub 2011 Apr 28.
65. Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. Quantius J, etal., PLoS Pathog. 2016 Jun 20;12(6):e1005544. doi: 10.1371/journal.ppat.1005544. eCollection 2016 Jun.
66. Evidence for digenic inheritance in some cases of Antley-Bixler syndrome? Reardon W, etal., J Med Genet. 2000 Jan;37(1):26-32.
67. Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome. Reardon W, etal., Nat Genet. 1994 Sep;8(1):98-103. doi: 10.1038/ng0994-98.
68. GOA pipeline RGD automated data pipeline
69. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
70. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
71. Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer. Ricol D, etal., Oncogene. 1999 Dec 2;18(51):7234-43.
72. Ovarian dysgerminoma and Apert syndrome. Rouzier C, etal., Pediatr Blood Cancer. 2008 Mar;50(3):696-8.
73. Ethanol exposure during embryogenesis decreases the radial glial progenitorpool and affects the generation of neurons and astrocytes. Rubert G, etal., J Neurosci Res. 2006 Aug 15;84(3):483-96.
74. Sequence analysis of fibroblast growth factor receptor 2 ( FGFR2 ) in Japanese patients with craniosynostosis. Sakai N, etal., J Craniofac Surg. 2001 Nov;12(6):580-5.
75. Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells. Savagner P, etal., Mol Biol Cell 1994 Aug;5(8):851-62.
76. Mutations in FGFR1 and FGFR2 cause familial and sporadic Pfeiffer syndrome. Schell U, etal., Hum Mol Genet. 1995 Mar;4(3):323-8. doi: 10.1093/hmg/4.3.323.
77. Medical treatment of craniosynostosis: recombinant Noggin inhibits coronal suture closure in the rat craniosynostosis model. Shen K, etal., Orthod Craniofac Res. 2009 Aug;12(3):254-62. doi: 10.1111/j.1601-6343.2009.01460.x.
78. A novel long noncoding RNA FAF inhibits apoptosis via upregulating FGF9 through PI3K/AKT signaling pathway in ischemia-hypoxia cardiomyocytes. Shi HJ, etal., J Cell Physiol. 2019 Dec;234(12):21973-21987. doi: 10.1002/jcp.28760. Epub 2019 May 15.
79. RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Shukla V, etal., Nat Genet. 2007 Sep;39(9):1145-50. Epub 2007 Aug 12.
80. Novel FGFR2 deletion in a patient with Beare-Stevenson-like syndrome. Slavotinek A, etal., Am J Med Genet A. 2009 Aug;149A(8):1814-7.
81. High-dose retinoic acid modulates rat calvarial osteoblast biology. Song HM, etal., J Cell Physiol. 2005 Jan;202(1):255-62.
82. Aberrant fibroblast growth factor receptor 2 signalling in esophageal atresia with tracheoesophageal fistula. Spilde TL, etal., J Pediatr Surg. 2004 Apr;39(4):537-9.
83. Induction of FGF receptor 2-IIIb expression and response to its ligands in epithelial ovarian cancer. Steele IA, etal., Oncogene. 2001 Sep 13;20(41):5878-87.
84. Luteolin limits infarct size and improves cardiac function after myocardium ischemia/reperfusion injury in diabetic rats. Sun D, etal., PLoS One. 2012;7(3):e33491. doi: 10.1371/journal.pone.0033491. Epub 2012 Mar 14.
85. Aberrant expression of keratinocyte growth factor receptor in ovarian surface epithelial cells of endometrioma. Taniguchi F, etal., Fertil Steril. 2008 Feb;89(2):478-80. Epub 2007 May 4.
86. Reduced expression of basic fibroblast growth factor and its receptor mRNAs and proteins in portal hypertensive esophageal mucosa: a mechanism responsible for muscularis mucosae thinning and variceal rupture. Tanoue K, etal., Surgery. 1996 Apr;119(4):424-30. doi: 10.1016/s0039-6060(96)80143-7.
87. Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth. Tarkkonen KM, etal., PLoS One. 2012;7(11):e49970. doi: 10.1371/journal.pone.0049970. Epub 2012 Nov 21.
88. Mutation analysis of Crouzon syndrome and identification of one novel mutation in Taiwanese patients. Tsai FJ, etal., Pediatr Int. 2001 Jun;43(3):263-6.
89. Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure. Villanueva S, etal., Biol Res. 2012;45(1):51-60. doi: 10.4067/S0716-97602012000100007.
90. Intrarenal urothelium proliferation: an unexpected early event following ischemic injury. Vinsonneau C, etal., Am J Physiol Renal Physiol. 2010 Sep;299(3):F479-86. doi: 10.1152/ajprenal.00585.2009. Epub 2010 Jun 30.
91. Genotype-phenotype analysis in Apert syndrome suggests opposite effects of the two recurrent mutations on syndactyly and outcome of craniofacial surgery. von Gernet S, etal., Clin Genet. 2000 Feb;57(2):137-9.
92. Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation. White KE, etal., Am J Hum Genet. 2005 Feb;76(2):361-7. Epub 2004 Dec 28.
93. Preclinical Combination Studies of an FGFR2 Targeted Thorium-227 Conjugate and the ATR Inhibitor BAY 1895344. Wickstroem K, etal., Int J Radiat Oncol Biol Phys. 2019 Oct 1;105(2):410-422. doi: 10.1016/j.ijrobp.2019.06.2508. Epub 2019 Jun 27.
94. KGF-2 Protects against Lung Ischemia-Reperfusion Injury by Inhibiting Inflammation-Induced Damage to Endothelial Barrier Function. Xia F, etal., Evid Based Complement Alternat Med. 2022 May 11;2022:3055039. doi: 10.1155/2022/3055039. eCollection 2022.
95. Ablation of FGFR2 in Fibroblasts Ameliorates Kidney Fibrosis after Ischemia/Reperfusion Injury in Mice. Xu Z and Dai C, Kidney Dis (Basel). 2017 Dec;3(4):160-170. doi: 10.1159/000484604. Epub 2017 Nov 16.
96. FGF/FGFR2 Protects against Tubular Cell Death and Acute Kidney Injury Involving Erk1/2 Signaling Activation. Xu Z, etal., Kidney Dis (Basel). 2020 May;6(3):181-194. doi: 10.1159/000505661. Epub 2020 Feb 7.
97. Exon skipping causes alteration of the COOH-terminus and deletion of the phospholipase C gamma 1 interaction site in the FGF receptor 2 kinase in normal prostate epithelial cells. Yan G, etal., Biochem Biophys Res Commun 1993 Jul 15;194(1):512-8.
98. Genotypic and phenotypic analyses of Korean patients with syndromic craniosynostosis. Yu JE, etal., Clin Genet. 2009 Sep;76(3):287-91. Epub 2009 Jul 17.
99. TM2D3 rs675436 or FGFR2 rs755793 polymorphisms and susceptibility to Epstein-Barr virus-associated tumors in Chinese Han population. Zhang Q, etal., J Med Virol. 2018 Jun;90(6):1128-1133. doi: 10.1002/jmv.25057. Epub 2018 Feb 27.
100. Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk. Zhao ZZ, etal., Hum Reprod. 2008 Jul;23(7):1661-8. Epub 2008 Feb 18.
101. Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP). Zhu YJ, etal., Toxicology. 2009 Jun 16;260(1-3):120-5. Epub 2009 Apr 5.
Additional References at PubMed
PMID:8386828   PMID:8663044   PMID:8875318   PMID:8889548   PMID:9435295   PMID:9528792   PMID:9700203   PMID:10518547   PMID:10821755   PMID:10830168   PMID:10934262   PMID:11312155  
PMID:11731698   PMID:11782400   PMID:11834506   PMID:11891329   PMID:11923311   PMID:12608893   PMID:12666202   PMID:12756187   PMID:12828933   PMID:12947022   PMID:14530295   PMID:14645542  
PMID:15126509   PMID:15199404   PMID:15229180   PMID:15234214   PMID:15509736   PMID:15601847   PMID:15621532   PMID:15629145   PMID:15684416   PMID:15843416   PMID:15944199   PMID:15972105  
PMID:16442091   PMID:16540513   PMID:16597614   PMID:16618415   PMID:16720875   PMID:16778080   PMID:16844695   PMID:16856175   PMID:16963563   PMID:16989802   PMID:17202188   PMID:17215304  
PMID:17418794   PMID:17471512   PMID:17687036   PMID:17708356   PMID:17951031   PMID:17959718   PMID:18039182   PMID:18184727   PMID:18187602   PMID:18363829   PMID:18455718   PMID:18533146  
PMID:19053057   PMID:19060208   PMID:19103595   PMID:19224135   PMID:19389359   PMID:19410646   PMID:20345253   PMID:20410112   PMID:21412257   PMID:21492869   PMID:21550054   PMID:21691921  
PMID:21994076   PMID:23136392   PMID:23564461   PMID:24058167   PMID:32626929   PMID:35599572  


Genomics

Comparative Map Data
Fgfr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21184,745,418 - 184,850,655 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,745,420 - 184,850,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,095,683 - 193,200,892 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01200,270,134 - 200,375,502 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01192,941,908 - 193,047,272 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01200,590,951 - 200,696,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1200,590,953 - 200,696,928 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01207,626,732 - 207,731,841 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41189,482,975 - 189,589,279 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11189,667,865 - 189,734,790 (-)NCBI
Celera1182,362,666 - 182,467,651 (-)NCBICelera
Cytogenetic Map1q37NCBI
FGFR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810121,478,330 - 121,598,458 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10121,478,332 - 121,598,458 (-)EnsemblGRCh38hg38GRCh38
GRCh3710123,237,844 - 123,357,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610123,227,845 - 123,347,962 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410123,266,837 - 123,347,907NCBI
Celera10116,970,097 - 117,089,799 (-)NCBICelera
Cytogenetic Map10q26.13NCBI
HuRef10116,868,799 - 116,988,666 (-)NCBIHuRef
CHM1_110123,522,903 - 123,642,701 (-)NCBICHM1_1
T2T-CHM13v2.010122,374,405 - 122,494,614 (-)NCBIT2T-CHM13v2.0
Fgfr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397129,764,181 - 129,868,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7129,764,181 - 132,725,079 (-)EnsemblGRCm39 Ensembl
GRCm387130,162,451 - 130,266,808 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7130,162,451 - 133,123,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv377137,305,965 - 137,410,322 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367129,954,867 - 130,057,411 (-)NCBIMGSCv36mm8
Celera7129,989,855 - 130,093,942 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map773.19NCBI
Fgfr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555512,321,190 - 2,427,000 (-)NCBIChiLan1.0ChiLan1.0
FGFR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan110133,347,267 - 133,466,495 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010118,055,854 - 118,175,440 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110121,469,735 - 121,588,815 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10121,469,735 - 121,588,815 (-)Ensemblpanpan1.1panPan2
