Nat2 (N-acetyltransferase 2) - Rat Genome Database
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Gene: Nat2 (N-acetyltransferase 2) Rattus norvegicus
Analyze
Symbol: Nat2
Name: N-acetyltransferase 2
RGD ID: 70492
Description: Exhibits arylamine N-acetyltransferase activity. Involved in several processes, including digestive tract development; response to hypoxia; and response to lipopolysaccharide. Localizes to cytosol. Biomarker of end stage renal disease. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to several human genes including NAT1 (N-acetyltransferase 1); PARTICIPATES IN caffeine pharmacokinetics pathway; caffeine metabolic pathway; INTERACTS WITH 4,4'-diaminodiphenylmethane; 4-aminobenzoic acid; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: arylamide acetylase 2; arylamine N-acetyltransferase 2; AT-2; N-acetyltransferase 2 (arylamine N-acetyltransferase); N-acetyltransferase type 2; N-Acetyltransferase-2 (arylamine N-acetyltransferase); NAT-2; Nat2a
Orthologs:
Homo sapiens (human) : NAT2 (N-acetyltransferase 2)  HGNC  Alliance
Mus musculus (house mouse) : Nat2 (N-acetyltransferase 2 (arylamine N-acetyltransferase))  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : NAT2 (N-acetyltransferase 2)
Chlorocebus sabaeus (African green monkey) : NAT2 (N-acetyltransferase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01623,960,709 - 23,991,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1623,961,067 - 23,991,570 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01623,844,909 - 23,875,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41623,845,894 - 23,876,528 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11623,845,891 - 23,876,526 (-)NCBI
Celera1622,342,838 - 22,372,771 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1,7-dimethylxanthine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetamidofluorene  (ISO)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (ISO)
2-Amino-9H-pyrido[2,3-b]indole  (ISO)
2-naphthylamine  (ISO)
3'-phospho-5'-adenylyl sulfate  (ISO)
3,4-dichloroaniline  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4-aminobenzoic acid  (EXP,ISO)
4-aminosalicylic acid  (ISO)
4-chloroaniline  (ISO)
4-Nitrosobiphenyl  (ISO)
5-acetamido-6-formamido-3-methyluracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetyl-CoA  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aniline  (ISO)
asbestos  (ISO)
benzene  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
biphenyl-4-amine  (EXP,ISO)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carotenoid  (ISO)
chlorzoxazone  (ISO)
cyclosporin A  (ISO)
dapsone  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (ISO)
dimethocaine  (ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
folic acid  (ISO)
genistein  (ISO)
Glu-P-1  (ISO)
Glu-P-2  (ISO)
GW 4064  (ISO)
hexamethylene diisocyanate  (ISO)
hydralazine  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
isoniazide  (EXP,ISO)
MeIQ  (ISO)
MeIQx  (EXP,ISO)
mesalamine  (ISO)
metacetamol  (ISO)
N-hydroxy-2-acetamidofluorene  (ISO)
N-hydroxy-4-acetylaminobiphenyl  (ISO)
N-hydroxy-4-aminobiphenyl  (ISO)
N-hydroxy-PhIP  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nitrofen  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (ISO)
phenobarbital  (ISO)
phenylhydrazine  (ISO)
PhIP  (ISO)
procainamide  (ISO)
procymidone  (EXP)
quercetin  (ISO)
silibinin  (EXP)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulfadiazine  (ISO)
sulfamethazine  (ISO)
sulfamethoxazole  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
xanthohumol  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Arif E, etal., Clin Chim Acta. 2007 Jul;382(1-2):37-42. Epub 2007 Mar 24.
