Ephx1 (epoxide hydrolase 1) - Rat Genome Database

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Gene: Ephx1 (epoxide hydrolase 1) Rattus norvegicus
Analyze
Symbol: Ephx1
Name: epoxide hydrolase 1
RGD ID: 2557
Description: Enables cis-stilbene-oxide hydrolase activity and enzyme binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; diol biosynthetic process; and liver development. Located in intracellular membrane-bounded organelle and membrane. Biomarker of aflatoxins-related hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1); PARTICIPATES IN carbamazepine pharmacokinetics pathway; phenytoin pharmacodynamics pathway; bile acid transport pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: epoxide hydratase; Epoxide hydrolase 1 (microsomal xenobiotic hydrolase; Epoxide hydrolase 1 (microsomal xenobiotic hydrolase); epoxide hydrolase 1, microsomal; epoxide hydrolase 1, microsomal (xenobiotic); liver microsomal xenobiotic epoxide hydrolase; mEH; MEH8; microsomal epoxide hydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81395,246,079 - 95,275,852 (-)NCBIGRCr8
mRatBN7.21392,714,315 - 92,744,105 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,714,315 - 92,790,235 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1395,219,628 - 95,249,435 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01396,619,561 - 96,649,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01393,794,258 - 93,824,062 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01399,271,390 - 99,300,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1399,271,366 - 99,300,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013104,268,704 - 104,297,617 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,722,973 - 96,752,940 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,912,126 - 96,925,415 (-)NCBI
Celera1392,256,740 - 92,285,424 (-)NCBICelera
RH 3.4 Map13631.9RGD
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(9R,10S)-9,10-epoxy-9,10-dihydrophenanthrene  (ISO)
(S)-mandelic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dibromoethane  (ISO)
1,2-dihydronaphthalene-1,2-diol  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trimethylbenzene  (ISO)
1,4-dioxane  (ISO)
1-benzofuran  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-tetramine  (EXP)
2,2-Bis(bromomethyl)propane-1,3-diol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-D  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
2-Oxohexane  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dihydrocoumarin  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-vinylcyclohexene dioxide  (EXP,ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8,9-EET  (ISO)
8-Br-cAMP  (ISO)
9,10-epoxy-9,10-dihydrophenanthrene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
aniline  (ISO)
antimonite  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
barbiturates  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
Benzo[a]pyrene-7,8-oxide  (EXP)
benzo[b]fluoranthene  (ISO)
benzo[c]phenanthrene  (ISO)
benzothiazole  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbamazepine-10,11-epoxide  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
catechol  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clomipramine  (EXP)
clonazepam  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
cyproconazole  (EXP,ISO)
DDE  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP,ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
dibenzoylmethane  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (EXP)
Dihydroxycarbazepine  (ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (EXP,ISO)
Erucin  (EXP)
estradiol  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (EXP)
ethylparaben  (ISO)
etoposide  (ISO)
felbamate  (EXP)
fenamidone  (ISO)
fenvalerate  (EXP)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folpet  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucoerucin  (EXP)
glucoerucin(1-)  (EXP)
glucoraphanin  (EXP)
glutathione  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
Heliotrine  (EXP)
Heptachlor epoxide  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
HT-2 toxin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP)
imipramine  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
lanosterol  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
levofloxacin  (EXP)
lithocholic acid  (ISO)
m-xylene  (ISO)
malathion  (ISO)
mandelic acid  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
muconic acid  (ISO)
N,N'-diphenylthiourea  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-Methylolacrylamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
naphthalene-1,5-diamine  (ISO)
nefazodone  (EXP,ISO)
nickel atom  (ISO)
nimesulide  (EXP,ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
oxirane  (EXP,ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
pentachloronitrobenzene  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenol  (EXP)
phenols  (ISO)
phenylglyoxylic acid  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramide mustard  (EXP)
pimecrolimus  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (EXP,ISO)
propionamide  (EXP,ISO)
pyrazinecarboxamide  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
stilbene oxide  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP)
styrene  (EXP,ISO)
styrene oxide  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
Tetramethylthiourea  (EXP)
tetraphene  (ISO)
thiazoles  (EXP)
thioacetamide  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
Tridiphane  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
warfarin  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GSTM1 and mEPHX polymorphisms in Parkinson's disease and age of onset. Ahmadi A, etal., Biochem Biophys Res Commun. 2000 Mar 24;269(3):676-80.
