Bcl2l11 (Bcl2-like 11) - Rat Genome Database

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Gene: Bcl2l11 (Bcl2-like 11) Rattus norvegicus
Analyze
Symbol: Bcl2l11
Name: Bcl2-like 11
RGD ID: 628774
Description: Predicted to enable protein kinase binding activity. Predicted to contribute to microtubule binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to estradiol stimulus; and positive regulation of autophagy in response to ER overload. Predicted to be located in several cellular components, including cytosol; intracellular membrane-bounded organelle; and microtubule. Predicted to be part of BIM-BCL-2 complex and BIM-BCL-xl complex. Predicted to be active in mitochondrion. Orthologous to human BCL2L11 (BCL2 like 11); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bcl-2 related apoptotic gene product BimL; bcl-2-like protein 11; bcl-2-related ovarian death protein; BCL2 like 11; bcl2-interacting mediator of cell death; bcl2-L-11; BCL2-like 11 (apoptosis facilitator); Bim; BimL; Bod
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,820,042 - 135,857,330 (+)NCBIGRCr8
mRatBN7.23115,366,783 - 115,404,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,366,646 - 115,404,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3119,256,253 - 119,293,586 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,851,801 - 127,889,132 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,512,142 - 125,549,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,726,906 - 120,764,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,726,906 - 120,764,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,567,484 - 126,604,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43115,692,323 - 115,722,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13115,597,895 - 115,628,274 (+)NCBI
Celera3114,200,283 - 114,237,903 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-amphetamine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7-ketocholesterol  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
9,10-anthraquinone  (ISO)
9-cis-retinoic acid  (ISO)
ABT-737  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
bufalin  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cobimetinib  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin B  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (EXP)
D-glucose  (EXP)
dactolisib  (ISO)
dantrolene  (ISO)
DDE  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl malate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enniatin  (EXP)
entinostat  (ISO)
epichlorohydrin  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ferric oxide  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furosemide  (EXP)
gallic acid  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
glucose  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (ISO)
GW 6471  (ISO)
halothane  (ISO)
harmine  (ISO)
hydrogen peroxide  (ISO)
ibrutinib  (ISO)
icariin  (EXP,ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP,ISO)
ketoconazole  (ISO)
lead diacetate  (ISO)
lovastatin  (EXP,ISO)
LY294002  (EXP,ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
Mitotane  (EXP)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nimustine  (ISO)
NORCANTHARIDIN  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omipalisib  (ISO)
osthole  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
pevonedistat  (ISO)
PF-4708671  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phloretin  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP)
ponatinib  (ISO)
potassium chromate  (ISO)
Pramanicin  (ISO)
proanthocyanidin  (ISO)
prochloraz  (EXP)
procyanidin B2  (ISO)
propylparaben  (ISO)
protein kinase inhibitor  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
quizartinib  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
remdesivir  (ISO)
resveratrol  (EXP,ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
ryanodine  (ISO)
S-allylcysteine  (EXP)
sapanisertib  (ISO)
sarin  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
selumetinib  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium chromate  (ISO)
sorafenib  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
taurine  (EXP)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tomentosin  (ISO)
trametinib  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vemurafenib  (ISO)
vorinostat  (EXP,ISO)
withaferin A  (EXP,ISO)
xanthohumol  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
apoptotic process involved in embryonic digit morphogenesis  (ISO)
B cell homeostasis  (ISO)
cell-matrix adhesion  (ISO)
cellular response to amyloid-beta  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
developmental pigmentation  (ISO)
ear development  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
in utero embryonic development  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
kidney development  (ISO)
leukocyte homeostasis  (ISO)
lymphocyte apoptotic process  (ISO)
lymphocyte homeostasis  (ISO)
male gonad development  (ISO)
mammary gland development  (ISO)
meiosis I  (IBA)
myeloid cell homeostasis  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
positive regulation of apoptotic process  (IBA,IMP,ISO)
positive regulation of autophagy in response to ER overload  (IMP)
positive regulation of cell cycle  (ISO)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of lymphocyte apoptotic process  (ISO)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of T cell apoptotic process  (ISO)
post-embryonic development  (ISO)
regulation of apoptotic process  (ISO)
regulation of developmental pigmentation  (ISO)
regulation of organ growth  (ISO)
response to endoplasmic reticulum stress  (ISO)
spermatogenesis  (ISO)
spleen development  (ISO)
T cell apoptotic process  (ISO)
T cell homeostasis  (ISO)
thymocyte apoptotic process  (ISO)
thymus development  (ISO)
tube formation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation. Biswas SC and Greene LA, J Biol Chem 2002 Dec 20;277(51):49511-6.
2. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Bouillet P, etal., Science 1999 Nov 26;286(5445):1735-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons. Harris CA and Johnson EM Jr, J Biol Chem 2001 Oct 12;276(41):37754-60.
6. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Hsu SY, etal., Mol Endocrinol 1998 Sep;12(9):1432-40.
7. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, etal., Endocrinology 1999 Dec;140(12):5469-77.
8. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
9. [Impact of stress response genes induced by L-glutamine on warm ischemia and reperfusion injury in the rat small intestine] Masuko Y Hokkaido Igaku Zasshi 2002 Mar;77(2):169-83.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. Soane L, etal., J Neurosci Res. 2008 May 1;86(6):1267-76.
13. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. Thompson S, etal., J Biol Chem. 2011 Jun 3;286(22):19331-9. doi: 10.1074/jbc.M110.197707. Epub 2011 Apr 8.
14. Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death. Yao M, etal., J Neurosci. 2007 Feb 7;27(6):1422-33. doi: 10.1523/JNEUROSCI.2382-06.2007.
15. Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression. Zhang J, etal., J Surg Res. 2015 May 15;195(2):588-95. doi: 10.1016/j.jss.2015.01.039. Epub 2015 Jan 28.
Additional References at PubMed
PMID:11546872   PMID:11709185   PMID:11997495   PMID:12142566   PMID:12818176   PMID:12913110   PMID:14667574   PMID:15136728   PMID:15231831   PMID:15356200   PMID:15384421   PMID:15818405  
PMID:15967824   PMID:16055554   PMID:16092929   PMID:16092944   PMID:16153157   PMID:16162916   PMID:16270031   PMID:16282323   PMID:16282979   PMID:16431916   PMID:16645638   PMID:16818494  
PMID:16832056   PMID:17251057   PMID:17276340   PMID:17289999   PMID:17591857   PMID:17658509   PMID:17702754   PMID:17705137   PMID:18195012   PMID:18351462   PMID:18465250   PMID:19438724  
PMID:19767770   PMID:20371704   PMID:20857401   PMID:21041309   PMID:21159964   PMID:21164521   PMID:21378313   PMID:21439021   PMID:21451041   PMID:21671007   PMID:21762482   PMID:22761832  
PMID:23661003   PMID:23815625   PMID:23828564   PMID:23896225   PMID:24014123   PMID:24567336   PMID:27220268   PMID:27483389   PMID:28125090   PMID:28202414   PMID:28770951   PMID:29048431  
PMID:31058341   PMID:32605511   PMID:35036441  


Genomics

Comparative Map Data
Bcl2l11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,820,042 - 135,857,330 (+)NCBIGRCr8
mRatBN7.23115,366,783 - 115,404,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,366,646 - 115,404,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3119,256,253 - 119,293,586 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,851,801 - 127,889,132 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,512,142 - 125,549,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,726,906 - 120,764,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,726,906 - 120,764,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,567,484 - 126,604,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43115,692,323 - 115,722,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13115,597,895 - 115,628,274 (+)NCBI
Celera3114,200,283 - 114,237,903 (+)NCBICelera
Cytogenetic Map3q36NCBI
BCL2L11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382111,120,914 - 111,168,445 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2111,119,378 - 111,168,444 (+)EnsemblGRCh38hg38GRCh38
GRCh372111,878,491 - 111,926,022 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362111,594,962 - 111,642,493 (+)NCBINCBI36Build 36hg18NCBI36
Build 342111,597,540 - 111,640,814NCBI
Celera2105,529,086 - 105,576,607 (+)NCBICelera
Cytogenetic Map2q13NCBI
HuRef2104,757,646 - 104,805,166 (+)NCBIHuRef
CHM1_12111,882,732 - 111,930,286 (+)NCBICHM1_1
T2T-CHM13v2.02111,543,978 - 111,591,507 (+)NCBIT2T-CHM13v2.0
Bcl2l11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,967,958 - 128,004,467 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,967,958 - 128,004,467 (+)EnsemblGRCm39 Ensembl
GRCm382128,126,038 - 128,162,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2128,126,038 - 128,162,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv372127,951,774 - 127,988,283 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,817,479 - 127,853,613 (+)NCBIMGSCv36mm8
Celera2129,356,352 - 129,393,704 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.23NCBI
Bcl2l11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554702,740,682 - 2,780,225 (-)NCBIChiLan1.0ChiLan1.0
BCL2L11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,914,260 - 16,961,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A16,917,024 - 16,964,367 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A90,862,070 - 90,909,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A112,337,927 - 112,385,079 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A112,337,927 - 112,385,079 (+)Ensemblpanpan1.1panPan2
BCL2L11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11735,619,804 - 35,665,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1735,619,582 - 35,664,587 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1735,391,228 - 35,441,388 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01736,397,661 - 36,447,779 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1736,397,342 - 36,445,321 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11735,515,071 - 35,565,168 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01735,589,049 - 35,639,236 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01735,800,089 - 35,850,247 (+)NCBIUU_Cfam_GSD_1.0
