NAT2 (N-acetyltransferase 2) - Rat Genome Database

Name: NAT2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: NAT2 (N-acetyltransferase 2) Chlorocebus sabaeus

Analyze

Symbol:

NAT2

Name:

N-acetyltransferase 2

RGD ID:

18384677

Description:

ENCODES a protein that exhibits arylamine N-acetyltransferase activity (ortholog); N-acetyltransferase activity (ortholog); INVOLVED IN digestive tract development (ortholog); response to hypoxia (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN caffeine pharmacokinetics pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); allergic contact dermatitis (ortholog); FOUND IN membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

arylamine N-acetyltransferase 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	16,451,144 - 16,494,961 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	16,493,749 - 16,494,621 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	25,767,584 - 25,768,860 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

acute myeloid leukemia (ISO)

allergic contact dermatitis (ISO)

asthma (ISO)

atopic dermatitis (ISO)

autism spectrum disorder (ISO)

Behcet's disease (ISO)

Breast Neoplasms (ISO)

Chemical and Drug Induced Liver Injury (ISO)

cholangiocarcinoma (ISO)

chronic obstructive pulmonary disease (ISO)

coronary artery disease (ISO)

diabetes mellitus (ISO)

Diabetic Nephropathies (ISO)

Discoid Lupus Erythematosus (ISO)

drug allergy (ISO)

Drug-Induced Agranulocytosis (ISO)

end stage renal disease (ISO)

eye disease (ISO)

Gallbladder Neoplasms (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hereditary spastic paraplegia 53 (ISO)

laryngeal squamous cell carcinoma (ISO)

leukemia (ISO)

leukopenia (ISO)

Liver Neoplasms (ISO)

lung cancer (ISO)

lung disease (ISO)

malignant mesothelioma (ISO)

Mouth Neoplasms (ISO)

neural tube defect (ISO)

occupational dermatitis (ISO)

oral mucosa leukoplakia (ISO)

pancreatic cancer (ISO)

Parkinson's disease (ISO)

Presbycusis (ISO)

progressive supranuclear palsy (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

psoriasis (ISO)

pulmonary tuberculosis (ISO)

senile cataract (ISO)

systemic lupus erythematosus (ISO)

systemic scleroderma (ISO)

transitional cell carcinoma (ISO)

urinary bladder cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

digestive tract development (ISO)

response to hypoxia (ISO)

response to lipopolysaccharide (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

membrane (IEA)

Molecular Function

acetyltransferase activity (IEA)

acyltransferase activity (IEA)

arylamine N-acetyltransferase activity (IEA,ISO)

N-acetyltransferase activity (ISO)

protein binding (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

caffeine pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

NAT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	16,451,144 - 16,494,961 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	16,493,749 - 16,494,621 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	25,767,584 - 25,768,860 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

NAT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	18,386,301 - 18,401,218 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	18,391,282 - 18,401,218 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	18,248,792 - 18,258,728 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	18,293,035 - 18,303,003 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	18,293,034 - 18,302,962	NCBI
Celera	8	17,214,719 - 17,224,685 (+)	NCBI		Celera
Cytogenetic Map	8	p22	NCBI
HuRef	8	16,793,030 - 16,802,996 (+)	NCBI		HuRef
CHM1_1	8	18,450,223 - 18,460,188 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	18,654,127 - 18,668,742 (+)	NCBI		T2T-CHM13v2.0

Nat2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	67,947,527 - 67,955,296 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	67,947,510 - 67,955,236 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	67,494,875 - 67,502,644 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	67,494,858 - 67,502,584 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	70,018,774 - 70,026,479 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	70,423,937 - 70,431,559 (+)	NCBI		MGSCv36	mm8
Celera	8	70,048,329 - 70,056,034 (+)	NCBI		Celera
Cytogenetic Map	8	B3.2	NCBI
cM Map	8	33.38	NCBI

Nat2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	26,974,874 - 27,005,191 (-)	NCBI		GRCr8
mRatBN7.2	16	22,207,362 - 22,238,513 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	22,208,194 - 22,238,520 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	25,582,055 - 25,607,839 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	29,012,550 - 29,042,472 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	24,947,433 - 24,973,215 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	23,960,709 - 23,991,570 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	23,961,067 - 23,991,570 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	23,844,909 - 23,875,348 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	23,845,894 - 23,876,528 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	23,845,891 - 23,876,526 (-)	NCBI
Celera	16	22,342,838 - 22,372,771 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

NAT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	36,864,493 - 36,879,973 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	12,589,733 - 12,605,213 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	17,606,445 - 17,623,397 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	14,561,281 - 14,576,669 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	14,575,455 - 14,576,327 (+)	Ensembl	panpan1.1		panPan2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low	3	10	2
Below cutoff	28	7	20

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007961781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007961782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007961783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007961784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007961785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007961786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000018612 ⟹ ENSCSAP00000018061

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	8	16,493,749 - 16,494,621 (+)	Ensembl

RefSeq Acc Id:

XM_007961784 ⟹ XP_007959975

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	8	16,483,938 - 16,494,961 (+)	NCBI
Vero_WHO_p1.0	NW_023666052	25,767,584 - 25,768,860 (-)	NCBI