2. Bladder cancer SNP panel predicts susceptibility and survival. Andrew AS, etal., Hum Genet. 2009 Jun;125(5-6):527-39. Epub 2009 Mar 1.
3. Catalytic triad of microsomal epoxide hydrolase: replacement of Glu404 with Asp leads to a strongly increased turnover rate. Arand M, etal., Biochem J. 1999 Jan 1;337 ( Pt 1):37-43.
4. Expression of rat microsomal epoxide hydrolase in Escherichia coli. Identification of a histidyl residue essential for catalysis. Bell PA and Kasper CB, J Biol Chem. 1993 Jul 5;268(19):14011-7.
5. Glucocorticoid repression and basal regulation of the epoxide hydrolase promoter. Bell PA, etal., Arch Biochem Biophys. 1990 Jun;279(2):363-9.
6. Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE). Bonaventure A, etal., Cancer Causes Control. 2012 Feb;23(2):329-45. doi: 10.1007/s10552-011-9882-9. Epub 2011 Dec 27.
7. Genetic susceptibility for emphysematous changes of the lung in Japanese. Budhi A, etal., Int J Mol Med. 2003 Mar;11(3):321-9.
8. Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells. Chang HS, etal., Nutr Res. 2010 Jun;30(6):435-40.
9. Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD. Chappell S, etal., Eur Respir J. 2008 Oct;32(4):931-7. Epub 2008 Jul 9.
10. Association of glutathione S-transferase, EPHX, and p53 codon 72 gene polymorphisms with adult acute myeloid leukemia. Chauhan PS, etal., DNA Cell Biol. 2011 Jan;30(1):39-46. doi: 10.1089/dna.2010.1092. Epub 2010 Aug 23.
11. High order interactions of xenobiotic metabolizing genes and P53 codon 72 polymorphisms in acute leukemia. Chauhan PS, etal., Environ Mol Mutagen. 2012 Oct;53(8):619-30. doi: 10.1002/em.21723. Epub 2012 Aug 29.
12. Epoxide hydratase: sex specific expression and rate-limiting role in DMBA metabolism. Christou M, etal., Carcinogenesis. 1989 Oct;10(10):1883-90.
13. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. Decker M, etal., J Lipid Res. 2012 Oct;53(10):2038-45. doi: 10.1194/jlr.M024448. Epub 2012 Jul 12.
14. Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma. Durie BG, etal., Leukemia. 2009 Oct;23(10):1913-9. doi: 10.1038/leu.2009.129. Epub 2009 Aug 6.
15. Structure and organization of the microsomal xenobiotic epoxide hydrolase gene. Falany CN, etal., J Biol Chem 1987 Apr 25;262(12):5924-30.
16. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. Farin FM, etal., Pharmacogenetics. 2001 Nov;11(8):703-8.
17. Studies on the importance of microsomal epoxide hydrolase in the detoxification of arene oxides using the heterologous expression of the enzyme in mammalian cells. Friedberg T, etal., Carcinogenesis. 1994 Feb;15(2):171-5.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. Gold LS, etal., Cancer Epidemiol. 2009 Oct;33(3-4):276-80. doi: 10.1016/j.canep.2009.08.005. Epub 2009 Sep 6.
21. The membrane anchor of microsomal epoxide hydrolase from human, rat, and rabbit displays an unexpected membrane topology. Holler R, etal., Biochem Biophys Res Commun. 1997 Jul 30;236(3):754-9.
22. Genetic predisposition and health effect of occupational exposure to asbestos. Horska A, etal., Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:100-3.
23. Association between polymorphisms of microsomal epoxide hydrolase and COPD: results from meta-analyses. Hu G, etal., Respirology. 2008 Nov;13(6):837-50.
24. Genetic variants of TP53 and EPHX1 in Leber's hereditary optic neuropathy and their relationship to age at onset. Ishikawa K, etal., Jpn J Ophthalmol. 2005 Mar-Apr;49(2):121-6.
25. In vivo optical imaging of revascularization after brain trauma in mice. Jia Y, etal., Microvasc Res. 2011 Jan;81(1):73-80. Epub 2010 Nov 12.
