Ephx1 (epoxide hydrolase 1) - Rat Genome Database

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Gene: Ephx1 (epoxide hydrolase 1) Rattus norvegicus
Analyze
Symbol: Ephx1
Name: epoxide hydrolase 1
RGD ID: 2557
Description: Exhibits cis-stilbene-oxide hydrolase activity; enzyme binding activity; and epoxide hydrolase activity. Involved in several processes, including cellular response to glucocorticoid stimulus; diol biosynthetic process; and liver development. Localizes to intracellular membrane-bounded organelle and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1); PARTICIPATES IN carbamazepine pharmacokinetics pathway; phenytoin pharmacodynamics pathway; bile acid transport pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: epoxide hydratase; Epoxide hydrolase 1 (microsomal xenobiotic hydrolase; Epoxide hydrolase 1 (microsomal xenobiotic hydrolase); epoxide hydrolase 1, microsomal; epoxide hydrolase 1, microsomal (xenobiotic); liver microsomal xenobiotic epoxide hydrolase; mEH; MEH8; microsomal epoxide hydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,714,315 - 92,744,124 (-)NCBI
Rnor_6.0 Ensembl1399,271,366 - 99,300,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01399,271,390 - 99,300,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013104,268,704 - 104,297,617 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,722,973 - 96,752,940 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,912,126 - 96,925,415 (-)NCBI
Celera1392,256,740 - 92,285,424 (-)NCBICelera
RH 3.4 Map13631.9RGD
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(9R,10S)-9,10-epoxy-9,10-dihydrophenanthrene  (ISO)
(S)-mandelic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dibromoethane  (ISO)
1,2-dihydronaphthalene-1,2-diol  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzofuran  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-tetramine  (EXP)
2,2-Bis(bromomethyl)propane-1,3-diol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-D  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP,ISO)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
2-Oxohexane  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dihydrocoumarin  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-vinylcyclohexene dioxide  (EXP,ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8,9-EET  (ISO)
8-Br-cAMP  (ISO)
9,10-epoxy-9,10-dihydrophenanthrene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
aniline  (ISO)
aristolochic acid  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
barbiturates  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
Benzo[a]pyrene-7,8-oxide  (EXP)
benzo[b]fluoranthene  (ISO)
benzo[c]phenanthrene  (ISO)
benzothiazole  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbamazepine-10,11-epoxide  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
catechol  (EXP)
chenodeoxycholic acid  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clomipramine  (EXP)
clonazepam  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
cyproconazole  (EXP,ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (EXP)
Dihydroxycarbazepine  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (EXP,ISO)
ethanol  (EXP,ISO)
ethoxyquin  (EXP)
etoposide  (ISO)
felbamate  (EXP)
fenamidone  (ISO)
fenvalerate  (EXP)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
glafenine  (EXP)
glucoerucin  (EXP)
glucoerucin(1-)  (EXP)
glucoraphanin  (EXP)
glutathione  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
Heliotrine  (EXP)
Heptachlor epoxide  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
HT-2 toxin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP)
imipramine  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
ketoconazole  (EXP)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
lanosterol  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levofloxacin  (EXP)
lithocholic acid  (ISO)
malathion  (ISO)
mandelic acid  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
muconic acid  (ISO)
N,N'-diphenylthiourea  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-Methylolacrylamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
naphthalene-1,5-diamine  (ISO)
nefazodone  (EXP,ISO)
nickel atom  (ISO)
nimesulide  (EXP,ISO)
ochratoxin A  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
oxirane  (EXP,ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
pentachloronitrobenzene  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenol  (EXP)
phenols  (ISO)
phenylglyoxylic acid  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramide mustard  (EXP)
pimecrolimus  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (EXP,ISO)
propionamide  (EXP,ISO)
pyrazinecarboxamide  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
stilbene oxide  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP)
styrene  (EXP,ISO)
styrene oxide  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thiazoles  (EXP)
thioacetamide  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tridiphane  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
warfarin  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
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2. Andrew AS, etal., Hum Genet. 2009 Jun;125(5-6):527-39. Epub 2009 Mar 1.
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4. Bell PA and Kasper CB, J Biol Chem. 1993 Jul 5;268(19):14011-7.
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12. Christou M, etal., Carcinogenesis. 1989 Oct;10(10):1883-90.
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16. Farin FM, etal., Pharmacogenetics. 2001 Nov;11(8):703-8.
17. Friedberg T, etal., Carcinogenesis. 1994 Feb;15(2):171-5.
18. GOA data from the GO Consortium
19. Gold LS, etal., Cancer Epidemiol. 2009 Oct;33(3-4):276-80. doi: 10.1016/j.canep.2009.08.005. Epub 2009 Sep 6.
20. Holler R, etal., Biochem Biophys Res Commun. 1997 Jul 30;236(3):754-9.
21. Horska A, etal., Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:100-3.
22. Hu G, etal., Respirology. 2008 Nov;13(6):837-50.
23. Ishikawa K, etal., Jpn J Ophthalmol. 2005 Mar-Apr;49(2):121-6.
24. Jia Y, etal., Microvasc Res. 2011 Jan;81(1):73-80. Epub 2010 Nov 12.
25. KEGG
26. Kezic S, etal., Toxicol Ind Health. 2006 Aug;22(7):281-9.
27. Khrunin AV, etal., Pharmacogenomics. 2014 Feb;15(3):329-37. doi: 10.2217/pgs.13.237.
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38. Makhlouf MM and Magdy RI, Biomarkers. 2016 Mar 21:1-8.
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41. Mesange F, etal., Biochem J. 1998 Aug 15;334 ( Pt 1):107-12.
42. MGD data from the GO Consortium
43. NCBI rat LocusLink and RefSeq merged data July 26, 2002
44. Neri M, etal., Int J Hyg Environ Health. 2006 Jul;209(4):393-8. Epub 2006 May 11.
45. OMIM Disease Annotation Pipeline
46. Pipeline to import KEGG annotations from KEGG into RGD
47. Pipeline to import SMPDB annotations from SMPDB into RGD
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51. RGD automated data pipeline
52. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:10446164   PMID:15047867   PMID:15489334   PMID:20396348   PMID:22061827   PMID:24958911   PMID:28736260  


Genomics

Comparative Map Data
Ephx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,714,315 - 92,744,124 (-)NCBI
Rnor_6.0 Ensembl1399,271,366 - 99,300,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01399,271,390 - 99,300,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013104,268,704 - 104,297,617 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,722,973 - 96,752,940 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,912,126 - 96,925,415 (-)NCBI
Celera1392,256,740 - 92,285,424 (-)NCBICelera
RH 3.4 Map13631.9RGD
Cytogenetic Map13q26NCBI
EPHX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1225,810,124 - 225,845,563 (+)EnsemblGRCh38hg38GRCh38
GRCh381225,810,124 - 225,845,563 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371225,997,826 - 226,033,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,079,599 - 224,099,884 (+)NCBINCBI36hg18NCBI36
Build 341222,319,710 - 222,339,996NCBI
Celera1199,188,853 - 199,224,327 (+)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1196,515,661 - 196,550,964 (+)NCBIHuRef
CHM1_11227,270,100 - 227,305,585 (+)NCBICHM1_1
Ephx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,817,121 - 180,845,134 (-)NCBIGRCm39mm39
GRCm39 Ensembl1180,803,775 - 180,848,469 (-)Ensembl
GRCm381180,989,556 - 181,017,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,976,210 - 181,020,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,919,687 - 182,947,626 (-)NCBIGRCm37mm9NCBIm37
MGSCv361182,826,231 - 182,854,170 (-)NCBImm8
Celera1188,055,356 - 188,083,565 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.48NCBI
Ephx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955520116,363 - 128,665 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955520116,363 - 142,983 (-)NCBIChiLan1.0ChiLan1.0
EPHX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11206,272,866 - 206,307,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1206,272,866 - 206,307,581 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01201,271,366 - 201,306,635 (+)NCBIMhudiblu_PPA_v0panPan3
EPHX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,964,319 - 39,004,902 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,964,338 - 38,999,238 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha738,446,530 - 38,481,524 (-)NCBI
ROS_Cfam_1.0738,798,288 - 38,833,289 (-)NCBI
UMICH_Zoey_3.1738,638,072 - 38,673,037 (-)NCBI
UNSW_CanFamBas_1.0738,646,207 - 38,681,169 (-)NCBI
UU_Cfam_GSD_1.0738,915,983 - 38,950,983 (-)NCBI
Ephx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934452,094,468 - 52,163,372 (-)NCBI
SpeTri2.0NW_0049365262,589,254 - 2,652,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1013,735,170 - 13,773,071 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11013,757,489 - 13,773,071 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,016,584 - 16,054,476 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHX1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,924,396 - 3,960,264 (-)NCBI
ChlSab1.1 Ensembl253,924,606 - 3,945,535 (-)Ensembl
Vero_WHO_p1.0NW_0236660553,930,701 - 3,966,856 (-)NCBI
Ephx1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248356,161,930 - 6,181,016 (-)NCBI

Position Markers
Ephx1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,716,681 - 92,716,790 (+)MAPPER
Rnor_6.01399,273,757 - 99,273,865NCBIRnor6.0
Rnor_5.013104,271,071 - 104,271,179UniSTSRnor5.0
RGSC_v3.41396,725,337 - 96,725,445UniSTSRGSC3.4
Celera1392,259,107 - 92,259,215UniSTS
