Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628774
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l11
Name: BCL2 like 11
Acc ID: CHEBI:47575
Term: ABT-737
Definition: A biphenyl that is 4-chloro-1,1'-biphenyl substituted by a (4-{4-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene-1-sulfonyl)carbamoyl]phenyl}piperazin-1-yl)methyl group at position 2'. It is a BH3-mimetic drug which targets the anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins, including BCL-2, BCL-xL, and BCL-w, and induces apoptosis in cancer cells.
Chemical ID: MESH:C501332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l11increases response to substanceISORGD:7343006480464CTDBCL2L11 protein results in increased susceptibility to ABT-737

PMID:20038611
Bcl2l11multiple interactionsISORGD:7342996480464CTD[ABT-737 inhibits the reaction [BCL2L11 protein binds to BCL2 protein]] promotes the reaction [BCL2L11 protein results in increased activity of BAX protein] [BCL2L11 protein binds to BCL2 protein] which affects the susceptibility to ABT-737 [MCL1 protein results in decreased activity of BCL2L11 protein] which results in decreased susceptibility to ABT-737 ABT-737 inhibits the reaction [BCL2L11 protein binds to BCL2 protein]

PMID:17097560 PMID:17200714 PMID:23341456
Go Back to source page   Continue to Ontology report