26. Induced hepatotoxicity in female rats by aflatoxin B1 and ethynylestradiol interaction. Kamdem L, etal., Toxicol Appl Pharmacol. 1983 Jan;67(1):26-40. doi: 10.1016/0041-008x(83)90241-7.
27. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
28. Genetic polymorphism of metabolic enzymes modifies the risk of chronic solvent-induced encephalopathy. Kezic S, etal., Toxicol Ind Health. 2006 Aug;22(7):281-9.
29. Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer. Khrunin AV, etal., Pharmacogenomics. 2014 Feb;15(3):329-37. doi: 10.2217/pgs.13.237.
30. Association of COPD candidate genes with CT emphysema and airway phenotypes in severe COPD. Kim WJ, etal., Eur Respir J. 2010 Jun 4.
31. [Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases] Korytina GF, etal., Mol Biol (Mosk). 2003 Sep-Oct;37(5):784-92.
32. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
33. Microsomal Epoxide Hydrolase Gene Polymorphisms and Susceptibility to Chronic Obstructive Pulmonary Disease in Tunisian Population. Lakhdar R, etal., Genet Test Mol Biomarkers. 2010 Oct 9.
34. Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities. Lebailly P, etal., Br J Haematol. 2002 Mar;116(3):587-94.
35. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. Li N, etal., J Mol Cell Cardiol. 2009 Dec;47(6):835-45. Epub 2009 Aug 28.
36. Genetic polymorphism and gene expression of microsomal epoxide hydrolase in non-small cell lung cancer. Lin TS, etal., Oncol Rep. 2007 Mar;17(3):565-72.
37. Genetic variations in benzene metabolism and susceptibility to multiple myeloma. Lincz LF, etal., Leuk Res. 2007 Jun;31(6):759-63. Epub 2006 Sep 1.
38. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. Liu JY, etal., Br J Pharmacol. 2009 Jan;156(2):284-96. Epub 2009 Jan 13.
39. Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin. Liu M, etal., Eur J Neurosci. 2006 Apr;23(8):2027-34.
40. The clinical relevance and prognostic significance of microsomal epoxide hydrolase gene polymorphisms and their susceptibility to acquired aplastic anemia: an Egyptian study. Makhlouf MM and Magdy RI, Biomarkers. 2016 Mar 21:1-8.
41. Genetic variants and multiple myeloma risk: IMMEnSE validation of the best reported associations--an extensive replication of the associations from the candidate gene era. Martino A, etal., Cancer Epidemiol Biomarkers Prev. 2014 Apr;23(4):670-4. doi: 10.1158/1055-9965.EPI-13-1115. Epub 2014 Feb 12.
42. Microsomal epoxide hydrolase is not associated with COPD in a community-based sample. Matheson MC, etal., Hum Biol. 2006 Dec;78(6):705-17.
43. Microsomal epoxide hydrolase of rat liver is a subunit of theanti-oestrogen-binding site. Mesange F, etal., Biochem J. 1998 Aug 15;334 ( Pt 1):107-12.
44. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
45. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations. Neri M, etal., Int J Hyg Environ Health. 2006 Jul;209(4):393-8. Epub 2006 May 11.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
50. Complementary DNA and amino acid sequence of rat liver microsomal, xenobiotic epoxide hydrolase. Porter TD, etal., Arch Biochem Biophys 1986 Jul;248(1):121-9.
51. Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase. Qamar W, etal., Toxicology. 2012 Jan 27;291(1-3):25-31. Epub 2011 Oct 25.
52. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Revermann M, etal., Arterioscler Thromb Vasc Biol. 2010 May;30(5):909-14. Epub 2010 Mar 11.
53. GOA pipeline RGD automated data pipeline
54. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
55. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
56. Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma. Salam MT, etal., Thorax. 2007 Dec;62(12):1050-7. Epub 2007 Aug 21.
57. Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas. Sarmanova J, etal., Hum Mol Genet. 2001 Jun 1;10(12):1265-73.
58. Effects of hepatocarcinogens and hepatocarcinogenesis on the activity of rat liver microsomal epoxide hydrolase and observations on the electrophoretic behavior of this enzyme. Sharma RN, etal., Cancer Res. 1981 Sep;41(9 Pt 1):3311-9.
59. Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children. Silveira Vda S, etal., Environ Mol Mutagen. 2010 Jan;51(1):48-56. doi: 10.1002/em.20510.
60. Quantitation of mRNAs specific for the mixed-function oxidase system in rat liver and extrahepatic tissues during development. Simmons DL and Kasper CB, Arch Biochem Biophys. 1989 May 15;271(1):10-20.
61. Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema. Smith CA and Harrison DJ, Lancet. 1997 Aug 30;350(9078):630-3.
62. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
63. Gene polymorphism for microsomal epoxide hydrolase and susceptibility to emphysema in a Japanese population. Takeyabu K, etal., Eur Respir J. 2000 May;15(5):891-4.
64. Interaction between cytochrome P450 and other drug-metabolizing enzymes: evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase. Taura KI, etal., Biochem Biophys Res Commun. 2000 Jul 14;273(3):1048-52.
65. Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia. Tumer TB, etal., Arch Toxicol. 2012 Mar;86(3):431-9. doi: 10.1007/s00204-011-0760-8. Epub 2011 Oct 9.
66. Genetic polymorphisms of glutathione-S-transferase and microsomal epoxide hydrolase in egyptian acquired aplastic anemia patients. Youssry I, etal., J Pediatr Hematol Oncol. 2011 Mar;33(2):89-92. doi: 10.1097/MPH.0b013e3181ff78ce.
67. Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia. Zhang W, etal., J Cereb Blood Flow Metab. 2009 Aug;29(8):1475-81. Epub 2009 May 27.
68. Membrane topology and cell surface targeting of microsomal epoxide hydrolase. Evidence for multiple topological orientations. Zhu Q, etal., J Biol Chem. 1999 Sep 24;274(39):27898-904.
69. Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia. Zhu QS, etal., Biochim Biophys Acta. 2003 Jul 30;1638(3):208-16.
70. A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. Zusterzeel PL, etal., J Med Genet. 2001 Apr;38(4):234-7.
Additional References at PubMed
PMID:10446164   PMID:15047867   PMID:15489334   PMID:20396348   PMID:22061827   PMID:24958911   PMID:28736260  


Genomics

Comparative Map Data
Ephx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81395,246,079 - 95,275,852 (-)NCBIGRCr8
mRatBN7.21392,714,315 - 92,744,105 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,714,315 - 92,790,235 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1395,219,628 - 95,249,435 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01396,619,561 - 96,649,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01393,794,258 - 93,824,062 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01399,271,390 - 99,300,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1399,271,366 - 99,300,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013104,268,704 - 104,297,617 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,722,973 - 96,752,940 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,912,126 - 96,925,415 (-)NCBI
Celera1392,256,740 - 92,285,424 (-)NCBICelera
RH 3.4 Map13631.9RGD
Cytogenetic Map13q26NCBI
EPHX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381225,810,124 - 225,845,563 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1225,810,124 - 225,845,563 (+)EnsemblGRCh38hg38GRCh38
GRCh371225,997,826 - 226,033,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,079,599 - 224,099,884 (+)NCBINCBI36Build 36hg18NCBI36
Build 341222,319,710 - 222,339,996NCBI
Celera1199,188,853 - 199,224,327 (+)NCBICelera
Cytogenetic Map1q42.12NCBI
HuRef1196,515,661 - 196,550,964 (+)NCBIHuRef
CHM1_11227,270,121 - 227,305,585 (+)NCBICHM1_1
T2T-CHM13v2.01224,998,070 - 225,033,336 (+)NCBIT2T-CHM13v2.0
Ephx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,817,121 - 180,845,134 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,803,775 - 180,848,469 (-)EnsemblGRCm39 Ensembl
GRCm381180,989,556 - 181,017,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,976,210 - 181,020,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,919,687 - 182,947,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,826,231 - 182,854,170 (-)NCBIMGSCv36mm8
Celera1188,055,356 - 188,083,565 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.48NCBI
Ephx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955520116,363 - 128,665 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955520116,363 - 142,983 (-)NCBIChiLan1.0ChiLan1.0
