Mir221 (microRNA 221) - Rat Genome Database

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Gene: Mir221 (microRNA 221) Rattus norvegicus
Analyze
Symbol: Mir221
Name: microRNA 221
RGD ID: 2325451
Description: Predicted to enable mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of Schwann cell migration; and positive regulation of Schwann cell proliferation. Predicted to be located in synapse. Predicted to be part of RISC complex. Biomarker of breast cancer; diabetes mellitus; hepatocellular carcinoma; and sciatic neuropathy. Human ortholog(s) of this gene implicated in gastrointestinal stromal tumor; hepatocellular carcinoma; and oral squamous cell carcinoma. Orthologous to human MIR221 (microRNA 221); INTERACTS WITH 2-acetamidofluorene; aflatoxin B1; atrazine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-221; rno-mir-221
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X6,023,182 - 6,023,290 (+)NCBIGRCr8
mRatBN7.2X3,429,465 - 3,429,573 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX3,429,465 - 3,429,573 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX3,495,164 - 3,495,272 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X6,970,960 - 6,971,068 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X3,288,051 - 3,288,159 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X3,684,480 - 3,684,588 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX3,684,480 - 3,684,588 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X4,475,295 - 4,475,403 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX3,969,242 - 3,969,350 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Mir221RatAcute Liver Failure treatmentISOMir221 (Mus musculus)18337268 RGD 
Mir221Ratbreast cancer  IEP 152025189RNA:increased expression:serum more ...RGD 
Mir221RatCardiac Fibrosis severityISOMIR221 (Homo sapiens)18337269associated with dilated cardiomyopathyRGD 
Mir221Ratcolorectal cancer  ISOMIR221 (Homo sapiens)153002793miRNA:increased expression:colorectum (human)RGD 
Mir221Ratcolorectal cancer  ISOMIR221 (Homo sapiens)151708745RNA:increased expression:colorectumRGD 
Mir221Ratdiabetes mellitus  IEP 152025220RNA:increased expression:mandibleRGD 
Mir221Ratgastrointestinal stromal tumor  ISOMIR221 (Homo sapiens)151709005 RGD 
Mir221Rathepatocellular carcinoma disease_progressionISOMIR221 (Homo sapiens)18337267 RGD 
Mir221Rathepatocellular carcinoma treatmentIEP 151893509 RGD 
Mir221Rathepatocellular carcinoma treatmentISOMIR221 (Homo sapiens)18337267 RGD 
Mir221Rathepatocellular carcinoma disease_progressionISOMIR221 (Homo sapiens)11086123 RGD 
Mir221Rathepatocellular carcinoma treatmentISOMIR221 (Homo sapiens)18337275 RGD 
Mir221Rathepatocellular carcinoma treatmentISOMIR221 (Homo sapiens)18337273 RGD 
Mir221Rathepatocellular carcinoma treatmentISOMir221 (Mus musculus)18337275 RGD 
Mir221Rathepatocellular carcinoma treatmentIEP 18337275 RGD 
Mir221Ratintrahepatic cholangiocarcinoma severityISOMIR221 (Homo sapiens)14928335 RGD 
Mir221Ratliver cirrhosis  ISOMir221 (Mus musculus)151709001RNA:increased expression:liverRGD 
Mir221Ratmetabolic dysfunction-associated steatohepatitis treatmentISOMir221 (Mus musculus)18337274 RGD 
Mir221Ratmetabolic dysfunction-associated steatohepatitis disease_progressionISOMIR221 (Homo sapiens)151709001 RGD 
Mir221RatNeuralgia treatmentIMP 151347419 RGD 
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Original Reference(s)
Mir221Ratautistic disorder  ISOMIR221 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Mir221RatKabuki Syndrome 2  ISOMIR221 (Homo sapiens)8554872ClinVar Annotator: match by term: Kabuki syndrome 2ClinVarPMID:25972376
Mir221RatNeurodevelopmental Disorders  ISOMIR221 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Mir221Ratsyndromic X-linked intellectual disability Lubs type  ISOMIR221 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
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Original Reference(s)
Mir221RatBreast Neoplasms  ISOMIR221 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20099276
Mir221Ratcataract  ISOMIR221 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30926320
Mir221RatChemical and Drug Induced Liver Injury  ISOMIR221 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28545106
Mir221RatExperimental Liver Neoplasms  ISOMIR221 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21035526
Mir221RatNeoplasm Metastasis  ISOMIR221 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19487542
Mir221RatNeoplastic Cell Transformation  ISOMIR221 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22048643
Mir221Rattype 2 diabetes mellitus  ISOMIR221 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28545106
Mir221Raturinary bladder cancer  ISOMIR221 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35764155

