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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70492
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nat2
Name: N-acetyltransferase 2
Acc ID: CHEBI:102265
Term: sulfamethazine
Definition: A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.
Chemical ID: MESH:D013418
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nat2affects acetylationISONAT2 (Homo sapiens)6480464CTDNAT2 polymorphism affects the acetylation of SulfamethazinePMID:28516247
Nat2increases acetylationISONAT2 (Homo sapiens)6480464CTDNAT2 protein results in increased acetylation of SulfamethazinePMID:12222688 PMID:15627487 PMID:15880531 PMID:21317369
Nat2increases metabolic processingISONAT2 (Homo sapiens)6480464CTDNAT2 protein results in increased metabolism of SulfamethazinePMID:30358977
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