Cytogenetic Map13q26UniSTS
RH94562  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,714,240 - 92,714,327 (+)MAPPER
mRatBN7.21392,790,387 - 92,790,474 (+)MAPPER
Rnor_6.01399,346,749 - 99,346,835NCBIRnor6.0
Rnor_6.01399,271,316 - 99,271,402NCBIRnor6.0
Rnor_5.013104,343,786 - 104,343,872UniSTSRnor5.0
Rnor_5.013104,268,630 - 104,268,716UniSTSRnor5.0
RGSC_v3.41396,722,896 - 96,722,982UniSTSRGSC3.4
RGSC_v3.41396,799,199 - 96,799,285UniSTSRGSC3.4
Celera1392,331,667 - 92,331,753UniSTS
Celera1392,256,666 - 92,256,752UniSTS
RH 3.4 Map13631.9UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:142997  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,716,681 - 92,716,791 (+)MAPPER
Rnor_6.01399,273,757 - 99,273,866NCBIRnor6.0
Rnor_5.013104,271,071 - 104,271,180UniSTSRnor5.0
RGSC_v3.41396,725,337 - 96,725,446UniSTSRGSC3.4
Celera1392,259,107 - 92,259,216UniSTS
Cytogenetic Map13q26UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1357903612102903612Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1379567081103613733Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1380403559108770687Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1386833393114033958Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000004780
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 1 1
Medium 3 6 52 40 15 40 2 39 35 34 11
Low 37 4 4 8 9 35 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004780   ⟹   ENSRNOP00000004780
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1399,271,390 - 99,287,887 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085279   ⟹   ENSRNOP00000074206
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1399,271,366 - 99,300,579 (-)Ensembl
RefSeq Acc Id: NM_001034090   ⟹   NP_001029262
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21392,714,315 - 92,744,124 (-)NCBI
Rnor_6.01399,271,390 - 99,300,580 (-)NCBI
Rnor_5.013104,268,704 - 104,297,617 (-)NCBI
RGSC_v3.41396,722,973 - 96,752,940 (-)RGD
Celera1392,256,740 - 92,285,424 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012844   ⟹   NP_036976
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21392,714,315 - 92,731,364 (-)NCBI
Rnor_6.01399,271,390 - 99,287,887 (-)NCBI
Rnor_5.013104,268,704 - 104,297,617 (-)NCBI
RGSC_v3.41396,722,973 - 96,752,940 (-)RGD
Celera1392,256,740 - 92,272,686 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090378   ⟹   XP_038946306
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21392,714,315 - 92,731,911 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001029262   ⟸   NM_001034090
- Peptide Label: precursor
- UniProtKB: P07687 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_036976   ⟸   NM_012844
- Peptide Label: precursor
- UniProtKB: P07687 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074206   ⟸   ENSRNOT00000085279
RefSeq Acc Id: ENSRNOP00000004780   ⟸   ENSRNOT00000004780
RefSeq Acc Id: XP_038946306   ⟸   XM_039090378
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699065
Promoter ID:EPDNEW_R9590
Type:multiple initiation site
Name:Ephx1_2
Description:epoxide hydrolase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9591  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01399,287,887 - 99,287,947EPDNEW
RGD ID:13699066
Promoter ID:EPDNEW_R9591
Type:initiation region
Name:Ephx1_1
Description:epoxide hydrolase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9590  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01399,300,536 - 99,300,596EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2557 AgrOrtholog
Ensembl Genes ENSRNOG00000003515 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004780 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074206 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004780 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000085279 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889368 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Epox_hydrolase-like UniProtKB/Swiss-Prot
  Epoxide_hydro_N UniProtKB/Swiss-Prot
  Epoxide_hydrolase UniProtKB/Swiss-Prot
KEGG Report rno:25315 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72921 IMAGE-MGC_LOAD
NCBI Gene 25315 ENTREZGENE
Pfam EHN UniProtKB/Swiss-Prot
PharmGKB EPHX1 RGD
PhenoGen Ephx1 PhenoGen
PIRSF Epoxide_hydrolase UniProtKB/Swiss-Prot
PRINTS EPOXHYDRLASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt HYEP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Ephx1  epoxide hydrolase 1  Ephx1  epoxide hydrolase 1, microsomal (xenobiotic)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Ephx1  epoxide hydrolase 1, microsomal (xenobiotic)  Ephx1  epoxide hydrolase 1, microsomal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ephx1  epoxide hydrolase 1, microsomal    epoxide hydrolase 1  Name updated 1299863 APPROVED
2002-11-06 Ephx1  epoxide hydrolase 1    Epoxide hydrolase 1 (microsomal xenobiotic hydrolase)  Name updated 625702 APPROVED
2002-06-10 Ephx1  Epoxide hydrolase 1 (microsomal xenobiotic hydrolase)      Symbol and Name status set to approved 70586 APPROVED