Nat1 (N-acetyltransferase 1) - Rat Genome Database

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Gene: Nat1 (N-acetyltransferase 1) Rattus norvegicus
Analyze
Symbol: Nat1
Name: N-acetyltransferase 1
RGD ID: 70490
Description: Enables arylamine N-acetyltransferase activity. Involved in liver development and response to thyroxine. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human NAT1 (N-acetyltransferase 1) and NAT2 (N-acetyltransferase 2); PARTICIPATES IN caffeine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arylamide acetylase 1; arylamine N-acetyltransferase 1; AT-1; N-acetyltransferase (arylamine N-acetyltransferase); N-acetyltransferase 1 (arylamine N-acetyltransferase); N-acetyltransferase type 1; Nat; NAT-1
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21622,218,217 - 22,238,516 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1622,208,194 - 22,238,520 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1625,591,728 - 25,607,842 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01629,022,213 - 29,042,475 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01624,957,106 - 24,973,218 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01623,970,742 - 23,991,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1623,970,743 - 23,991,573 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01623,854,942 - 23,875,351 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41623,855,555 - 23,876,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11623,855,618 - 23,858,152 (-)NCBI
Celera1622,352,492 - 22,372,774 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-naphthylamine  (ISO)
2-palmitoylglycerol  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,4-dimethylaniline  (ISO)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-aminobenzoic acid  (ISO)
4-aminosalicylic acid  (ISO)
4-chloroaniline  (ISO)
acetyl-CoA  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alizarin  (ISO)
Aloe emodin  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
anilines  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
baicalein  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bifenthrin  (ISO)
biphenyl-4-amine  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carotenoid  (ISO)
CGP 52608  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
CU-O LINKAGE  (ISO)
cyanamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
deguelin  (ISO)
dehydroepiandrosterone sulfate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dihydrofolic acid  (ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hexamethylene diisocyanate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
inulin  (ISO)
L-1,4-dithiothreitol  (ISO)
lead diacetate  (ISO)
linsidomine  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-hydroxy-2-acetamidofluorene  (ISO)
N-hydroxy-4-acetylaminobiphenyl  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
niclosamide  (ISO)
o-anisidine  (ISO)
ozone  (ISO)
p-anisidine  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
peroxynitrous acid  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
potassium chromate  (ISO)
procainamide  (ISO)
progesterone  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of the NAT1*10 genotype with increased chromosome aberrations and higher lung cancer risk in cigarette smokers. Abdel-Rahman SZ, etal., Mutat Res. 1998 Feb 26;398(1-2):43-54.
2. The association between N-acetyltransferase 2 gene polymorphisms and pancreatic cancer. Ayaz L, etal., Cell Biochem Funct. 2008 Apr;26(3):329-33.
3. Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease. Bandmann O, etal., Lancet. 1997 Oct 18;350(9085):1136-9.
4. Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat. Barker DF, etal., Drug Metab Dispos. 2008 Dec;36(12):2445-51. Epub 2008 Sep 17.
5. Para-phenylenediamine and allergic sensitization: risk modification by N-acetyltransferase 1 and 2 genotypes. Blomeke B, etal., Br J Dermatol. 2009 Nov;161(5):1130-5. doi: 10.1111/j.1365-2133.2009.09352.x. Epub 2009 Jun 11.
6. N-acetyltransferase 2 acetylation polymorphism: prevalence of slow acetylators does not differ between atopic dermatitis patients and healthy subjects. Brocvielle H, etal., Skin Pharmacol Appl Skin Physiol. 2003 Nov-Dec;16(6):386-92.
7. Effects of genetic polymorphisms of N-Acetyltransferase on trichloroethylene-induced hypersensitivity dermatitis among exposed workers. Dai Y, etal., Ind Health. 2009 Oct;47(5):479-86.
8. Complementary DNAs for two arylamine N-acetyltransferases with identical 5' non-coding regions from rat pineal gland. Ebisawa T, etal., Eur J Biochem 1995 Feb 15;228(1):129-37.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study. Hein DW, etal., Environ Mol Mutagen. 2002;40(3):161-7.
12. Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer. Jiao L, etal., Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2379-86.
13. Recombinant rat and hamster N-acetyltransferases-1 and -2: relative rates of N-acetylation of arylamines and N,O-acyltransfer with arylhydroxamic acids. Jones RF, etal., Carcinogenesis. 1996 Aug;17(8):1729-33.
14. N-acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathy. Korpinen E, etal., Pharmacogenetics. 1999 Oct;9(5):627-33.
15. Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators. Majumder M, etal., Int J Cancer. 2007 May 15;120(10):2148-56.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Combination therapy with 5-azacytidine plus beta-2'-deoxythioguanosine in adult acute leukemia. Omura GA Cancer Treat Rep 1977 Aug;61(5):915-7.
19. Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population. Ozawa S, etal., Int J Cancer. 2002 Dec 1;102(4):418-21.
20. Developmental regulation of the translational repressor NAT1 during cardiac development. Pak BJ and Pang SC, J Mol Cell Cardiol 1999 Sep;31(9):1717-24.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study. Potts LF, etal., BMC Med Genet. 2012 Mar 17;13:16. doi: 10.1186/1471-2350-13-16.
23. Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma. Prawan A, etal., Eur J Cancer Prev. 2005 Jun;14(3):245-50.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Novel translational repressor (NAT-1) expression is modified by thyroid state and age in brain and liver. Shah GN, etal., Eur J Endocrinol. 1998 Dec;139(6):649-53.
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer. Suzuki H, etal., Carcinogenesis. 2008 Jun;29(6):1184-91. Epub 2008 May 21.
30. N-acetyltransferase 2 polymorphisms in patients with Behcet's disease. Tamer L, etal., Clin Exp Dermatol. 2005 Jan;30(1):56-60.
31. N-acetyltransferase 2 phenotype may be associated with susceptibility to age-related cataract. Tamer L, etal., Curr Eye Res. 2005 Oct;30(10):835-9.
32. N-acetyltransferase 2 gene polymorphism and presbycusis. Unal M, etal., Laryngoscope. 2005 Dec;115(12):2238-41.
33. Polymorphisms of arylamine N-acetyltransferase (NAT1 and NAT2) and larynx cancer susceptibility. Varzim G, etal., ORL J Otorhinolaryngol Relat Spec. 2002 May-Jun;64(3):206-12.
34. Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility. Wikman H, etal., Pharmacogenetics. 2001 Mar;11(2):157-68.
35. N-acetyltransferase 2 polymorphism in patients with diabetes mellitus. Yalin S, etal., Cell Biochem Funct. 2007 Jul-Aug;25(4):407-11.
36. 4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat. Zhang X, etal., J Pharmacol Exp Ther. 2006 Jan;316(1):289-94. Epub 2005 Sep 28.
37. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Zienolddiny S, etal., Carcinogenesis. 2008 Jun;29(6):1164-9. Epub 2008 Feb 6.
Additional References at PubMed
PMID:7545952   PMID:7773298   PMID:10862519   PMID:15489334   PMID:15719143   PMID:17567587   PMID:22225631  


Genomics

Comparative Map Data
Nat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21622,218,217 - 22,238,516 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1622,208,194 - 22,238,520 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1625,591,728 - 25,607,842 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01629,022,213 - 29,042,475 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01624,957,106 - 24,973,218 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01623,970,742 - 23,991,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1623,970,743 - 23,991,573 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01623,854,942 - 23,875,351 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41623,855,555 - 23,876,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11623,855,618 - 23,858,152 (-)NCBI
Celera1622,352,492 - 22,372,774 (-)NCBICelera
Cytogenetic Map16p14NCBI
NAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38818,170,467 - 18,223,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl818,170,477 - 18,223,689 (+)EnsemblGRCh38hg38GRCh38
GRCh37818,027,976 - 18,081,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36818,111,895 - 18,125,100 (+)NCBINCBI36Build 36hg18NCBI36
Build 34818,111,894 - 18,125,099NCBI
Celera817,033,182 - 17,047,129 (+)NCBICelera
Cytogenetic Map8p22NCBI
HuRef816,572,274 - 16,625,520 (+)NCBIHuRef
CHM1_1818,229,426 - 18,282,651 (+)NCBICHM1_1
T2T-CHM13v2.0818,437,966 - 18,491,198 (+)NCBIT2T-CHM13v2.0
Nat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,943,620 - 67,945,183 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl867,933,573 - 67,944,756 (+)EnsemblGRCm39 Ensembl
GRCm38867,490,968 - 67,492,531 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl867,480,921 - 67,492,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv37870,014,657 - 70,016,003 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36870,419,747 - 70,421,093 (+)NCBIMGSCv36mm8
Celera870,044,212 - 70,045,558 (+)NCBICelera
Cytogenetic Map8B3.2NCBI
cM Map833.38NCBI
NAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1812,407,985 - 12,420,964 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0817,425,852 - 17,439,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1814,339,766 - 14,393,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl814,386,481 - 14,392,462 (+)Ensemblpanpan1.1panPan2
LOC100511905
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11713,383,478 - 13,393,287 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21714,206,990 - 14,216,786 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103215401
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1816,302,296 - 16,315,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl816,314,446 - 16,315,318 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605225,953,627 - 25,966,142 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Nat1
76 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:52
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000018854
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 19 12 19 10 10 11
Low 43 31 22 7 22 8 10 74 25 31 8
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001037315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001037316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB580886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB919754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB961368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC977163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD018778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM559314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000018854   ⟹   ENSRNOP00000018854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,218,220 - 22,238,516 (-)Ensembl
Rnor_6.0 Ensembl1623,970,743 - 23,991,573 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000044198   ⟹   ENSRNOP00000051430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,208,555 - 22,238,513 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090726   ⟹   ENSRNOP00000070053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,217,885 - 22,238,520 (-)Ensembl
Rnor_6.0 Ensembl1623,970,743 - 23,975,061 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097045   ⟹   ENSRNOP00000078955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,208,327 - 22,238,520 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098891   ⟹   ENSRNOP00000086542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,217,800 - 22,238,520 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101421   ⟹   ENSRNOP00000087047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,208,282 - 22,238,520 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103383   ⟹   ENSRNOP00000086204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,208,282 - 22,222,886 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107612   ⟹   ENSRNOP00000086645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,218,082 - 22,238,520 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112079   ⟹   ENSRNOP00000086070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,208,194 - 22,216,331 (-)Ensembl
RefSeq Acc Id: NM_001037315   ⟹   NP_001032392
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,238,516 (-)NCBI
Rnor_6.01623,970,742 - 23,991,573 (-)NCBI
Rnor_5.01623,854,942 - 23,875,351 (-)NCBI
RGSC_v3.41623,855,555 - 23,876,531 (-)RGD
Celera1622,352,492 - 22,372,774 (-)RGD
Sequence:
RefSeq Acc Id: NM_001037316   ⟹   NP_001032393
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,222,534 (-)NCBI
Rnor_6.01623,970,742 - 23,975,059 (-)NCBI
Rnor_5.01623,854,942 - 23,875,351 (-)NCBI
RGSC_v3.41623,855,555 - 23,876,531 (-)RGD
Celera1622,352,492 - 22,356,809 (-)NCBI
Sequence:
RefSeq Acc Id: NM_053853   ⟹   NP_446305
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,220,318 (-)NCBI
Rnor_6.01623,970,742 - 23,972,843 (-)NCBI
Rnor_5.01623,854,942 - 23,875,351 (-)NCBI
RGSC_v3.41623,855,555 - 23,876,531 (-)RGD
Celera1622,352,492 - 22,354,593 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253001   ⟹   XP_006253063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,238,487 (-)NCBI
Rnor_6.01623,970,742 - 23,991,525 (-)NCBI
Rnor_5.01623,854,942 - 23,875,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253002   ⟹   XP_006253064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,238,489 (-)NCBI
Rnor_6.01623,970,742 - 23,991,517 (-)NCBI
Rnor_5.01623,854,942 - 23,875,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253004   ⟹   XP_006253066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,238,381 (-)NCBI
Rnor_6.01623,970,742 - 23,991,437 (-)NCBI
Rnor_5.01623,854,942 - 23,875,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599977   ⟹   XP_017455466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,238,432 (-)NCBI
Rnor_6.01623,970,742 - 23,991,437 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599978   ⟹   XP_017455467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,238,291 (-)NCBI
Rnor_6.01623,970,742 - 23,991,437 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094151   ⟹   XP_038950079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,238,477 (-)NCBI
RefSeq Acc Id: XM_039094152   ⟹   XP_038950080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,238,435 (-)NCBI
RefSeq Acc Id: XM_039094153   ⟹   XP_038950081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21622,218,217 - 22,238,447 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001032392 (Get FASTA)   NCBI Sequence Viewer  
  NP_001032393 (Get FASTA)   NCBI Sequence Viewer  
  NP_446305 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253063 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253064 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253066 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455466 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455467 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950079 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950080 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950081 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA56771 (Get FASTA)   NCBI Sequence Viewer  
