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Gene: Nat2 (N-acetyltransferase 2) Rattus norvegicus
Symbol: Nat2
Name: N-acetyltransferase 2
Description: Exhibits arylamine N-acetyltransferase activity. Involved in several processes, including digestive tract development; response to hypoxia; and response to lipopolysaccharide. Localizes to the cytosol. Biomarker of end stage renal failure. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); dermatitis (multiple); leukemia (multiple); lung disease (multiple); and rheumatic disease (multiple). Orthologous to several human genes including NAT1 (N-acetyltransferase 1); PARTICIPATES IN caffeine pharmacokinetics pathway; caffeine metabolic pathway; INTERACTS WITH 4,4'-diaminodiphenylmethane; 4-aminobenzoic acid; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: arylamide acetylase 2; arylamine N-acetyltransferase 2; AT-2; N-acetyltransferase 2 (arylamine N-acetyltransferase); N-acetyltransferase type 2; N-Acetyltransferase-2 (arylamine N-acetyltransferase); NAT-2; Nat2a
Homo sapiens (human) : NAT2 (N-acetyltransferase 2)  HGNC  Alliance
Mus musculus (house mouse) : Nat2 (N-acetyltransferase 2 (arylamine N-acetyltransferase))  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : NAT2 (N-acetyltransferase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01623,960,709 - 23,991,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01623,844,909 - 23,875,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41623,845,894 - 23,876,528 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11623,845,891 - 23,876,526 (-)NCBI
Celera1622,342,838 - 22,372,771 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nat2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70492
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.