Mir221 (microRNA 221) - Rat Genome Database
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Gene: Mir221 (microRNA 221) Mus musculus
Analyze
Symbol: Mir221
Name: microRNA 221
RGD ID: 1608224
MGI Page MGI
Description: Is expressed in bronchiole; bronchiole epithelium; lung; and lung mesenchyme. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MIR221 (microRNA 221).
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-221; Mirn; Mirn221; mmu-mir-2; mmu-mir-221
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X19,012,533 - 19,012,627 (-)NCBIGRCm39mm39
GRCm39 EnsemblX19,012,533 - 19,012,627 (-)Ensembl
GRCm38X19,146,294 - 19,146,388 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX19,146,294 - 19,146,388 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X18,723,420 - 18,723,514 (-)NCBIGRCm37mm9NCBIm37
CeleraX16,722,452 - 16,722,546 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:12624257   PMID:15634332   PMID:16381832   PMID:16682203   PMID:17369397   PMID:17604727   PMID:18723672   PMID:19109175   PMID:19147652   PMID:19188425   PMID:19859555   PMID:20018759  
PMID:20215419   PMID:20378849   PMID:20413612   PMID:20548288   PMID:20668074   PMID:20813046   PMID:21037258   PMID:21267068   PMID:21993888   PMID:22022537   PMID:22275134   PMID:22473819  
PMID:22511778   PMID:22562984   PMID:22821679   PMID:23185045   PMID:23221369   PMID:23390134   PMID:23409087   PMID:23409140   PMID:23646144   PMID:23716169   PMID:23770133   PMID:23797704  
PMID:24308935   PMID:24401748   PMID:25190143   PMID:25858512   PMID:26206211   PMID:26549234   PMID:26901347   PMID:27338035   PMID:27513632   PMID:28232457   PMID:28274991   PMID:28674181  
PMID:29236311   PMID:29242498   PMID:29276985   PMID:29474925   PMID:29505092   PMID:30089112   PMID:30107296   PMID:30362166   PMID:30582979   PMID:30589396   PMID:31081202   PMID:31208297  
PMID:31312877   PMID:31469602   PMID:32659442   PMID:33276305  


Genomics

Comparative Map Data
Mir221
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X19,012,533 - 19,012,627 (-)NCBIGRCm39mm39
GRCm39 EnsemblX19,012,533 - 19,012,627 (-)Ensembl
GRCm38X19,146,294 - 19,146,388 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX19,146,294 - 19,146,388 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X18,723,420 - 18,723,514 (-)NCBIGRCm37mm9NCBIm37
CeleraX16,722,452 - 16,722,546 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
MIR221
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX45,746,157 - 45,746,266 (-)EnsemblGRCh38hg38GRCh38
GRCh38X45,746,157 - 45,746,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X45,605,585 - 45,605,694 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X45,490,528 - 45,490,637 (-)NCBINCBI36hg18NCBI36
CeleraX49,797,482 - 49,797,591 (-)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX43,320,976 - 43,321,084 (-)NCBIHuRef
CHM1_1X45,638,042 - 45,638,151 (-)NCBICHM1_1
Mir221
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X3,429,465 - 3,429,573 (+)NCBI
Rnor_6.0 EnsemblX3,684,480 - 3,684,588 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X3,684,480 - 3,684,588 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X4,475,295 - 4,475,403 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX3,969,242 - 3,969,350 (+)NCBICelera
Cytogenetic MapXq11NCBI
MIR221
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX39,523,885 - 39,523,954 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X39,523,890 - 39,523,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MIR221
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX40,571,068 - 40,571,137 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X40,571,068 - 40,571,137 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X45,274,873 - 45,274,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301551Spha1_msperm head anomaly 1 (mouse)Not determinedX1039998640832775Mouse
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126335934Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7360056151324042Mouse
13208553Wght11_mweight 11 (mouse)X1200000060000000Mouse
13208557Lgth13_mbody length 13 (mouse)X1200000060000000Mouse