2. Ayaz L, etal., Cell Biochem Funct. 2008 Apr;26(3):329-33.
3. Bandmann O, etal., Lancet. 1997 Oct 18;350(9085):1136-9.
4. Barker DF, etal., Drug Metab Dispos. 2008 Dec;36(12):2445-51. Epub 2008 Sep 17.
5. Belogubova EV, etal., Cancer Lett. 2005 Apr 28;221(2):177-83.
6. Brocvielle H, etal., Skin Pharmacol Appl Skin Physiol. 2003 Nov-Dec;16(6):386-92.
7. Chatzimichalis M, etal., J Laryngol Otol. 2010 Mar;124(3):318-23. Epub 2009 Nov 19.
8. Dai Y, etal., Ind Health. 2009 Oct;47(5):479-86.
9. Dani M, etal., Drug Metab Dispos. 2010 Mar;38(3):357-60. doi: 10.1124/dmd.109.029991. Epub 2009 Dec 9.
10. Ebisawa T, etal., Eur J Biochem 1995 Feb 15;228(1):129-37.
11. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. GOA data from the GO Consortium
13. Gra OA, etal., Genetika. 2010 Feb;46(2):262-71.
14. Hein DW, etal., Environ Mol Mutagen. 2002;40(3):161-7.
15. Higuchi N, etal., World J Gastroenterol. 2007 Dec 7;13(45):6003-8.
16. Hirvonen A, etal., J Natl Cancer Inst. 1996 Dec 18;88(24):1853-6.
17. Jefferson FA, etal., Toxicol Sci. 2009 Jan;107(1):293-7. Epub 2008 Oct 8.
18. Jiao L, etal., Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2379-86.
19. Jones RF, etal., Carcinogenesis. 1996 Aug;17(8):1729-33.
20. Kamel AM, etal., Tumour Biol. 2015 Aug;36(8):6341-8. doi: 10.1007/s13277-015-3320-7. Epub 2015 Mar 25.
21. Kim JM, etal., Pharmacogenomics. 2010 Jul;11(7):951-8.
22. Korpinen E, etal., Pharmacogenetics. 1999 Oct;9(5):627-33.
23. Kozhekbaeva ZhM, etal., Mol Biol (Mosk). 2009 Jan-Feb;43(1):62-76.
24. Lemos MC, etal., Carcinogenesis. 1999 Jul;20(7):1225-9.
25. Li X, etal., Pharmacology. 2014;93(1-2):76-83. doi: 10.1159/000358128. Epub 2014 Feb 15.
26. Lu CM, etal., Urol Int. 2005;75(4):360-4.
27. Majumder M, etal., Int J Cancer. 2007 May 15;120(10):2148-56.
28. Makarova SI, etal., Bull Exp Biol Med. 2005 Jun;139(6):662-4.
29. MGD data from the GO Consortium
30. Nacak M, etal., Int J Dermatol. 2006 Mar;45(3):323-6.
31. NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Neri M, etal., Mutat Res. 2005 Dec 30;592(1-2):36-44. Epub 2005 Jul 1.
33. Ohtani T, etal., Br J Dermatol. 2003 May;148(5):1035-9.
34. OMIM Disease Annotation Pipeline
35. Ozawa S, etal., Int J Cancer. 2002 Dec 1;102(4):418-21.
36. Pipeline to import KEGG annotations from KEGG into RGD
37. Pipeline to import SMPDB annotations from SMPDB into RGD
38. Potts LF, etal., BMC Med Genet. 2012 Mar 17;13:16. doi: 10.1186/1471-2350-13-16.
39. Prawan A, etal., Eur J Cancer Prev. 2005 Jun;14(3):245-50.
40. Pronko PS, etal., Pharmacol Toxicol. 2002 Mar;90(3):150-4.
41. Purewal M, etal., Cancer Epidemiol Biomarkers Prev 2000 May;9(5):529-32.
42. RGD automated data pipeline
43. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. RGD automated import pipeline for gene-chemical interactions
45. RGD comprehensive gene curation
46. Rollinson S, etal., Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):567-8.
47. Rothman N, etal., Nat Genet. 2010 Nov;42(11):978-84. doi: 10.1038/ng.687. Epub 2010 Oct 24.
48. Sabbagh N, etal., Pharmacogenetics. 1997 Apr;7(2):131-5.
49. Silveira VS, etal., Mol Cell Biochem. 2012 May;364(1-2):217-23. doi: 10.1007/s11010-011-1220-8. Epub 2012 Jan 4.
50. Sobti RC, etal., DNA Cell Biol. 2009 Sep;28(9):443-9.
51. Suzuki H, etal., Carcinogenesis. 2008 Jun;29(6):1184-91. Epub 2008 May 21.
52. Tamer L, etal., Clin Exp Dermatol. 2005 Jan;30(1):56-60.
53. Tamer L, etal., Curr Eye Res. 2005 Oct;30(10):835-9.
54. Tamer L, etal., Tuberk Toraks. 2006;54(2):137-43.
55. Unal M, etal., Head Neck. 2005 Dec;27(12):1056-60.
56. Unal M, etal., Laryngoscope. 2005 Dec;115(12):2238-41.
57. Viktorova TV, etal., Genetika. 2003 Jun;39(6):855-7.
58. von Schmiedeberg S, etal., Adv Exp Med Biol. 1999;455:147-52.
59. Wadelius M, etal., Pharmacogenetics. 2000 Feb;10(1):35-41.
60. Wakefield L, etal., Mamm Genome. 2007 Apr;18(4):270-6. Epub 2007 May 9.
61. Yalin S, etal., Cell Biochem Funct. 2007 Jul-Aug;25(4):407-11.
62. Zanrosso CW, etal., Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3037-43. doi: 10.1158/1055-9965.EPI-10-0508. Epub 2010 Sep 30.