  AAA70156 (Get FASTA)   NCBI Sequence Viewer  
  AAA70157 (Get FASTA)   NCBI Sequence Viewer  
  AAA70158 (Get FASTA)   NCBI Sequence Viewer  
  AAA70160 (Get FASTA)   NCBI Sequence Viewer  
  AAH78765 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53264 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53265 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53266 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53267 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53268 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53269 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53270 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53271 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53272 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53273 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53274 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53275 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37262 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37263 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37264 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37265 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37266 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37267 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37268 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37269 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37270 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37271 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37272 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37273 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37274 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37275 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37276 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37277 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37278 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37279 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37280 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37281 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37282 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37283 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37284 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37285 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37286 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37287 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37288 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37289 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37290 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37291 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37292 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37293 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37294 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37295 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37296 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37297 (Get FASTA)   NCBI Sequence Viewer  
  ADQ37298 (Get FASTA)   NCBI Sequence Viewer  
  CBF94882 (Get FASTA)   NCBI Sequence Viewer  
  CBG15309 (Get FASTA)   NCBI Sequence Viewer  
  CBV08402 (Get FASTA)   NCBI Sequence Viewer  
  CBV28755 (Get FASTA)   NCBI Sequence Viewer  
  EDL75951 (Get FASTA)   NCBI Sequence Viewer  
  EDL75952 (Get FASTA)   NCBI Sequence Viewer  
  EDL75953 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018854
  ENSRNOP00000018854.3
  ENSRNOP00000070053
  ENSRNOP00000070053.1
  ENSRNOP00000078955.1
  ENSRNOP00000086542.1
  ENSRNOP00000086645
  ENSRNOP00000086645.1
  ENSRNOP00055005010
  ENSRNOP00055005012
  ENSRNOP00055005013
  ENSRNOP00055005015
  ENSRNOP00060023644
  ENSRNOP00060023653
  ENSRNOP00060023675
  ENSRNOP00060023680
  ENSRNOP00065005040
  ENSRNOP00065005046
  ENSRNOP00065005050
  ENSRNOP00065005053
  ENSRNOP00065005054
  ENSRNOP00065005056
  ENSRNOP00065005058
GenBank Protein P50297 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001032392   ⟸   NM_001037315
- UniProtKB: P50297 (UniProtKB/Swiss-Prot),   Q45G71 (UniProtKB/TrEMBL),   Q45G61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001032393   ⟸   NM_001037316
- UniProtKB: P50297 (UniProtKB/Swiss-Prot),   Q45G71 (UniProtKB/TrEMBL),   Q45G61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_446305   ⟸   NM_053853
- UniProtKB: P50297 (UniProtKB/Swiss-Prot),   Q45G71 (UniProtKB/TrEMBL),   Q45G61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253063   ⟸   XM_006253001
- Peptide Label: isoform X3
- UniProtKB: P50297 (UniProtKB/Swiss-Prot),   Q45G71 (UniProtKB/TrEMBL),   Q45G61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253064   ⟸   XM_006253002
- Peptide Label: isoform X3
- UniProtKB: P50297 (UniProtKB/Swiss-Prot),   Q45G71 (UniProtKB/TrEMBL),   Q45G61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253066   ⟸   XM_006253004
