RGD Reference Report - N-acetyltransferase 2 polymorphisms in patients with Behcet's disease. - Rat Genome Database

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N-acetyltransferase 2 polymorphisms in patients with Behcet's disease.

Authors: Tamer, L  Tursen, U  Eskandari, G  Ates, NA  Ercan, B  Yildirim, H  Atik, U 
Citation: Tamer L, etal., Clin Exp Dermatol. 2005 Jan;30(1):56-60.
RGD ID: 8552650
Pubmed: PMID:15663505   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2230.2004.01685.x   (Journal Full-text)

It is possible that dietary, environmental factors and/or genetic polymorphisms in xenobiotic-metabolizing enzymes may contribute to the development of Behcet's disease. As N-acetyltransferase (NAT) 2 is an important xenobiotic-metabolizing enzyme and theoretically the nonacetylated xenobiotics may induce an autoimmune mechanism, the aim of the present study was to investigate whether the genetic polymorphism of NAT2 plays a role in susceptibility to Behcet's disease. Forty Behcet's disease patients and 82 control subjects were enrolled in the study. NAT2*5A, NAT2*6A, NAT27*A/B and NAT2*14A polymorphisms were detected by using real time PCR with LightCycler (Roche Diagnostics GmbH, Mannheim, Germany). The NAT2*5A and NAT2*6A mutant genotypes carried an increased risk of developing Behcet's disease [odds ratio (OR) = 66.29, 95% confidence interval (CI) = 8.21-535.33; and OR = 24; 95% CI = 2.04-304.98, respectively]. The NAT2*7A/B and NAT2*14A gene polymorphisms were not an increased risk for developing Behcet's disease. As a result of this study we conclude the NAT2 slow acetylator status may be a determinant in susceptibility to Behcet's disease. This finding may have implications for the theories of the pathogenesis of the disease as well as for therapeutic aspects.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
NAT2HumanBehcet's disease susceptibilityIAGP DNA:polymorphisms: :RGD 
Nat2RatBehcet's disease susceptibilityISORGD:732527DNA:polymorphisms: :RGD 
Nat2MouseBehcet's disease susceptibilityISORGD:732527DNA:polymorphisms: :RGD 


Genes (Rattus norvegicus)
Nat2  (N-acetyltransferase 2)

Genes (Mus musculus)
Nat2  (N-acetyltransferase 2 (arylamine N-acetyltransferase))

Genes (Homo sapiens)
NAT2  (N-acetyltransferase 2)

Gene Nat1 N-acetyl transferase 1 Mus musculus
Gene Nat1 N-acetyltransferase 1 Rattus norvegicus