MIR221 (microRNA mir-221) - Rat Genome Database

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Pathways
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Gene: MIR221 (microRNA mir-221) Canis lupus familiaris
Analyze
Symbol: MIR221
Name: microRNA mir-221 (Ensembl:microRNA 221)
RGD ID: 12258079
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-221; microRNA 221
RGD Orthologs
Human
Mouse
Rat
Pig
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X39,523,890 - 39,523,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX39,523,885 - 39,523,954 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX26,756,912 - 26,756,973 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X39,655,841 - 39,655,902 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X39,646,201 - 39,646,262 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X39,633,218 - 39,633,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X39,725,537 - 39,725,598 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to forskolin  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to inorganic substance  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
inflammatory response  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of double-strand break repair  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of hematopoietic stem cell proliferation  (ISO)
negative regulation of heterotypic cell-cell adhesion  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-21 production  (ISO)
negative regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
negative regulation of necroptotic process  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of TRAIL-activated apoptotic signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell differentiation  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of Schwann cell migration  (ISO)
positive regulation of Schwann cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular associated smooth muscle cell dedifferentiation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of wound healing, spreading of epidermal cells  (ISO)
response to estradiol  (ISO)
response to glucose  (ISO)
response to oxygen levels  (ISO)
sensory perception of sound  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component
RISC complex  (IEA)
synapse  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:18392026  


Genomics

Comparative Map Data
MIR221
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X39,523,890 - 39,523,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX39,523,885 - 39,523,954 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX26,756,912 - 26,756,973 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X39,655,841 - 39,655,902 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X39,646,201 - 39,646,262 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X39,633,218 - 39,633,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X39,725,537 - 39,725,598 (-)NCBIUU_Cfam_GSD_1.0
MIR221
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X45,746,157 - 45,746,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX45,746,157 - 45,746,266 (-)EnsemblGRCh38hg38GRCh38
GRCh37X45,605,585 - 45,605,694 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X45,490,528 - 45,490,637 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX49,797,482 - 49,797,591 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX43,320,976 - 43,321,084 (-)NCBIHuRef
CHM1_1X45,638,042 - 45,638,151 (-)NCBICHM1_1
T2T-CHM13v2.0X45,155,612 - 45,155,721 (-)NCBIT2T-CHM13v2.0
Mir221
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X19,012,533 - 19,012,627 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX19,012,533 - 19,012,627 (-)EnsemblGRCm39 Ensembl
GRCm38X19,146,294 - 19,146,388 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX19,146,294 - 19,146,388 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X18,723,420 - 18,723,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX16,722,452 - 16,722,546 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX14.52NCBI
Mir221
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X6,023,182 - 6,023,290 (+)NCBIGRCr8
mRatBN7.2X3,429,465 - 3,429,573 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX3,429,465 - 3,429,573 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX3,495,164 - 3,495,272 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X6,970,960 - 6,971,068 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X3,288,051 - 3,288,159 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X3,684,480 - 3,684,588 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX3,684,480 - 3,684,588 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X4,475,295 - 4,475,403 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX3,969,242 - 3,969,350 (+)NCBICelera
Cytogenetic MapXq11NCBI
MIR221
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX40,571,068 - 40,571,137 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X40,571,068 - 40,571,137 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X45,274,873 - 45,274,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system nervous system respiratory system adipose tissue
High
Medium
Low 2 1 3 5 3 1 6 2
Below cutoff 2 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000032672
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX39,523,885 - 39,523,954 (-)Ensembl
RefSeq Acc Id: NR_049409
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X39,523,890 - 39,523,951 (-)NCBI
Dog10K_Boxer_TashaX26,756,912 - 26,756,973 (-)NCBI
ROS_Cfam_1.0X39,655,841 - 39,655,902 (-)NCBI
UMICH_Zoey_3.1X39,646,201 - 39,646,262 (-)NCBI
UNSW_CanFamBas_1.0X39,633,218 - 39,633,279 (-)NCBI
UU_Cfam_GSD_1.0X39,725,537 - 39,725,598 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020565 Ensembl
  ENSCAFG00845029258 ENTREZGENE
Ensembl Transcript ENSCAFT00845051762 ENTREZGENE
miRBase MI0008183 ENTREZGENE
NCBI Gene MIR221 ENTREZGENE
RNAcentral URS000009C94C RNACentral
  URS00007E4031 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR221  microRNA mir-221    microRNA 221  Symbol and/or name change 5135510 APPROVED