Nat1 (N-acetyl transferase 1) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Nat1 (N-acetyl transferase 1) Mus musculus
Analyze
Symbol: Nat1
Name: N-acetyl transferase 1
RGD ID: 735739
MGI Page MGI
Description: Exhibits arylamine N-acetyltransferase activity. Predicted to localize to cytosol. Is expressed in several structures, including adrenal gland; brain; genitourinary system; submandibular gland; and thymus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human NAT1 (N-acetyltransferase 1) and NAT2 (N-acetyltransferase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bifenthrin; biphenyl-4-amine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: arylamide acetylase 1; arylamine N-acetyltransferase 1; N(alpha)-acetyltransferase 15, NatA auxiliary subunit; N-acetyl transferase 1, liver, blood; N-acetyltransferase type 1; Nat; Nat-1
RGD Orthologs
Human
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,943,620 - 67,945,183 (+)NCBIGRCm39mm39
GRCm38867,490,968 - 67,492,531 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl867,480,921 - 67,492,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv37870,014,657 - 70,016,003 (+)NCBIGRCm37mm9NCBIm37
MGSCv36870,419,747 - 70,421,093 (+)NCBImm8
Celera870,044,212 - 70,045,558 (+)NCBICelera
Cytogenetic Map8B3.2NCBI
cM Map833.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-naphthylamine  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-aminobenzoic acid  (ISO)
4-aminosalicylic acid  (ISO)
4-chloroaniline  (ISO)
acetyl-CoA  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aloe emodin  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
anilines  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
baicalein  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bifenthrin  (EXP)
biphenyl-4-amine  (EXP,ISO)
bisphenol A  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carotenoid  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
CU-O LINKAGE  (ISO)
cyanamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
dehydroepiandrosterone sulfate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dihydrofolic acid  (ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
hexamethylene diisocyanate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-1,4-dithiothreitol  (ISO)
lead diacetate  (EXP)
linsidomine  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-hydroxy-2-acetamidofluorene  (ISO)
N-hydroxy-4-acetylaminobiphenyl  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
o-anisidine  (ISO)
ozone  (ISO)
p-anisidine  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
peroxynitrous acid  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
potassium chromate  (ISO)
procainamide  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (ISO)
urethane  (ISO)
valproic acid  (ISO)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Abdel-Rahman SZ, etal., Mutat Res. 1998 Feb 26;398(1-2):43-54.
2. Bandmann O, etal., Lancet. 1997 Oct 18;350(9085):1136-9.
3. Blomeke B, etal., Br J Dermatol. 2009 Nov;161(5):1130-5. doi: 10.1111/j.1365-2133.2009.09352.x. Epub 2009 Jun 11.
4. Brocvielle H, etal., Skin Pharmacol Appl Skin Physiol. 2003 Nov-Dec;16(6):386-92.
5. Dai Y, etal., Ind Health. 2009 Oct;47(5):479-86.
6. Hein DW, etal., Environ Mol Mutagen. 2002;40(3):161-7.
7. Jiao L, etal., Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2379-86.
8. Majumder M, etal., Int J Cancer. 2007 May 15;120(10):2148-56.
9. MGD and Homologene mouse data transfer
10. MGD data from the GO Consortium
11. MGD IEA
12. OMIM Disease Annotation Pipeline
13. Ozawa S, etal., Int J Cancer. 2002 Dec 1;102(4):418-21.
14. Potts LF, etal., BMC Med Genet. 2012 Mar 17;13:16. doi: 10.1186/1471-2350-13-16.
15. RGD automated import pipeline
16. RGD automated import pipeline for gene-chemical interactions
17. Suzuki H, etal., Carcinogenesis. 2008 Jun;29(6):1184-91. Epub 2008 May 21.
18. Tamer L, etal., Clin Exp Dermatol. 2005 Jan;30(1):56-60.
19. Tamer L, etal., Curr Eye Res. 2005 Oct;30(10):835-9.
20. Unal M, etal., Laryngoscope. 2005 Dec;115(12):2238-41.
21. Varzim G, etal., ORL J Otorhinolaryngol Relat Spec. 2002 May-Jun;64(3):206-12.
22. Vatsis KP, etal., Pharmacogenetics 1995 Feb;5(1):1-17.
23. von Schmiedeberg S, etal., Adv Exp Med Biol. 1999;455:147-52.
24. Wikman H, etal., Pharmacogenetics. 2001 Mar;11(2):157-68.
25. Zienolddiny S, etal., Carcinogenesis. 2008 Jun;29(6):1164-9. Epub 2008 Feb 6.
Additional References at PubMed
PMID:1513324   PMID:1875909   PMID:2227380   PMID:3209851   PMID:3941912   PMID:6976963   PMID:7545952   PMID:9070359   PMID:9839355   PMID:9929513   PMID:10640510   PMID:10862519  
PMID:11060463   PMID:12054539   PMID:12142728   PMID:12477932   PMID:12815173   PMID:12888564   PMID:14681479   PMID:16098511   PMID:17403913   PMID:18373979   PMID:19090811   PMID:21267068  
PMID:21347396   PMID:21873635   PMID:22193722   PMID:22644701   PMID:24067652   PMID:24194600   PMID:25432241   PMID:25798622   PMID:27626380   PMID:27705799   PMID:28003464   PMID:28700664  
PMID:28888949   PMID:29237750   PMID:29447909   PMID:30883722  


Genomics

Comparative Map Data
Nat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,943,620 - 67,945,183 (+)NCBIGRCm39mm39
GRCm38867,490,968 - 67,492,531 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl867,480,921 - 67,492,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv37870,014,657 - 70,016,003 (+)NCBIGRCm37mm9NCBIm37
MGSCv36870,419,747 - 70,421,093 (+)NCBImm8
Celera870,044,212 - 70,045,558 (+)NCBICelera
Cytogenetic Map8B3.2NCBI
cM Map833.38NCBI
NAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl818,170,477 - 18,223,689 (+)EnsemblGRCh38hg38GRCh38
GRCh38818,170,419 - 18,223,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37818,027,971 - 18,081,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36818,111,895 - 18,125,100 (+)NCBINCBI36hg18NCBI36
Build 34818,111,894 - 18,125,099NCBI
Celera817,033,182 - 17,047,129 (+)NCBI
Cytogenetic Map8p22NCBI
HuRef816,572,274 - 16,625,520 (+)NCBIHuRef
CHM1_1818,229,426 - 18,282,651 (+)NCBICHM1_1
Nat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01623,970,742 - 23,991,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1623,970,743 - 23,991,573 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01623,854,942 - 23,875,351 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41623,855,555 - 23,876,531 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11623,855,618 - 23,858,152 (-)NCBI
Celera1622,352,492 - 22,372,774 (-)NCBICelera
Cytogenetic Map16p14NCBI
NAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1814,339,766 - 14,393,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl814,386,481 - 14,392,462 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0817,425,852 - 17,439,684 (+)NCBIMhudiblu_PPA_v0panPan3
LOC100511905
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11713,383,478 - 13,393,287 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21714,206,990 - 14,216,786 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103215401
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1816,302,296 - 16,315,406 (+)NCBI
ChlSab1.1 Ensembl816,314,446 - 16,315,318 (+)Ensembl

Position Markers
U35885  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38867,491,920 - 67,492,023UniSTSGRCm38
MGSCv37870,015,819 - 70,015,922UniSTSGRCm37
Celera870,045,374 - 70,045,477UniSTS
Cytogenetic Map8B3.1UniSTS
Whitehead/MRC_RH8718.43UniSTS
Nat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map831.0UniSTS
UniSTS:492572  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38867,490,953 - 67,491,948UniSTSGRCm38
MGSCv37870,014,852 - 70,015,847UniSTSGRCm37
Celera870,044,407 - 70,045,402UniSTS
Cytogenetic Map8B3.1UniSTS
Nat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8B3.1UniSTS
cM Map831.0UniSTS
Nat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8B3.1UniSTS
cM Map831.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:44
Interacting mature miRNAs:44
Transcripts:ENSMUST00000026677
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000026677   ⟹   ENSMUSP00000026677
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl867,490,758 - 67,492,104 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212171   ⟹   ENSMUSP00000148354
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl867,480,921 - 67,492,080 (+)Ensembl
RefSeq Acc Id: NM_008673   ⟹   NP_032699
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39867,943,620 - 67,945,183 (+)NCBI
GRCm38867,490,968 - 67,492,531 (+)NCBI
MGSCv37870,014,657 - 70,016,003 (+)RGD
Celera870,044,212 - 70,045,558 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032699   ⟸   NM_008673
- UniProtKB: P50294 (UniProtKB/Swiss-Prot),   Q546L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026677   ⟸   ENSMUST00000026677
RefSeq Acc Id: ENSMUSP00000148354   ⟸   ENSMUST00000212171


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97279 AgrOrtholog
Ensembl Genes ENSMUSG00000025588 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000026677 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148354 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026677 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000212171 UniProtKB/TrEMBL
InterPro Arylamine_N-AcTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97279 ENTREZGENE
NCBI Gene 17960 ENTREZGENE
PANTHER PTHR11786 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acetyltransf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NAT2 RGD
PhenoGen Nat1 PhenoGen
PRINTS ANATRNSFRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.14125 ENTREZGENE
UniProt A0A1D5RLG2_MOUSE UniProtKB/TrEMBL
  ARY1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q546L3 ENTREZGENE, UniProtKB/TrEMBL
  Q9ER94_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Nat1  N-acetyl transferase 1  Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Symbol and/or name change 5135510 APPROVED
2010-03-17 Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Naa15  N(alpha)-acetyltransferase 15, NatA auxiliary subunit  Symbol and Name updated 1299863 APPROVED