EPHX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2123,692,322 - 23,727,663 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1123,640,786 - 23,675,962 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01201,271,366 - 201,306,635 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11206,272,866 - 206,307,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1206,272,866 - 206,307,581 (+)Ensemblpanpan1.1panPan2
EPHX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,964,319 - 39,004,902 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,964,338 - 38,999,238 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha738,446,530 - 38,481,524 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,798,288 - 38,833,289 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl738,798,291 - 38,833,208 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1738,638,072 - 38,673,037 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0738,646,207 - 38,681,169 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0738,915,983 - 38,950,983 (-)NCBIUU_Cfam_GSD_1.0
Ephx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934452,094,468 - 52,163,372 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365262,614,059 - 2,653,286 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365262,589,254 - 2,652,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1013,751,881 - 13,773,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11013,757,489 - 13,773,071 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,016,584 - 16,054,476 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,924,396 - 3,960,264 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl253,924,606 - 3,945,535 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660553,930,701 - 3,966,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ephx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248356,162,111 - 6,168,714 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248356,161,930 - 6,181,016 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ephx1
257 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000004780
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
Ephx1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,716,681 - 92,716,790 (+)MAPPERmRatBN7.2
Rnor_6.01399,273,757 - 99,273,865NCBIRnor6.0
Rnor_5.013104,271,071 - 104,271,179UniSTSRnor5.0
RGSC_v3.41396,725,337 - 96,725,445UniSTSRGSC3.4
Celera1392,259,107 - 92,259,215UniSTS
Cytogenetic Map13q26UniSTS
RH94562  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,714,240 - 92,714,327 (+)MAPPERmRatBN7.2
mRatBN7.21392,790,387 - 92,790,474 (+)MAPPERmRatBN7.2
Rnor_6.01399,346,749 - 99,346,835NCBIRnor6.0
Rnor_6.01399,271,316 - 99,271,402NCBIRnor6.0
Rnor_5.013104,343,786 - 104,343,872UniSTSRnor5.0
Rnor_5.013104,268,630 - 104,268,716UniSTSRnor5.0
RGSC_v3.41396,722,896 - 96,722,982UniSTSRGSC3.4
RGSC_v3.41396,799,199 - 96,799,285UniSTSRGSC3.4
Celera1392,331,667 - 92,331,753UniSTS
Celera1392,256,666 - 92,256,752UniSTS
RH 3.4 Map13631.9UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:142997  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,716,681 - 92,716,791 (+)MAPPERmRatBN7.2
Rnor_6.01399,273,757 - 99,273,866NCBIRnor6.0
Rnor_5.013104,271,071 - 104,271,180UniSTSRnor5.0
RGSC_v3.41396,725,337 - 96,725,446UniSTSRGSC3.4
Celera1392,259,107 - 92,259,216UniSTS
Cytogenetic Map13q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004780   ⟹   ENSRNOP00000004780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,714,319 - 92,790,235 (-)Ensembl
Rnor_6.0 Ensembl1399,271,390 - 99,287,887 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000029787   ⟹   ENSRNOP00000034917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,714,316 - 92,744,054 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085279   ⟹   ENSRNOP00000074206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,714,315 - 92,727,979 (-)Ensembl
Rnor_6.0 Ensembl1399,271,366 - 99,300,579 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109605   ⟹   ENSRNOP00000080132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,714,315 - 92,725,978 (-)Ensembl
RefSeq Acc Id: NM_001034090   ⟹   NP_001029262
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81395,246,079 - 95,275,852 (-)NCBI
mRatBN7.21392,714,318 - 92,744,105 (-)NCBI
Rnor_6.01399,271,390 - 99,300,580 (-)NCBI
Rnor_5.013104,268,704 - 104,297,617 (-)NCBI
RGSC_v3.41396,722,973 - 96,752,940 (-)RGD
Celera1392,256,740 - 92,285,424 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012844   ⟹   NP_036976
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81395,246,079 - 95,263,117 (-)NCBI