- Peptide Label: isoform X3
- UniProtKB: P50297 (UniProtKB/Swiss-Prot),   Q45G71 (UniProtKB/TrEMBL),   Q45G61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455466   ⟸   XM_017599977
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455467   ⟸   XM_017599978
- Peptide Label: isoform X3
- UniProtKB: P50297 (UniProtKB/Swiss-Prot),   Q45G71 (UniProtKB/TrEMBL),   Q45G61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018854   ⟸   ENSRNOT00000018854
RefSeq Acc Id: ENSRNOP00000070053   ⟸   ENSRNOT00000090726
RefSeq Acc Id: XP_038950079   ⟸   XM_039094151
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950081   ⟸   XM_039094153
- Peptide Label: isoform X3
- UniProtKB: P50297 (UniProtKB/Swiss-Prot),   Q45G71 (UniProtKB/TrEMBL),   Q45G61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950080   ⟸   XM_039094152
- Peptide Label: isoform X3
- UniProtKB: P50297 (UniProtKB/Swiss-Prot),   Q45G71 (UniProtKB/TrEMBL),   Q45G61 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086070   ⟸   ENSRNOT00000112079
RefSeq Acc Id: ENSRNOP00000051430   ⟸   ENSRNOT00000044198
RefSeq Acc Id: ENSRNOP00000086645   ⟸   ENSRNOT00000107612
RefSeq Acc Id: ENSRNOP00000078955   ⟸   ENSRNOT00000097045
RefSeq Acc Id: ENSRNOP00000086542   ⟸   ENSRNOT00000098891
RefSeq Acc Id: ENSRNOP00000087047   ⟸   ENSRNOT00000101421
RefSeq Acc Id: ENSRNOP00000086204   ⟸   ENSRNOT00000103383

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50297-F1-model_v2 AlphaFold P50297 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70490 AgrOrtholog
BioCyc Gene G2FUF-11676 BioCyc
Ensembl Genes ENSRNOG00000014055 Ensembl
  ENSRNOG00000049498 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004106 UniProtKB/Swiss-Prot
  ENSRNOG00060017218 UniProtKB/Swiss-Prot
  ENSRNOG00065004978 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018854 ENTREZGENE
  ENSRNOT00000018854.7 UniProtKB/Swiss-Prot
  ENSRNOT00000090726 ENTREZGENE
  ENSRNOT00000090726.2 UniProtKB/Swiss-Prot
  ENSRNOT00000097045.1 UniProtKB/TrEMBL
  ENSRNOT00000098891.1 UniProtKB/Swiss-Prot
  ENSRNOT00000107612 ENTREZGENE
  ENSRNOT00000107612.1 UniProtKB/Swiss-Prot
  ENSRNOT00055006559 UniProtKB/Swiss-Prot
  ENSRNOT00055006561 UniProtKB/Swiss-Prot
  ENSRNOT00055006562 UniProtKB/Swiss-Prot
  ENSRNOT00055006564 UniProtKB/Swiss-Prot
  ENSRNOT00060029403 UniProtKB/Swiss-Prot
  ENSRNOT00060029417 UniProtKB/Swiss-Prot
  ENSRNOT00060029452 UniProtKB/Swiss-Prot
  ENSRNOT00060029458 UniProtKB/Swiss-Prot
  ENSRNOT00065007264 UniProtKB/Swiss-Prot
  ENSRNOT00065007270 UniProtKB/Swiss-Prot
  ENSRNOT00065007274 UniProtKB/Swiss-Prot
  ENSRNOT00065007277 UniProtKB/Swiss-Prot
  ENSRNOT00065007278 UniProtKB/Swiss-Prot
  ENSRNOT00065007280 UniProtKB/Swiss-Prot
  ENSRNOT00065007282 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.2140.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127165 IMAGE-MGC_LOAD
InterPro Arylamine_N-AcTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116631 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93278 IMAGE-MGC_LOAD
NCBI Gene 116631 ENTREZGENE
PANTHER ARYLAMINE N-ACETYLTRANSFERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARYLAMINE N-ACETYLTRANSFERASE 1 UniProtKB/TrEMBL
  PTHR11786 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acetyltransf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NAT2 RGD
PhenoGen Nat1 PhenoGen
PRINTS ANATRNSFRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014055 RatGTEx
  ENSRNOG00000049498 RatGTEx
  ENSRNOG00055004106 RatGTEx
  ENSRNOG00060017218 RatGTEx
  ENSRNOG00065004978 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZLT4_RAT UniProtKB/TrEMBL
  ARY1_RAT UniProtKB/Swiss-Prot
  E5FI08_RAT UniProtKB/TrEMBL
  P50297 ENTREZGENE
  Q45G61 ENTREZGENE, UniProtKB/TrEMBL
  Q45G71 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Nat1  N-acetyltransferase 1  Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-04-23 Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nat2  N-acetyltransferase 2 (arylamine N-acetyltransferase)  Name and Symbol changed 629549 APPROVED
2013-02-27 Nat2  N-acetyltransferase 2 (arylamine N-acetyltransferase)  Nat1  N-acetyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-27 Nat1  N-acetyltransferase 1  Nat2  N-acetyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Nat  N-acetyltransferase (arylamine N-acetyltransferase)  Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Nat2  N-acetyltransferase 2  Nat  N-acetyltransferase (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)      Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expresion in heart peaks at postnatal day 7 70273
gene_expression protein expressed predominantly in heart, also in vascular smooth muscle 70273
gene_homology homologous to the carboxy-terminal two-thirds of the Eif4F subunit Eif4G 70273
gene_process represses both cap dependent and cap independent translation of a bicistronic reporter gene 70294
gene_protein 290 amino acid protein 70294
gene_regulation nocturnal regulation of gene expression is driven by norepinephrine 729099
gene_regulation edited by apolipoprotein B mRNA-editing complex 1 (Apobec1), which deaminates cytidine to uridine 70273