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Gene: Nat1 (N-acetyltransferase 1) Rattus norvegicus
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Symbol: Nat1
Name: N-acetyltransferase 1
Description: Exhibits arylamine N-acetyltransferase activity. Involved in aging; liver development; and response to thyroxine. Localizes to the cytosol. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); dermatitis (multiple); leukemia (multiple); lung disease (multiple); and rheumatic disease (multiple). Orthologous to human NAT1 (N-acetyltransferase 1) and NAT2 (N-acetyltransferase 2); PARTICIPATES IN caffeine metabolic pathway; INTERACTS WITH 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: arylamide acetylase 1; arylamine N-acetyltransferase 1; AT-1; N-acetyltransferase (arylamine N-acetyltransferase); N-acetyltransferase 1 (arylamine N-acetyltransferase); N-acetyltransferase type 1; Nat; NAT-1
Orthologs:
Homo sapiens (human) : NAT1 (N-acetyltransferase 1)  HGNC  Alliance
Mus musculus (house mouse) : Nat1 (N-acetyl transferase 1)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : NAT1 (N-acetyltransferase 1)
Sus scrofa (pig) : LOC100511905 (arylamine N-acetyltransferase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01623,970,742 - 23,991,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1623,970,743 - 23,991,573 (-)Ensembl
Rnor_5.01623,854,942 - 23,875,351 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41623,855,555 - 23,876,531 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11623,855,618 - 23,858,152 (-)NCBI
Celera1622,352,492 - 22,372,774 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nat1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70490
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.