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Fosmmu-miR-221-3pOncomiRDBexternal_infoNANA23400877
Timp3mmu-miR-221-3pOncomiRDBexternal_infoNANA22681957
Gja1mmu-miR-221-3pOncomiRDBexternal_infoNANA22294051
Apaf1mmu-miR-221-3pOncomiRDBexternal_infoNANA22157681
Timp3mmu-miR-221-3pOncomiRDBexternal_infoNANA22009755
Trps1mmu-miR-221-3pOncomiRDBexternal_infoNANA21868360
Dicer1mmu-miR-221-3pOncomiRDBexternal_infoNANA21761362
Ptprmmmu-miR-221-3pOncomiRDBexternal_infoNANA21743492
Trps1mmu-miR-221-3pOncomiRDBexternal_infoNANA21673316
Cdkn1cmmu-miR-221-3pOncomiRDBexternal_infoNANA21278784
Bbc3mmu-miR-221-3pOncomiRDBexternal_infoNANA21042732
Bbc3mmu-miR-221-3pOncomiRDBexternal_infoNANA20813046
Ptenmmu-miR-221-3pOncomiRDBexternal_infoNANA20618998
Kitmmu-miR-221-3pTarbaseexternal_infoOtherPOSITIVE
Foxo3mmu-miR-221-3pOncomiRDBexternal_infoNANA20388878
Ddit4mmu-miR-221-3pOncomiRDBexternal_infoNANA20018759
Ptenmmu-miR-221-3pOncomiRDBexternal_infoNANA19962668
Cdkn1bmmu-miR-221-3pOncomiRDBexternal_infoNANA19749093
Bmfmmu-miR-221-3pOncomiRDBexternal_infoNANA19671867
Cdkn1bmmu-miR-221-3pOncomiRDBexternal_infoNANA21475881
Cdkn1ammu-miR-221-3pOncomiRDBexternal_infoNANA19153141
Kitmmu-miR-221-3pOncomiRDBexternal_infoNANA19126397
Esr1mmu-miR-221-3pOncomiRDBexternal_infoNANA18790736
Cdkn1bmmu-miR-221-3pOncomiRDBexternal_infoNANA18708351
Cdkn1cmmu-miR-221-3pOncomiRDBexternal_infoNANA18521080
Cdkn1bmmu-miR-221-3pOncomiRDBexternal_infoNANA18417445
Kitmmu-miR-221-3pOncomiRDBexternal_infoNANA18246122
Cdkn1bmmu-miR-221-3pOncomiRDBexternal_infoNANA17914108
Cdkn1bmmu-miR-221-3pOncomiRDBexternal_infoNANA17721077
Cdkn1bmmu-miR-221-3pOncomiRDBexternal_infoNANA17627278
Cdkn1bmmu-miR-221-3pOncomiRDBexternal_infoNANA17569667
Kitmmu-miR-221-3pOncomiRDBexternal_infoNANA16330772
Bcl2l11mmu-miR-221-5pMirecordsexternal_infoNANA21911815
Ddit4mmu-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI20018759
Kitmmu-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCRFunctional MTI16330772

Predicted Targets
Summary Value
Count of predictions:30137
Count of gene targets:12213
Count of transcripts:20963
Interacting mature miRNAs:mmu-miR-221-3p, mmu-miR-221-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083488
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX19,146,294 - 19,146,388 (-)Ensembl
RefSeq Acc Id: NR_029806
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X19,012,533 - 19,012,627 (-)NCBI
GRCm38X19,146,294 - 19,146,388 (-)ENTREZGENE
MGSCv37X18,723,420 - 18,723,514 (-)RGD
CeleraX16,722,452 - 16,722,546 (-)RGD
cM MapX ENTREZGENE
Sequence:
Promoters
RGD ID:13680158
Promoter ID:EPDNEW_M24228
Type:single initiation site
Name:Mir221_1
Description:Mus musculus microRNA 221 , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X19,146,305 - 19,146,365EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3619066 AgrOrtholog
Ensembl Genes ENSMUSG00000065422 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083488 ENTREZGENE
MGD MGI:3619066 ENTREZGENE
miRBase MI0000709 ENTREZGENE
NCBI Gene 723827 ENTREZGENE
PhenoGen Mir221 PhenoGen
RNAcentral URS0000170CF4 RNACentral
  URS00003713CD RNACentral
  URS000075A91F RNACentral