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Original Reference(s)
Mir221Rat1,2-dichloroethane increases expressionISOMir221 (Mus musculus)6480464ethylene dichloride results in increased expression of MIR221 mRNACTDPMID:28960355
Mir221Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOMir221 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:34967706
Mir221Rat17beta-hydroxy-5alpha-androstan-3-one decreases expressionISOMIR221 (Homo sapiens)6480464Dihydrotestosterone results in decreased expression of MIR221 mRNACTDPMID:25846647
Mir221Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMir221 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of MIR221 mRNACTDPMID:37854252
Mir221Rat2-acetamidofluorene increases expressionEXP 64804642-Acetylaminofluorene results in increased expression of MIR221 mRNACTDPMID:19167416
Mir221Rataflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of MIR221 mRNACTDPMID:24472605
Mir221Ratantigen increases expressionISOMir221 (Mus musculus)6480464Antigens results in increased expression of MIR221 mRNACTDPMID:27038180
Mir221Rataristolochic acid A decreases expressionISOMIR221 (Homo sapiens)6480464aristolochic acid I results in decreased expression of MIR221 mRNACTDPMID:33212167
Mir221Ratarsane multiple interactionsISOMIR221 (Homo sapiens)6480464[sodium arsenate results in increased abundance of Arsenic] which results in increased expression of MIR221 mRNACTDPMID:32525701
Mir221Ratarsenic atom multiple interactionsISOMIR221 (Homo sapiens)6480464[sodium arsenate results in increased abundance of Arsenic] which results in increased expression of MIR221 mRNACTDPMID:32525701
Mir221Ratarsenite(3-) increases expressionISOMIR221 (Homo sapiens)6480464arsenite results in increased expression of MIR221 mRNACTDPMID:22728250
Mir221Ratatorvastatin calcium decreases expressionISOMIR221 (Homo sapiens)6480464Atorvastatin results in decreased expression of MIR221CTDPMID:25517390
Mir221Ratatrazine affects expressionEXP 6480464Atrazine affects the expression of MIR221 mRNACTDPMID:31185338
Mir221Ratatrazine decreases expressionEXP 6480464Atrazine results in decreased expression of MIR221 mRNACTDPMID:34030342 and PMID:36841081
Mir221Ratbenzene decreases expressionISOMir221 (Mus musculus)6480464Benzene results in decreased expression of MIR221 mRNACTDPMID:32105654
Mir221RatBenzo[k]fluoranthene increases expressionISOMIR221 (Homo sapiens)6480464benzo(k)fluoranthene results in increased expression of MIR221 mRNACTDPMID:23993976
Mir221Ratbenzophenone decreases expressionEXP 6480464benzophenone results in decreased expression of MIR221 mRNACTDPMID:22584684
Mir221Ratbis(2-ethylhexyl) phthalate increases expressionEXP 6480464Diethylhexyl Phthalate results in increased expression of MIR221 mRNACTDPMID:22584684
Mir221Ratbis(2-ethylhexyl) phthalate decreases expressionISOMIR221 (Homo sapiens)6480464Diethylhexyl Phthalate results in decreased expression of MIR221CTDPMID:33229049
Mir221Ratbis(2-ethylhexyl) phthalate multiple interactionsISOMir221 (Mus musculus)6480464[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with nonylphenol co-treated with octylphenol] results in decreased expression of MIR221CTDPMID:33086190