Bcl2l11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629281,122,091 - 81,156,497 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493678318,194 - 50,983 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493678315,493 - 50,959 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2L11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl345,160,155 - 45,201,186 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1345,156,791 - 45,202,996 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2347,180,506 - 47,223,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2L11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11414,178,159 - 14,205,337 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660805,463,438 - 5,508,960 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl2l11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247491,091,096 - 1,125,341 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247491,033,824 - 1,130,099 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcl2l11
196 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir222rno-miR-222-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//ReFunctional MTI19438724
Mir221rno-miR-221-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//ReFunctional MTI19438724

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:97
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000022596, ENSRNOT00000051069
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
BF402027  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23115,390,987 - 115,391,128 (+)MAPPERmRatBN7.2
Rnor_6.03120,751,113 - 120,751,253NCBIRnor6.0
Rnor_5.03126,580,423 - 126,580,563UniSTSRnor5.0
RGSC_v3.43115,713,859 - 115,713,999UniSTSRGSC3.4
Celera3114,224,824 - 114,224,964UniSTS
RH 3.4 Map3986.9UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000022596   ⟹   ENSRNOP00000022596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,366,805 - 115,370,549 (+)Ensembl
Rnor_6.0 Ensembl3120,728,688 - 120,760,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051069   ⟹   ENSRNOP00000039006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,368,335 - 115,404,068 (+)Ensembl
Rnor_6.0 Ensembl3120,726,906 - 120,764,192 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108485   ⟹   ENSRNOP00000076665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,368,335 - 115,401,099 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113569   ⟹   ENSRNOP00000080342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,366,646 - 115,404,068 (+)Ensembl
RefSeq Acc Id: NM_171988   ⟹   NP_741985
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83135,820,042 - 135,857,330 (+)NCBI
mRatBN7.23115,366,783 - 115,404,068 (+)NCBI
Rnor_6.03120,726,906 - 120,764,192 (+)NCBI
Rnor_5.03126,567,484 - 126,604,461 (-)NCBI
RGSC_v3.43115,692,323 - 115,722,701 (+)RGD
Celera3114,200,283 - 114,237,903 (+)NCBI
Sequence:
RefSeq Acc Id: NP_741985   ⟸   NM_171988
- UniProtKB: O88497 (UniProtKB/Swiss-Prot),   Q9WUI8 (UniProtKB/Swiss-Prot),   O88498 (UniProtKB/Swiss-Prot),   A6HQ32 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039006   ⟸   ENSRNOT00000051069
Ensembl Acc Id: ENSRNOP00000022596   ⟸   ENSRNOT00000022596
Ensembl Acc Id: ENSRNOP00000076665   ⟸   ENSRNOT00000108485
Ensembl Acc Id: ENSRNOP00000080342   ⟸   ENSRNOT00000113569
Protein Domains
Apoptosis Bim N-terminal   Bcl-x interacting BH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88498-F1-model_v2 AlphaFold O88498 1-196 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692412
Promoter ID:EPDNEW_R2937
Type:single initiation site
Name:Bcl2l11_1
Description:BCL2 like 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03120,726,929 - 120,726,989EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628774 AgrOrtholog
BioCyc Gene G2FUF-47955 BioCyc
Ensembl Genes ENSRNOG00000016551 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022596.7 UniProtKB/TrEMBL
  ENSRNOT00000051069.6 UniProtKB/TrEMBL
  ENSRNOT00000108485.1 UniProtKB/TrEMBL
  ENSRNOT00000113569 ENTREZGENE
  ENSRNOT00000113569.1 UniProtKB/TrEMBL
InterPro Apoptosis_Bim_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-2-like_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-x_interacting_BH3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immune_Signaling-Apoptosis_Reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64547 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64547 ENTREZGENE
PANTHER BCL-2-LIKE PROTEIN 11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCL2 INTERACTING MEDIATOR OF CELL DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Bclx_interact UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bim_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bcl2l11 PhenoGen
PIRSF Bcl-2-like_p11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016551 RatGTEx
UniProt A0A8I5ZK47_RAT UniProtKB/TrEMBL
  A0A8I5ZPX5_RAT UniProtKB/TrEMBL
  A0A8L2QCL5_RAT UniProtKB/TrEMBL
  A0A8L2QJ59_RAT UniProtKB/TrEMBL
  A6HQ30_RAT UniProtKB/TrEMBL
  A6HQ31_RAT UniProtKB/TrEMBL
  A6HQ32 ENTREZGENE, UniProtKB/TrEMBL
  B2L11_RAT UniProtKB/Swiss-Prot
  O88497 ENTREZGENE
  O88498 ENTREZGENE
  Q9WUI8 ENTREZGENE
UniProt Secondary O88497 UniProtKB/Swiss-Prot
  Q9WUI8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-05 Bcl2l11  Bcl2-like 11  BCL2l11  BCL2-like 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-04-05 BCL2l11  BCL2-like 11  Bcl2l11  BCL2 like 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 Bcl2l11  BCL2 like 11  Bcl2l11  BCL2-like 11 (apoptosis facilitator)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Bcl2l11  BCL2-like 11 (apoptosis facilitator)      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Bcl2l11  BCL2-like 11 (apoptosis facilitator)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression deletion delays neuronal apoptosis 70303
gene_pathway proapoptotic activity is inhibited by NGF phosphorylation and down-regulation of expression, both of which occur via the MEK/MAPK signaling pathway 704413
gene_process apoptosis facilitator 70303
gene_regulation mRNA increases after NGF withdrawal of sympathetic neurons 70303