63. Zanrosso CW, etal., Leuk Lymphoma. 2012 Feb;53(2):323-7. doi: 10.3109/10428194.2011.619605. Epub 2011 Nov 25.
64. Zhang X, etal., J Pharmacol Exp Ther. 2006 Jan;316(1):289-94. Epub 2005 Sep 28.
Additional References at PubMed
PMID:7545952   PMID:7773298   PMID:8528272   PMID:10862519   PMID:12815365   PMID:15081601   PMID:15872051   PMID:17567587   PMID:18799801   PMID:28359264  


Genomics

Comparative Map Data
Nat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01623,960,709 - 23,991,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1623,961,067 - 23,991,570 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01623,844,909 - 23,875,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41623,845,894 - 23,876,528 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11623,845,891 - 23,876,526 (-)NCBI
Celera1622,342,838 - 22,372,771 (-)NCBICelera
Cytogenetic Map16p14NCBI
NAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl818,391,282 - 18,401,218 (+)EnsemblGRCh38hg38GRCh38
GRCh38818,386,585 - 18,401,219 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37818,248,755 - 18,258,723 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36818,293,035 - 18,303,003 (+)NCBINCBI36hg18NCBI36
Build 34818,293,034 - 18,302,962NCBI
Celera817,214,719 - 17,224,685 (+)NCBI
Cytogenetic Map8p22NCBI
HuRef816,793,030 - 16,802,996 (+)NCBIHuRef
CHM1_1818,450,223 - 18,460,188 (+)NCBICHM1_1
Nat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,947,527 - 67,955,296 (+)NCBI
GRCm38867,494,875 - 67,502,644 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl867,494,858 - 67,502,584 (+)EnsemblGRCm38mm10GRCm38
MGSCv37870,018,774 - 70,026,479 (+)NCBIGRCm37mm9NCBIm37
MGSCv36870,423,937 - 70,431,559 (+)NCBImm8
Celera870,048,329 - 70,056,034 (+)NCBICelera
Cytogenetic Map8B3.2NCBI
cM Map833.38NCBI
NAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1814,561,281 - 14,576,669 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl814,575,455 - 14,576,327 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0817,606,445 - 17,623,397 (+)NCBI
NAT2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl816,493,749 - 16,494,621 (+)Ensembl
ChlSab1.1816,451,144 - 16,494,961 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16124228366Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16127556253Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16127556253Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16127556253Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16131816439Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16133160624Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16134465490Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16141240937Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16141240937Rat
631561Hcuc2Hepatic copper content QTL 22.8hepatic copper amount (VT:0003065)liver total copper weight (CMO:0001507)16141240957Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)1624459345244593Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16134074146340741Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)16155018749247447Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)16155018763210301Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16155018763210301Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)16155018763210301Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)16155018763210301Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16172829746728297Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16413635545905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16501380245905331Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380250013802Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16501380250169318Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16501380252144919Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16501380264012784Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161939818770590230Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161939818770590230Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161939818770590230Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161939818770590230Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)162075555680316424Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:115
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000044198
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 1
Low 1 41 57 41 19 41 7 9 42 35 37 11 7
Below cutoff 2 1 2 32 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07024985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07024986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01086971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01086972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01086973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB919766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB961380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC977175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD018790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U19272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U23418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000044198   ⟹   ENSRNOP00000051430
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1623,961,067 - 23,991,570 (-)Ensembl
RefSeq Acc Id: NM_053854   ⟹   NP_446306
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01623,961,067 - 23,991,570 (-)NCBI
Rnor_5.01623,844,909 - 23,875,348 (-)NCBI
RGSC_v3.41623,845,894 - 23,876,528 (-)RGD
Celera1622,342,838 - 22,372,771 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253007   ⟹   XP_006253069
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01623,960,709 - 23,970,375 (-)NCBI
Rnor_5.01623,844,909 - 23,875,348 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253008   ⟹   XP_006253070
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01623,960,709 - 23,991,517 (-)NCBI