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Biological Process
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Original Reference(s)
Mir221Ratcellular response to amino acid stimulus acts_upstream_of_or_withinISOMir221 (Mus musculus)1624291 PMID:20548288RGDPMID:20548288
Mir221Ratcellular response to decreased oxygen levels acts_upstream_of_or_withinISOMir221 (Mus musculus)1624291 PMID:19147652RGDPMID:19147652
Mir221Ratcellular response to glucose stimulus  IEP 152025220 RGD 
Mir221Ratcellular response to nerve growth factor stimulus  IEP 152025188 RGD 
Mir221Ratcellular response to tumor necrosis factor acts_upstream_of_or_withinISOMir221 (Mus musculus)1624291 PMID:19188425RGDPMID:19188425
Mir221Ratinflammatory response acts_upstream_ofISOMIR221 (Homo sapiens)1624291 PMID:20110463RGDPMID:20110463
Mir221Ratlong-term synaptic potentiation acts_upstream_of_or_withinISOMir221 (Mus musculus)1624291 PMID:25858512RGDPMID:25858512
Mir221RatmiRNA-mediated gene silencing by inhibition of translation involved_inISOMIR221 (Homo sapiens)1624291 PMID:19088079 more ...RGDPMID:19088079 more ...
Mir221RatmiRNA-mediated post-transcriptional gene silencing involved_inISOMIR221 (Homo sapiens)1624291RNAcentral:URS00002C6949_9606 PMID:16330772 more ...RGDPMID:16330772 more ...
Mir221Ratnegative regulation of apoptotic process involved_inISOMIR221 (Homo sapiens)1624291 PMID:19671867 and PMID:20813046RGDPMID:19671867 and PMID:20813046
Mir221Ratnegative regulation of cell adhesion molecule production involved_inISOMIR221 (Homo sapiens)1624291RNAcentral:URS00002C6949_9606 PMID:21310411RGDPMID:21310411
Mir221Ratnegative regulation of cell migration involved in sprouting angiogenesis involved_inISOMIR221 (Homo sapiens)1624291UniProtKB:P50222 and PMID:20516212RGDPMID:20516212
Mir221Ratnegative regulation of cell population proliferation involved_inISOMIR221 (Homo sapiens)1624291 PMID:23333386RGDPMID:23333386
Mir221Ratnegative regulation of double-strand break repair involved_inISOMIR221 (Homo sapiens)1624291 PMID:24147153RGDPMID:24147153
Mir221Ratnegative regulation of ERK1 and ERK2 cascade involved_inISOMIR221 (Homo sapiens)1624291 PMID:23333386RGDPMID:23333386
Mir221Ratnegative regulation of hematopoietic stem cell proliferation involved_inISOMIR221 (Homo sapiens)1624291 PMID:16330772RGDPMID:16330772
Mir221Ratnegative regulation of heterotypic cell-cell adhesion involved_inISOMIR221 (Homo sapiens)1624291 PMID:20110463RGDPMID:20110463
Mir221Ratnegative regulation of inflammatory response involved_inISOMIR221 (Homo sapiens)1624291RNAcentral:URS00002C6949_9606 PMID:21310411RGDPMID:21310411
Mir221Ratnegative regulation of interleukin-21 production involved_inISOMIR221 (Homo sapiens)1624291 PMID:28798470RGDPMID:28798470
Mir221Ratnegative regulation of leukocyte adhesion to vascular endothelial cell involved_inISOMIR221 (Homo sapiens)1624291RNAcentral:URS00002C6949_9606 PMID:21310411RGDPMID:21310411
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Cellular Component

  
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Original Reference(s)
Mir221RatRISC complex part_ofISOMir221 (Mus musculus)1624291 PMID:23185045RGDPMID:23185045
Mir221Ratsynapse located_inISOMir221 (Mus musculus)1624291 PMID:23390134RGDPMID:23390134

Molecular Function

  
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Original Reference(s)
Mir221RatmRNA base-pairing translational repressor activity enablesISOMIR221 (Homo sapiens)1624291RNAcentral:URS00002C6949_9606 PMID:16330772 more ...RGDPMID:16330772 more ...