mRatBN7.21392,714,318 - 92,731,364 (-)NCBI
Rnor_6.01399,271,390 - 99,287,887 (-)NCBI
Rnor_5.013104,268,704 - 104,297,617 (-)NCBI
RGSC_v3.41396,722,973 - 96,752,940 (-)RGD
Celera1392,256,740 - 92,272,686 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090378   ⟹   XP_038946306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81395,246,079 - 95,263,682 (-)NCBI
mRatBN7.21392,714,315 - 92,731,911 (-)NCBI
RefSeq Acc Id: NP_001029262   ⟸   NM_001034090
- UniProtKB: P07687 (UniProtKB/Swiss-Prot),   A6JGI7 (UniProtKB/TrEMBL),   A0A8L2R8K5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_036976   ⟸   NM_012844
- UniProtKB: P07687 (UniProtKB/Swiss-Prot),   A6JGI7 (UniProtKB/TrEMBL),   A0A8L2R8K5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074206   ⟸   ENSRNOT00000085279
Ensembl Acc Id: ENSRNOP00000004780   ⟸   ENSRNOT00000004780
RefSeq Acc Id: XP_038946306   ⟸   XM_039090378
- Peptide Label: isoform X1
- UniProtKB: P07687 (UniProtKB/Swiss-Prot),   A6JGI7 (UniProtKB/TrEMBL),   A0A8L2R8K5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080132   ⟸   ENSRNOT00000109605
Ensembl Acc Id: ENSRNOP00000034917   ⟸   ENSRNOT00000029787
Protein Domains
AB hydrolase-1   Epoxide hydrolase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTS8-F1-model_v2 AlphaFold F1LTS8 1-453 view protein structure
AF-P07687-F1-model_v2 AlphaFold P07687 1-455 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699065
Promoter ID:EPDNEW_R9590
Type:multiple initiation site
Name:Ephx1_2
Description:epoxide hydrolase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9591  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01399,287,887 - 99,287,947EPDNEW
RGD ID:13699066
Promoter ID:EPDNEW_R9591
Type:initiation region
Name:Ephx1_1
Description:epoxide hydrolase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9590  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01399,300,536 - 99,300,596EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2557 AgrOrtholog
BioCyc Gene G2FUF-17106 BioCyc
Ensembl Genes ENSRNOG00000003515 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055012533 UniProtKB/Swiss-Prot
  ENSRNOG00060007277 UniProtKB/Swiss-Prot
  ENSRNOG00065017103 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004780.5 UniProtKB/Swiss-Prot
  ENSRNOT00000029787.6 UniProtKB/TrEMBL
  ENSRNOT00000085279.2 UniProtKB/TrEMBL
  ENSRNOT00000109605.1 UniProtKB/TrEMBL
  ENSRNOT00055021371 UniProtKB/Swiss-Prot
  ENSRNOT00060011971 UniProtKB/Swiss-Prot
  ENSRNOT00065028582 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6889368 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/TrEMBL
  Epox_hydrolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Epoxide_hydro_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Epoxide_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25315 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72921 IMAGE-MGC_LOAD
NCBI Gene 25315 ENTREZGENE
PANTHER EPOXIDE HYDROLASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPOXIDE HYDROLASE 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Abhydrolase_1 UniProtKB/TrEMBL
  EHN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EPHX1 RGD
PhenoGen Ephx1 PhenoGen
PIRSF Epoxide_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EPOXHYDRLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003515 RatGTEx
  ENSRNOG00055012533 RatGTEx
  ENSRNOG00060007277 RatGTEx
  ENSRNOG00065017103 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZSE7_RAT UniProtKB/TrEMBL
  A0A8L2R8K5 ENTREZGENE, UniProtKB/TrEMBL
  A6JGI6_RAT UniProtKB/TrEMBL
  A6JGI7 ENTREZGENE, UniProtKB/TrEMBL
  A6JGI8_RAT UniProtKB/TrEMBL
  A6JGI9_RAT UniProtKB/TrEMBL
  A6JGJ0_RAT UniProtKB/TrEMBL
  F1LTS8_RAT UniProtKB/TrEMBL
  HYEP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Ephx1  epoxide hydrolase 1  Ephx1  epoxide hydrolase 1, microsomal (xenobiotic)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Ephx1  epoxide hydrolase 1, microsomal (xenobiotic)  Ephx1  epoxide hydrolase 1, microsomal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ephx1  epoxide hydrolase 1, microsomal    epoxide hydrolase 1  Name updated 1299863 APPROVED
2002-11-06 Ephx1  epoxide hydrolase 1    Epoxide hydrolase 1 (microsomal xenobiotic hydrolase)  Name updated 625702 APPROVED
2002-06-10 Ephx1  Epoxide hydrolase 1 (microsomal xenobiotic hydrolase)      Symbol and Name status set to approved 70586 APPROVED