FGFR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12831,303,882 - 31,411,015 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2831,303,894 - 31,411,621 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2831,443,692 - 31,545,836 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02831,838,529 - 31,945,124 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2831,835,438 - 31,945,708 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12831,369,550 - 31,471,773 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02831,390,735 - 31,492,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02831,595,945 - 31,698,233 (-)NCBIUU_Cfam_GSD_1.0
Fgfr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721314,955,026 - 15,055,733 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648610,507,097 - 10,602,019 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648610,506,680 - 10,606,272 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14131,181,713 - 131,289,425 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114131,183,095 - 131,285,001 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214142,500,502 - 142,565,883 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19114,234,344 - 114,354,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9114,234,250 - 114,354,704 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604875,522,971 - 75,644,166 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgfr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473725,052,606 - 25,158,529 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473725,052,698 - 25,158,346 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgfr2
398 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1101
Count of miRNA genes:222
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000022253, ENSRNOT00000022331, ENSRNOT00000065448, ENSRNOT00000068183
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat

Markers in Region
D1Smu5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,740,646 - 184,740,858 (+)MAPPERmRatBN7.2
Rnor_6.01200,586,180 - 200,586,391NCBIRnor6.0
Rnor_5.01207,621,961 - 207,622,172UniSTSRnor5.0
RGSC_v3.41189,478,204 - 189,478,415UniSTSRGSC3.4
Celera1182,357,916 - 182,358,106UniSTS
Cytogenetic Map1q37UniSTS
RH11106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,782,109 - 184,782,243 (+)MAPPERmRatBN7.2
Rnor_6.01200,627,842 - 200,627,975NCBIRnor6.0
Rnor_5.01207,663,652 - 207,663,785UniSTSRnor5.0
RGSC_v3.41189,520,207 - 189,520,340UniSTSRGSC3.4
Celera1182,399,275 - 182,399,408UniSTS
Cytogenetic Map1q37UniSTS
RH143520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,848,106 - 184,848,253 (+)MAPPERmRatBN7.2
Rnor_6.01200,694,409 - 200,694,555NCBIRnor6.0
Rnor_5.01207,729,322 - 207,729,468UniSTSRnor5.0
RGSC_v3.41189,586,760 - 189,586,906UniSTSRGSC3.4
Celera1182,465,132 - 182,465,278UniSTS
RH 3.4 Map11382.4UniSTS
Cytogenetic Map1q37UniSTS
RH140672  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,850,267 - 184,850,447 (+)MAPPERmRatBN7.2
Rnor_6.01200,696,570 - 200,696,749NCBIRnor6.0
Rnor_5.01207,731,483 - 207,731,662UniSTSRnor5.0
RGSC_v3.41189,588,921 - 189,589,100UniSTSRGSC3.4
Celera1182,467,293 - 182,467,472UniSTS
RH 3.4 Map11383.69UniSTS
Cytogenetic Map1q37UniSTS
BM383187  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,777,963 - 184,778,118 (+)MAPPERmRatBN7.2
Rnor_6.01200,623,696 - 200,623,850NCBIRnor6.0
Rnor_5.01207,659,506 - 207,659,660UniSTSRnor5.0
RGSC_v3.41189,516,061 - 189,516,215UniSTSRGSC3.4
Celera1182,395,108 - 182,395,262UniSTS
RH 3.4 Map11418.99UniSTS
Cytogenetic Map1q37UniSTS
PMC20217P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,782,049 - 184,782,194 (+)MAPPERmRatBN7.2
Rnor_6.01200,627,782 - 200,627,926NCBIRnor6.0
Rnor_5.01207,663,592 - 207,663,736UniSTSRnor5.0
RGSC_v3.41189,520,147 - 189,520,291UniSTSRGSC3.4
Celera1182,399,215 - 182,399,359UniSTS
Cytogenetic Map1q37UniSTS
Fgfr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,826,519 - 184,826,638 (+)MAPPERmRatBN7.2
Rnor_6.01200,672,201 - 200,672,319NCBIRnor6.0
Rnor_5.01207,707,977 - 207,708,095UniSTSRnor5.0
RGSC_v3.41189,564,823 - 189,564,941UniSTSRGSC3.4
Celera1182,443,660 - 182,443,778UniSTS
Cytogenetic Map1q37UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 14 42 33 1 33 74 26 34 11
Low 26 15 8 18 8 8 9 9 5 8
Below cutoff 3 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001109893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001109894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001109895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001109896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF147757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF294649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF294650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF456422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ312745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW531062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF420170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB716134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB769194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB777398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB780941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF109832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO397781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV718561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U59800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000022253   ⟹   ENSRNOP00000022253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,745,420 - 184,850,626 (-)Ensembl
Rnor_6.0 Ensembl1200,590,953 - 200,696,928 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000022331   ⟹   ENSRNOP00000022331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,745,420 - 184,850,626 (-)Ensembl
Rnor_6.0 Ensembl1200,590,953 - 200,696,928 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000065448   ⟹   ENSRNOP00000061479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,745,420 - 184,850,626 (-)Ensembl
Rnor_6.0 Ensembl1200,590,953 - 200,696,928 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000068183   ⟹   ENSRNOP00000059005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,745,420 - 184,850,626 (-)Ensembl
Rnor_6.0 Ensembl1200,590,953 - 200,696,928 (-)Ensembl
RefSeq Acc Id: NM_001109892   ⟹   NP_001103362
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,850,626 (-)NCBI
Rnor_6.01200,590,951 - 200,696,928 (-)NCBI
Rnor_5.01207,626,732 - 207,731,841 (-)NCBI
RGSC_v3.41189,482,975 - 189,589,279 (-)RGD
Celera1182,362,666 - 182,467,651 (-)RGD
Sequence:
RefSeq Acc Id: NM_001109893   ⟹   NP_001103363
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,850,626 (-)NCBI
Rnor_6.01200,590,951 - 200,696,928 (-)NCBI
Rnor_5.01207,626,732 - 207,731,841 (-)NCBI
RGSC_v3.41189,482,975 - 189,589,279 (-)RGD
Celera1182,362,666 - 182,467,651 (-)RGD
Sequence:
RefSeq Acc Id: NM_001109894   ⟹   NP_001103364
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,850,626 (-)NCBI
Rnor_6.01200,590,951 - 200,696,928 (-)NCBI
Rnor_5.01207,626,732 - 207,731,841 (-)NCBI
RGSC_v3.41189,482,975 - 189,589,279 (-)RGD
Celera1182,362,666 - 182,467,651 (-)RGD
Sequence:
RefSeq Acc Id: NM_001109895   ⟹   NP_001103365
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,850,626 (-)NCBI
Rnor_6.01200,590,951 - 200,696,928 (-)NCBI
Rnor_5.01207,626,732 - 207,731,841 (-)NCBI
RGSC_v3.41189,482,975 - 189,589,279 (-)RGD
Celera1182,362,666 - 182,467,651 (-)RGD
Sequence:
RefSeq Acc Id: NM_001109896   ⟹   NP_001103366
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,850,626 (-)NCBI
Rnor_6.01200,590,951 - 200,696,928 (-)NCBI
Rnor_5.01207,626,732 - 207,731,841 (-)NCBI
RGSC_v3.41189,482,975 - 189,589,279 (-)RGD
Celera1182,362,666 - 182,467,651 (-)RGD
Sequence:
RefSeq Acc Id: NM_012712   ⟹   NP_036844
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,850,626 (-)NCBI
Rnor_6.01200,590,951 - 200,696,928 (-)NCBI
Rnor_5.01207,626,732 - 207,731,841 (-)NCBI
RGSC_v3.41189,482,975 - 189,589,279 (-)RGD
Celera1182,362,666 - 182,467,651 (-)RGD
Sequence:
RefSeq Acc Id: XM_006230389   ⟹   XP_006230451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,850,655 (-)NCBI
Rnor_6.01200,590,951 - 200,696,946 (-)NCBI
Rnor_5.01207,626,732 - 207,731,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230390   ⟹   XP_006230452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,850,654 (-)NCBI
Rnor_6.01200,590,951 - 200,696,946 (-)NCBI
Rnor_5.01207,626,732 - 207,731,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230392   ⟹   XP_006230454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,746,951 - 184,850,655 (-)NCBI
Rnor_6.01200,592,528 - 200,696,946 (-)NCBI
Rnor_5.01207,626,732 - 207,731,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230393   ⟹   XP_006230455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,850,653 (-)NCBI
Rnor_6.01200,590,951 - 200,696,945 (-)NCBI
Rnor_5.01207,626,732 - 207,731,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759861   ⟹   XP_008758083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,828,617 (-)NCBI
Rnor_6.01200,590,951 - 200,677,146 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101195   ⟹   XP_038957123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,846,673 (-)NCBI
RefSeq Acc Id: XM_039101196   ⟹   XP_038957124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,848,415 (-)NCBI
RefSeq Acc Id: XM_039101199   ⟹   XP_038957127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,745,418 - 184,847,982 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001103362 (Get FASTA)   NCBI Sequence Viewer  
  NP_001103363 (Get FASTA)   NCBI Sequence Viewer  
  NP_001103364 (Get FASTA)   NCBI Sequence Viewer  
  NP_001103365 (Get FASTA)   NCBI Sequence Viewer  
  NP_001103366 (Get FASTA)   NCBI Sequence Viewer  
  NP_036844 (Get FASTA)   NCBI Sequence Viewer  
  XP_006230451 (Get FASTA)   NCBI Sequence Viewer  
  XP_006230452 (Get FASTA)   NCBI Sequence Viewer  
  XP_006230454 (Get FASTA)   NCBI Sequence Viewer  
  XP_006230455 (Get FASTA)   NCBI Sequence Viewer  
  XP_008758083 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957123 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957124 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957127 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA02628 (Get FASTA)   NCBI Sequence Viewer  
  AAA02629 (Get FASTA)   NCBI Sequence Viewer  
  AAA02690 (Get FASTA)   NCBI Sequence Viewer  
  AAA02691 (Get FASTA)   NCBI Sequence Viewer  
  AAA02692 (Get FASTA)   NCBI Sequence Viewer  
  AAA02693 (Get FASTA)   NCBI Sequence Viewer  
  AAA02694 (Get FASTA)   NCBI Sequence Viewer  
  AAB02867 (Get FASTA)   NCBI Sequence Viewer  
  AAB03225 (Get FASTA)   NCBI Sequence Viewer  
  AAD31529 (Get FASTA)   NCBI Sequence Viewer  
  AAD31530 (Get FASTA)   NCBI Sequence Viewer  
  AAG31575 (Get FASTA)   NCBI Sequence Viewer  
  AAG31576 (Get FASTA)   NCBI Sequence Viewer  
  AAL77411 (Get FASTA)   NCBI Sequence Viewer  
  AAL77412 (Get FASTA)   NCBI Sequence Viewer  
  BAA77278 (Get FASTA)   NCBI Sequence Viewer  
  BAA77279 (Get FASTA)   NCBI Sequence Viewer  
  CAC37408 (Get FASTA)   NCBI Sequence Viewer  
  EDM17149 (Get FASTA)   NCBI Sequence Viewer  
  EDM17150 (Get FASTA)   NCBI Sequence Viewer  
  EDM17151 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_036844   ⟸   NM_012712
- Peptide Label: isoform a
- UniProtKB: F1LSG7 (UniProtKB/TrEMBL),   Q63236 (UniProtKB/TrEMBL),   Q63240 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103362   ⟸   NM_001109892
- Peptide Label: isoform b
- UniProtKB: Q63240 (UniProtKB/TrEMBL),   F1LNW0 (UniProtKB/TrEMBL),   Q63236 (UniProtKB/TrEMBL),   Q63237 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103363   ⟸   NM_001109893
- Peptide Label: isoform c
- UniProtKB: F1LRU8 (UniProtKB/TrEMBL),   Q63238 (UniProtKB/TrEMBL),   Q63240 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103364   ⟸   NM_001109894
- Peptide Label: isoform d
- UniProtKB: Q63236 (UniProtKB/TrEMBL),   Q63240 (UniProtKB/TrEMBL),   Q63242 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103365   ⟸   NM_001109895
- Peptide Label: isoform e
- UniProtKB: F1LN06 (UniProtKB/TrEMBL),   Q63239 (UniProtKB/TrEMBL),   Q63240 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103366   ⟸   NM_001109896
- Peptide Label: isoform f
- UniProtKB: Q63236 (UniProtKB/TrEMBL),   Q63240 (UniProtKB/TrEMBL),   Q63241 (UniProtKB/TrEMBL),   Q63242 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230455   ⟸   XM_006230393
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006230452   ⟸   XM_006230390
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006230451   ⟸   XM_006230389
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006230454   ⟸   XM_006230392
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008758083   ⟸   XM_008759861
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000061479   ⟸   ENSRNOT00000065448
RefSeq Acc Id: ENSRNOP00000022331   ⟸   ENSRNOT00000022331
RefSeq Acc Id: ENSRNOP00000022253   ⟸   ENSRNOT00000022253
RefSeq Acc Id: ENSRNOP00000059005   ⟸   ENSRNOT00000068183
RefSeq Acc Id: XP_038957124   ⟸   XM_039101196
- Peptide Label: isoform X1
- UniProtKB: F1LSG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957127   ⟸   XM_039101199
- Peptide Label: isoform X1
- UniProtKB: F1LSG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957123   ⟸   XM_039101195
- Peptide Label: isoform X1
- UniProtKB: F1LSG7 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Immunoglobulin I-set   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LSG7-F1-model_v2 AlphaFold F1LSG7 1-841 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2611 AgrOrtholog
BioCyc Gene G2FUF-57260 BioCyc
Ensembl Genes ENSRNOG00000016374 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022253 ENTREZGENE
  ENSRNOP00000022253.4 UniProtKB/TrEMBL
  ENSRNOP00000022331 ENTREZGENE
  ENSRNOP00000022331.5 UniProtKB/TrEMBL
  ENSRNOP00000059005 ENTREZGENE
  ENSRNOP00000059005.1 UniProtKB/TrEMBL
  ENSRNOP00000061479 ENTREZGENE
  ENSRNOP00000061479.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022253 ENTREZGENE
  ENSRNOT00000022253.7 UniProtKB/TrEMBL
  ENSRNOT00000022331 ENTREZGENE
  ENSRNOT00000022331.7 UniProtKB/TrEMBL
  ENSRNOT00000065448 ENTREZGENE
  ENSRNOT00000065448.4 UniProtKB/TrEMBL
  ENSRNOT00000068183 ENTREZGENE
  ENSRNOT00000068183.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_fibroblast_GF_rcpt UniProtKB/TrEMBL
KEGG Report rno:25022 UniProtKB/TrEMBL
NCBI Gene 25022 ENTREZGENE
PANTHER FIBROBLAST GROWTH FACTOR RECEPTOR UniProtKB/TrEMBL
  FIBROBLAST GROWTH FACTOR RECEPTOR UniProtKB/TrEMBL
  FIBROBLAST GROWTH FACTOR RECEPTOR 2 UniProtKB/TrEMBL
  FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Fgfr2 PhenoGen
PIRSF FGFR UniProtKB/TrEMBL
  TyrPK_CSF1-R UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A6IA29_RAT UniProtKB/TrEMBL
  F1LN06 ENTREZGENE, UniProtKB/TrEMBL
  F1LNW0 ENTREZGENE, UniProtKB/TrEMBL
  F1LRU8 ENTREZGENE, UniProtKB/TrEMBL
  F1LSG7 ENTREZGENE, UniProtKB/TrEMBL
  Q63236 ENTREZGENE, UniProtKB/TrEMBL
  Q63237 ENTREZGENE, UniProtKB/TrEMBL
  Q63238 ENTREZGENE, UniProtKB/TrEMBL
  Q63239 ENTREZGENE, UniProtKB/TrEMBL
  Q63240 ENTREZGENE, UniProtKB/TrEMBL
  Q63241 ENTREZGENE, UniProtKB/TrEMBL
  Q63242 ENTREZGENE, UniProtKB/TrEMBL
  Q9R293_RAT UniProtKB/TrEMBL
  Q9R294_RAT UniProtKB/TrEMBL
  Q9R299_RAT UniProtKB/TrEMBL
  Q9R2A0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fgfr2  fibroblast growth factor receptor 2      Name updated 70584 APPROVED