Rnor_5.01623,844,909 - 23,875,348 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253009   ⟹   XP_006253071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01623,960,709 - 23,966,609 (-)NCBI
Rnor_5.01623,844,909 - 23,875,348 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_446306 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253069 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253070 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253071 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA56772 (Get FASTA)   NCBI Sequence Viewer  
  AAA70161 (Get FASTA)   NCBI Sequence Viewer  
  AAB53956 (Get FASTA)   NCBI Sequence Viewer  
  AAB60501 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53276 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53277 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53278 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53279 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53280 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53281 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53282 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53283 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53284 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53285 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53286 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53287 (Get FASTA)   NCBI Sequence Viewer  
  ADD64385 (Get FASTA)   NCBI Sequence Viewer  
  ADD64386 (Get FASTA)   NCBI Sequence Viewer  
  ADD64387 (Get FASTA)   NCBI Sequence Viewer  
  ADD64388 (Get FASTA)   NCBI Sequence Viewer  
  ADD64389 (Get FASTA)   NCBI Sequence Viewer  
  ADD64390 (Get FASTA)   NCBI Sequence Viewer  
  ADD64391 (Get FASTA)   NCBI Sequence Viewer  
  ADD64392 (Get FASTA)   NCBI Sequence Viewer  
  ADD64393 (Get FASTA)   NCBI Sequence Viewer  
  ADD64394 (Get FASTA)   NCBI Sequence Viewer  
  ADD64395 (Get FASTA)   NCBI Sequence Viewer  
  ADD64396 (Get FASTA)   NCBI Sequence Viewer  
  ADD64397 (Get FASTA)   NCBI Sequence Viewer  
  ADD64398 (Get FASTA)   NCBI Sequence Viewer  
  CBF94888 (Get FASTA)   NCBI Sequence Viewer  
  CBG15315 (Get FASTA)   NCBI Sequence Viewer  
  CBV08408 (Get FASTA)   NCBI Sequence Viewer  
  CBV28761 (Get FASTA)   NCBI Sequence Viewer  
  EDL75947 (Get FASTA)   NCBI Sequence Viewer  
  EDL75948 (Get FASTA)   NCBI Sequence Viewer  
  EDL75949 (Get FASTA)   NCBI Sequence Viewer  
  EDL75950 (Get FASTA)   NCBI Sequence Viewer  
  P50298 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446306   ⟸   NM_053854
- UniProtKB: P50298 (UniProtKB/Swiss-Prot),   Q45G59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253070   ⟸   XM_006253008
- Peptide Label: isoform X1
- UniProtKB: G3V9K9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253069   ⟸   XM_006253007
- Peptide Label: isoform X1
- UniProtKB: G3V9K9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253071   ⟸   XM_006253009
- Peptide Label: isoform X1
- UniProtKB: G3V9K9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051430   ⟸   ENSRNOT00000044198

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700061
Promoter ID:EPDNEW_R10585
Type:multiple initiation site
Name:Nat2_1
Description:N-acetyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01623,991,528 - 23,991,588EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 23845970 23845971 C T snv WKY/Gcrc (KNAW), WKY/N (KNAW), KFRS3B/Kyo (KyushuU), WKY/NHsd (KNAW), LEC/Tj (KyushuU), WKY/NCrl (KNAW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 23961770 23961771 C T snv WKY/N (MCW), WKY/NHsd (RGD), WKY/Gcrc (RGD), WKY/NCrl (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70492 AgrOrtholog
Ensembl Genes ENSRNOG00000049498 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000051430 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044198 ENTREZGENE, UniProtKB/TrEMBL
InterPro Arylamine_N-AcTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116632 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116632 ENTREZGENE
PANTHER PTHR11786 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acetyltransf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NAT1 RGD
PhenoGen Nat2 PhenoGen
PRINTS ANATRNSFRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.37420 ENTREZGENE
UniProt ARY2_RAT UniProtKB/Swiss-Prot
  G3V9K9 ENTREZGENE, UniProtKB/TrEMBL
  P50298 ENTREZGENE
  Q45G59 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Nat2  N-acetyltransferase 2  Nat2  N-acetyltransferase 2 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-04-23 Nat2  N-acetyltransferase 2 (arylamine N-acetyltransferase)  Nat1h  N-acetyltransferase 1h (arylamine N-acetyltransferase)  Name and Symbol changed 629549 APPROVED
2014-04-23 Nat1h  N-acetyltransferase 1h (arylamine N-acetyltransferase)  Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Name and Symbol changed 629549 APPROVED
2013-02-27 Nat1h  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nat2  N-acetyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-27 Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nat1h  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-27 Nat2a  N-acetyltransferase 2 (arylamine N-acetyltransferase)  Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-27 Nat2  N-acetyltransferase 2  Nat2a  N-acetyltransferase 2 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nat2  N-Acetyltransferase-2 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nat2  N-Acetyltransferase-2 (arylamine N-acetyltransferase)    N-Acetyltransferase-2  Name updated 1299863 APPROVED
2002-06-10 Nat2  N-Acetyltransferase-2      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease rapid NAT2 genotype associated with increased colorectal cancer risk 70274
gene_function catalyses conversion of Phip and other heterocyclic amines to DNA reactive form 70274
gene_function catalyses conversion of Phip and other heterocyclic amines to DNA reactive form 70294
 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.