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#
Reference Title
Reference Citation
1. MicroRNA-221 governs tumor suppressor HDAC6 to potentiate malignant progression of liver cancer. Bae HJ, etal., J Hepatol. 2015 Aug;63(2):408-19. doi: 10.1016/j.jhep.2015.03.019. Epub 2015 Mar 25.
2. Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma. Correa-Gallego C, etal., PLoS One. 2016 Sep 29;11(9):e0163699. doi: 10.1371/journal.pone.0163699. eCollection 2016.
3. Evaluation of circulating miR-21 and miR-222 as diagnostic biomarkers for gastric cancer. Emami SS, etal., J Cancer Res Ther. 2019 Jan-Mar;15(1):115-119. doi: 10.4103/jcrt.JCRT_592_17.
4. In Hepatocellular Carcinoma miR-221 Modulates Sorafenib Resistance through Inhibition of Caspase-3-Mediated Apoptosis. Fornari F, etal., Clin Cancer Res. 2017 Jul 15;23(14):3953-3965. doi: 10.1158/1078-0432.CCR-16-1464. Epub 2017 Jan 17.
5. miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition. Gan K, etal., Diabetes Res Clin Pract. 2020 Sep;167:108121. doi: 10.1016/j.diabres.2020.108121. Epub 2020 Mar 16.
6. Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice. Jiang X, etal., EBioMedicine. 2018 Nov;37:307-321. doi: 10.1016/j.ebiom.2018.09.051. Epub 2018 Oct 10.
7. Correlation of the Levels of microRNA with Cell Composition of Axillary Lymph Node in Wistar Rats with Breast Cancer. Kabakov AV, etal., Bull Exp Biol Med. 2020 Feb;168(4):500-502. doi: 10.1007/s10517-020-04740-w. Epub 2020 Mar 10.
8. Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors. Koelz M, etal., Int J Oncol. 2011 Feb;38(2):503-11. doi: 10.3892/ijo.2010.857. Epub 2010 Dec 3.
9. miR-221 suppression through nanoparticle-based miRNA delivery system for hepatocellular carcinoma therapy and its diagnosis as a potential biomarker. Li F, etal., Int J Nanomedicine. 2018 Apr 13;13:2295-2307. doi: 10.2147/IJN.S157805. eCollection 2018.
10. Oroxin B Induces Apoptosis by Down-Regulating MicroRNA-221 Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver Cancer. Li N, etal., Molecules. 2019 Nov 30;24(23). pii: molecules24234384. doi: 10.3390/molecules24234384.
11. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Liu S, etal., Gastroenterology. 2014 Oct;147(4):847-859.e11. doi: 10.1053/j.gastro.2014.06.006. Epub 2014 Jun 12.
12. MicroRNA-221-3p promotes pulmonary artery smooth muscle cells proliferation by targeting AXIN2 during pulmonary arterial hypertension. Nie X, etal., Vascul Pharmacol. 2019 May;116:24-35. doi: 10.1016/j.vph.2017.07.002. Epub 2017 Jul 8.
13. MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis. Ogawa T, etal., Gut. 2012 Nov;61(11):1600-9. doi: 10.1136/gutjnl-2011-300717. Epub 2012 Jan 20.
14. MicroRNA deregulation in human thyroid papillary carcinomas. Pallante P, etal., Endocr Relat Cancer. 2006 Jun;13(2):497-508. doi: 10.1677/erc.1.01209.
15. Estradiol-mediated regulation of hepatic iNOS in obese rats: Impact of Src, ERK1/2, AMPKα, and miR-221. Panic A, etal., Biotechnol Appl Biochem. 2018 Nov;65(6):797-806. doi: 10.1002/bab.1680. Epub 2018 Aug 6.
16. miR-221 silencing blocks hepatocellular carcinoma and promotes survival. Park JK, etal., Cancer Res. 2011 Dec 15;71(24):7608-16. doi: 10.1158/0008-5472.CAN-11-1144. Epub 2011 Oct 18.
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. MicroRNA-221 regulates FAS-induced fulminant liver failure. Sharma AD, etal., Hepatology. 2011 May;53(5):1651-61. doi: 10.1002/hep.24243. Epub 2011 Mar 11.
20. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
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PMID:14691248   PMID:16381832   PMID:16682203   PMID:17604727   PMID:17805466   PMID:18723672   PMID:19147652   PMID:19150885   PMID:19188425   PMID:20403161   PMID:20548288   PMID:21993888  
PMID:23185045   PMID:23390134   PMID:23646144   PMID:24015301   PMID:24604335   PMID:25135725   PMID:25858512   PMID:26232787   PMID:27113449   PMID:27412651   PMID:28821887   PMID:29577996  
PMID:29693157   PMID:30463111   PMID:31587871   PMID:31878844   PMID:32305038   PMID:32648125   PMID:32858649   PMID:33313941   PMID:34018345   PMID:34519137   PMID:34687039   PMID:35186224  
PMID:35591810   PMID:36690096   PMID:37270133   PMID:38043936   PMID:38297513   PMID:38407972  



Mir221
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X6,023,182 - 6,023,290 (+)NCBIGRCr8
mRatBN7.2X3,429,465 - 3,429,573 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX3,429,465 - 3,429,573 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX3,495,164 - 3,495,272 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X6,970,960 - 6,971,068 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X3,288,051 - 3,288,159 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X3,684,480 - 3,684,588 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX3,684,480 - 3,684,588 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X4,475,295 - 4,475,403 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX3,969,242 - 3,969,350 (+)NCBICelera
Cytogenetic MapXq11NCBI
MIR221
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X45,746,157 - 45,746,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX45,746,157 - 45,746,266 (-)EnsemblGRCh38hg38GRCh38
GRCh37X45,605,585 - 45,605,694 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X45,490,528 - 45,490,637 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX49,797,482 - 49,797,591 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX43,320,976 - 43,321,084 (-)NCBIHuRef
CHM1_1X45,638,042 - 45,638,151 (-)NCBICHM1_1
T2T-CHM13v2.0X45,155,612 - 45,155,721 (-)NCBIT2T-CHM13v2.0
Mir221
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X19,012,533 - 19,012,627 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX19,012,533 - 19,012,627 (-)EnsemblGRCm39 Ensembl
GRCm38X19,146,294 - 19,146,388 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX19,146,294 - 19,146,388 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X18,723,420 - 18,723,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX16,722,452 - 16,722,546 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX14.52NCBI
MIR221
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X39,523,890 - 39,523,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX39,523,885 - 39,523,954 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX26,756,912 - 26,756,973 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X39,655,841 - 39,655,902 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X39,646,201 - 39,646,262 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X39,633,218 - 39,633,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X39,725,537 - 39,725,598 (-)NCBIUU_Cfam_GSD_1.0
MIR221
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX40,571,068 - 40,571,137 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X40,571,068 - 40,571,137 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X45,274,873 - 45,274,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3

.

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Cdkn1brno-miR-221-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19150885
Bcl2l11rno-miR-221-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//ReFunctional MTI19438724

Predicted Targets
Summary Value
Count of predictions:8631
Count of gene targets:5787
Count of transcripts:6320
Interacting mature miRNAs:rno-miR-221-3p, rno-miR-221-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 22 60 45 43 13 23 13 6 113 66 40 20 38 30


RefSeq Transcripts NR_031934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX3,429,465 - 3,429,573 (+)Ensembl
Rnor_6.0 EnsemblX3,684,480 - 3,684,588 (+)Ensembl
RefSeq Acc Id: NR_031934
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,023,182 - 6,023,290 (+)NCBI
mRatBN7.2X3,429,465 - 3,429,573 (+)NCBI
Rnor_6.0X3,684,480 - 3,684,588 (+)NCBI
Rnor_5.0X4,475,295 - 4,475,403 (+)NCBI
CeleraX3,969,242 - 3,969,350 (+)NCBI
Sequence:

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 10 of 10 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-3140 BioCyc
Ensembl Genes ENSRNOG00000035631 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053754 ENTREZGENE
miRBase MI0000961 ENTREZGENE
NCBI Gene 100314163 ENTREZGENE
PhenoGen Mir221 PhenoGen
RatGTEx ENSRNOG00000035631 RatGTEx
RNAcentral URS0000170CF4 RNACentral
  URS000075AF41 RNACentral
  URS000075CB96 RNACentral
1 to 10 of 10 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir221  microRNA 221  Mir221  microRNA mir-221  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir221  microRNA mir-221      Symbol and Name status set to provisional 70820 PROVISIONAL