Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Aifm1 (apoptosis inducing factor, mitochondria associated 1) Rattus norvegicus
Analyze
Symbol: Aifm1
Name: apoptosis inducing factor, mitochondria associated 1
RGD ID: 620817
Description: Predicted to have DNA binding activity; FAD binding activity; and NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including cellular response to lipid; cellular response to oxygen-glucose deprivation; and cellular response to reactive oxygen species. Localizes to cytosol; mitochondrion; and nucleus. Biomarker of middle cerebral artery infarction; retinal detachment; retinitis pigmentosa; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to several human genes including TXNDC12 (thioredoxin domain containing 12); PARTICIPATES IN ceramide signaling pathway; apoptotic cell death pathway; INTERACTS WITH (+)-schisandrin B; (+)-sesamin; (Z)-3-butylidenephthalide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Aif; apoptosis-inducing factor 1, mitochondrial; apoptosis-inducing factor, mitochondrion-associated 1; Pdcd8; programmed cell death 8; programmed cell death 8 (apoptosis-inducing factor); programmed cell death protein 8
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X135,304,063 - 135,343,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX135,304,066 - 135,343,087 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X135,375,533 - 135,414,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,868,878 - 134,908,166 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X134,942,310 - 134,981,599 (-)NCBI
CeleraX126,598,666 - 126,637,656 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Aifm1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620817
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.