Sequence:

show sequence

ACAATGTATGCATGAATCAGAACATCACACTCTACCAAATAAATATATACAACTGTTGTGTCAA
AAAACATTATATACAATGTTAATATTTTATATTAATGTAAATAAAAATTTACATTCGTATTAAT
GTAAATTAAAAAGCAGCAACAAAGCCATATGATACATGTGACACTTATGCCACATGCATCGAGT
TATTTCAGACACATTGTGTGGTACCTTTGGGTAAAGAAGGGAATGAGAGTGAGGATAAGATATG
AAAAGAGGCAGAAGAAAACGAGAGGCCTTATAGGAATTGATGAAGAAAGAGTGCCATAATCTGA
GAGTGTGACTAAAACCTTTCATCTTCCTCTTCTGCCTCTTCTAAGTTACTGGTTCTGCTTTTCC
CCTTGACCTGTTTCAAGTTCTCACCTTCCATATCACACATGGGAAGTCTGGCATCAGACTTCCA
GAGAGCAAGAACTAGGTGAAATACAGGGGCACAGCTCTCCTAGCCTGTGGCATGGGTGTCATCA
GATAATATAATTATCCACACCATTTTTAATGAAAAGATTTGCGTAAGAGATTCACAGAGGCAAC
CTGAGGCCCTGCAACTACATTTCCCAGAGATCCCTGAGGTGATCCTAACTAGACTCTGGGGTCA
AGGTGATACGGAATTCCAGTGAGATCACTTCCCTTGCAGACTTTGGAAGGGAGATCACTTTATT
ACAGACCTTGGAAGCAAGAGGATTGCATTCAGTCTAGTTCCTGGTTGCTGGCCAAAGGGATCAT
GGACATTGAAGCATACTTTGAAAGAATTGGCTATAAGAACTCTAGGAACAAACTGGACTTGGAA
ACATTAACTGACATTCTTGAGCACCAGATCCGAGCTGTTCCCTTTGAGAACCTTAACATGCATT
GTGGGGAAACTATGGAGTTGGGCTTAGAGACTATTTTTGATCACATTGTAAGAAGAAACCGGGG
TGGATGGTGTCTCCAGGTCAATCAACTTCTGTACTGGGCTCTGACCACAATCGGTTTTCAGACC
ACAATGTTAGGAGGGTATGTTTACATCCCTGCAGCTAACAAATACAGCACTGGCATGATTCACC
TTCTCCTGCAGGTAACCATTGATGGCAGGAACTACATTGCTGATGCTGGGTTTGGAAGCTCCTC
CCAGATGTGGCAGCCTCTGGAATTAATTTCTGAGAAGGATCAGCCTCAGATGCCTTCCATTTTC
CGCTTGACAGAAGAGAAAGGAATCTGGTACCTGGACCAAATCAGAAGAGAGCAGTATATTCCAA
ACGCAGAATTTCTTAATTCTGATCTCCTGCCAAAGACGACACACCAAAAAGTGTACTCTTTTAC
GCTTGAACCTCGAAAAATTGAAGATTTTGAGTCTATTAATACATACCTGCAAACGTCTCCAACA
TCTGCATTTACAACCACATCATTTTGTTCCTTGCAGACCCCAGAAGGGGTTCACTGTTTGGTGG
GCTTCACCCTCACCTATAGAATATTCAATTATAAAGACAATACAGATCTGATCGAGTTTAAAAC
TCTGATTGAGGAAGAAGTTGAAGAAGTGCTGAAAAACATATTTAAGATTTCCTTGGCGAGAAAG
CTCGTGCCCAAACCTGGTAATGGATCCTTCACTATTTAGAATTAGGAACAAAATAAACCCTTAT
GTATGTATCACCCAACTCACTAATTATCAACTAATGTACAATCACATATCCTCTCTACCCTCAC
ATTATTTTGAAGAAAATCCTAGACATCAAATAGTTTCATCCATAAAATACCAGCATTTATTGAA
AAACAATAACCTTTTAAAGAAACATAAGGACACATTTTCAAATTGATAAAAATAAAGGCATTTT
AAGGATGGCATGTGATTATCTTGGGAAGCAGAGTGATTATGCTAGAAAACATTTAATATTGATT
TATTGTTGAATTTGTAGTAAGTTTTTACTGGTAAATGAATAAAGAATATTGTGGAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007959975	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000018061.1

RefSeq Acc Id:	XP_007959975 ⟸ XM_007961784
- UniProtKB:	A0A0D9SB22 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000018061 ⟸ ENSCSAT00000018612

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000018521	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000018612.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.2140.20	UniProtKB/TrEMBL
InterPro	Arylamine_N-AcTrfase	UniProtKB/TrEMBL
	Papain-like_cys_pep_sf	UniProtKB/TrEMBL
KEGG Report	csab:103215403	UniProtKB/TrEMBL
NCBI Gene	NAT2	ENTREZGENE
PANTHER	ARYLAMINE N-ACETYLTRANSFERASE 2	UniProtKB/TrEMBL
	PTHR11786	UniProtKB/TrEMBL
Pfam	Acetyltransf_2	UniProtKB/TrEMBL
PRINTS	ANATRNSFRASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54001	UniProtKB/TrEMBL
UniProt	A0A0D9SB22	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB